Protein: GRHL1
Grainyhead-like protein 1 homolog (Mammalian grainyhead) (NH32) (Transcription factor CP2-like 2) (Transcription factor LBP-32)

Gene: GRHL1
Organism: Homo sapiens
Interactions: 136
UniProt ID: Q9NZI5

Gene Ontology (top 5):
GO:0000785 - chromatin
GO:0000976 - transcription cis-regulatory region binding
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001228 - DNA-binding transcription activator activity, RNA polymerase II-specific

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1235222

GRHL2
Grainyhead-like protein 2 homolog

4

16

Small-scale

0.884

High

1352201

GRHL3
Grainyhead-like protein 3 homolog

1

15

Small-scale

0.680

High

1453265

GRHL1
Grainyhead-like protein 1 homolog

1

15

Small-scale

0.653

High

783761

ZNF76
Zinc finger protein 76

2

2

High-throughput

0.628

High

1086332

TFCP2
Alpha-globin transcription factor CP2

1

14

High-throughput

0.575

High

1453266

UBIP1
Upstream-binding protein 1

1

15

High-throughput

0.575

High

1447637

SAS10
Something about silencing protein 10

1

0

High-throughput

0.493

High

520411

ANDR
Androgen receptor

1

13

High-throughput

0.479

High

161517

KMT2D
Histone-lysine N-methyltransferase 2D

1

4

High-throughput

0.445

High

173475

XPO1
Exportin-1

1

3

High-throughput

0.445

High

176311

ZBT39
Zinc finger and BTB domain-containing protein 39

1

1

High-throughput

0.445

High

186079

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

2

High-throughput

0.445

High

194619

KDM6A
Lysine-specific demethylase 6A

1

2

High-throughput

0.445

High

216995

KLF4
Krueppel-like factor 4

1

4

High-throughput

0.445

High

246994

KDM1A
Lysine-specific histone demethylase 1A

1

3

High-throughput

0.445

High

334590

ZBT7A
Zinc finger and BTB domain-containing protein 7A

1

7

High-throughput

0.445

High

373340

MYC
Myc proto-oncogene protein

1

1

High-throughput

0.445

High

535609

BIP
Endoplasmic reticulum chaperone BiP

1

5

High-throughput

0.445

High

542676

TOP2A
DNA topoisomerase 2-alpha

1

1

High-throughput

0.445

High

600386

ZNF24
Zinc finger protein 24

1

3

High-throughput

0.445

High

600448

ZKSC1
Zinc finger protein with KRAB and SCAN domains 1

1

2

High-throughput

0.445

High

617747

XRCC1
DNA repair protein XRCC1

1

1

High-throughput

0.445

High

629500

PO3F3
POU domain, class 3, transcription factor 3

1

7

High-throughput

0.445

High

629514

PO3F2
POU domain, class 3, transcription factor 2

1

7

High-throughput

0.445

High

662509

GATA2
Endothelial transcription factor GATA-2

1

1

High-throughput

0.445

High

696710

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

2

High-throughput

0.445

High

724948

HXA10
Homeobox protein Hox-A10

1

3

High-throughput

0.445

High

775347

FUS
RNA-binding protein FUS

1

3

High-throughput

0.445

High

814878

CUX1
Homeobox protein cut-like 1

1

5

High-throughput

0.445

High

879550

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

4

High-throughput

0.445

High

892636

DNLI3
DNA ligase 3

1

2

High-throughput

0.445

High

926424

BLM
RecQ-like DNA helicase BLM

1

6

High-throughput

0.445

High

926691

HIRA
Protein HIRA

1

2

High-throughput

0.445

High

937358

DSRAD
Double-stranded RNA-specific adenosine deaminase

1

1

High-throughput

0.445

High

939910

DLX6
Homeobox protein DLX-6

1

3

High-throughput

0.445

High

940423

MAZ
Myc-associated zinc finger protein

1

1

High-throughput

0.445

High

941585

CTBP2
C-terminal-binding protein 2

1

2

High-throughput

0.445

High

944754

KLF3
Krueppel-like factor 3

1

4

High-throughput

0.445

High

965286

WDR5
WD repeat-containing protein 5

1

1

High-throughput

0.445

High

977395

RS4X
Small ribosomal subunit protein eS4, X isoform

1

1

High-throughput

0.445

High

981145

H2B1C
Histone H2B type 1-C/E/F/G/I

1

2

High-throughput

0.445

High

1029958

RUNX1
Runt-related transcription factor 1

1

1

High-throughput

