Protein: SMC3
Structural maintenance of chromosomes protein 3 (DA-box protein SMC3)

Gene: SMC3
Organism: Saccharomyces cerevisiae S288C
Interactions: 124
UniProt ID: P47037

Gene Ontology (top 5):
GO:0003690 - double-stranded DNA binding
GO:0005524 - ATP binding
GO:0005634 - nucleus
GO:0007064 - mitotic sister chromatid cohesion
GO:0007130 - synaptonemal complex assembly

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

810784

SCC1
Sister chromatid cohesion protein 1

36

20

Small-scale

0.994

High

700779

SMC1
Structural maintenance of chromosomes protein 1

24

17

Small-scale

0.992

High

810771

SCC2
Sister chromatid cohesion protein 2

5

7

Small-scale

0.909

High

758746

SMC2
Structural maintenance of chromosomes protein 2

2

16

Small-scale

0.775

High

810789

SMC4
Structural maintenance of chromosomes protein 4

2

19

Small-scale

0.775

High

810757

SMC3
Structural maintenance of chromosomes protein 3

2

19

Small-scale

0.767

High

810785

REC8
Meiotic recombination protein REC8

2

1

Small-scale

0.754

High

775340

SCC3
Cohesin subunit SCC3

9

20

Small-scale

0.748

High

693130

CDC5
Cell cycle serine/threonine-protein kinase CDC5/MSD2

4

4

Small-scale

0.699

High

810772

PDS5
Sister chromatid cohesion protein PDS5

5

20

Small-scale

0.699

High

797892

ECO1
N-acetyltransferase ECO1

3

1

Small-scale

0.655

High

356566

H4
Histone H4

3

4

High-throughput

0.643

High

730847

CENPA
Histone H3-like centromeric protein CSE4

3

8

Small-scale

0.640

High

810788

HOS1
Histone deacetylase HOS1

2

7

Small-scale

0.639

High

810759

TCPQ
T-complex protein 1 subunit theta

2

1

High-throughput

0.621

High

810793

SMC6
Structural maintenance of chromosomes protein 6

1

17

High-throughput

0.618

High

511836

SSB1
Ribosome-associated molecular chaperone SSB1

2

11

High-throughput

0.601

High

707885

GCN1
eIF-2-alpha kinase activator GCN1

2

3

High-throughput

0.588

High

763169

FHP
Flavohemoprotein

2

1

High-throughput

0.588

High

810790

RUVB2
RuvB-like protein 2

2

2

High-throughput

0.588

High

355537

H2B1
Histone H2B.1

2

11

High-throughput

0.571

High

810766

H3
Histone H3

2

8

High-throughput

0.571

High

810780

NOP12
Nucleolar protein 12

2

1

High-throughput

0.567

High

634886

MRC1
Mediator of replication checkpoint protein 1

1

1

Small-scale

0.561

High

810764

TOF1
Topoisomerase 1-associated factor 1

1

1

Small-scale

0.561

High

494321

HSP72
Heat shock protein SSA2

2

9

High-throughput

0.552

High

810767

NUM1
Nuclear migration protein NUM1

2

20

High-throughput

0.548

High

606064

RAD53
Serine/threonine-protein kinase RAD53

1

6

High-throughput

0.536

High

768270

SCC4
MAU2 chromatid cohesion factor homolog

1

1

High-throughput

0.515

High

340188

KPYK1
Pyruvate kinase 1

1

0

High-throughput

0.513

High

708020

NUF2
Kinetochore protein NUF2

1

4

High-throughput

0.508

High

810617

YJ41B
Transposon Ty4-J Gag-Pol polyprotein

1

2

High-throughput

0.508

High

810777

BRE1
E3 ubiquitin-protein ligase BRE1

1

11

High-throughput

0.508

High

810774

CSM3
Chromosome segregation in meiosis protein 3

1

1

Small-scale

0.501

High

687419

EF2
Elongation factor 2

1

4

High-throughput

0.489

High

810779

LUC7
Protein LUC7

1

0

High-throughput

0.486

High

676168

XPO1
Exportin-1

1

1

Small-scale

0.481

High

810794

RAD61
Protein RAD61

1

0

Small-scale

0.480

High

355931

H2B2
Histone H2B.2

1

11

