Protein: IF2G
Eukaryotic translation initiation factor 2 subunit gamma (eIF2-gamma) (EC 3.6.5.3)

Gene: IF2G, GCD11
Organism: Saccharomyces cerevisiae S288C
Interactions: 172
UniProt ID: P32481

Gene Ontology (top 5):
GO:0001731 - formation of translation preinitiation complex
GO:0003743 - translation initiation factor activity
GO:0003924 - GTPase activity
GO:0005525 - GTP binding
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

593826

IF2A
Eukaryotic translation initiation factor 2 subunit alpha

14

8

Small-scale

0.986

High

447168

IF2B
Eukaryotic translation initiation factor 2 subunit beta

14

6

Small-scale

0.984

High

690917

IF5
Eukaryotic translation initiation factor 5

10

10

Small-scale

0.975

High

690978

CD123
Translation initiation factor eIF2 assembly protein

9

2

Small-scale

0.876

High

690931

IF2P
Eukaryotic translation initiation factor 5B

2

14

Small-scale

0.776

High

446976

EI2BG
Translation initiation factor eIF2B subunit gamma

9

8

Small-scale

0.757

High

690896

EI2BE
Translation initiation factor eIF2B subunit epsilon

9

8

Small-scale

0.752

High

690897

EI2BB
Translation initiation factor eIF2B subunit beta

8

7

Small-scale

0.749

High

521176

EI2BD
Translation initiation factor eIF2B subunit delta

6

7

Small-scale

0.732

High

690914

EIF3A
Eukaryotic translation initiation factor 3 subunit A

5

5

Small-scale

0.709

High

539960

EI2BA
Translation initiation factor eIF2B subunit alpha

4

7

High-throughput

0.697

High

690895

EIF3C
Eukaryotic translation initiation factor 3 subunit C

4

4

High-throughput

0.694

High

690893

IF2G
Eukaryotic translation initiation factor 2 subunit gamma

1

10

High-throughput

0.665

High

410092

EIF3B
Eukaryotic translation initiation factor 3 subunit B

3

4

Small-scale

0.650

High

644978

RL16A
Large ribosomal subunit protein uL13A

2

5

High-throughput

0.611

High

690973

EIF3G
Eukaryotic translation initiation factor 3 subunit G

2

13

Small-scale

0.611

High

690901

PP12
Serine/threonine-protein phosphatase PP1-2

3

3

Small-scale

0.599

High

690913

LSM2
U6 snRNA-associated Sm-like protein LSm2

1

2

High-throughput

0.587

High

510619

SSB1
Ribosome-associated molecular chaperone SSB1

2

8

High-throughput

0.584

High

680529

HS104
Heat shock protein 104

2

8

High-throughput

0.584

High

690903

RSSA1
Small ribosomal subunit protein uS2A

2

9

Small-scale

0.584

High

690944

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

2

16

High-throughput

0.584

High

367856

EF1A
Elongation factor 1-alpha

1

8

High-throughput

0.575

High

690934

LSM5
U6 snRNA-associated Sm-like protein LSm5

1

0

High-throughput

0.549

High

406115

RL36A
Large ribosomal subunit protein eL36A

1

3

High-throughput

0.536

High

613655

RS3A2
Small ribosomal subunit protein eS1B

1

7

High-throughput

0.536

High

667135

RL8B
Large ribosomal subunit protein eL8B

1

3

High-throughput

0.536

High

690916

ATG12
Ubiquitin-like protein ATG12

1

1

High-throughput

0.536

High

690924

DMA1
E3 ubiquitin-protein ligase DMA1

1

