Protein: NPHP4
Nephrocystin-4 (Nephroretinin)

Gene: NPHP4
Organism: Homo sapiens
Interactions: 69
UniProt ID: O75161

Gene Ontology (top 5):
GO:0005198 - structural molecule activity
GO:0005654 - nucleoplasm
GO:0005813 - centrosome
GO:0005814 - centriole
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

184253

NPHP1
Nephrocystin-1

6

4

Small-scale

0.735

High

273357

RPGR
X-linked retinitis pigmentosa GTPase regulator

5

2

Small-scale

0.714

High

273350

FTM
Protein fantom

5

7

Small-scale

0.713

High

273359

RPGR1
X-linked retinitis pigmentosa GTPase regulator-interacting protein 1

4

7

Small-scale

0.688

High

273363

DNJC7
DnaJ homolog subfamily C member 7

3

2

High-throughput

0.667

High

273353

SKAP1
Src kinase-associated phosphoprotein 1

3

0

High-throughput

0.638

High

273323

BAG2
BAG family molecular chaperone regulator 2

2

1

High-throughput

0.611

High

273320

ST1C4
Sulfotransferase 1C4

1

0

High-throughput

0.513

High

273328

FRIL
Ferritin light chain

1

0

High-throughput

0.513

High

273334

PRPS2
Ribose-phosphate pyrophosphokinase 2

1

0

High-throughput

0.513

High

273347

TEBP
Prostaglandin E synthase 3

1

0

High-throughput

0.513

High

273358

TRI52
E3 ubiquitin-protein ligase TRIM52

1

0

High-throughput

0.513

High

273371

PP4R2
Serine/threonine-protein phosphatase 4 regulatory subunit 2

1

0

High-throughput

0.513

High

273348

DDB1
DNA damage-binding protein 1

1

0

Small-scale

0.493

High

273351

JADE1
Protein Jade-1

1

0

Small-scale

0.493

High

273365

TBB1
Tubulin beta-1 chain

1

8

High-throughput

0.489

High

124695

AIP
AH receptor-interacting protein

1

1

High-throughput

0.479

High

240264

PRKN
E3 ubiquitin-protein ligase parkin

1

1

High-throughput

0.479

High

273322

TTC4
Tetratricopeptide repeat protein 4

1

3

High-throughput

0.479

High

273326

EGFR
Epidermal growth factor receptor

1

2

High-throughput

0.479

High

273330

TBB5
Tubulin beta chain

1

7

High-throughput

0.479

High

273331

HS90A
Heat shock protein HSP 90-alpha

1

4

High-throughput

0.479

High

273332

HS90B
Heat shock protein HSP 90-beta

1

4

High-throughput

0.479

High

273333

HSP7C
Heat shock cognate 71 kDa protein

1

5

High-throughput

0.479

High

273335

HSP76
Heat shock 70 kDa protein 6

1

5

High-throughput

0.479

High

273337

STIP1
Stress-induced-phosphoprotein 1

1

2

High-throughput

0.479

High

273338

HS71L
Heat shock 70 kDa protein 1-like

1

5

High-throughput

0.479

High

273341

HSP72
Heat shock-related 70 kDa protein 2

1

5

High-throughput

0.479

High

273343

TBB4B
Tubulin beta-4B chain

1

7

High-throughput

0.479

High

273344

FKBP4
Peptidyl-prolyl cis-trans isomerase FKBP4

1

2

High-throughput

0.479

High

273346

FAK2
Protein-tyrosine kinase 2-beta

1

2

Small-scale

0.479

High

273352

CE128
Centrosomal protein of 128 kDa

1

3

High-throughput

0.479

High

273356

NUDC2
NudC domain-containing protein 2

1

2

High-throughput

0.479

High

273362

CEP89
Centrosomal protein of 89 kDa

1

3

High-throughput

0.479

High

273367

RPAP3
RNA polymerase II-associated protein 3

1

2

High-throughput

0.479

High

273372

SPAT7
Spermatogenesis-associated protein 7

1

1

Small-scale

0.479

High

273375

CE164
Centrosomal protein of 164 kDa

1

2

Small-scale

0.479

High

273377

NUDC
Nuclear migration protein nudC

1

2

High-throughput

0.479

High

273379

SGT1
Protein SGT1 homolog

1

1

High-throughput

0.479

High

273380

DAAM1
Disheveled-associated activator of morphogenesis 1

1

1

Small-scale

0.479

High

160368

IRS4
Insulin receptor substrate 4

1

0

High-throughput

0.458

High

273321

TRI37
E3 ubiquitin-protein ligase TRIM37

1

0

High-throughput

0.458

High

273324

LATS1
Serine/threonine-protein kinase LATS1

1

0

Small-scale

0.458

High

273329

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

0

High-throughput

0.458

High

273339

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

1

0

High-throughput

0.458

High

273340

NEK4
Serine/threonine-protein kinase Nek4

1

0

High-throughput

0.458

High

273345

SPIR1
Protein spire homolog 1

1

0

Small-scale

0.458

High

273349

GKAP1
G kinase-anchoring protein 1

1

0

High-throughput

0.458

High

273366

RHOJ
Rho-related GTP-binding protein RhoJ

1

0

High-throughput

0.458

High

273368

ECT2
Protein ECT2

1

0

High-throughput

0.458

High

273369

CYBP
Calcyclin-binding protein

1

0

High-throughput

0.458

High

273374

INTU
Protein inturned

1

0

Small-scale

0.458

High

273376

RUVB1
RuvB-like 1

1

0

Small-scale

0.458

High

273378

INVS
Inversin

1

0

High-throughput

0.458

High

65539

TBAL3
Tubulin alpha chain-like 3

1

8

High-throughput

0.437

High

273354

NUDC3
NudC domain-containing protein 3

1

2

High-throughput

0.437

High

273364

TBB2B
Tubulin beta-2B chain

1

7

High-throughput

0.437

High

273325

ECD
Protein ecdysoneless homolog

1

0

High-throughput

0.426

High

273342

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

0

Small-scale

0.426

High

238980

ZNRD2
Protein ZNRD2

2

0

High-throughput

0.328

High

273336

LCN1
Lipocalin-1

1

0

High-throughput

0.279

Low

273360

CC140
Coiled-coil domain-containing protein 140

1

0

High-throughput

0.279

Low

273373

PNMA2
Paraneoplastic antigen Ma2

1

0

High-throughput

0.279

Low

273030

CLU
Clustered mitochondria protein homolog

1

0

High-throughput

0.249

Low

273355

RP25L
Ribonuclease P protein subunit p25-like protein

1

0

High-throughput

0.249

Low

273361

TEFM
Transcription elongation factor, mitochondrial

1

0

High-throughput

0.249

Low

273370

PIHD1
PIH1 domain-containing protein 1

1

0

High-throughput

0.249

Low

58774

PIPSL
Putative PIP5K1A and PSMD4-like protein

1

0

High-throughput

0.232

Low

273327

IGHA1
Immunoglobulin heavy constant alpha 1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025