High-throughput

0.479

High

366526

HSP82
ATP-dependent molecular chaperone HSP82

1

7

High-throughput

0.479

High

392149

H2A1
Histone H2A.1

1

4

High-throughput

0.479

High

392489

H2A2
Histone H2A.2

1

4

High-throughput

0.479

High

407153

RS3
Small ribosomal subunit protein uS3

1

1

High-throughput

0.479

High

558133

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

3

High-throughput

0.479

High

628220

SIS1
Protein SIS1

1

4

High-throughput

0.479

High

650327

SPT5
Transcription elongation factor SPT5

1

4

High-throughput

0.479

High

662630

TF2B
Transcription initiation factor IIB

1

4

High-throughput

0.479

High

664492

HRR25
Casein kinase I homolog HRR25

1

6

Small-scale

0.479

High

688313

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

1

High-throughput

0.479

High

696226

STH1
Nuclear protein STH1/NPS1

1

8

Small-scale

0.479

High

716284

SPT10
Protein SPT10

1

2

High-throughput

0.479

High

742871

GBLP
Small ribosomal subunit protein RACK1

1

3

High-throughput

0.479

High

750983

KPR2
Ribose-phosphate pyrophosphokinase 2

1

1

High-throughput

0.479

High

765310

RSP5
E3 ubiquitin-protein ligase RSP5

1

2

Small-scale

0.479

High

772295

ATAD2
ATPase histone chaperone YTA7

1

1

Small-scale

0.479

High

810765

APJ1
J domain-containing protein APJ1

1

6

High-throughput

0.479

High

810776

CND3
Condensin complex subunit 3

1

10

Small-scale

0.479

High

810781

SGO1
Shugoshin

1

3

High-throughput

0.479

High

810783

YL11B
Transposon Ty1-LR1 Gag-Pol polyprotein

1

1

High-throughput

0.479

High

810786

RIO1
Serine/threonine-protein kinase RIO1

1

4

High-throughput

0.479

High

810791

CMR1
DNA damage-binding protein CMR1

1

3

High-throughput

0.479

High

810614

YJ41A
Transposon Ty4-J Gag polyprotein

1

1

High-throughput

0.464

High

810775

KAR5
Nuclear fusion protein KAR5

1

1

High-throughput

0.464

High

691911

CBF3A
Centromere DNA-binding protein complex CBF3 subunit A

1

0

Small-scale

0.458

High

716457

SPT21
Protein SPT21

1

0

High-throughput

0.458

High

756049

WSS1
DNA-dependent metalloprotease WSS1

1

0

Small-scale

0.458

High

810758

MPS3
Spindle pole body assembly component MPS3

1

0

High-throughput

0.458

High

368186

EF1A
Elongation factor 1-alpha

1

2

High-throughput

0.445

High

376836

PABP
Polyadenylate-binding protein, cytoplasmic and nuclear

1

3

High-throughput

0.445

High

424587

PYR1
Multifunctional protein URA2

1

1

High-throughput

0.445

High

454383

TBA1
Tubulin alpha-1 chain

1

9

High-throughput

0.445

High

544000

HSC82
ATP-dependent molecular chaperone HSC82

1

7

High-throughput

0.445

High

556138

VATB
V-type proton ATPase subunit B

1

1

High-throughput

0.445

High

633346

MAS5
Mitochondrial protein import protein MAS5

1

6

High-throughput

0.445

High

694995

HSP7F
Heat shock protein homolog SSE1

1

15

High-throughput

0.445

High

705363

HSP78
Heat shock protein 78, mitochondrial

1

2

High-throughput

0.445

High

755781

SET1
Histone-lysine N-methyltransferase, H3 lysine-4 specific

1

5

High-throughput

0.445

High

810770

HMO1
High mobility group protein 1

1

6

Small-scale

0.445

High

810792

H2AZ
Histone H2A.Z

1

4

High-throughput

0.445

High

378365

LEU3
3-isopropylmalate dehydrogenase

1

1

Small-scale

0.437

High

405701

RL26A
Large ribosomal subunit protein uL24A

1

2

High-throughput

0.437

High

480185

RS6A
Small ribosomal subunit protein eS6A

