Protein: PLD1
Phospholipase D1 (PLD 1) (hPLD1) (EC 3.1.4.4) (Choline phosphatase 1) (Phosphatidylcholine-hydrolyzing phospholipase D1)

Gene: PLD1
Organism: Homo sapiens
Interactions: 144
UniProt ID: Q13393

Gene Ontology (top 5):
GO:0000139 - Golgi membrane
GO:0004630 - phospholipase D activity
GO:0005765 - lysosomal membrane
GO:0005768 - endosome
GO:0005789 - endoplasmic reticulum membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

962013

RHOA
Transforming protein RhoA

4

4

Small-scale

0.902

High

975017

ARF6
ADP-ribosylation factor 6

3

2

Small-scale

0.827

High

955125

CDC42
Cell division control protein 42 homolog

2

4

Small-scale

0.806

High

539800

RALA
Ras-related protein Ral-A

2

5

Small-scale

0.778

High

1103795

OSBL5
Oxysterol-binding protein-related protein 5

2

0

High-throughput

0.770

High

1103784

ARL11
ADP-ribosylation factor-like protein 11

1

5

High-throughput

0.761

High

977978

RHOB
Rho-related GTP-binding protein RhoB

2

5

High-throughput

0.754

High

1014887

ARF1
ADP-ribosylation factor 1

2

2

Small-scale

0.754

High

1103752

RHEB
GTP-binding protein Rheb

1

3

Small-scale

0.747

High

1103777

ARL14
ADP-ribosylation factor-like protein 14

1

3

High-throughput

0.747

High

1103753

PKN1
Serine/threonine-protein kinase N1

1

4

Small-scale

0.724

High

1103763

PKN3
Serine/threonine-protein kinase N3

1

5

Small-scale

0.724

High

761219

RYK
Tyrosine-protein kinase RYK

1

2

High-throughput

0.691

High

1103814

TX264
Testis-expressed protein 264

3

1

High-throughput

0.667

High

1103779

GP156
Probable G-protein coupled receptor 156

3

1

High-throughput

0.662

High

557283

SRC
Proto-oncogene tyrosine-protein kinase Src

1

3

Small-scale

0.647

High

1103756

DDR2
Discoidin domain-containing receptor 2

1

3

High-throughput

0.646

High

1103767

RHEX
Regulator of hemoglobinization and erythroid cell expansion protein

3

0

High-throughput

0.638

High

1103778

KCD17
BTB/POZ domain-containing protein KCTD17

4

1

High-throughput

0.630

High

749767

CADH5
Cadherin-5

2

2

High-throughput

0.628

High

1103801

TNR19
Tumor necrosis factor receptor superfamily member 19

2

1

High-throughput

0.628

High

1103804

C5AR2
C5a anaphylatoxin chemotactic receptor 2

2

4

High-throughput

0.628

High

660053

COF1
Cofilin-1

2

1

Small-scale

0.624

High

375483

RASK
GTPase KRas

1

5

High-throughput

0.618

High

400777

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

5

High-throughput

0.618

High

463501

LYN
Tyrosine-protein kinase Lyn

1

3

High-throughput

0.618

High

581022

RAC2
Ras-related C3 botulinum toxin substrate 2

1

4

High-throughput

0.618

High

599287

PLCG2
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2

1

2

Small-scale

0.618

High

601269

RHOQ
Rho-related GTP-binding protein RhoQ

1

5

High-throughput

0.618

High

603262

KPCA
Protein kinase C alpha type

1

2

Small-scale

0.618

High

900797

RAB5C
Ras-related protein Rab-5C

1

1

High-throughput

0.618

High

901221

RAB7A
Ras-related protein Rab-7a

1

3

High-throughput

0.618

High

901794

RAB9A
Ras-related protein Rab-9A

1

3

High-throughput

0.618

High

956275

RAB2A
Ras-related protein Rab-2A

1

1

High-throughput

0.618

High

1103751

RAB35
Ras-related protein Rab-35

1

1

High-throughput

0.618

High

1103805

CCG5
Voltage-dependent calcium channel gamma-5 subunit

3

2

High-throughput

0.604

High

391244

FRIL
Ferritin light chain

2

1

High-throughput

0.601

High

791362

SYUA
Alpha-synuclein

2

0

Small-scale

0.598

High

976244

RB11A
Ras-related protein Rab-11A

1

0

High-throughput

0.586

High

1103747

KIF14
Kinesin-like protein KIF14

1

0

High-throughput

0.586

High

1103787

SNX27
Sorting nexin-27

1

0

High-throughput

0.586

High

619050

PLCG1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1

1

2

Small-scale

0.584

High

1103749

PEA15
Astrocytic phosphoprotein PEA-15

2

1

Small-scale

0.578

High

822647

VHL
von Hippel-Lindau disease tumor suppressor

1

1

Small-scale

0.561

High

883046

AMPH
Amphiphysin

1

3

Small-scale

0.561

High

993160

ACTG
Actin, cytoplasmic 2

1

2

