Protein: ECM1
Extracellular matrix protein 1 (Secretory component p85)

Gene: ECM1
Organism: Homo sapiens
Interactions: 146
UniProt ID: Q16610

Gene Ontology (top 5):
GO:0001503 - ossification
GO:0001525 - angiogenesis
GO:0001938 - positive regulation of endothelial cell proliferation
GO:0001960 - negative regulation of cytokine-mediated signaling pathway
GO:0002020 - protease binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

705358

GRN
Progranulin

3

0

Small-scale

0.622

High

1159406

GMCL1
Germ cell-less protein-like 1

3

1

High-throughput

0.609

High

376989

ANF
Natriuretic peptides A

2

0

High-throughput

0.602

High

1156001

ZIC1
Zinc finger protein ZIC 1

2

0

High-throughput

0.602

High

1098192

MMRN1
Multimerin-1

2

0

High-throughput

0.585

High

389399

FINC
Fibronectin

2

0

Small-scale

0.580

High

70222

CRTP1
Cysteine-rich tail protein 1

2

0

High-throughput

0.580

High

167703

LIN7A
Protein lin-7 homolog A

2

0

High-throughput

0.580

High

220248

FRS3
Fibroblast growth factor receptor substrate 3

2

0

High-throughput

0.580

High

288302

GCM2
Chorion-specific transcription factor GCMb

2

0

High-throughput

0.580

High

592656

ITB4
Integrin beta-4

2

0

High-throughput

0.580

High

725056

HXC8
Homeobox protein Hox-C8

2

0

High-throughput

0.580

High

725504

KAP3
cAMP-dependent protein kinase type II-beta regulatory subunit

2

0

High-throughput

0.580

High

869488

TNFL6
Tumor necrosis factor ligand superfamily member 6

2

0

High-throughput

0.580

High

1061517

ACTN3
Alpha-actinin-3

2

0

High-throughput

0.580

High

425245

CFAI
Complement factor I

2

0

High-throughput

0.576

High

1086403

FBLN3
EGF-containing fibulin-like extracellular matrix protein 1

1

1

Small-scale

0.573

High

276688

FKBP6
Inactive peptidyl-prolyl cis-trans isomerase FKBP6

2

1

High-throughput

0.553

High

1159384

KRA53
Keratin-associated protein 5-3

2

1

High-throughput

0.553

High

1159432

UBQL2
Ubiquilin-2

2

1

High-throughput

0.553

High

1159434

UBQL1
Ubiquilin-1

2

1

High-throughput

0.553

High

703607

MK01
Mitogen-activated protein kinase 1

1

1

High-throughput

0.536

High

1159440

IRAK3
Interleukin-1 receptor-associated kinase 3

1

0

High-throughput

0.518

High

213941

M3K7
Mitogen-activated protein kinase kinase kinase 7

1

0

High-throughput

0.513

High

282728

E2F6
Transcription factor E2F6

1

0

High-throughput

0.513

High

292640

RENR
Renin receptor

1

0

High-throughput

0.513

High

391620

FRIH
Ferritin heavy chain

1

0

High-throughput

0.513

High

463109

YES
Tyrosine-protein kinase Yes

1

0

High-throughput

0.513

High

551789

CO6A1

1

0

High-throughput

0.513

High

642557

TGM2
Protein-glutamine gamma-glutamyltransferase 2

1

0

High-throughput

0.513

High

722788

AL3A1
Aldehyde dehydrogenase, dimeric NADP-preferring

1

0

High-throughput

0.513

High

877126

KC1D
Casein kinase I isoform delta

1

0

High-throughput

0.513

High

930314

AAKG1
5'-AMP-activated protein kinase subunit gamma-1

1

0

High-throughput

0.513

High

1097202

PAK2
Serine/threonine-protein kinase PAK 2

1

0

High-throughput

0.513

High

1112512

CUL1
Cullin-1

1

0

High-throughput

0.513

High

1159387

AMTN
Amelotin

1

0

High-throughput

0.513

High

1159410

SRPK1
SRSF protein kinase 1

1

1

High-throughput

0.502

High

691757

MK03
Mitogen-activated protein kinase 3

1

1

High-throughput

0.489

High

728864

3HIDH
3-hydroxyisobutyrate dehydrogenase, mitochondrial

1

1

High-throughput

0.489

High

1159376

GLYR1
Cytokine-like nuclear factor N-PAC

1

1

High-throughput

0.489

High

1159391

CTU1
Cytoplasmic tRNA 2-thiolation protein 1

1

1

High-throughput

0.489

High

1159412

SH23A
SH2 domain-containing protein 3A

1

1

High-throughput

0.489

High

1159422

SNTG1
Gamma-1-syntrophin

1

1

High-throughput

0.489

High

1116989

LAMB3
Laminin subunit beta-3

1

0

Small-scale

0.484

High

422184

A4
Amyloid-beta precursor protein

1

0

Small-scale

0.480

High

575830

IL2RB
Interleukin-2 receptor subunit beta

1

1

Small-scale

0.479

High

1159417

TRI31
E3 ubiquitin-protein ligase TRIM31

1

2

High-throughput

0.479

High

928278

ATN1
Atrophin-1

1

1

High-throughput

0.464

High

