Protein: CFAI
Complement factor I (EC 3.4.21.45) (C3B/C4B inactivator) [Cleaved into: Complement factor I heavy chain; Complement factor I light chain]

Gene: CFAI, CFI
Organism: Homo sapiens
Interactions: 15
UniProt ID: P05156

Gene Ontology (top 5):
GO:0004252 - serine-type endopeptidase activity
GO:0005576 - extracellular region
GO:0005615 - extracellular space
GO:0006508 - proteolysis
GO:0006958 - complement activation, classical pathway

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

369806

CO3
Complement C3

4

1

Small-scale

0.873

High

210680

KLK10
Kallikrein-10

1

18

High-throughput

0.691

High

425246

FHR4
Complement factor H-related protein 4

1

6

Small-scale

0.647

High

425245

ECM1
Extracellular matrix protein 1

2

0

High-throughput

0.576

High

425237

CO4B
Complement C4-B

1

1

Small-scale

0.575

High

425240

MCP
Membrane cofactor protein

1

7

Small-scale

0.575

High

425242

CR1
Complement receptor type 1

1

15

Small-scale

0.575

High

425243

GLP1R
Glucagon-like peptide 1 receptor

1

6

Small-scale

0.552

High

425247

PLCA
1-acyl-sn-glycerol-3-phosphate acyltransferase alpha

1

4

High-throughput

0.536

High

425238

POTEI
POTE ankyrin domain family member I

1

1

High-throughput

0.515

High

425239

PLAK
Junction plakoglobin

1

0

High-throughput

0.493

High

425241

TIMP2
Metalloproteinase inhibitor 2

1

6

High-throughput

0.479

High

425248

TRI31
E3 ubiquitin-protein ligase TRIM31

1

3

High-throughput

0.479

High

425249

ZRAN1
Ubiquitin thioesterase ZRANB1

1

4

High-throughput

0.437

High

425244

DC1I2
Cytoplasmic dynein 1 intermediate chain 2

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025