Small-scale

0.561

High

908108

KS6A3
Ribosomal protein S6 kinase alpha-3

1

1

Small-scale

0.553

High

1103758

DCAF6
DDB1- and CUL4-associated factor 6

1

2

High-throughput

0.553

High

1103799

ANLN
Anillin

1

1

High-throughput

0.553

High

1103769

HEAT3
HEAT repeat-containing protein 3

2

1

High-throughput

0.549

High

1103780

ZCH10
Zinc finger CCHC domain-containing protein 10

2

1

High-throughput

0.549

High

176191

PER2
Period circadian protein homolog 2

1

2

High-throughput

0.536

High

956858

CXCR4
C-X-C chemokine receptor type 4

1

3

High-throughput

0.536

High

1103754

ASIC2
Acid-sensing ion channel 2

1

1

High-throughput

0.536

High

1103789

TMM74
Transmembrane protein 74

1

1

High-throughput

0.536

High

1103770

RHG22
Rho GTPase-activating protein 22

1

0

High-throughput

0.517

High

422057

A4
Amyloid-beta precursor protein

1

1

High-throughput

0.515

High

190356

COPT1
High affinity copper uptake protein 1

1

0

High-throughput

0.513

High

230018

SAHH2
S-adenosylhomocysteine hydrolase-like protein 1

1

0

High-throughput

0.513

High

292623

RENR
Renin receptor

1

0

High-throughput

0.513

High

323989

CSTN1
Calsyntenin-1

1

0

High-throughput

0.513

High

648771

KCNA4
Potassium voltage-gated channel subfamily A member 4

1

0

High-throughput

0.513

High

659461

CRCM
Colorectal mutant cancer protein

1

0

High-throughput

0.513

High

718393

CD6
T-cell differentiation antigen CD6

1

0

High-throughput

0.513

High

725378

KAP1
cAMP-dependent protein kinase type I-beta regulatory subunit

1

0

High-throughput

0.513

High

1103759

FAXC
Failed axon connections homolog

1

0

High-throughput

0.513

High

1103791

APBA2
Amyloid-beta A4 precursor protein-binding family A member 2

1

0

High-throughput

0.513

High

1103803

TM63C
Osmosensitive cation channel TMEM63C

1

0

High-throughput

0.513

High

1103807

AKA11
A-kinase anchor protein 11

1

0

High-throughput

0.513

High

1103755

HIF1A
Hypoxia-inducible factor 1-alpha

1

1

Small-scale

0.512

High

1103794

EGLN1
Egl nine homolog 1

1

1

Small-scale

0.512

High

138486

BIN1
Myc box-dependent-interacting protein 1

1

3

Small-scale

0.501

High

954948

S10AA
Protein S100-A10

1

0

High-throughput

0.493

High

1103783

LMO7
LIM domain only protein 7

1

0

High-throughput

0.493

High

1065795

SPIR1
Protein spire homolog 1

1

0

High-throughput

0.493

High

1103796

SYNCI
Syncoilin

1

0

High-throughput

0.493

High

298905

DNJB5
DnaJ homolog subfamily B member 5

1

6

High-throughput

0.489

High

848612

MAGA9
Melanoma-associated antigen 9

1

1

High-throughput

0.489

High

1095874

EI2BE
Translation initiation factor eIF2B subunit epsilon

1

1

High-throughput

0.489

High

1103750

TEBP
Prostaglandin E synthase 3

1

2

High-throughput

0.489

High

1103757

INSY1
Inhibitory synaptic factor 1

1

1

High-throughput

0.489

High

1103788

LURA1
Leucine rich adaptor protein 1

1

1

High-throughput

0.489

High

126103

AP3B1
AP-3 complex subunit beta-1

1

2

High-throughput

0.479

High

187075

PPM1G
Protein phosphatase 1G

1

1

High-throughput

0.479

High

540436

LAMP1
Lysosome-associated membrane glycoprotein 1

1

2

High-throughput

0.479

High

562039

LAMP2
Lysosome-associated membrane glycoprotein 2

1

2

High-throughput

0.479

High

1103486

AP3B2
AP-3 complex subunit beta-2

1

2

High-throughput

0.479

High

1103772

PLD3
5'-3' exonuclease PLD3

1

1

High-throughput

0.479

High

1103809

LAMP3
Lysosome-associated membrane glycoprotein 3

1

2

High-throughput

0.479

High

1103811

AP3M1
AP-3 complex subunit mu-1

1

2

High-throughput

0.479

High

1103762

ESRP1
Epithelial splicing regulatory protein 1

1

1

High-throughput

0.470

High

159638

DVL2
Segment polarity protein dishevelled homolog DVL-2

1

0

High-throughput

0.458

High

178258

NPC1
NPC intracellular cholesterol transporter 1

1

0

High-throughput

0.458

High

208500

PJA2
E3 ubiquitin-protein ligase Praja-2

1

0

High-throughput

0.458

High

413767

P53
Cellular tumor antigen p53

1

0

High-throughput

0.458

High

715568

MARCS
Myristoylated alanine-rich C-kinase substrate