1159429

RERE
Arginine-glutamic acid dipeptide repeats protein

1

1

High-throughput

0.464

High

179212

ARC1B
Actin-related protein 2/3 complex subunit 1B

1

0

Small-scale

0.458

High

372147

MYC
Myc proto-oncogene protein

1

0

High-throughput

0.458

High

1092141

NFX1
Transcriptional repressor NF-X1

1

0

High-throughput

0.458

High

1137723

TNIP1
TNFAIP3-interacting protein 1

1

0

High-throughput

0.458

High

1159400

NHLC2
NHL repeat-containing protein 2

1

0

High-throughput

0.458

High

1159402

ESR2
Estrogen receptor beta

1

0

High-throughput

0.458

High

1159427

PD1L1
Programmed cell death 1 ligand 1

1

0

High-throughput

0.458

High

1159438

TRRAP
Transformation/transcription domain-associated protein

1

0

High-throughput

0.458

High

1159439

LOXL2
Lysyl oxidase homolog 2

1

0

High-throughput

0.458

High

464451

TSP1
Thrombospondin-1

1

1

Small-scale

0.457

High

772315

FBN2
Fibrillin-2 [Cleaved into: Placensin]

1

1

Small-scale

0.457

High

1117032

LAMC2
Laminin subunit gamma-2

1

1

Small-scale

0.457

High

839460

PI4KA
Phosphatidylinositol 4-kinase alpha

1

2

High-throughput

0.445

High

1043625

COAA1

1

1

High-throughput

0.445

High

1159377

Q4LE69
Phosphatidylinositol 4-kinase alpha

1

2

High-throughput

0.437

High

1159389

TRI67
Tripartite motif-containing protein 67

1

1

High-throughput

0.437

High

213409

ZSC12
Zinc finger and SCAN domain-containing protein 12

1

0

High-throughput

0.426

High

389830

TTHY
Transthyretin

1

0

High-throughput

0.426

High

583564

ATF2
Cyclic AMP-dependent transcription factor ATF-2

1

0

High-throughput

0.426

High

1159399

PI4P1
Putative inactive phosphatidylinositol 4-kinase alpha-like protein P1

1

2

High-throughput

0.407

High

943845

CF298
Cilia- and flagella-associated protein 298

3

0

High-throughput

0.347

High

1159423

TB22B
TBC1 domain family member 22B

2

0

High-throughput

0.328

High

764231

CAH8
Carbonic anhydrase-related protein

2

0

High-throughput

0.318

High

1060263

MCL1
Induced myeloid leukemia cell differentiation protein Mcl-1

2

0

High-throughput

0.318

High

1159405

MITOK
Mitochondrial potassium channel

2

0

High-throughput

0.318

High

297995

SPF27
Pre-mRNA-splicing factor SPF27

2

0

High-throughput

0.316

High

350461

GPAN1
G patch domain and ankyrin repeat-containing protein 1

2

0

High-throughput

0.316

High

480157

RU1C
U1 small nuclear ribonucleoprotein C

2

0

High-throughput

0.316

High

965458

LMO4
LIM domain transcription factor LMO4

2

0

High-throughput

0.316

High

1093623

MKRN3
E3 ubiquitin-protein ligase makorin-3

2

0

High-throughput

0.316

High

1159375

KLH38
Kelch-like protein 38

2

0

High-throughput

0.316

High

1159380

LCE2A
Late cornified envelope protein 2A

2

0

High-throughput

0.316

High

1159392

DTX2
Probable E3 ubiquitin-protein ligase DTX2

2

0

High-throughput

0.316

High

1159404

SGTB
Small glutamine-rich tetratricopeptide repeat-containing protein beta

2

0

High-throughput

0.316

High

1159408

SAM11
Sterile alpha motif domain-containing protein 11

2

0

High-throughput

0.316

High

1159416

KRA93
Keratin-associated protein 9-3

2

0

High-throughput

0.316

High

1159418

ENKD1
Enkurin domain-containing protein 1

2

0

High-throughput

0.316

High

1159419

A1CF
APOBEC1 complementation factor

2

0

High-throughput

0.316

High

1159425

AIRIM
AFG2-interacting ribosome maturation factor

2

0

High-throughput

0.316

High

1159435

GLCNE
Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase

2

0

High-throughput

0.316

High

239372

BNI3L
BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like

1

0

High-throughput

0.282

High

899929

FXR1
RNA-binding protein FXR1

1

0

High-throughput

0.282

High

1159379

CPTP
Ceramide-1-phosphate transfer protein

1

0

High-throughput

0.282

High

227170

DYRK3
Dual specificity tyrosine-phosphorylation-regulated kinase 3

1

0

High-throughput

0.279

Low

251769

BUB1B
Mitotic checkpoint serine/threonine-protein kinase BUB1 beta

1

0

High-throughput

0.279

Low

261953

RNH1
Ribonuclease H1

1

0

High-throughput

0.279

Low

622816

ERCC3
General transcription and DNA repair factor IIH helicase/translocase subunit XPB

