Protein: DC1I2
Cytoplasmic dynein 1 intermediate chain 2 (Cytoplasmic dynein intermediate chain 2) (Dynein intermediate chain 2, cytosolic) (DH IC-2)

Gene: DC1I2, DYNC1I2
Organism: Homo sapiens
Interactions: 222
UniProt ID: Q13409

Gene Ontology (top 5):
GO:0003777 - microtubule motor activity
GO:0005737 - cytoplasm
GO:0005813 - centrosome
GO:0005829 - cytosol
GO:0005868 - cytoplasmic dynein complex

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1104189

DYHC1
Cytoplasmic dynein 1 heavy chain 1

13

14

Small-scale

0.980

High

991836

DYLT1
Dynein light chain Tctex-type 1

8

14

Small-scale

0.969

High

907968

DYLT3
Dynein light chain Tctex-type 3

7

14

High-throughput

0.967

High

991513

DYL1
Dynein light chain 1, cytoplasmic

6

14

Small-scale

0.949

High

1104242

DYL2
Dynein light chain 2, cytoplasmic

5

14

High-throughput

0.919

High

156621

DC1I1
Cytoplasmic dynein 1 intermediate chain 1

4

15

High-throughput

0.900

High

845294

LIS1
Platelet-activating factor acetylhydrolase IB subunit beta

3

18

High-throughput

0.861

High

837220

ACTY
Beta-centractin

2

9

High-throughput

0.789

High

958425

ACTZ
Alpha-centractin

2

9

High-throughput

0.789

High

1104271

ARP10
Actin-related protein 10

2

7

High-throughput

0.789

High

1065078

ITK
Tyrosine-protein kinase ITK/TSK

2

0

High-throughput

0.770

High

821336

TCPZ
T-complex protein 1 subunit zeta

2

20

High-throughput

0.754

High

875943

TCPE
T-complex protein 1 subunit epsilon

2

20

High-throughput

0.754

High

899023

TCPQ
T-complex protein 1 subunit theta

2

20

High-throughput

0.754

High

1007000

TCPB
T-complex protein 1 subunit beta

2

20

High-throughput

0.754

High

210559

DC1L2
Cytoplasmic dynein 1 light intermediate chain 2

6

8

Small-scale

0.734

High

1104289

DC1L1
Cytoplasmic dynein 1 light intermediate chain 1

5

8

High-throughput

0.720

High

1104265

DLRB1
Dynein light chain roadblock-type 1

4

8

Small-scale

0.702

High

993161

ACTG
Actin, cytoplasmic 2

1

7

High-throughput

0.691

High

1104188

DCTN1
Dynactin subunit 1

4

18

High-throughput

0.691

High

1104183

DC1I2
Cytoplasmic dynein 1 intermediate chain 2

1

13

High-throughput

0.665

High

1104184

DCTN2
Dynactin subunit 2

3

6

High-throughput

0.656

High

1104279

DCTN4
Dynactin subunit 4

3

2

High-throughput

0.656

High

1104218

NIN
Ninein

3

20

High-throughput

0.640

High

1104193

MARE1
Microtubule-associated protein RP/EB family member 1

2

6

High-throughput

0.628

High

610645

TCPA
T-complex protein 1 subunit alpha

1

20

High-throughput

0.618

High

754831

H2B1B
Histone H2B type 1-B

1

9

High-throughput

0.618

High

881906

TCPG
T-complex protein 1 subunit gamma

1

20

High-throughput

0.618

High

899373

TCPD
T-complex protein 1 subunit delta

1

20

High-throughput

0.618

High

970448

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

8

High-throughput

0.618

High

1103610

PHLP
Phosducin-like protein

1

3

High-throughput

0.618

High

1104190

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

4

High-throughput

0.618

High

1104201

TRI67
Tripartite motif-containing protein 67

1

15

High-throughput

0.618

High

1104233

DYH7
Dynein axonemal heavy chain 7

1

14

High-throughput

0.618

High

1104234

TCPW
T-complex protein 1 subunit zeta-2

1

20

High-throughput

0.618

High

1104252

TCPH
T-complex protein 1 subunit eta

1

20

High-throughput

0.618

High

1104258

PKHA4
Pleckstrin homology domain-containing family A member 4

1

13

High-throughput

0.618

High

1104281

NOB1
RNA-binding protein NOB1

1

1

High-throughput

0.618

High

1104251

RING2
E3 ubiquitin-protein ligase RING2

2

18

High-throughput

0.611

High

1095524

LIPA1
Liprin-alpha-1

2

2

High-throughput

