Protein: RIR1
Ribonucleoside-diphosphate reductase large subunit (EC 1.17.4.1) (Ribonucleoside-diphosphate reductase subunit M1) (Ribonucleotide reductase large subunit)

Gene: RIR1, RRM1
Organism: Homo sapiens
Interactions: 93
UniProt ID: P23921

Gene Ontology (top 5):
GO:0000731 - DNA synthesis involved in DNA repair
GO:0004748 - ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor
GO:0005524 - ATP binding
GO:0005635 - nuclear envelope
GO:0005739 - mitochondrion

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

621223

RIR2
Ribonucleoside-diphosphate reductase subunit M2

10

13

Small-scale

0.976

High

621219

RIR1
Ribonucleoside-diphosphate reductase large subunit

4

9

Small-scale

0.908

High

621259

RIR2B
Ribonucleoside-diphosphate reductase subunit M2 B

4

13

Small-scale

0.897

High

621265

KAT5
Histone acetyltransferase KAT5

4

1

Small-scale

0.705

High

280354

GLRX3
Glutaredoxin-3

2

1

High-throughput

0.628

High

621260

TRI69
E3 ubiquitin-protein ligase TRIM69

2

0

High-throughput

0.602

High

455096

PARP1
Poly [ADP-ribose] polymerase 1

2

0

High-throughput

0.585

High

621225

BMI1
Polycomb complex protein BMI-1

1

1

Small-scale

0.561

High

226548

PRKN
E3 ubiquitin-protein ligase parkin

2

0

High-throughput

0.559

High

621237

RS24
Small ribosomal subunit protein eS24

2

0

High-throughput

0.559

High

621253

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

2

0

High-throughput

0.547

High

621268

OTUB1
Ubiquitin thioesterase OTUB1

2

0

High-throughput

0.547

High

621241

G3BP1
Ras GTPase-activating protein-binding protein 1

1

1

High-throughput

0.536

High

621264

CSN5
COP9 signalosome complex subunit 5

1

1

High-throughput

0.536

High

537597

NCF1
Neutrophil cytosol factor 1

1

0

High-throughput

0.513

High

621222

GCH1
GTP cyclohydrolase 1

1

0

High-throughput

0.513

High

621261

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

0

High-throughput

0.513

High

621286

PFD2
Prefoldin subunit 2

1

0

High-throughput

0.513

High

621271

RING2
E3 ubiquitin-protein ligase RING2

1

1

Small-scale

0.512

High

621227

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

1

1

Small-scale

0.508

High

621233

CDC42
Cell division control protein 42 homolog

1

0

High-throughput

0.480

High

621242

ATM
Serine-protein kinase ATM

1

0

Small-scale

0.479

High

241451

H2B1K
Histone H2B type 1-K

1

3

High-throughput

0.479

High

272491

OFD1
Centriole and centriolar satellite protein OFD1

1

1

High-throughput

0.479

High

621224

STIP1
Stress-induced-phosphoprotein 1

1

1

High-throughput

0.479

High

621231

GSK3B
Glycogen synthase kinase-3 beta

1

1

High-throughput

0.479

High

621236

H2B1C
Histone H2B type 1-C/E/F/G/I

1

3

High-throughput

0.479

High

621239

EP300
Histone acetyltransferase p300

1

1

High-throughput

0.479

High

621243

SQSTM
Sequestosome-1

1

1

High-throughput

0.479

High

621245

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

1

High-throughput

0.479

High

621272

DNJC7
DnaJ homolog subfamily C member 7

1

1

High-throughput

0.479

High

148407

CTRO
Citron Rho-interacting kinase

1

0

High-throughput

0.458

High

260006

TBCA
Tubulin-specific chaperone A

1

0

High-throughput

0.458

High

302479

CE152
Centrosomal protein of 152 kDa

1

0

High-throughput

0.458

High

384283

NTRK1
High affinity nerve growth factor receptor

1

0

High-throughput

0.458

High

417157

ENOA
Alpha-enolase

1

0

High-throughput

0.458

High

617427

CRCM
Colorectal mutant cancer protein

1

0

High-throughput

0.458

High

621220

CDK2
Cyclin-dependent kinase 2

1

0

High-throughput

0.458

High

621221

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.458

High

621226

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.458

High

621228

CCNF
Cyclin-F

1

0

High-throughput

0.458

High

621229

UB2R1
Ubiquitin-conjugating enzyme E2 R1

1

0

High-throughput

0.458

High

621232

IF6
Eukaryotic translation initiation factor 6

1

0

High-throughput

0.458

High

621235

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

