Protein: IL1AP
Interleukin-1 receptor accessory protein (IL-1 receptor accessory protein) (IL-1RAcP) (EC 3.2.2.6) (Interleukin-1 receptor 3) (IL-1R-3) (IL-1R3)

Gene: IL1AP, IL1RAP
Organism: Homo sapiens
Interactions: 61
UniProt ID: Q9NPH3

Gene Ontology (top 5):
GO:0002114 - interleukin-33 receptor activity
GO:0004908 - interleukin-1 receptor activity
GO:0005576 - extracellular region
GO:0005886 - plasma membrane
GO:0006954 - inflammatory response

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

575765

IL1R1
Interleukin-1 receptor type 1

6

13

Small-scale

0.935

High

378579

IL1B
Interleukin-1 beta

2

11

Small-scale

0.767

High

905687

IRAK1
Interleukin-1 receptor-associated kinase 1

4

17

Small-scale

0.683

High

1031681

ILRL1
Interleukin-1 receptor-like 1

1

13

Small-scale

0.665

High

658934

PTPRD
Receptor-type tyrosine-protein phosphatase delta

1

10

Small-scale

0.647

High

1106470

IL18R
Interleukin-18 receptor 1

1

12

Small-scale

0.647

High

1407670

MYD88
Myeloid differentiation primary response protein MyD88

3

20

Small-scale

0.640

High

1446380

PCDGG
Protocadherin gamma-B4

2

1

High-throughput

0.628

High

1446381

PCDAC
Protocadherin alpha-12

2

1

High-throughput

0.628

High

1429853

TOLIP
Toll-interacting protein

2

9

Small-scale

0.620

High

845816

MUC18
Cell surface glycoprotein MUC18

1

15

High-throughput

0.618

High

1437925

ILRL2
Interleukin-1 receptor-like 2

1

13

Small-scale

0.618

High

1351535

HAVR2
Hepatitis A virus cellular receptor 2

2

0

High-throughput

0.602

High

988736

RAC1
Ras-related C3 botulinum toxin substrate 1

2

15

Small-scale

0.584

High

1446382

VSIG4
V-set and immunoglobulin domain-containing protein 4

1

13

High-throughput

0.575

High

1211672

MARH8
E3 ubiquitin-protein ligase MARCHF8

1

2

Small-scale

0.561

High

733290

MC4R
Melanocortin receptor 4

1

4

High-throughput

0.541

High

835761

KPCI
Protein kinase C iota type

1

8

High-throughput

0.541

High

911393

IMA5
Importin subunit alpha-5

1

0

High-throughput

0.518

High

344445

IL33
Interleukin-33

1

2

Small-scale

0.515

High

699579

IL1R2
Interleukin-1 receptor type 2

1

13

Small-scale

0.515

High

1294148

TCAM2
TIR domain-containing adapter molecule 2

1

7

Small-scale

0.515

High

190494

COPT1
High affinity copper uptake protein 1

1

0

High-throughput

0.513

High

260967

RAMP3
Receptor activity-modifying protein 3

1

0

High-throughput

0.513

High

1203803

TTMP
TPA-induced transmembrane protein

1

0

High-throughput

0.513

High

1315998

NRSN1
Neurensin-1

1

0

High-throughput

0.513

High

1333610

SIDT2
SID1 transmembrane family member 2

1

0

High-throughput

0.513

High

1399061

TMM74
Transmembrane protein 74

1

0

High-throughput

0.513

High

280829

PR40A
Pre-mRNA-processing factor 40 homolog A

1

2

High-throughput

0.508

High

1340817

COP1
E3 ubiquitin-protein ligase COP1

1

3

Small-scale

0.504

High

1446385

TRAF6
TNF receptor-associated factor 6

1

12

Small-scale

0.500

High

218816

TGON2
Trans-Golgi network integral membrane protein 2

1

3

High-throughput

0.479

High

466478

RHOC
Rho-related GTP-binding protein RhoC

1

16

High-throughput

0.479

High

827932

STAT3
Signal transducer and activator of transcription 3

1

7

Small-scale

0.479

High

877428

PK3CG
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform

1

7

Small-scale

0.479

High

978326

RHOB
Rho-related GTP-binding protein RhoB

1

16

High-throughput

0.479

High

1208896

H2B2F
Histone H2B type 2-F

1

2

High-throughput

0.470

High

1094985

TRAF3
TNF receptor-associated factor 3

1

13

Small-scale

0.457

High

73857

C1T9B
Complement C1q and tumor necrosis factor-related protein 9B

1

3

High-throughput

0.445

High

139328

UPK2
Uroplakin-2

1

1

High-throughput

0.445

High

255225

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

1

High-throughput

0.445

High

457723

TBB5
Tubulin beta chain

1

7

High-throughput

0.445

High

669366

ACKR3
Atypical chemokine receptor 3

1

2

High-throughput

0.445

High

839093

PK3CA
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

1

7

High-throughput

0.445

High

948939

CD81
CD81 antigen

1

4

High-throughput

0.445

High

976863

LCN6
Epididymal-specific lipocalin-6

1

1

High-throughput

0.445

High

1010108

DLK1
Protein delta homolog 1

1

16

High-throughput

0.445

High

1065031

FGL1
Fibrinogen-like protein 1

1

7

High-throughput

0.445

High

1119320

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

2

High-throughput

0.445

High

1273809

NIPA1
Magnesium transporter NIPA1

1

1

High-throughput

0.445

High

1397991

MF14A
Hippocampus abundant transcript 1 protein

1

4

High-throughput

0.445

High

1446386

SRPRB
Signal recognition particle receptor subunit beta

1

9

High-throughput

0.445

High

971131

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

2

High-throughput

0.437

High

1153923

SMAD2
Mothers against decapentaplegic homolog 2

1

2

High-throughput

0.437

High

1255659

TRI67
Tripartite motif-containing protein 67

1

9

High-throughput

0.437

High

1446384

TMED7
Transmembrane emp24 domain-containing protein 7

1

4

Small-scale

0.437

High

1399620

OPALI
Opalin

1

0

High-throughput

0.426

High

1446383

TMED5
Transmembrane emp24 domain-containing protein 5

1

4

High-throughput

0.407

High

1120142

CCNI
Cyclin-I

1

0

High-throughput

0.282

High

1286621

GLT10
Polypeptide N-acetylgalactosaminyltransferase 10

1

0

High-throughput

0.279

Low

294372

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025