0.606

High

211489

PAPS1
Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1

2

0

High-throughput

0.602

High

168046

RGS12
Regulator of G-protein signaling 12

1

0

High-throughput

0.586

High

1104202

MOB3C
MOB kinase activator 3C

1

0

High-throughput

0.586

High

298166

DCTN3
Dynactin subunit 3

2

0

High-throughput

0.585

High

182122

PFD6
Prefoldin subunit 6

2

5

High-throughput

0.584

High

241592

PRKN
E3 ubiquitin-protein ligase parkin

2

10

High-throughput

0.584

High

258863

DNJA2
DnaJ homolog subfamily A member 2

2

14

High-throughput

0.584

High

963287

PFD3
Prefoldin subunit 3

2

4

High-throughput

0.584

High

1035500

CENPE
Centromere-associated protein E

2

4

High-throughput

0.584

High

1104197

LARP7
La-related protein 7

2

12

High-throughput

0.584

High

1104228

BICD2
Protein bicaudal D homolog 2

2

12

High-throughput

0.584

High

1104249

RUFY1
RUN and FYVE domain-containing protein 1

2

13

High-throughput

0.584

High

1104250

PFD5
Prefoldin subunit 5

2

5

High-throughput

0.584

High

1104275

PFD2
Prefoldin subunit 2

2

3

High-throughput

0.584

High

1104278

HOOK1
Protein Hook homolog 1

2

6

High-throughput

0.584

High

1104288

NINL
Ninein-like protein

2

17

High-throughput

0.584

High

1104206

NECA2
N-terminal EF-hand calcium-binding protein 2

2

0

High-throughput

0.580

High

787496

GNL1
Guanine nucleotide-binding protein-like 1

2

7

High-throughput

0.574

High

934565

TERA
Transitional endoplasmic reticulum ATPase

2

6

High-throughput

0.571

High

979603

H4
Histone H4

1

6

High-throughput

0.553

High

1104203

H32
Histone H3.2

1

20

High-throughput

0.553

High

1104231

DEP1B
DEP domain-containing protein 1B

1

4

High-throughput

0.553

High

1104262

AKTIP
AKT-interacting protein

1

5

High-throughput

0.553

High

1104264

WDR76
WD repeat-containing protein 76

1

19

High-throughput

0.553

High

1104267

SPHK2
Sphingosine kinase 2

1

3

Small-scale

0.552

High

270929

CLAP2
CLIP-associating protein 2

1

3

High-throughput

0.536

High

281317

GGYF1
GRB10-interacting GYF protein 1

1

6

High-throughput

0.536

High

559337

XRCC5
X-ray repair cross-complementing protein 5

1

3

High-throughput

0.536

High

691732

MK03
Mitogen-activated protein kinase 3

1

1

High-throughput

0.536

High

720996

CLIP1
CAP-Gly domain-containing linker protein 1

1

13

High-throughput

0.536

High

725491

KAP3
cAMP-dependent protein kinase type II-beta regulatory subunit

1

1

High-throughput

0.536

High

755343

ABCD1
ATP-binding cassette sub-family D member 1

1

3

High-throughput

0.536

High

971483

1433E
14-3-3 protein epsilon

1

2

High-throughput

0.536

High

997315

TBB4B
Tubulin beta-4B chain

1

14

High-throughput

0.536

High

1104185

CUL3
Cullin-3

1

20

High-throughput

0.536

High

1104186

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

7

High-throughput

0.536

High

1104205

CLAP1
CLIP-associating protein 1

1

6

High-throughput

0.536

High

1104225

RIN3
Ras and Rab interactor 3

1

8

High-throughput

0.536

High

1104268

S39A9
Zinc transporter ZIP9

2

2

High-throughput

0.521

High

446981

NPM
Nucleophosmin

1

4

High-throughput

0.515

High

1104220

KDM1B
Lysine-specific histone demethylase 2

1

6

High-throughput

0.489

High

1104232

DNJB3
DnaJ homolog subfamily B member 3

1

10

High-throughput

0.489

High

124773

AIP
AH receptor-interacting protein

1

10

High-throughput

0.479

High

138096

PSDE
26S proteasome non-ATPase regulatory subunit 14

1

3

High-throughput

0.479

High

163927

NDC80
Kinetochore protein NDC80 homolog

1

10

High-throughput

0.479

High

211312

RFOX2
RNA binding protein fox-1 homolog 2

1

7

High-throughput

0.479

High

261799

PFD1
