Protein: MRAP2
Melanocortin-2 receptor accessory protein 2 (MC2R accessory protein 2)

Gene: MRAP2
Organism: Homo sapiens
Interactions: 102
UniProt ID: Q96G30

Gene Ontology (top 5):
GO:0005783 - endoplasmic reticulum
GO:0005789 - endoplasmic reticulum membrane
GO:0005886 - plasma membrane
GO:0006112 - energy reserve metabolic process
GO:0007631 - feeding behavior

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1032101

ACTHR
Adrenocorticotropic hormone receptor

2

4

Small-scale

0.793

High

141947

PODXL
Podocalyxin

3

0

High-throughput

0.634

High

1309868

TEX2
Testis-expressed protein 2

3

0

High-throughput

0.634

High

1391387

RDH14
Retinol dehydrogenase 14

3

0

High-throughput

0.634

High

522721

PTPRF
Receptor-type tyrosine-protein phosphatase F

2

2

High-throughput

0.628

High

641231

FGFR2
Fibroblast growth factor receptor 2

2

2

High-throughput

0.628

High

648628

FGFR4
Fibroblast growth factor receptor 4

2

3

High-throughput

0.628

High

690114

AVR2A
Activin receptor type-2A

2

5

High-throughput

0.628

High

787229

BMR1A
Bone morphogenetic protein receptor type-1A

2

5

High-throughput

0.628

High

787330

ACV1B
Activin receptor type-1B

2

5

High-throughput

0.628

High

931281

AT12A
Potassium-transporting ATPase alpha chain 2

2

1

High-throughput

0.628

High

931980

EPHB4
Ephrin type-B receptor 4

2

2

High-throughput

0.628

High

1048379

ACVR1
Activin receptor type-1

2

5

High-throughput

0.628

High

1102739

PTPRS
Receptor-type tyrosine-protein phosphatase S

2

2

High-throughput

0.628

High

1118382

BMPR2
Bone morphogenetic protein receptor type-2

2

5

High-throughput

0.628

High

1278303

LRP10
Low-density lipoprotein receptor-related protein 10

2

1

High-throughput

0.628

High

1307549

ZDH13
Palmitoyltransferase ZDHHC13

2

1

High-throughput

0.628

High

1334505

RN149
E3 ubiquitin-protein ligase RNF149

2

1

High-throughput

0.628

High

1391395

LRP12
Low-density lipoprotein receptor-related protein 12

2

1

High-throughput

0.628

High

1391397

KC1G3
Casein kinase I isoform gamma-3

2

1

High-throughput

0.628

High

733287

MC4R
Melanocortin receptor 4

1

4

Small-scale

0.618

High

749454

MC5R
Melanocortin receptor 5

1

4

Small-scale

0.618

High

837018

MC3R
Melanocortin receptor 3

1

4

Small-scale

0.618

High

1032112

MSHR
Melanocyte-stimulating hormone receptor

1

4

Small-scale

0.618

High

1391384

S2551
Mitochondrial nicotinamide adenine dinucleotide transporter SLC25A51

3

1

High-throughput

0.604

High

155493

C2C2L
Phospholipid transfer protein C2CD2L

2

0

High-throughput

0.602

High

226169

STX6
Syntaxin-6

2

0

High-throughput

0.602

High

846775

GRK6
G protein-coupled receptor kinase 6

2

0

High-throughput

0.602

High

935695

MFAP3
Microfibril-associated glycoprotein 3

2

0

High-throughput

0.602

High

1225904

STEA3
Metalloreductase STEAP3

2

0

High-throughput

0.602

High

1241108

C2D1A
Coiled-coil and C2 domain-containing protein 1A

2

0

High-throughput

0.602

High

1313219

PLPL6
Patatin-like phospholipase domain-containing protein 6

2

0

High-throughput

0.602

High

1349969

CERK1
Ceramide kinase

2

0

High-throughput

0.602

High

1384619

S67A1
Solute carrier family 67 member A1

2

0

High-throughput

0.602

High

1391377

MYADM
Myeloid-associated differentiation marker

2

0

High-throughput

0.602

High

1391380

NFIP1
NEDD4 family-interacting protein 1

2

0

High-throughput

0.602

High

1391389

ABCB6
ATP-binding cassette sub-family B member 6

2

0

High-throughput

0.602

High

1391390

CD320
CD320 antigen

2

0

High-throughput

0.602

High

1350278

MRAP
Melanocortin-2 receptor accessory protein

2

1

Small-scale

0.584

High

1249937

ISLR2
Immunoglobulin superfamily containing leucine-rich repeat protein 2

2

0

High-throughput

0.580

High

1384643

APH1A
Gamma-secretase subunit APH-1A

2

0

High-throughput

0.580

High

1391373

MRAP2
Melanocortin-2 receptor accessory protein 2

2

0

Small-scale

0.559

High

331911

GOSR1
Golgi SNAP receptor complex member 1

2

1

High-throughput

0.558

High

611284

PTN1
Tyrosine-protein phosphatase non-receptor type 1

1

3

High-throughput

0.536

High

658754

JAK1
Tyrosine-protein kinase JAK1

1

3

High-throughput

0.536

High

658921

PTPRD
Receptor-type tyrosine-protein phosphatase delta

1

2

High-throughput

0.536

High

710425

EPHA2
Ephrin type-A receptor 2

1

2

High-throughput

0.536

High

1006933

KC1G2
Casein kinase I isoform gamma-2

1

1

High-throughput

0.536

High

1055343