1

High-throughput

0.536

High

690927

TEM1
Protein TEM1

1

3

High-throughput

0.536

High

690957

BRE5
UBP3-associated protein BRE5

1

4

High-throughput

0.536

High

690965

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

1

6

High-throughput

0.536

High

690969

GCN5
Histone acetyltransferase GCN5

1

6

High-throughput

0.536

High

690997

RL11B
Large ribosomal subunit protein uL5B

1

5

High-throughput

0.536

High

690998

RS22B
Small ribosomal subunit protein uS8B

1

4

High-throughput

0.536

High

690963

H3
Histone H3

2

5

High-throughput

0.521

High

419459

PDE2
3',5'-cyclic-nucleotide phosphodiesterase 2

1

1

High-throughput

0.515

High

627818

SIS1
Protein SIS1

1

8

High-throughput

0.515

High

629260

HAL4
Serine/threonine-protein kinase HAL4/SAT4

1

5

High-throughput

0.515

High

690951

SGF73
SAGA-associated factor 73

1

0

High-throughput

0.513

High

412688

KAPA
cAMP-dependent protein kinase type 1

1

11

Small-scale

0.501

High

605951

RAD53
Serine/threonine-protein kinase RAD53

1

1

Small-scale

0.501

High

690970

PKH1
Serine/threonine-protein kinase PKH1

1

10

Small-scale

0.501

High

410952

PDC1
Pyruvate decarboxylase isozyme 1

1

3

High-throughput

0.500

High

429663

RPAC1
DNA-directed RNA polymerases I and III subunit RPAC1

1

3

High-throughput

0.489

High

579407

GBB
Guanine nucleotide-binding protein subunit beta

1

11

High-throughput

0.489

High

604517

RPA2
DNA-directed RNA polymerase I subunit RPA135

1

6

High-throughput

0.489

High

644739

RFA2
Replication factor A protein 2

1

6

High-throughput

0.489

High

657719

YJU2
Splicing factor YJU2

1

1

High-throughput

0.489

High

675887

XPO1
Exportin-1

1

10

High-throughput

0.489

High

690912

TAF5
Transcription initiation factor TFIID subunit 5

1

11

High-throughput

0.489

High

690953

FMP48
Probable serine/threonine-protein kinase FMP48

1

9

High-throughput

0.489

High

690977

TAF9
Transcription initiation factor TFIID subunit 9

1

1

High-throughput

0.489

High

690993

RAD59
DNA repair protein RAD59

1

1

High-throughput

0.489

High

342686

ENO1
Enolase 1

1

0

High-throughput

0.479

High

404314

METE
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase

1

0

High-throughput

0.479

High

690932

SAHH
Adenosylhomocysteinase

1

0

High-throughput

0.479

High

141219

RS9A
Small ribosomal subunit protein uS4A

1

2

High-throughput

0.479

High

357948

RS17A
Small ribosomal subunit protein eS17A

1

3

High-throughput

0.479

High

365983

HSP82
ATP-dependent molecular chaperone HSP82

1

11

High-throughput

0.479

High

383015

RL25
Large ribosomal subunit protein uL23

1

3

High-throughput

0.479

High

405499

RL26A
Large ribosomal subunit protein uL24A

1

6

High-throughput

0.479

High

406885

RS3
Small ribosomal subunit protein uS3

1

7

High-throughput

0.479

High

407798

RS13
Small ribosomal subunit protein uS15

1

3

High-throughput

0.479

High

408302

RS31
Ubiquitin-ribosomal protein eS31 fusion protein [Cleaved into: Ubiquitin; Small ribosomal subunit protein eS31