Prefoldin subunit 1

1

3

High-throughput

0.479

High

293651

CD123
Translation initiation factor eIF2 assembly protein

1

2

High-throughput

0.479

High

324838

HEXI1
Protein HEXIM1

1

2

High-throughput

0.479

High

335119

ARI2
E3 ubiquitin-protein ligase ARIH2

1

9

High-throughput

0.479

High

345763

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

7

High-throughput

0.479

High

408049

TBB4A
Tubulin beta-4A chain

1

14

High-throughput

0.479

High

413768

P53
Cellular tumor antigen p53

1

4

High-throughput

0.479

High

459884

APT
Adenine phosphoribosyltransferase

1

1

High-throughput

0.479

High

467901

PFKAM
ATP-dependent 6-phosphofructokinase, muscle type

1

2

High-throughput

0.479

High

468334

HS90B
Heat shock protein HSP 90-beta

1

8

High-throughput

0.479

High

475571

K1C19
Keratin, type I cytoskeletal 19

1

6

High-throughput

0.479

High

507925

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

7

High-throughput

0.479

High

521337

ARAF
Serine/threonine-protein kinase A-Raf

1

6

High-throughput

0.479

High

537102

HSP7C
Heat shock cognate 71 kDa protein

1

10

High-throughput

0.479

High

563720

CFTR
Cystic fibrosis transmembrane conductance regulator

1

4

High-throughput

0.479

High

573951

MYL6B
Myosin light chain 6B

1

1

High-throughput

0.479

High

582773

EZRI
Ezrin

1

2

High-throughput

0.479

High

606723

CEBPB
CCAAT/enhancer-binding protein beta

1

7

High-throughput

0.479

High

690977

1433T
14-3-3 protein theta

1

10

High-throughput

0.479

High

727787

DNJA1
DnaJ homolog subfamily A member 1

1

14

High-throughput

0.479

High

731258

STIP1
Stress-induced-phosphoprotein 1

1

15

High-throughput

0.479

High

771989

K1C9
Keratin, type I cytoskeletal 9

1

8

High-throughput

0.479

High

772156

MSX2
Homeobox protein MSX-2

1

7

High-throughput

0.479

High

799072

BRCA1
Breast cancer type 1 susceptibility protein

1

9

High-throughput

0.479

High

830681

CCNF
Cyclin-F

1

4

High-throughput

0.479

High

859814

RL28
Large ribosomal subunit protein eL28

1

2

High-throughput

0.479

High

867097

CAPZB
F-actin-capping protein subunit beta

1

4

High-throughput

0.479

High

878447

PAXI
Paxillin

1

4

Small-scale

0.479

High

883091

AL7A1
Alpha-aminoadipic semialdehyde dehydrogenase

1

5

High-throughput

0.479

High

891514

GSK3B
Glycogen synthase kinase-3 beta

1

5

High-throughput

0.479

High

897259

CDK7
Cyclin-dependent kinase 7

1

4

High-throughput

0.479

High

960707

RL15
Large ribosomal subunit protein eL15

1

2

High-throughput

0.479

High

1038615

FKBP4
Peptidyl-prolyl cis-trans isomerase FKBP4

1

12

High-throughput

0.479

High

1040792

MECOM
Histone-lysine N-methyltransferase MECOM

1

6

High-throughput

0.479

High

1062227

TGM3
Protein-glutamine gamma-glutamyltransferase E

1

2

High-throughput

0.479

High

1064873

PPID
Peptidyl-prolyl cis-trans isomerase D

1

2

High-throughput

0.479

High

1093222

FLII
Protein flightless-1 homolog

1

2

High-throughput

0.479

High

1104187

TRI14
Tripartite motif-containing protein 14

1

7

High-throughput

0.479

High

1104192

RSU1
Ras suppressor protein 1

1

2

High-throughput

0.479

High

1104194

STXB2
Syntaxin-binding protein 2

1

1

High-throughput

0.479

High

1104195

DREB
Drebrin

1

3

High-throughput

0.479

High

1104196

DECR
2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing], mitochondrial

1

1

High-throughput

0.479

High

1104200

RICTR
Rapamycin-insensitive companion of mTOR

1

5

High-throughput

0.479

High

1104207

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

4

High-throughput

0.479

High

1104209

HOOK3
Protein Hook homolog 3

1

7

High-throughput

0.479

High

1104210

COMD2
COMM domain-containing protein 2