APLP2
Amyloid beta precursor like protein 2

1

1

High-throughput

0.536

High

1063006

DDR1
Epithelial discoidin domain-containing receptor 1

1

2

High-throughput

0.536

High

1116833

AVR2B
Activin receptor type-2B

1

5

High-throughput

0.536

High

1147407

EPHA7
Ephrin type-A receptor 7

1

3

High-throughput

0.536

High

1150465

NHRF2
Na(+)/H(+) exchange regulatory cofactor NHE-RF2

1

1

High-throughput

0.536

High

1391379

OSMR
Oncostatin-M-specific receptor subunit beta

1

3

High-throughput

0.536

High

1391392

ZNRF3
E3 ubiquitin-protein ligase ZNRF3

1

1

High-throughput

0.536

High

174043

AT2A1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1

1

0

High-throughput

0.513

High

253881

TPST2
Protein-tyrosine sulfotransferase 2

1

0

High-throughput

0.513

High

440675

FYN
Tyrosine-protein kinase Fyn

1

0

High-throughput

0.513

High

719736

HLAF
HLA class I histocompatibility antigen, alpha chain F

1

0

High-throughput

0.513

High

834686

TNFL9
Tumor necrosis factor ligand superfamily member 9

1

0

High-throughput

0.513

High

902000

RAB9A
Ras-related protein Rab-9A

1

0

High-throughput

0.513

High

1031494

IFM3
Interferon-induced transmembrane protein 3

1

0

High-throughput

0.513

High

1382477

PAQR1
Adiponectin receptor protein 1

1

0

High-throughput

0.513

High

1391378

PKP4
Plakophilin-4

1

0

High-throughput

0.513

High

1391382

ABCA2
ATP-binding cassette sub-family A member 2

1

0

High-throughput

0.513

High

422866

A4
Amyloid-beta precursor protein

1

1

High-throughput

0.501

High

1139024

SNX17
Sorting nexin-17

1

1

High-throughput

0.489

High

1391375

SNX27
Sorting nexin-27

1

2

High-throughput

0.489

High

633428

ANPRB
Atrial natriuretic peptide receptor 2

1

0

High-throughput

0.426

High

1324383

ABD12
Lysophosphatidylserine lipase ABHD12

1

0

High-throughput

0.426

High

1385185

SARAF
Store-operated calcium entry-associated regulatory factor

1

0

High-throughput

0.426

High

1391376

FRMD6
FERM domain-containing protein 6

1

0

High-throughput

0.426

High

1391393

MYO6
Unconventional myosin-VI

1

0

High-throughput

0.426

High

96854

E9PCW1
Golgi SNAP receptor complex member 1

1

1

High-throughput

0.407

High

671840

ZA2G
Zinc-alpha-2-glycoprotein

1

1

High-throughput

0.407

High

136535

GOLI4
Golgi integral membrane protein 4

2

0

High-throughput

0.328

High

227028

MCAT
Mitochondrial carnitine/acylcarnitine carrier protein

2

0

High-throughput

0.328

High

1162328

CEGT
Ceramide glucosyltransferase

2

0

High-throughput

0.328

High

1391381

CA043
Protein C1orf43

2

0

High-throughput

0.328

High

1391386

WDR41
WD repeat-containing protein 41

2

0

High-throughput

0.328

High

1391391

KDIS
Kinase D-interacting substrate of 220 kDa

2

0

High-throughput

0.328

High

1391394

UST
Uronyl 2-sulfotransferase

2

0

High-throughput

0.328

High

1391396

BIG2
Brefeldin A-inhibited guanine nucleotide-exchange protein 2

2

0

High-throughput

0.328

High

226855

SGTA
Small glutamine-rich tetratricopeptide repeat-containing protein alpha

2

0

High-throughput

0.316

High

1391374

TMM80
Transmembrane protein 80

2

0

High-throughput

0.316

High

249648

SNX3
Sorting nexin-3

1

0

High-throughput

0.279

Low

946184

MLF1
Myeloid leukemia factor 1

1

0

High-throughput

0.279

Low

1382743

ISOC2
Isochorismatase domain-containing protein 2

1

0

High-throughput

0.279

Low

1391385

PCX3
Pecanex-like protein 3

1

0

High-throughput

0.279

Low

660288

BDNF
Neurotrophic factor BDNF precursor form

1

0

High-throughput

0.268

Low

69531

A2ML1
Alpha-2-macroglobulin-like protein 1

1

0

High-throughput

0.232

Low

212087

B4GT5
Beta-1,4-galactosyltransferase 5

1

0

High-throughput

0.232

Low

485813

CATH
Pro-cathepsin H [Cleaved into: Cathepsin H mini chain; Cathepsin H

1

0

High-throughput

0.232

Low

839609

HUTH
Histidine ammonia-lyase

1

0

High-throughput

0.232

Low

892129

KLK7
Kallikrein-7

1

0

High-throughput

0.232

Low

1256975

FBX50
F-box only protein 50

1

0

High-throughput

0.232

Low

1272023

ARMX2
Armadillo repeat-containing X-linked protein 2

1

0

High-throughput

0.232

Low

1338059

DR9C7
Short-chain dehydrogenase/reductase family 9C member 7

1

0

High-throughput

0.232

Low

1358550

POF1B
Protein POF1B

1

0

High-throughput

0.232

Low

1391383

TOLIP
Toll-interacting protein

1

0

High-throughput

0.232

Low

1391388

S38AA
Solute carrier family 38 member 10

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025