0.445

High

1036865

SP4
Transcription factor Sp4

1

1

High-throughput

0.445

High

1036904

SP3
Transcription factor Sp3

1

2

High-throughput

0.445

High

1039578

TOP2B
DNA topoisomerase 2-beta

1

2

High-throughput

0.445

High

1040227

M2OM
Mitochondrial 2-oxoglutarate/malate carrier protein

1

6

High-throughput

0.445

High

1060018

DLX2
Homeobox protein DLX-2

1

3

High-throughput

0.445

High

1097599

CBX3
Chromobox protein homolog 3

1

1

High-throughput

0.445

High

1102669

MTA1
Metastasis-associated protein MTA1

1

5

High-throughput

0.445

High

1103416

CTBP1
C-terminal-binding protein 1

1

2

High-throughput

0.445

High

1119464

CASP
Protein CASP

1

5

High-throughput

0.445

High

1122959

WRN
Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN

1

5

High-throughput

0.445

High

1127707

HIC1
Hypermethylated in cancer 1 protein

1

1

High-throughput

0.445

High

1134069

ZN638
Zinc finger protein 638

1

1

High-throughput

0.445

High

1141426

WDR43
WD repeat-containing protein 43

1

2

High-throughput

0.445

High

1143288

PLEC
Plectin

1

5

High-throughput

0.445

High

1145546

RBBP5
Retinoblastoma-binding protein 5

1

3

High-throughput

0.445

High

1146851

PCBP1
Poly(rC)-binding protein 1

1

3

High-throughput

0.445

High

1238136

HMBX1
Homeobox-containing protein 1

1

5

High-throughput

0.445

High

1241515

EDC4
Enhancer of mRNA-decapping protein 4

1

4

High-throughput

0.445

High

1247637

SAMD1
Sterile alpha motif domain-containing protein 1

1

5

High-throughput

0.445

High

1275344

APTX
Aprataxin

1

4

High-throughput

0.445

High

1275726

ZCCHV
Zinc finger CCCH-type antiviral protein 1

1

3

High-throughput

0.445

High

1288849

ZFHX4
Zinc finger homeobox protein 4

1

2

High-throughput

0.445

High

1295315

P66A
Transcriptional repressor p66-alpha

1

4

High-throughput

0.445

High

1309376

ARI3B
AT-rich interactive domain-containing protein 3B

1

2

High-throughput

0.445

High

1314881

FANCM
Fanconi anemia group M protein

1

7

High-throughput

0.445

High

1338278

KMT2C
Histone-lysine N-methyltransferase 2C

1

5

High-throughput

0.445

High

1353696

ZN384
Zinc finger protein 384

1

1

High-throughput

0.445

High

1365817

ZN516
Zinc finger protein 516

1

1

High-throughput

0.445

High

1368010

RREB1
Ras-responsive element-binding protein 1

1

1

High-throughput

0.445

High

1380980

LMBL2
Lethal(3)malignant brain tumor-like protein 2

1

2

High-throughput

0.445

High

1387854

ZBT10
Zinc finger and BTB domain-containing protein 10

1

6

High-throughput

0.445

High

1395253

LMBL3
Lethal(3)malignant brain tumor-like protein 3

1

4

High-throughput

0.445

High

1404810

RING2
E3 ubiquitin-protein ligase RING2

1

7

High-throughput

0.445

High

1414871

WDR18
WD repeat-containing protein 18

1

3

High-throughput

0.445

High

1430396

DDX47
Probable ATP-dependent RNA helicase DDX47

1

3

High-throughput

0.445

High

1446885

TF7L2
Transcription factor 7-like 2

1

2

High-throughput

0.445

High

1447293

PRD10
PR domain zinc finger protein 10

1

1

High-throughput

0.445

High

1448635

BAZ1A
Bromodomain adjacent to zinc finger domain protein 1A

1

3

High-throughput

0.445

High

1449303

SALL1
Sal-like protein 1

1

6

High-throughput

0.445

High

1449643

ZF64B
Zinc finger protein 64

1

1

High-throughput

0.445

High

1453268

HM20B
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related

1

1

High-throughput

0.445

High

1453269

CHD7
Chromodomain-helicase-DNA-binding protein 7

1

3

High-throughput

0.445

High

1453270

ASH2L
Set1/Ash2 histone methyltransferase complex subunit ASH2

1

3

High-throughput

0.445

High

1453271

DIC
Mitochondrial dicarboxylate carrier

1

6

High-throughput

0.445

High

1453272

PARP2
Poly [ADP-ribose] polymerase 2

1

2

High-throughput

0.445

High

1453273

TRPS1
Zinc finger transcription factor Trps1

1

1

High-throughput

0.445