1

1

High-throughput

0.479

High

1104211

RB6I2
ELKS/Rab6-interacting/CAST family member 1

1

8

High-throughput

0.479

High

1104212

LRC49
Leucine-rich repeat-containing protein 49

1

1

High-throughput

0.479

High

1104213

NUDC3
NudC domain-containing protein 3

1

15

High-throughput

0.479

High

1104214

SIR2
NAD-dependent protein deacetylase sirtuin-2

1

9

High-throughput

0.479

High

1104216

KBTB2
Kelch repeat and BTB domain-containing protein 2

1

1

High-throughput

0.479

High

1104217

RASEF
Ras and EF-hand domain-containing protein

1

3

High-throughput

0.479

High

1104221

SERB1
SERPINE1 mRNA-binding protein 1

1

3

High-throughput

0.479

High

1104224

TNIP2
TNFAIP3-interacting protein 2

1

1

High-throughput

0.479

High

1104226

F110B
Protein FAM110B

1

1

High-throughput

0.479

High

1104235

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

4

High-throughput

0.479

High

1104236

NDRG1
Protein NDRG1

1

1

High-throughput

0.479

High

1104238

GLMN
Glomulin

1

1

High-throughput

0.479

High

1104240

GCP3
Gamma-tubulin complex component 3

1

1

High-throughput

0.479

High

1104243

BICD1
Protein bicaudal D homolog 1

1

13

High-throughput

0.479

High

1104244

ELMO2
Engulfment and cell motility protein 2

1

1

High-throughput

0.479

High

1104247

CI072
Guanine nucleotide exchange factor C9orf72

1

2

High-throughput

0.479

High

1104253

SH3G2
Endophilin-A1

1

5

High-throughput

0.479

High

1104254

TBA1C
Tubulin alpha-1C chain

1

16

High-throughput

0.479

High

1104256

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

5

High-throughput

0.479

High

1104257

UN45A
Protein unc-45 homolog A

1

19

High-throughput

0.479

High

1104260

EGLN3
Prolyl hydroxylase EGLN3

1

4

High-throughput

0.479

High

1104261

CCSE2
Serine-rich coiled-coil domain-containing protein 2

1

1

High-throughput

0.479

High

1104263

ECT2
Protein ECT2

1

12

High-throughput

0.479

High

1104266

PFD4
Prefoldin subunit 4

1

4

High-throughput

0.479

High

1104272

TLS1
Splicing factor C9orf78

1

2

High-throughput

0.479

High

1104273

VPS29
Vacuolar protein sorting-associated protein 29

1

1

High-throughput

0.479

High

1104274

ZRAN1
Ubiquitin thioesterase ZRANB1

1

8

High-throughput

0.479

High

1104276

TR112
Multifunctional methyltransferase subunit TRM112-like protein

1

1

High-throughput

0.479

High

1104277

XPO7
Exportin-7

1

12

High-throughput

0.479

High

1104280

DJC12
DnaJ homolog subfamily C member 12

1

9

High-throughput

0.479

High

1104282

UBQL1
Ubiquilin-1

1

3

High-throughput

0.479

High

1104283

CHIP
E3 ubiquitin-protein ligase CHIP

1

10

High-throughput

0.479

High

1104285

RUVB2
RuvB-like 2

1

7

High-throughput

0.479

High

1104286

RUVB1
RuvB-like 1

1

7

High-throughput

0.479

High

1104287

NUDC
Nuclear migration protein nudC

1

15

High-throughput

0.479

High

1104290

CAN7
Calpain-7

1

3

High-throughput

0.479

High

133352

DCTN6
Dynactin subunit 6

1

0

High-throughput

0.458

High

331863

GOSR1
Golgi SNAP receptor complex member 1

1

0

High-throughput

0.458

High

332301

ATE1
Arginyl-tRNA--protein transferase 1

1

0

High-throughput

0.458

High

733871

DCTD
Deoxycytidylate deaminase

1

0

High-throughput

0.458

High

946102

MLF1
Myeloid leukemia factor 1

1

0

High-throughput

0.458

High

1092696

AF1Q
Protein AF1q

1

0

High-throughput

0.458

High

1104223

SIMC1
SUMO-interacting motif-containing protein 1

1

0

High-throughput

0.458

High

1104239

KPBB
Phosphorylase b kinase regulatory subunit beta

1

0

High-throughput

0.458

High

278853

PEX14
Peroxisomal membrane protein PEX14

1

1

Small-scale

0.445

High

422059

A4
Amyloid-beta precursor protein

1

5

