Protein: GCN4
General control transcription factor GCN4 (Amino acid biosynthesis regulatory protein) (General control protein GCN4)

Gene: GCN4
Organism: Saccharomyces cerevisiae S288C
Interactions: 69
UniProt ID: P03069

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001080 - nitrogen catabolite activation of transcription from RNA polymerase II promoter
GO:0001094 - TFIID-class transcription factor complex binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

368702

GCN4
General control transcription factor GCN4

16

0

Small-scale

0.932

High

368717

MED15
Mediator of RNA polymerase II transcription subunit 15

7

0

Small-scale

0.719

High

368729

SPT7
Transcriptional activator SPT7

4

1

Small-scale

0.688

High

368754

ADA2
Transcriptional adapter 2

4

0

Small-scale

0.669

High

368758

TAF9
Transcription initiation factor TFIID subunit 9

4

0

Small-scale

0.660

High

368713

PHO85
Cyclin-dependent protein kinase PHO85

3

1

Small-scale

0.655

High

368757

TAF12
Transcription initiation factor TFIID subunit 12

4

0

Small-scale

0.654

High

368714

SNF5
SWI/SNF chromatin-remodeling complex subunit SNF5

4

0

Small-scale

0.648

High

368705

SPT3
Protein SPT3

3

1

Small-scale

0.647

High

368719

SNF2
Transcription regulatory protein SNF2

3

1

Small-scale

0.642

High

368711

TBP
TATA-box-binding protein

3

0

Small-scale

0.641

High

368747

MED21
Mediator of RNA polymerase II transcription subunit 21

4

0

Small-scale

0.639

High

368735

TRA1
Transcription-associated protein 1

3

0

Small-scale

0.623

High

368732

TAF5
Transcription initiation factor TFIID subunit 5

3

0

Small-scale

0.622

High

368727

MED20
Mediator of RNA polymerase II transcription subunit 20

3

0

Small-scale

0.613

High

368737

RPN10
26S proteasome regulatory subunit RPN10

2

0

Small-scale

0.609

High

368740

SSB2
Ribosome-associated molecular chaperone SSB2

3

0

Small-scale

0.597

High

368739

SSN3
Meiotic mRNA stability protein kinase SSN3

2

2

Small-scale

0.595

High

368706

CDC4
Cell division control protein 4

2

0

Small-scale

0.579

High

368726

PRS6A
26S proteasome regulatory subunit 6A

2

0

Small-scale

0.577

High

368716

SNF6
Transcription regulatory protein SNF6

2

0

Small-scale

0.577

High

368750

TAF6
Transcription initiation factor TFIID subunit 6

2

0

Small-scale

0.576

High

368710

RAP1
DNA-binding protein RAP1

1

0

Small-scale

0.571

High

368707

SWI1
SWI/SNF chromatin-remodeling complex subunit SWI1

2

0

Small-scale

0.559

High

368724

MED17
Mediator of RNA polymerase II transcription subunit 17

2

0

Small-scale

0.559

High

368752

SNF12
Transcription regulatory protein SNF12

2

0

Small-scale

0.559

High

368766

AHC1
Protein AHC1

2

0

Small-scale

0.559

High

145851

MBF1
Multiprotein-bridging factor 1

1

0

Small-scale

0.537

High

368741

MED3
Mediator of RNA polymerase II transcription subunit 3

1

0

Small-scale

0.537

High

368756

GCN5
Histone acetyltransferase GCN5

1

0

Small-scale

0.494

High

368755

MET31
Transcriptional regulator MET31

1

0

High-throughput

0.486

High

339314

CDK1
Cyclin-dependent kinase 1

1

1

Small-scale

0.481

High

368709

TAF13
Transcription initiation factor TFIID subunit 13

1

1

Small-scale

0.481

High

368753

AF9
Protein AF-9 homolog

1

1

High-throughput

0.481

High

368703

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

0

Small-scale

0.480

High

368704

UBC2
Ubiquitin-conjugating enzyme E2 2

1

0

Small-scale

0.480

High

368721

RPB9
DNA-directed RNA polymerase II subunit RPB9

1

0

Small-scale

0.480

High

368734

YNG2
Chromatin modification-related protein YNG2

1

0

Small-scale

0.480

High

368744

EPL1
Enhancer of polycomb-like protein 1

1

0

Small-scale

0.480

High

368745

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

1

0

Small-scale

0.480

High

368725

STH1
Nuclear protein STH1/NPS1

1

1

Small-scale

0.479

High

368730

TAF14
Transcription initiation factor TFIID subunit 14

1

1

Small-scale

0.479

High

368712

GCN2
eIF-2-alpha kinase GCN2

1

0

Small-scale

0.460

High

368722

TF2B
Transcription initiation factor IIB

1

0

Small-scale

0.460

High

368728

CASP
Protein CASP

1

0

High-throughput

0.460

High

368731

CCL1
Cyclin CCL1

1

0

Small-scale

0.460

High

368742

RPAB4
DNA-directed RNA polymerases I, II, and III subunit RPABC4

1

0

Small-scale

0.460

High

368751

MCM6
DNA replication licensing factor MCM6

1

0

Small-scale

0.460

High

368760

NOP53
Ribosome biogenesis protein NOP53

1

0

High-throughput

0.460

High

368762

CENPH
Inner kinetochore subunit MCM16

1

0

High-throughput

0.460

High

368708

UBI4P
Polyubiquitin [Cleaved into: Ubiquitin]

1

0

Small-scale

0.458

High

368715

GLN3
Nitrogen regulatory protein GLN3

1

0

Small-scale

0.458

High

368720

CDC48
Cell division control protein 48

1

0

Small-scale

0.458

High

368723

NGG1
Chromatin-remodeling complexes subunit NGG1

1

0

Small-scale

0.458

High

368736

SOL3
6-phosphogluconolactonase 3

1

0

High-throughput

0.458

High

368746

TAF1
Transcription initiation factor TFIID subunit 1

1

0

Small-scale

0.458

High

368748

SPT20
Transcription factor SPT20

1

0

Small-scale

0.458

High

368761

MED2
Mediator of RNA polymerase II transcription subunit 2

1

0

Small-scale

0.458

High

368763

MED4
Mediator of RNA polymerase II transcription subunit 4

1

0

Small-scale

0.458

High

368765

ARP7
Actin-related protein 7

1

0

Small-scale

0.458

High

368733

APN2
DNA-(apurinic or apyrimidinic site) endonuclease 2

1

0

High-throughput

0.438

High

368749

SKP1
Suppressor of kinetochore protein 1

1

0

Small-scale

0.391

High

368738

END3
Actin cytoskeleton-regulatory complex protein END3

1

0

High-throughput

0.269

Low

368764

RPN6
26S proteasome regulatory subunit RPN6

1

0

High-throughput

0.265

Low

141689

YH145
Putative uncharacterized protein YHR145C

1

0

High-throughput

0.238

Low

368743

RGD2
Rho-GTPase-activating protein RGD2

1

0

High-throughput

0.238

Low

368759

TIM14
Mitochondrial import inner membrane translocase subunit TIM14

1

0

High-throughput

0.238

Low

368718

SRP54
Signal recognition particle subunit SRP54

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024