1

0

High-throughput

0.458

High

1103761

LTOR1
Ragulator complex protein LAMTOR1

1

0

High-throughput

0.458

High

1103775

CXD3
Gap junction delta-3 protein

1

0

High-throughput

0.458

High

58812

PIPSL
Putative PIP5K1A and PSMD4-like protein

1

1

High-throughput

0.445

High

182522

GP182
G-protein coupled receptor 182

1

5

High-throughput

0.445

High

1103774

S22AF
Solute carrier family 22 member 15

1

1

High-throughput

0.445

High

1103782

MOT10
Monocarboxylate transporter 10

1

1

High-throughput

0.445

High

293650

CD123
Translation initiation factor eIF2 assembly protein

1

1

High-throughput

0.437

High

1103773

ANKY2
Ankyrin repeat and MYND domain-containing protein 2

1

1

High-throughput

0.437

High

1103800

EI2BG
Translation initiation factor eIF2B subunit gamma

1

1

High-throughput

0.437

High

963414

STXB1
Syntaxin-binding protein 1

1

0

Small-scale

0.433

High

337093

NPT2B
Sodium-dependent phosphate transport protein 2B

1

0

High-throughput

0.426

High

388406

B3AT
Band 3 anion transport protein

1

0

High-throughput

0.426

High

538584

GTR1
Solute carrier family 2, facilitated glucose transporter member 1

1

0

High-throughput

0.426

High

946552

EVA1C
Protein eva-1 homolog C

1

0

High-throughput

0.426

High

948813

CD81
CD81 antigen

1

0

High-throughput

0.426

High

1103797

PACC1
Proton-activated chloride channel

1

0

High-throughput

0.426

High

239052

ZNRD2
Protein ZNRD2

1

1

High-throughput

0.407

High

1103786

EAF1
ELL-associated factor 1

1

1

High-throughput

0.407

High

329741

ZRAB2
Zinc finger Ran-binding domain-containing protein 2

3

0

High-throughput

0.347

High

1103776

MIER2
Mesoderm induction early response protein 2

3

0

High-throughput

0.347

High

1103793

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

3

0

High-throughput

0.347

High

1103798

SACA1
Sperm acrosome membrane-associated protein 1

3

0

High-throughput

0.347

High

1103785

SIR1
NAD-dependent protein deacetylase sirtuin-1

2

0

High-throughput

0.318

High

664517

ALAT1
Alanine aminotransferase 1

1

0

High-throughput

0.279

Low

1103746

LTBP2
Latent-transforming growth factor beta-binding protein 2

1

0

High-throughput

0.279

Low

1103760

CP135
Centrosomal protein of 135 kDa

1

0

High-throughput

0.279

Low

1103766

ANKS3
Ankyrin repeat and SAM domain-containing protein 3

1

0

High-throughput

0.279

Low

1103790

CC85A
Coiled-coil domain-containing protein 85A

1

0

High-throughput

0.279

Low

1103792

BACH2
Transcription regulator protein BACH2

1

0

High-throughput

0.279

Low

1103802

ING3
Inhibitor of growth protein 3

1

0

High-throughput

0.279

Low

1103810

POLH
DNA polymerase eta

1

0

High-throughput

0.279

Low

185191

FANCG
Fanconi anemia group G protein

1

0

High-throughput

0.268

Low

587464

TFE2
Transcription factor E2-alpha

1

0

High-throughput

0.268

Low

1081361

INCA1
Protein INCA1

1

0

High-throughput

0.268

Low

1088827

TP53B
TP53-binding protein 1

1

0

High-throughput

0.268

Low

1103764

ASCL4
Achaete-scute homolog 4

1

0

High-throughput

0.268

Low

1103765

LIAT1
Protein LIAT1

1

0

High-throughput

0.268

Low

67470

ZSWM8
Zinc finger SWIM domain-containing protein 8

1

0

High-throughput

0.249

Low

1103748

BRD3
Bromodomain-containing protein 3

1

0

High-throughput

0.249

Low

1103771

ZCH18
Zinc finger CCCH domain-containing protein 18

1

0

High-throughput

0.249

Low

1103781

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

0

High-throughput

0.249

Low

1103806

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.249

Low

1103812

DCAF1
DDB1- and CUL4-associated factor 1

1

0

High-throughput

0.249

Low

1103813

CFA20
Cilia- and flagella-associated protein 20

1

0

High-throughput

0.249

Low

351100

ECD
Protein ecdysoneless homolog

1

0

High-throughput

0.232

Low

653295

HEMH
Ferrochelatase, mitochondrial

1

0

High-throughput

0.232

Low

1103768

P4HA3
Prolyl 4-hydroxylase subunit alpha-3

1

0

High-throughput

0.232

Low

1103808

PNMA2
Paraneoplastic antigen Ma2

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025