Small-scale

0.445

High

529742

TAU
Microtubule-associated protein tau

1

15

High-throughput

0.445

High

1104245

CC136
Coiled-coil domain-containing protein 136

1

10

High-throughput

0.439

High

105870

APRIO
Alternative prion protein

1

4

High-throughput

0.437

High

132846

ODPX
Pyruvate dehydrogenase protein X component, mitochondrial

1

5

High-throughput

0.437

High

221575

TIM44
Mitochondrial import inner membrane translocase subunit TIM44

1

2

High-throughput

0.437

High

278661

NDUS6
NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial

1

2

High-throughput

0.437

High

371946

MYC
Myc proto-oncogene protein

1

16

High-throughput

0.437

High

411872

NTRK1
High affinity nerve growth factor receptor

1

5

High-throughput

0.437

High

472305

CFAH
Complement factor H

1

2

Small-scale

0.437

High

588613

RFA2
Replication protein A 32 kDa subunit

1

6

High-throughput

0.437

High

729042

HNRH3
Heterogeneous nuclear ribonucleoprotein H3

1

9

High-throughput

0.437

High

768106

RFA3
Replication protein A 14 kDa subunit

1

4

High-throughput

0.437

High

1099848

TIF1B
Transcription intermediary factor 1-beta

1

8

High-throughput

0.437

High

1104191

UBE3C
Ubiquitin-protein ligase E3C

1

6

High-throughput

0.437

High

1104199

RM14
Large ribosomal subunit protein uL14m

1

1

High-throughput

0.437

High

1104204

ASXL2
Putative Polycomb group protein ASXL2

1

15

High-throughput

0.437

High

1104208

TBCD1
TBC1 domain family member 1

1

2

High-throughput

0.437

High

1104215

ASXL1
Polycomb group protein ASXL1

1

7

High-throughput

0.437

High

1104230

BRX1
Ribosome biogenesis protein BRX1 homolog

1

4

High-throughput

0.437

High

1104237

ESR2
Estrogen receptor beta

1

20

High-throughput

0.437

High

1104246

BT3L4
Transcription factor BTF3 homolog 4

1

6

High-throughput

0.437

High

1104284

SRRM2
Serine/arginine repetitive matrix protein 2

1

20

High-throughput

0.437

High

429831

JUN
Transcription factor Jun

1

12

High-throughput

0.407

High

844766

EAA1
Excitatory amino acid transporter 1

1

1

High-throughput

0.407

High

1104222

MOT11
Monocarboxylate transporter 11

1

3

High-throughput

0.407

High

1104229

HUMMR
Protein MGARP

1

0

High-throughput

0.279

Low

1104255

RSRP1
Arginine/serine-rich protein 1

1

0

High-throughput

0.279

Low

76226

B4DJ38
Pentatricopeptide repeat-containing protein 1, mitochondrial

1

0

High-throughput

0.249

Low

166651

BCKD
Branched-chain alpha-ketoacid dehydrogenase kinase

1

0

High-throughput

0.249

Low

283242

ERLN1
Erlin-1

1

0

High-throughput

0.249

Low

425244

CFAI
Complement factor I

1

0

High-throughput

0.249

Low

528752

MGST1
Microsomal glutathione S-transferase 1

1

0

High-throughput

0.249

Low

1012688

RT06
Small ribosomal subunit protein bS6m

1

0

High-throughput

0.249

Low

1053453

FHI1A
FHF complex subunit HOOK-interacting protein 1A

1

0

High-throughput

0.249

Low

1104198

TM41B
Transmembrane protein 41B

1

0

High-throughput

0.249

Low

1104219

ZN565
Zinc finger protein 565

1

0

High-throughput

0.249

Low

1104227

MIPO1
Mirror-image polydactyly gene 1 protein

1

0

High-throughput

0.249

Low

1104241

RMC1
Regulator of MON1-CCZ1 complex

1

0

High-throughput

0.249

Low

1104248

TM209
Transmembrane protein 209

1

0

High-throughput

0.249

Low

1104259

TFB2M
Dimethyladenosine transferase 2, mitochondrial

1

0

High-throughput

0.249

Low

1104269

PLCE
1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon

1

0

High-throughput

0.249

Low

1104270

NECP2
Adaptin ear-binding coat-associated protein 2

1

0

High-throughput

0.249

Low

1010912

BAT1
b(0,+)-type amino acid transporter 1

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025