1

8

High-throughput

0.479

High

413377

RS14A
Small ribosomal subunit protein uS11A

1

4

High-throughput

0.479

High

425826

RS19A
Small ribosomal subunit protein eS19A

1

3

High-throughput

0.479

High

470929

RS22A
Small ribosomal subunit protein uS8A

1

4

High-throughput

0.479

High

472081

RL31A
Large ribosomal subunit protein eL31A

1

3

High-throughput

0.479

High

479986

RS6A
Small ribosomal subunit protein eS6A

1

4

High-throughput

0.479

High

480549

RS8A
Small ribosomal subunit protein eS8A

1

4

High-throughput

0.479

High

481483

RS11B
Small ribosomal subunit protein uS17B

1

5

High-throughput

0.479

High

481877

RL12B
Large ribosomal subunit protein uL11B

1

2

High-throughput

0.479

High

482144

RS18A
Small ribosomal subunit protein uS13A

1

3

High-throughput

0.479

High

524223

CAF20
Cap-associated protein CAF20

1

1

Small-scale

0.479

High

543392

HSC82
ATP-dependent molecular chaperone HSC82

1

11

High-throughput

0.479

High

615244

IF5A1
Eukaryotic translation initiation factor 5A-1

1

1

Small-scale

0.479

High

631740

RS2
Small ribosomal subunit protein uS5

1

7

High-throughput

0.479

High

645322

RS7A
Small ribosomal subunit protein eS7A

1

3

High-throughput

0.479

High

690907

RS3A1
Small ribosomal subunit protein eS1A

1

7

High-throughput

0.479

High

690909

RS27A
Small ribosomal subunit protein eS27A

1

7

High-throughput

0.479

High

690911

GBLP
Small ribosomal subunit protein RACK1

1

14

High-throughput

0.479

High

690919

RS20
Small ribosomal subunit protein uS10

1

4

High-throughput

0.479

High

690925

RPN10
26S proteasome regulatory subunit RPN10

1

1

High-throughput

0.479

High

690930

LAA1
AP-1 accessory protein LAA1

1

2

High-throughput

0.479

High

690937

EIF3I
Eukaryotic translation initiation factor 3 subunit I

1

13

Small-scale

0.479

High

690939

RL34B
Large ribosomal subunit protein eL34B

1

2

High-throughput

0.479

High

690949

RS12
Small ribosomal subunit protein eS12

1

4

High-throughput

0.479

High

690954

EIF2A
Eukaryotic translation initiation factor 2A

1

4

High-throughput

0.479

High

690960

UBP10
Ubiquitin carboxyl-terminal hydrolase 10

1

7

High-throughput

0.479

High

690966

RS15
Small ribosomal subunit protein uS19

1

3

High-throughput

0.479

High

690986

RS10A
Small ribosomal subunit protein eS10A

1

1

High-throughput

0.479

High

690900

STH1
Nuclear protein STH1/NPS1

1

5

High-throughput

0.470

High

690902

RT04
Small ribosomal subunit protein uS2m

1

9

High-throughput

0.470

High

690988

TMA46
Translation machinery-associated protein 46

1

0

High-throughput

0.458

High

515171

SCH9
Serine/threonine-protein kinase SCH9

1

8

Small-scale

0.457

High

424403

PYR1
Multifunctional protein URA2

1

6

High-throughput

0.445

High

490649

HSP71
Heat shock protein SSA1

1

8

High-throughput

0.445

High

534914

RL3
Large ribosomal subunit protein uL3

1

3

High-throughput

0.445

High

633043

MAS5
Mitochondrial protein import protein MAS5

1

9

High-throughput

0.445

High

690898

HSP7F
Heat shock protein homolog SSE1

1

12

High-throughput

0.445

High

690899

HSP79
Heat shock protein homolog SSE2

1

12

High-throughput

0.445

High

690921

RL14B
Large ribosomal subunit protein eL14B

1

3

High-throughput

0.445

High

690935

SSB2
Ribosome-associated molecular chaperone SSB2

1

8

High-throughput

0.445

High

690936

RL13B
Large ribosomal subunit protein eL13B

1

3

High-throughput

0.445

High

690941

RL10
Large ribosomal subunit protein uL16

1

3

High-throughput

0.445

High

690946

RSSA2
Small ribosomal subunit protein uS2B

1

9

High-throughput

0.445

High

690961

APJ1
J domain-containing protein APJ1

1

10

High-throughput

0.445

High

690991

RIO1
Serine/threonine-protein kinase RIO1

1

3

High-throughput

0.445

High

690992

RL7B
Large ribosomal subunit protein uL30B

1

4

High-throughput

0.445

High

690906

XPOT
Exportin-T

1

11

Small-scale

0.439

High

410335

SC160
Protein SCP160

1

10

High-throughput

0.437

High

606584

RPC2
DNA-directed RNA polymerase III subunit RPC2

1

6

High-throughput

0.437

High

634526

KRR1
KRR1 small subunit processome component

1

2

High-throughput

0.437

High

661638

TF2B
Transcription initiation factor IIB

1

3

High-throughput

0.437

High

664701

BMH1
Protein BMH1

1

6

High-throughput

0.437

High

690894

HOG1
Mitogen-activated protein kinase HOG1