1

2

High-throughput

0.437

High

480754

RS8A
Small ribosomal subunit protein eS8A

1

1

High-throughput

0.437

High

631959

RS2
Small ribosomal subunit protein uS5

1

1

High-throughput

0.437

High

700496

RSSA1
Small ribosomal subunit protein uS2A

1

1

High-throughput

0.437

High

700965

SMY2
Protein SMY2

1

1

High-throughput

0.437

High

706355

RS3A1
Small ribosomal subunit protein eS1A

1

2

High-throughput

0.437

High

762343

LAA1
AP-1 accessory protein LAA1

1

1

High-throughput

0.437

High

810760

RS12
Small ribosomal subunit protein eS12

1

1

High-throughput

0.437

High

810769

BUL2
Ubiquitin ligase-binding protein BUL2

1

1

Small-scale

0.437

High

810778

VAM6
Vacuolar morphogenesis protein 6

1

2

High-throughput

0.437

High

810782

RS10A
Small ribosomal subunit protein eS10A

1

2

High-throughput

0.437

High

531685

DHAS
Aspartate-semialdehyde dehydrogenase

1

0

High-throughput

0.426

High

640992

RL5
Large ribosomal subunit protein uL18

1

0

High-throughput

0.426

High

810761

RL4B
Large ribosomal subunit protein uL4B

1

0

High-throughput

0.426

High

405033

RL6B
Large ribosomal subunit protein eL6B

1

1

High-throughput

0.407

High

613721

RS3A2
Small ribosomal subunit protein eS1B

1

2

High-throughput

0.407

High

775622

DJP1
DnaJ-like protein 1

1

5

High-throughput

0.407

High

810041

PFD1
Prefoldin subunit 1

1

1

High-throughput

0.407

High

810762

IMDH4
Inosine-5'-monophosphate dehydrogenase 4

1

1

High-throughput

0.407

High

535036

RL3
Large ribosomal subunit protein uL3

1

0

High-throughput

0.279

Low

770407

RL13B
Large ribosomal subunit protein eL13B

1

0

High-throughput

0.279

Low

785086

MPG1
Mannose-1-phosphate guanyltransferase

1

0

High-throughput

0.279

Low

810763

YGI1
Uncharacterized protein YGL081W

1

0

High-throughput

0.279

Low

696974

YEF3
Uncharacterized protein YEL043W

1

0

High-throughput

0.265

Low

762139

YM11
Uncharacterized protein YMR124W

1

0

High-throughput

0.265

Low

768289

PEA2
Protein PEA2

1

0

High-throughput

0.265

Low

763287

PO152
Nucleoporin POM152

1

0

High-throughput

0.251

Low

141411

RS9A
Small ribosomal subunit protein uS4A

1

0

High-throughput

0.249

Low

471136

RS22A
Small ribosomal subunit protein uS8A

1

0

High-throughput

0.249

Low

472271

RL31A
Large ribosomal subunit protein eL31A

1

0

High-throughput

0.249

Low

478922

RL20B
Large ribosomal subunit protein eL20B

1

0

High-throughput

0.249

Low

482333

RS18A
Small ribosomal subunit protein uS13A

1

0

High-throughput

0.249

Low

527199

RPOM
DNA-directed RNA polymerase, mitochondrial

1

0

High-throughput

0.249

Low

645528

RS7A
Small ribosomal subunit protein eS7A

1

0

High-throughput

0.249

Low

729991

RS27A
Small ribosomal subunit protein eS27A

1

0

High-throughput

0.249

Low

741393

GLY1
Low specificity L-threonine aldolase

1

0

Small-scale

0.249

Low

752536

RS20
Small ribosomal subunit protein uS10

1

0

High-throughput

0.249

Low

810768

RS15
Small ribosomal subunit protein uS19

1

0

High-throughput

0.249

Low

810773

GYL1
Probable GTPase-activating protein GYL1

1

0

High-throughput

0.238

Low

399530

RLA0
Large ribosomal subunit protein uL10

1

0

High-throughput

0.232

Low

534792

RL30
Large ribosomal subunit protein eL30

1

0

High-throughput

0.232

Low

810787

RL7B
Large ribosomal subunit protein uL30B

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024