Protein: IRAK1
Interleukin-1 receptor-associated kinase 1 (IRAK) (IRAK-1) (EC 2.7.11.1) (Pelle-like protein kinase) (mPLK)

Gene: IRAK1
Organism: Mus musculus
Interactions: 51
UniProt ID: Q62406

Gene Ontology (top 5):
GO:0004672 - protein kinase activity
GO:0004674 - protein serine/threonine kinase activity
GO:0005149 - interleukin-1 receptor binding
GO:0005524 - ATP binding
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

648059

MYD88
Myeloid differentiation primary response protein MyD88

9

20

Small-scale

0.968

High

562917

IL1R1
Interleukin-1 receptor type 1

4

12

Small-scale

0.881

High

1224128

IRAK4
Interleukin-1 receptor-associated kinase 4

3

20

Small-scale

0.829

High

1224116

IRAK1
Interleukin-1 receptor-associated kinase 1

3

20

Small-scale

0.817

High

1224127

IRAK3
Interleukin-1 receptor-associated kinase 3

2

20

Small-scale

0.754

High

1224133

TLR4
Toll-like receptor 4

2

20

Small-scale

0.754

High

999845

TRAF6
TNF receptor-associated factor 6

8

12

Small-scale

0.746

High

1224118

TIFA
TRAF-interacting protein with FHA domain-containing protein A

1

1

Small-scale

0.690

High

591053

KPCE
Protein kinase C epsilon type

1

3

Small-scale

0.665

High

1223470

M3K7
Mitogen-activated protein kinase kinase kinase 7

1

20

Small-scale

0.665

High

1224137

BCL10
B-cell lymphoma/leukemia 10

1

1

Small-scale

0.665

High

669422

TNR1A
Tumor necrosis factor receptor superfamily member 1A

1

1

Small-scale

0.618

High

1222362

FADD
FAS-associated death domain protein

1

2

Small-scale

0.618

High

1224131

TLR9
Toll-like receptor 9

1

20

Small-scale

0.618

High

1224138

IKBA
NF-kappa-B inhibitor alpha

1

5

Small-scale

0.618

High

1224136

TOLIP
Toll-interacting protein

2

2

Small-scale

0.601

High

1222120

XIAP
E3 ubiquitin-protein ligase XIAP

1

1

High-throughput

0.590

High

940799

IRF5
Interferon regulatory factor 5

2

2

Small-scale

0.584

High

1224135

PIN1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1

1

1

Small-scale

0.561

High

204907

NOTC2
Neurogenic locus notch homolog protein 2

1

0

High-throughput

0.560

High

1224130

ANR17
Ankyrin repeat domain-containing protein 17

1

0

High-throughput

0.560

High

838293

STAT3
Signal transducer and activator of transcription 3

1

2

Small-scale

0.515

High

1224121

PELI2
E3 ubiquitin-protein ligase pellino homolog 2

1

11

Small-scale

0.515

High

1224124

RSAD2
S-adenosylmethionine-dependent nucleotide dehydratase RSAD2

1

1

Small-scale

0.515

High

811910

TRAF2
TNF receptor-associated factor 2

1

12

Small-scale

0.479

High

1190488

FBW1A
F-box/WD repeat-containing protein 1A

1

2

Small-scale

0.479

High

1223280

IL1AP
Interleukin-1 receptor accessory protein

1

18

Small-scale

0.479

High

1223905

NR0B2
Nuclear receptor subfamily 0 group B member 2

1

1

Small-scale

0.479

High

1224117

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

2

High-throughput

0.479

High

1224123

PELI1
E3 ubiquitin-protein ligase pellino homolog 1

1

11

Small-scale

0.479

High

1224119

RNF41
E3 ubiquitin-protein ligase NRDP1

1

12

Small-scale

0.470

High

711228

PTN6
Tyrosine-protein phosphatase non-receptor type 6

1

0

Small-scale

0.458

High

845950

LIT1
Lithostathine-1

1

0

Small-scale

0.458

High

518550

ANXA1
Annexin A1

1

0

High-throughput

0.438

High

1189378

AASD1
Alanyl-tRNA editing protein Aarsd1

1

0

High-throughput

0.438

High

1224120

EEA1
Early endosome antigen 1

1

0

High-throughput

0.438

High

1224122

MDFIC
MyoD family inhibitor domain-containing protein

1

0

High-throughput

0.438

High

1224125

VCIP1
Deubiquitinating protein VCPIP1

1

0

High-throughput

0.438

High

1224129

LPXN
Leupaxin

1

0

High-throughput

0.438

High

1224134

DKK3
Dickkopf-related protein 3

1

0

High-throughput

0.438

High

947406

SENP1
Sentrin-specific protease 1

1

1

Small-scale

0.437

High

1222312

IL18R
Interleukin-18 receptor 1

1

18

Small-scale

0.437

High

791893

FBLN2
Fibulin-2

1

1

High-throughput

0.417

High

1066827

DLK1
Protein delta homolog 1

1

1

High-throughput

0.417

High

1224126

Q8K2C1
Angio-associated migratory cell protein

1

1

High-throughput

0.417

High

1224132

PARVG
Gamma-parvin

1

1

High-throughput

0.417

High

534032

OSTP
Osteopontin

1

0

Small-scale

0.249

Low

204866

ECH1
Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial

1

0

High-throughput

0.238

Low

467688

S10AA
Protein S100-A10

1

0

High-throughput

0.238

Low

907958

DYLT1
Dynein light chain Tctex-type 1

1

0

High-throughput

0.238

Low


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Last updated: 11Aug2025