Protein: SPIR1
Protein spire homolog 1 (Spir-1)

Gene: SPIR1, SPIRE1
Organism: Homo sapiens
Interactions: 31
UniProt ID: Q08AE8

Gene Ontology (top 5):
GO:0003779 - actin binding
GO:0005654 - nucleoplasm
GO:0005741 - mitochondrial outer membrane
GO:0005829 - cytosol
GO:0005856 - cytoskeleton

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

690944

1433T
14-3-3 protein theta

4

13

High-throughput

0.683

High

990146

1433Z
14-3-3 protein zeta/delta

3

13

High-throughput

0.662

High

1049233

1433F
14-3-3 protein eta

3

13

High-throughput

0.662

High

729779

1433B
14-3-3 protein beta/alpha

3

13

High-throughput

0.643

High

952779

ACTB
Actin, cytoplasmic 1

2

5

High-throughput

0.628

High

1065797

BCL7A
B-cell CLL/lymphoma 7 protein family member A

2

3

High-throughput

0.628

High

1065801

BCL7C
B-cell CLL/lymphoma 7 protein family member C

2

3

High-throughput

0.628

High

1065805

TMOD3
Tropomodulin-3

2

1

High-throughput

0.628

High

966243

1433G
14-3-3 protein gamma

2

13

High-throughput

0.601

High

1065803

BBS4
BBSome complex member BBS4

2

0

High-throughput

0.580

High

395989

ESR1
Estrogen receptor

2

1

High-throughput

0.571

High

1065808

MTCH2
Mitochondrial carrier homolog 2

2

0

High-throughput

0.547

High

971445

1433E
14-3-3 protein epsilon

1

1

High-throughput

0.536

High

993146

ACTG
Actin, cytoplasmic 2

1

5

High-throughput

0.536

High

730544

1433S
14-3-3 protein sigma

1

13

High-throughput

0.515

High

565605

AT1A3
Sodium/potassium-transporting ATPase subunit alpha-3

1

0

High-throughput

0.493

High

593743

PECA1
Platelet endothelial cell adhesion molecule

1

0

High-throughput

0.493

High

1065795

PLD1
Phospholipase D1

1

0

High-throughput

0.493

High

995554

ACTC
Actin, alpha cardiac muscle 1

1

5

High-throughput

0.479

High

1065802

ESR2
Estrogen receptor beta

1

1

High-throughput

0.479

High

157286

CTRO
Citron Rho-interacting kinase

1

0

High-throughput

0.458

High

273345

NPHP4
Nephrocystin-4

1

0

Small-scale

0.458

High

838525

GRIA3
Glutamate receptor 3

1

0

High-throughput

0.458

High

1065796

HDAC1
Histone deacetylase 1

1

0

High-throughput

0.458

High

1065799

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.458

High

1065804

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.458

High

1065806

FBW1B
F-box/WD repeat-containing protein 11

1

0

High-throughput

0.458

High

1065807

CBY1
Protein chibby homolog 1

1

0

High-throughput

0.458

High

942581

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

0

High-throughput

0.426

High

1065798

A16L1
Autophagy-related protein 16-1

1

0

High-throughput

0.426

High

1065800

CR3L2
Cyclic AMP-responsive element-binding protein 3-like protein 2

1

0

High-throughput

0.426

High


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Last updated: 11Aug2025