HitPredict
Protein: GRHL2
Grainyhead-like protein 2 homolog (Brother of mammalian grainyhead) (Transcription factor CP2-like 3)

Gene: GRHL2
Organism: Homo sapiens
Interactions: 17
UniProt ID: Q6ISB3

Gene Ontology (top 5):
GO:0000785 - chromatin
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001161 - intronic transcription regulatory region sequence-specific DNA binding
GO:0001216 - DNA-binding transcription activator activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score		 Confidence

1235222

 GRHL1
Grainyhead-like protein 1 homolog

4

16

Small-scale

 0.884

High

965473

 LMO4
LIM domain transcription factor LMO4

4

1

High-throughput

 0.698

High

1235220

 GRHL3
Grainyhead-like protein 3 homolog

1

16

Small-scale

 0.680

High

1235219

 GRHL2
Grainyhead-like protein 2 homolog

1

15

Small-scale

 0.653

High

297824

 PIAS2
E3 SUMO-protein ligase PIAS2

2

1

High-throughput

 0.606

High

685229

 PAX6
Paired box protein Pax-6

2

3

High-throughput

 0.606

High

1037722

 PAX5
Paired box protein Pax-5

2

3

High-throughput

 0.606

High

520132

 ANDR
Androgen receptor

2

13

High-throughput

 0.584

High

442364

 GELS
Gelsolin

2

1

High-throughput

 0.533

High

422332

 A4
Amyloid-beta precursor protein

1

0

High-throughput

 0.480

High

129180

 MEN1
Menin

1

1

High-throughput

 0.479

High

396321

 ESR1
Estrogen receptor

1

13

High-throughput

 0.479

High

655235

 SFPQ
Splicing factor, proline- and glutamine-rich

1

4

High-throughput

 0.479

High

937785

 FOXA1
Hepatocyte nuclear factor 3-alpha

1

8

High-throughput

 0.479

High

1235221

 ESR2
Estrogen receptor beta

1

13

High-throughput

 0.479

High

548511

 MPRI
Cation-independent mannose-6-phosphate receptor

1

0

High-throughput

 0.458

High

Service provided by Combinatics, Japan

Last updated: 11Aug2025