0

High-throughput

0.458

High

621238

MDM2
E3 ubiquitin-protein ligase Mdm2

1

0

Small-scale

0.458

High

621240

CACO2
Calcium-binding and coiled-coil domain-containing protein 2

1

0

High-throughput

0.458

High

621244

CUL3
Cullin-3

1

0

High-throughput

0.458

High

621246

IKKE
Inhibitor of nuclear factor kappa-B kinase subunit epsilon

1

0

High-throughput

0.458

High

621247

NBR1
Next to BRCA1 gene 1 protein

1

0

High-throughput

0.458

High

621249

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

0

High-throughput

0.458

High

621262

RHG24
Rho GTPase-activating protein 24

1

0

High-throughput

0.458

High

621267

OTUL
Ubiquitin thioesterase otulin

1

0

Small-scale

0.458

High

621273

RN126
E3 ubiquitin-protein ligase RNF126

1

0

High-throughput

0.458

High

621274

MLP3B
Microtubule-associated proteins 1A/1B light chain 3B

1

0

Small-scale

0.458

High

621275

ILKAP
Integrin-linked kinase-associated serine/threonine phosphatase 2C

1

0

High-throughput

0.458

High

621276

ATG5
Autophagy protein 5

1

0

High-throughput

0.458

High

621279

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.458

High

621280

FBX6
F-box only protein 6

1

0

High-throughput

0.458

High

621283

TRM7
tRNA

1

0

High-throughput

0.458

High

621284

EPHA6
Ephrin type-A receptor 6

1

0

High-throughput

0.458

High

621285

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

621287

TNIK
TRAF2 and NCK-interacting protein kinase

1

0

High-throughput

0.458

High

621288

FZR1
Fizzy-related protein homolog

1

0

High-throughput

0.458

High

621291

AAKB1
5'-AMP-activated protein kinase subunit beta-1

1

0

High-throughput

0.458

High

621234

SUMO2
Small ubiquitin-related modifier 2

1

1

High-throughput

0.457

High

621256

RIF1
Telomere-associated protein RIF1

1

0

High-throughput

0.438

High

551969

RFA2
Replication protein A 32 kDa subunit

1

1

High-throughput

0.437

High

621266

H2B1A
Histone H2B type 1-A

1

2

High-throughput

0.437

High

621278

PKHA4
Pleckstrin homology domain-containing family A member 4

1

1

High-throughput

0.437

High

349131

RASH
GTPase HRas

1

0

High-throughput

0.426

High

621257

T184A
Transmembrane protein 184A

2

0

High-throughput

0.328

High

621269

ARL5B
ADP-ribosylation factor-like protein 5B

2

0

High-throughput

0.328

High

621289

TRI33
E3 ubiquitin-protein ligase TRIM33

2

0

High-throughput

0.318

High

621263

ZN655
Zinc finger protein 655

2

0

High-throughput

0.316

High

345947

MYC
Myc proto-oncogene protein

2

0

High-throughput

0.298

High

175999

GPR37
Prosaposin receptor GPR37

1

0

High-throughput

0.279

Low

621251

ANR39
Ankyrin repeat domain-containing protein 39

1

0

High-throughput

0.279

Low

621255

RNH2B
Ribonuclease H2 subunit B

1

0

High-throughput

0.279

Low

621270

IMP2L
Mitochondrial inner membrane protease subunit 2

1

0

High-throughput

0.279

Low

621254

LRIF1
Ligand-dependent nuclear receptor-interacting factor 1

1

0

High-throughput

0.251

Low

205056

TGON2
Trans-Golgi network integral membrane protein 2

1

0

High-throughput

0.249

Low

302914

HEXI1
Protein HEXIM1

1

0

High-throughput

0.249

Low

354294

HLAB
HLA class I histocompatibility antigen, B alpha chain

1

0

High-throughput

0.249

Low

621248

EMC2
ER membrane protein complex subunit 2

1

0

High-throughput

0.249

Low

621250

UBE3C
Ubiquitin-protein ligase E3C

1

0

Small-scale

0.249

Low

621252

EMC4
ER membrane protein complex subunit 4

1

0

High-throughput

0.249

Low

621258

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

621277

SENP3
Sentrin-specific protease 3

1

0

Small-scale

0.249

Low

621281

PIHD1
PIH1 domain-containing protein 1

1

0

High-throughput

0.249

Low

621282

PD1L1
Programmed cell death 1 ligand 1

1

0

High-throughput

0.249

Low

621290

AAR2
Protein AAR2 homolog

1

0

High-throughput

0.249

Low

621230

CEBPA
CCAAT/enhancer-binding protein alpha

1

0

High-throughput

0.213

Low


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Last updated: 15 Jul 2024