High

1453276

RCOR1
REST corepressor 1

1

5

High-throughput

0.445

High

1453277

TTF2
Transcription termination factor 2

1

5

High-throughput

0.445

High

1453278

SATB2
DNA-binding protein SATB2

1

1

High-throughput

0.445

High

1453279

ZN148
Zinc finger protein 148

1

2

High-throughput

0.445

High

1453280

RUVB2
RuvB-like 2

1

4

High-throughput

0.445

High

1453281

RUVB1
RuvB-like 1

1

4

High-throughput

0.445

High

1453282

ZN281
Zinc finger protein 281

1

2

High-throughput

0.445

High

1453284

TRRAP
Transformation/transcription domain-associated protein

1

3

High-throughput

0.445

High

1453285

ZSC21
Zinc finger and SCAN domain-containing protein 21

1

3

High-throughput

0.445

High

134396

RPOM
DNA-directed RNA polymerase, mitochondrial

1

0

High-throughput

0.426

High

155363

CDKA1
Cyclin-dependent kinase 2-associated protein 1

1

0

High-throughput

0.426

High

167020

MGST3
Glutathione S-transferase 3, mitochondrial

1

0

High-throughput

0.426

High

257986

DKC1
H/ACA ribonucleoprotein complex subunit DKC1

1

0

High-throughput

0.426

High

274250

ANR17
Ankyrin repeat domain-containing protein 17

1

0

High-throughput

0.426

High

285730

BAF
Barrier-to-autointegration factor

1

0

High-throughput

0.426

High

349266

LATS1
Serine/threonine-protein kinase LATS1

1

0

High-throughput

0.426

High

447521

NPM
Nucleophosmin

1

0

High-throughput

0.426

High

769369

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.426

High

823866

PBX1
Pre-B-cell leukemia transcription factor 1

1

0

High-throughput

0.426

High

895117

EMD
Emerin

1

0

High-throughput

0.426

High

902620

RT29
Small ribosomal subunit protein mS29

1

0

High-throughput

0.426

High

979311

RS6
Small ribosomal subunit protein eS6

1

0

High-throughput

0.426

High

1048736

SSBP
Single-stranded DNA-binding protein, mitochondrial

1

0

High-throughput

0.426

High

1054802

SUH
Recombining binding protein suppressor of hairless

1

0

High-throughput

0.426

High

1180510

C19L2
CWF19-like protein 2

1

0

High-throughput

0.426

High

1213153

BEND3
BEN domain-containing protein 3

1

0

High-throughput

0.426

High

1243591

RSBNL
Lysine-specific demethylase RSBN1L

1

0

High-throughput

0.426

High

1252842

NFXL1
NF-X1-type zinc finger protein NFXL1

1

0

High-throughput

0.426

High

1275509

TRM1L
tRNA

1

0

High-throughput

0.426

High

1406269

KIF2C
Kinesin-like protein KIF2C

1

0

High-throughput

0.426

High

533021

CH60
60 kDa heat shock protein, mitochondrial

1

1

High-throughput

0.407

High

801565

HSPA9
Stress-70 protein, mitochondrial

1

7

High-throughput

0.407

High

829576

ECHA
Trifunctional enzyme subunit alpha, mitochondrial

1

1

High-throughput

0.407

High

1024482

S25A3
Solute carrier family 25 member 3

1

5

High-throughput

0.407

High

1124560

MAP7
Ensconsin

1

2

High-throughput

0.407

High

1201080

ACTBL
Beta-actin-like protein 2

1

6

High-throughput

0.407

High

1288808

KTN1
Kinectin

1

3

High-throughput

0.407

High

1326449

MINK1
Misshapen-like kinase 1

1

1

High-throughput

0.407

High

1453275

S2513
Electrogenic aspartate/glutamate antiporter SLC25A13, mitochondrial

1

4

High-throughput

0.407

High

1453283

RL36
Large ribosomal subunit protein eL36

1

1

High-throughput

0.407

High

289042

ERAL1
GTPase Era, mitochondrial

1

0

High-throughput

0.232

Low

903816

SSRD
Translocon-associated protein subunit delta

1

0

High-throughput

0.232

Low

1401818

PEO1
Twinkle mtDNA helicase

1

0

High-throughput

0.232

Low

1430447

MAGT1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit MAGT1

1

0

High-throughput

0.232

Low

1432593

CPVL
Probable serine carboxypeptidase CPVL

1

0

High-throughput

0.232

Low

1453267

CRIPT
Cysteine-rich PDZ-binding protein

1

0

High-throughput

0.232

Low

1453274

DPOG2
DNA polymerase subunit gamma-2

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025