Protein: P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase regulatory subunit alpha) (PI3K regulatory subunit alpha) (PtdIns-3-kinase regulatory subunit alpha) (Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha) (PI3-kinase subunit p85-alpha) (PtdIns-3-kinase regulatory subunit p85-alpha)

Gene: P85A, Pik3r1
Organism: Mus musculus
Interactions: 86
UniProt ID: P26450

Gene Ontology (top 5):
GO:0001678 - intracellular glucose homeostasis
GO:0001784 - phosphotyrosine residue binding
GO:0001953 - negative regulation of cell-matrix adhesion
GO:0002687 - positive regulation of leukocyte migration
GO:0005158 - insulin receptor binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

686942

PK3CA
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

9

20

Small-scale

0.961

High

431450

KIT
Mast/stem cell growth factor receptor Kit

5

20

Small-scale

0.919

High

483858

CSF1R
Macrophage colony-stimulating factor 1 receptor

3

20

Small-scale

0.854

High

686966

GRB2
Growth factor receptor-bound protein 2

2

20

Small-scale

0.834

High

205659

PK3CD
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform

3

20

Small-scale

0.821

High

686981

PK3CB
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform

3

20

Small-scale

0.821

High

686960

TIE2
Angiopoietin-1 receptor

2

20

Small-scale

0.808

High

686934

PTN11
Tyrosine-protein phosphatase non-receptor type 11

2

20

Small-scale

0.806

High

686974

CRK
Adapter molecule crk

2

20

Small-scale

0.789

High

651477

CBL
E3 ubiquitin-protein ligase CBL

16

20

Small-scale

0.759

High

686938

IRS1
Insulin receptor substrate 1

13

20

Small-scale

0.755

High

686939

BTK
Tyrosine-protein kinase BTK

2

20

Small-scale

0.754

High

686941

FYN
Tyrosine-protein kinase Fyn

2

20

Small-scale

0.754

High

686969

RASH
GTPase HRas

2

20

Small-scale

0.754

High

686971

JAK2
Tyrosine-protein kinase JAK2

2

20

Small-scale

0.754

High

411147

ARAF
Serine/threonine-protein kinase A-Raf

1

20

Small-scale

0.747

High

686982

ABI1
Abl interactor 1

1

20

Small-scale

0.747

High

440272

LCK
Proto-oncogene tyrosine-protein kinase LCK

1

20

Small-scale

0.724

High

686953

SHC1
SHC-transforming protein 1

1

20

Small-scale

0.724

High

575628

EPOR
Erythropoietin receptor

2

20

Small-scale

0.675

High

686988

GAB1
GRB2-associated-binding protein 1

3

20

Small-scale

0.664

High

686943

CRKL
Crk-like protein

1

20

Small-scale

0.647

High

686984

SNX9
Sorting nexin-9

1

6

Small-scale

0.646

High

686950

IRS2
Insulin receptor substrate 2

3

20

Small-scale

0.640

High

431948

PGFRB
Platelet-derived growth factor receptor beta

1

20

Small-scale

0.618

High

581951

INSR
Insulin receptor

1

20

Small-scale

0.618

High

593626

BLK
Tyrosine-protein kinase Blk

1

20

Small-scale

0.618

High

683087

LYN
Tyrosine-protein kinase Lyn

1

20

Small-scale

0.618

High

686932

FAK1
Focal adhesion kinase 1

1

20

Small-scale

0.618

High

686947

RAC1
Ras-related C3 botulinum toxin substrate 1

1

20

Small-scale

0.618

High

686949

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

20

Small-scale

0.618

High

686954

UFO
Tyrosine-protein kinase receptor UFO

1

20

Small-scale

0.618

High

686957

KPCT
Protein kinase C theta type

1

17

Small-scale

0.618

High

686962

EPS8
Epidermal growth factor receptor kinase substrate 8

1

20

Small-scale

0.618

High

686967

GRB10
Growth factor receptor-bound protein 10

1

20

Small-scale

0.618

High

686968

MERTK
Tyrosine-protein kinase Mer

1

20

Small-scale

0.618

High

686987

SHIP1
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1

1

17

Small-scale

0.618

High

686930

CD28
T-cell-specific surface glycoprotein CD28

2

7

Small-scale

0.594

High

686972

SH3G1
Endophilin-A2

1

20

High-throughput

0.590

High

686940

THB
Thyroid hormone receptor beta

2

20

Small-scale

