Protein: ACON
Aconitate hydratase, mitochondrial (Aconitase) (EC 4.2.1.3) (Citrate hydro-lyase)

Gene: ACON, Aco2
Organism: Mus musculus
Interactions: 62
UniProt ID: Q99KI0

Gene Ontology (top 5):
GO:0003994 - aconitate hydratase activity
GO:0005506 - iron ion binding
GO:0005739 - mitochondrion
GO:0006099 - tricarboxylic acid cycle
GO:0006101 - citrate metabolic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1408781

ACON
Aconitate hydratase, mitochondrial

3

8

High-throughput

0.827

High

469625

MDHM
Malate dehydrogenase, mitochondrial

3

4

High-throughput

0.640

High

940851

ATPB
ATP synthase F(1) complex catalytic subunit beta, mitochondrial

3

6

High-throughput

0.640

High

1042169

ATPA
ATP synthase F(1) complex subunit alpha, mitochondrial

3

6

High-throughput

0.640

High

926048

IDHP
Isocitrate dehydrogenase [NADP], mitochondrial

2

3

High-throughput

0.584

High

1021924

FUMH
Fumarate hydratase, mitochondrial

2

3

High-throughput

0.584

High

1408789

ATPO
ATP synthase peripheral stalk subunit OSCP, mitochondrial

2

1

High-throughput

0.584

High

1408786

GAL3A
Glutamine amidotransferase-like class 1 domain-containing protein 3, mitochondrial

2

0

High-throughput

0.559

High

1247170

NEB2
Neurabin-2

2

2

High-throughput

0.533

High

204867

ECH1
Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial

1

2

High-throughput

0.479

High

426409

AATM
Aspartate aminotransferase, mitochondrial

1

1

High-throughput

0.479

High

853089

ACADM
Medium-chain specific acyl-CoA dehydrogenase, mitochondrial

1

1

High-throughput

0.479

High

896354

ACADV
Very long-chain specific acyl-CoA dehydrogenase, mitochondrial

1

1

High-throughput

0.479

High

1021437

ATP5J
ATP synthase peripheral stalk subunit F6, mitochondrial

1

1

High-throughput

0.479

High

1222752

HCDH
Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial

1

1

High-throughput

0.479

High

1282907

Q80X68
Citrate synthase

1

5

High-throughput

0.479

High

1297003

ECHA
Trifunctional enzyme subunit alpha, mitochondrial

1

2

High-throughput

0.479

High

1362193

Q91VA7
Isocitrate dehydrogenase [NAD] subunit, mitochondrial

1

5

High-throughput

0.479

High

1408783

AT5F1
ATP synthase peripheral stalk subunit b, mitochondrial

1

1

High-throughput

0.479

High

1408784

QCR1
Cytochrome b-c1 complex subunit 1, mitochondrial

1

3

High-throughput

0.479

High

1408785

CISY
Citrate synthase, mitochondrial

1

5

High-throughput

0.479

High

1408790

QCR2
Cytochrome b-c1 complex subunit 2, mitochondrial

1

4

High-throughput

0.479

High

1408791

ETFB
Electron transfer flavoprotein subunit beta

1

2

High-throughput

0.479

High

1408792

ATP5H
ATP synthase peripheral stalk subunit d, mitochondrial

1

1

High-throughput

0.479

High

1408794

SUCA
Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial

1

1

High-throughput

0.479

High

1408795

SUCB1
Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial

1

1

High-throughput

0.479

High

147978

STXB1
Syntaxin-binding protein 1

1

0

High-throughput

0.458

High

878162

ADT1
ADP/ATP translocase 1

1

0

High-throughput

0.458

High

1195288

OXR1
Oxidation resistance protein 1

1

0

High-throughput

0.458

High

1222604

ABCD2
ATP-binding cassette sub-family D member 2

1

0

High-throughput

0.458

High

1317286

SDHA
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

1

0

High-throughput

0.458

High

1341523

RRF2M
Ribosome-releasing factor 2, mitochondrial

1

0

High-throughput

0.458

High

1362296

AS3MT
Arsenite methyltransferase

1

0

High-throughput

0.458

High

1362423

NDUV1
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial

1

0

High-throughput

0.458

High

1408782

ETFA
Electron transfer flavoprotein subunit alpha, mitochondrial

1

0

High-throughput

0.458

High

1408787

RL34
Large ribosomal subunit protein eL34

1

0

High-throughput

0.458

High

1408793

ASAH2
Neutral ceramidase

1

0

High-throughput

0.458

High

1021736

THIOM
Thioredoxin, mitochondrial

1

4

High-throughput

0.445

High

147867

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

1

High-throughput

0.437

High

915345

TIA1
Cytotoxic granule associated RNA binding protein TIA1

1

1

High-throughput

0.437

High

927982

ATX1
Ataxin-1

1

1

High-throughput

0.437

High

1296238

BACD1
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1

1

1

High-throughput

0.437

High

1297400

Q8BUJ0
Titin

1

3

High-throughput

0.437

High

1297801

A16L1
Autophagy-related protein 16-1

1

3

High-throughput

0.437

High

1298328

MT21E
Protein-lysine methyltransferase METTL21E

1

2

High-throughput

0.437

High

999189

1433F
14-3-3 protein eta

1

0

High-throughput

0.426

High

59500

A2AKD7
Alpha-1-syntrophin

1

1

High-throughput

0.407

High

1064152

KCMA1
Calcium-activated potassium channel subunit alpha-1

1

0

High-throughput

0.279

Low

104626

SYGP1
Ras/Rap GTPase-activating protein SynGAP

1

0

High-throughput

0.249

Low

398905

CFAD
Complement factor D

1

0

High-throughput

0.249

Low

549512

ITPR1
Inositol 1,4,5-trisphosphate-gated calcium channel ITPR1

1

0

Small-scale

0.249

Low

789768

THB
Thyroid hormone receptor beta

1

0

High-throughput

0.249

Low

1191182

UBP48
Ubiquitin carboxyl-terminal hydrolase 48

1

0

High-throughput

0.249

Low

1210805

CLU
Clustered mitochondria protein homolog

1

0

High-throughput

0.249

Low

1225228

TFE3
Transcription factor E3

1

0

High-throughput

0.249

Low

1257418

SPOP
Speckle-type POZ protein

1

0

High-throughput

0.249

Low

1298009

Q8C1W8
NAD(P) transhydrogenase, mitochondrial

1

0

High-throughput

0.249

Low

1317592

FNDC5
Fibronectin type III domain-containing protein 5

1

0

High-throughput

0.249

Low

1408788

Q9D881
Cytochrome c oxidase subunit 5B, mitochondrial

1

0

High-throughput

0.249

Low

905934

CAV3
Caveolin-3

1

0

High-throughput

0.232

Low

1223703

DLG4
Disks large homolog 4

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025