Protein: MC4R
Melanocortin receptor 4 (MC4-R)

Gene: MC4R
Organism: Homo sapiens
Interactions: 18
UniProt ID: P32245

Gene Ontology (top 5):
GO:0004977 - melanocortin receptor activity
GO:0004980 - melanocyte-stimulating hormone receptor activity
GO:0005737 - cytoplasm
GO:0005886 - plasma membrane
GO:0007188 - adenylate cyclase-modulating G protein-coupled receptor signaling pathway

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

377049

COLI
Pro-opiomelanocortin

2

3

Small-scale

0.778

High

733283

PDIA6
Protein disulfide-isomerase A6

1

4

High-throughput

0.698

High

733286

MRAP
Melanocortin-2 receptor accessory protein

1

9

Small-scale

0.618

High

733287

MRAP2
Melanocortin-2 receptor accessory protein 2

1

4

Small-scale

0.618

High

128581

AGRP
Agouti-related protein

2

0

Small-scale

0.577

High

178196

NPC1
NPC intracellular cholesterol transporter 1

1

9

High-throughput

0.541

High

252661

TSN3
Tetraspanin-3

1

16

High-throughput

0.541

High

636203

MAL
Myelin and lymphocyte protein

1

4

High-throughput

0.541

High

733281

CD81
CD81 antigen

1

13

High-throughput

0.541

High

733285

VA0E2
V-type proton ATPase subunit e 2

1

1

High-throughput

0.541

High

733288

TMM19
Transmembrane protein 19

1

1

High-throughput

0.541

High

733289

YIPF3
Protein YIPF3

1

4

High-throughput

0.541

High

733290

IL1AP
Interleukin-1 receptor accessory protein

1

4

High-throughput

0.541

High

733292

PLLP
Plasmolipin

1

4

High-throughput

0.541

High

733291

AIG1
Androgen-induced gene 1 protein

1

0

High-throughput

0.518

High

733282

TMM94
Transmembrane protein 94

1

1

High-throughput

0.494

High

733284

ATRN1
Attractin-like protein 1

1

4

Small-scale

0.481

High

244445

MGRN1
E3 ubiquitin-protein ligase MGRN1

1

2

Small-scale

0.479

High


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Last updated: 11Aug2025