1

0

High-throughput

0.279

Low

666837

CCNC
Cyclin-C

1

0

High-throughput

0.279

Low

822687

VHL
von Hippel-Lindau disease tumor suppressor

1

0

High-throughput

0.279

Low

943059

STX17
Syntaxin-17

1

0

High-throughput

0.279

Low

1125311

FASTK
Fas-activated serine/threonine kinase

1

0

High-throughput

0.279

Low

1133774

SL9A5
Sodium/hydrogen exchanger 5

1

0

High-throughput

0.279

Low

1143027

CDK10
Cyclin-dependent kinase 10

1

0

High-throughput

0.279

Low

1159374

CTU2
Cytoplasmic tRNA 2-thiolation protein 2

1

0

High-throughput

0.279

Low

1159378

COX20
Cytochrome c oxidase assembly protein COX20, mitochondrial

1

0

High-throughput

0.279

Low

1159381

AHDC1
Transcription factor Gibbin

1

0

High-throughput

0.279

Low

1159383

TRI68
E3 ubiquitin-protein ligase TRIM68

1

0

High-throughput

0.279

Low

1159385

CV039
Synaptic plasticity regulator PANTS

1

0

High-throughput

0.279

Low

1159390

DPPA4
Developmental pluripotency-associated protein 4

1

0

High-throughput

0.279

Low

1159393

PLCZ1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1

1

0

High-throughput

0.279

Low

1159394

CDKL3
Cyclin-dependent kinase-like 3

1

0

High-throughput

0.279

Low

1159396

S35F2
Solute carrier family 35 member F2

1

0

High-throughput

0.279

Low

1159397

YAF2
YY1-associated factor 2

1

0

High-throughput

0.279

Low

1159398

FRMD1
FERM domain-containing protein 1

1

0

High-throughput

0.279

Low

1159401

ZDH19
Palmitoyltransferase ZDHHC19

1

0

High-throughput

0.279

Low

1159403

SARAF
Store-operated calcium entry-associated regulatory factor

1

0

High-throughput

0.279

Low

1159407

RNPC3
RNA-binding region-containing protein 3

1

0

High-throughput

0.279

Low

1159409

TEFM
Transcription elongation factor, mitochondrial

1

0

High-throughput

0.279

Low

1159413

P4K2A
Phosphatidylinositol 4-kinase type 2-alpha

1

0

High-throughput

0.279

Low

1159415

SRRT
Serrate RNA effector molecule homolog

1

0

High-throughput

0.279

Low

1159424

RFOX1
RNA binding protein fox-1 homolog 1

1

0

High-throughput

0.279

Low

1159426

RM39
Large ribosomal subunit protein mL39

1

0

High-throughput

0.279

Low

1159437

NSG2
Neuronal vesicle trafficking-associated protein 2

1

0

High-throughput

0.279

Low

1159441

ATP23
Mitochondrial inner membrane protease ATP23 homolog

1

0

High-throughput

0.279

Low

1159395

DDIAS
DNA damage-induced apoptosis suppressor protein

1

0

Small-scale

0.251

Low

106010

APRIO
Alternative prion protein

1

0

High-throughput

0.249

Low

218231

TGON2
Trans-Golgi network integral membrane protein 2

1

0

High-throughput

0.249

Low

262518

MCE1
mRNA-capping enzyme

1

0

High-throughput

0.249

Low

418161

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

0

High-throughput

0.249

Low

563829

CFTR
Cystic fibrosis transmembrane conductance regulator

1

0

High-throughput

0.249

Low

702966

DPOD1
DNA polymerase delta catalytic subunit

1

0

High-throughput

0.249

Low

830822

CCNF
Cyclin-F

1

0

High-throughput

0.249

Low

872375

SOX2
Transcription factor SOX-2

1

0

High-throughput

0.249

Low

1118041

DX39B
Spliceosome RNA helicase DDX39B

1

0

High-throughput

0.249

Low

1159388

BAKOR
Beclin 1-associated autophagy-related key regulator

1

0

High-throughput

0.249

Low

1159420

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

0

High-throughput

0.249

Low

1159428

HECW2
E3 ubiquitin-protein ligase HECW2

1

0

High-throughput

0.249

Low

1159431

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.249

Low

1129811

EPN4
Clathrin interactor 1

1

0

High-throughput

0.232

Low

1159382

A16L1
Autophagy-related protein 16-1

1

0

High-throughput

0.232

Low

1159386

CNKR3
Connector enhancer of kinase suppressor of ras 3

1

0

High-throughput

0.232

Low

1159411

MYCBP
c-Myc-binding protein

1

0

High-throughput

0.232

Low

1159414

RSRP1
Arginine/serine-rich protein 1

1

0

High-throughput

0.232

Low

1159421

FBX6
F-box only protein 6

1

0

High-throughput

0.232

Low

1159430

ASH2L
Set1/Ash2 histone methyltransferase complex subunit ASH2

1

0

High-throughput

0.232

Low

1159433

TCAL9
Transcription elongation factor A protein-like 9

1

0

High-throughput

0.232

Low

1159436

RPC10
DNA-directed RNA polymerase III subunit RPC10

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025