0.584

High

686937

RET
Proto-oncogene tyrosine-protein kinase receptor Ret

1

20

Small-scale

0.579

High

686958

CTNB1
Catenin beta-1

2

12

Small-scale

0.576

High

686961

TIE1
Tyrosine-protein kinase receptor Tie-1

1

20

Small-scale

0.575

High

686935

CD22
B-cell receptor CD22

1

11

Small-scale

0.561

High

686929

NCKP1
Nck-associated protein 1

1

2

Small-scale

0.554

High

686976

CYFP1
Cytoplasmic FMR1-interacting protein 1

1

10

Small-scale

0.554

High

686963

PHAG1
Phosphoprotein associated with glycosphingolipid-enriched microdomains 1

1

4

High-throughput

0.553

High

686983

WASF1
Actin-binding protein WASF1

1

20

Small-scale

0.536

High

686964

Q3ZB59
Growth factor receptor bound protein 2-associated protein 2

1

20

Small-scale

0.528

High

74256

EP300
Histone acetyltransferase p300

1

7

Small-scale

0.515

High

534028

OSTP
Osteopontin

1

1

Small-scale

0.515

High

686965

MYO16
Unconventional myosin-XVI

1

14

Small-scale

0.515

High

686975

NYAP1
Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 1

1

15

Small-scale

0.515

High

686980

NYAP2
Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 2

1

14

Small-scale

0.515

High

686978

MAP6
Microtubule-associated protein 6

1

6

Small-scale

0.501

High

686948

WASP
Actin nucleation-promoting factor WAS

1

16

Small-scale

0.500

High

109255

ANK3
Ankyrin-3

1

11

Small-scale

0.479

High

204644

TNR11
Tumor necrosis factor receptor superfamily member 11A

1

14

Small-scale

0.479

High

236328

NKG2D
NKG2-D type II integral membrane protein

1

4

Small-scale

0.479

High

370839

FOS
Protein c-Fos

1

6

Small-scale

0.479

High

486808

CADH1
Cadherin-1

1

16

Small-scale

0.479

High

580348

CADH2
Cadherin-2

1

17

Small-scale

0.479

High

644246

TAL1
T-cell acute lymphocytic leukemia protein 1 homolog

1

2

High-throughput

0.479

High

686928

TNR5
Tumor necrosis factor receptor superfamily member 5

1

14

Small-scale

0.479

High

686931

AKT1
RAC-alpha serine/threonine-protein kinase

1

20

Small-scale

0.479

High

686933

IL2RG
Cytokine receptor common subunit gamma

1

20

Small-scale

0.479

High

686936

NMDZ1
Glutamate receptor ionotropic, NMDA 1

1

17

High-throughput

0.479

High

686944

PSN1
Presenilin-1

1

1

Small-scale

0.479

High

686951

DOK1
Docking protein 1

1

20

Small-scale

0.479

High

686952

SHPS1
Tyrosine-protein phosphatase non-receptor type substrate 1

1

16

Small-scale

0.479

High

686955

NMDE2
Glutamate receptor ionotropic, NMDA 2B

1

17

High-throughput

0.479

High

686959

PLAK
Junction plakoglobin

1

17

Small-scale

0.479

High

686985

TIRAP
Toll/interleukin-1 receptor domain-containing adapter protein

1

1

Small-scale

0.479

High

683134

CD19
B-lymphocyte antigen CD19

1

2

Small-scale

0.470

High

686945

PA2G4
Proliferation-associated protein 2G4

1

0

Small-scale

0.458

High

686986

BCAP
Phosphoinositide 3-kinase adapter protein 1

1

0

Small-scale

0.458

High

312763

BRD7
Bromodomain-containing protein 7

1

15

High-throughput

0.457

High

686956

NDKB
Nucleoside diphosphate kinase B

1

2

High-throughput

0.457

High

686970

PCBP2
Poly(rC)-binding protein 2

1

14

High-throughput

0.457

High

686973

IF4G2
Eukaryotic translation initiation factor 4 gamma 2

1

3

High-throughput

0.457

High

686989

ICOS
Inducible T-cell costimulator

1

1

Small-scale

0.457

High

236808

LAT
Linker for activation of T-cells family member 1

1

3

High-throughput

0.445

High

450383

CSF1
Macrophage colony-stimulating factor 1

1

4

Small-scale

0.445

High

686946

GOGA3
Golgin subfamily A member 3

1

19

High-throughput

0.417

High

686977

BTLA
B- and T-lymphocyte attenuator

1

0

Small-scale

0.249

Low

686979

Q8BK32
Nuclear receptor co-repressor 1

1

0

Small-scale

0.249

Low


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Last updated: 11Aug2025