1

15

High-throughput

0.437

High

690904

PRS6A
26S proteasome regulatory subunit 6A

1

1

High-throughput

0.437

High

690918

RCK1
Serine/threonine-protein kinase RCK1

1

6

High-throughput

0.437

High

690922

RPN1
26S proteasome regulatory subunit RPN1

1

3

High-throughput

0.437

High

690928

DHH1
ATP-dependent RNA helicase DHH1

1

7

High-throughput

0.437

High

690938

TM108
Protein TMA108

1

1

High-throughput

0.437

High

690940

DSN1
Kinetochore-associated protein DSN1

1

1

High-throughput

0.437

High

690943

UTP10
U3 small nucleolar RNA-associated protein 10

1

1

High-throughput

0.437

High

690956

COPA
Coatomer subunit alpha

1

5

High-throughput

0.437

High

690959

GIS2
Zinc finger protein GIS2

1

3

High-throughput

0.437

High

690962

SAM50
Sorting assembly machinery 50 kDa subunit

1

1

High-throughput

0.437

High

690964

NUM1
Nuclear migration protein NUM1

1

6

High-throughput

0.437

High

690968

TOM1
E3 ubiquitin-protein ligase TOM1

1

7

High-throughput

0.437

High

690971

FIN1
Filament protein FIN1

1

1

Small-scale

0.437

High

690972

RUVB1
RuvB-like protein 1

1

2

High-throughput

0.437

High

690974

DHR1
Probable ATP-dependent RNA helicase DHR1

1

9

High-throughput

0.437

High

690980

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

1

High-throughput

0.437

High

690982

IRC20
Uncharacterized ATP-dependent helicase IRC20

1

6

Small-scale

0.437

High

690983

VAM6
Vacuolar morphogenesis protein 6

1

1

High-throughput

0.437

High

690984

SGO1
Shugoshin

1

1

High-throughput

0.437

High

690985

ESA1
Histone acetyltransferase ESA1

1

1

Small-scale

0.437

High

690987

AP3D
AP-3 complex subunit delta

1

3

High-throughput

0.437

High

690990

RRP6
Exosome complex exonuclease RRP6

1

2

High-throughput

0.437

High

690995

CMR1
DNA damage-binding protein CMR1

1

10

High-throughput

0.437

High

360799

TBB
Tubulin beta chain

1

0

High-throughput

0.426

High

501338

RPA1
DNA-directed RNA polymerase I subunit RPA190

1

1

High-throughput

0.407

High

555896

VATB
V-type proton ATPase subunit B

1

3

High-throughput

0.407

High

628936

SCJ1
DnaJ-related protein SCJ1

1

6

High-throughput

0.407

High

690905

HSP78
Heat shock protein 78, mitochondrial

1

9

High-throughput

0.407

High

690908

SPT7
Transcriptional activator SPT7

1

9

High-throughput

0.407

High

690910

LHS1
Heat shock protein 70 homolog LHS1

1

9

High-throughput

0.407

High

690915

MKAR
Very-long-chain 3-oxoacyl-CoA reductase

1

1

High-throughput

0.407

High

690923

SSZ1
Ribosome-associated complex subunit SSZ1

1

5

High-throughput

0.407

High

690933

HSP7E
Heat shock protein SSC3, mitochondrial

1

11

High-throughput

0.407

High

690945

ERJ5
ER-localized J domain-containing protein 5

1

5

High-throughput

0.407

High

690947

JJJ2
J protein JJJ2

1

3

High-throughput

0.407

High

690948

TCPQ
T-complex protein 1 subunit theta

1

2

High-throughput

0.407

High

690950

UBP8
Ubiquitin carboxyl-terminal hydrolase 8

1

1

High-throughput

0.407

High

690952

YG1A
Uncharacterized membrane protein YGR016W

1

1

High-throughput

0.407

High

690955

UTP22
U3 small nucleolar RNA-associated protein 22

1

1

High-throughput

0.407

High

690976

RRP5
rRNA biogenesis protein RRP5

1

5

High-throughput

0.407

High

690979

HSP7Q
Iron-sulfur cluster biogenesis chaperone, mitochondrial

1

16

High-throughput

0.407

High

690989

HFI1
Transcriptional coactivator HFI1/ADA1

1

1

High-throughput

0.407

High

690994

HSP42
Heat shock protein 42

1

3

High-throughput

0.407

High

356328

H4
Histone H4

3

0

High-throughput

0.325

High

633837

SGF29
SAGA-associated factor 29

2

0

Small-scale

0.318

High

690975

SPC24
Kinetochore protein SPC24

1

0

High-throughput

0.279

Low

690958

ESF2
Pre-rRNA-processing protein ESF2

1

0

High-throughput

0.269

Low

690920

OTU2
OTU domain-containing protein 2

1

0

Small-scale

0.249

Low

690942

GLC8
Protein GLC8

1

0

High-throughput

0.249

Low

690967

ESP1
Separin

1

0

High-throughput

0.249

Low

690981

TFC6
Transcription factor tau 91 kDa subunit

1

0

High-throughput

0.249

Low

690926

SPT8
Transcription factor SPT8

1

0

High-throughput

0.232

Low

690929

YM11
Uncharacterized protein YMR124W

1

0

High-throughput

0.232

Low

690996

SET6
Potential protein lysine methyltransferase SET6

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024