Protein: EAF6
Chromatin modification-related protein MEAF6 (MYST/Esa1-associated factor 6) (Esa1-associated factor 6 homolog) (Protein EAF6 homolog) (hEAF6) (Sarcoma antigen NY-SAR-91)

Gene: EAF6, MEAF6
Organism: Homo sapiens
Interactions: 135
UniProt ID: Q9HAF1

Gene Ontology (top 5):
GO:0000123 - histone acetyltransferase complex
GO:0000776 - kinetochore
GO:0000786 - nucleosome
GO:0001558 - regulation of cell growth
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1437547

ING4
Inhibitor of growth protein 4

6

3

Small-scale

0.949

High

1361582

ING5
Inhibitor of growth protein 5

5

3

Small-scale

0.927

High

1437539

ING3
Inhibitor of growth protein 3

5

3

Small-scale

0.925

High

1234199

JADE1
Protein Jade-1

6

7

Small-scale

0.736

High

1371292

KAT5
Histone acetyltransferase KAT5

6

7

Small-scale

0.734

High

1437535

JADE2
E3 ubiquitin-protein ligase Jade-2

6

7

High-throughput

0.731

High

1368624

KAT6A
Histone acetyltransferase KAT6A

6

7

Small-scale

0.729

High

342329

BRD1
Bromodomain-containing protein 1

5

7

Small-scale

0.716

High

1053311

MBTD1
MBT domain-containing protein 1

5

1

Small-scale

0.716

High

1431813

EPC1
Enhancer of polycomb homolog 1

5

2

Small-scale

0.716

High

936677

BRPF1
Peregrin

5

7

Small-scale

0.714

High

332048

KAT7
Histone acetyltransferase KAT7

5

7

Small-scale

0.712

High

1437542

MO4L1
Mortality factor 4-like protein 1

5

1

Small-scale

0.712

High

1437546

BRPF3
Bromodomain and PHD finger-containing protein 3

5

7

High-throughput

0.712

High

1380969

LMBL2
Lethal(3)malignant brain tumor-like protein 2

4

1

High-throughput

0.700

High

1437548

RUVB2
RuvB-like 2

4

3

High-throughput

0.697

High

1244940

FOXR1
Forkhead box protein R1

4

1

High-throughput

0.694

High

1136860

MO4L2
Mortality factor 4-like protein 2

4

1

Small-scale

0.691

High

1365552

JADE3
Protein Jade-3

4

7

High-throughput

0.691

High

1381866

H2B1A
Histone H2B type 1-A

4

4

High-throughput

0.691

High

1437537

MRGBP
MRG/MORF4L-binding protein

5

0

Small-scale

0.684

High

1245361

FOXR2
Forkhead box protein R2

3

1

High-throughput

0.667

High

1361558

KAT6B
Histone acetyltransferase KAT6B

3

7

High-throughput

0.667

High

1198115

EPC2
Enhancer of polycomb homolog 2

3

2

High-throughput

0.662

High

1437534

DMAP1
DNA methyltransferase 1-associated protein 1

3

1

High-throughput

0.662

High

1437549

RUVB1
RuvB-like 1

3

3

High-throughput

0.662

High

1437552

TRRAP
Transformation/transcription domain-associated protein

3

1

High-throughput

0.662

High

340407

YETS4
YEATS domain-containing protein 4

4

0

High-throughput

0.661

High

1396747

EP400
E1A-binding protein p400

4

0

Small-scale

0.661

High

1429936

BRD8
Bromodomain-containing protein 8

4

0

High-throughput

0.661

High

1155328

VPS72
Vacuolar protein sorting-associated protein 72 homolog

4

0

Small-scale

0.658

High

848178

MAGA1
Melanoma-associated antigen 1

3

0

High-throughput

0.638

High

1291983

JAZF1
Juxtaposed with another zinc finger protein 1

3

0

Small-scale

0.638

High

1035926

KIF23
Kinesin-like protein KIF23

3

0

High-throughput

0.634

High

553765

MYCL
Protein L-Myc

2

3

High-throughput

0.628

High

900519

FXR2
RNA-binding protein FXR2

2

0

High-throughput

0.613

High

212688

DAPK3
Death-associated protein kinase 3

2

0

High-throughput

0.602

High

1290305

KBTB6
Kelch repeat and BTB domain-containing protein 6

2

0

High-throughput

0.602

High

274240

ANR17
Ankyrin repeat domain-containing protein 17

2

1

High-throughput

0.601

High

911382

IMA5
Importin subunit alpha-5

2

2

High-throughput

0.601

High

502135

H2AZ
Histone H2A.Z

2

0

Small-scale

0.585

High

373183

MYC
Myc proto-oncogene protein

2

3

High-throughput

0.584

High

343812

LDOC1
Protein LDOC1

1

0

High-throughput

0.549

High

179082

IMA6
Importin subunit alpha-6

1

2

High-throughput

0.536

High

253695

IMA7
Importin subunit alpha-7

1

2

High-throughput

0.536

High

1163215

H2B2E
Histone H2B type 2-E

1

4

High-throughput

0.536

High

1323984

H2B3B
Histone H2B type 3-B

1

4

High-throughput

0.536

High

1154595

CC85B
Coiled-coil domain-containing protein 85B

1

0

High-throughput

0.518

High

2851

A0A0C4DFT8
Jade family PHD finger 2

1

7

High-throughput

0.515

High

487769

PARP1
Poly [ADP-ribose] polymerase 1

1

0

High-throughput

0.513

High

693991

RL10
Large ribosomal subunit protein uL16

1

0

High-throughput

0.513

High

833780

KDM5C
Lysine-specific demethylase 5C

1

0

High-throughput

0.513

High

998035

CSK21
Casein kinase II subunit alpha

1

0

High-throughput

0.513

High

1123125

FHL2
Four and a half LIM domains protein 2

1

0

High-throughput

0.513

High

1134732

NUMA1
Nuclear mitotic apparatus protein 1

1

0

High-throughput

0.513

High

1275339

APTX
Aprataxin

1

0

High-throughput

0.513

High

1371699

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

0

High-throughput

0.513

High

1402774

STRBP
Spermatid perinuclear RNA-binding protein

1

0

High-throughput

0.513

High

829157

RFC5
Replication factor C subunit 5

1

0

High-throughput

0.493

High

843997

HD
Huntingtin

1

0

High-throughput

0.493

High

1118996

BYST
Bystin

1

0

High-throughput

0.493

High

1311407

ANKH1
Ankyrin repeat and KH domain-containing protein 1

1

1

High-throughput

0.489

High

339863

KLF8
Krueppel-like factor 8

1

1

High-throughput

0.479

High

406661

MYCN
N-myc proto-oncogene protein

1

3

High-throughput

0.479

High

659947

H2B1O
Histone H2B type 1-O

1

4

High-throughput

0.479

High

959659

MAX
Protein max

1

3

Small-scale

0.479

High

977089

CNBP
CCHC-type zinc finger nucleic acid binding protein

1

2

High-throughput

0.479

High

981107

H2B1C
Histone H2B type 1-C/E/F/G/I

1

4

High-throughput

0.479

High

998823

H31
Histone H3.1

1

1

High-throughput

0.479

High

1017222

H33
Histone H3.3

1

1

High-throughput

0.479

High

1405732

KLF6
Krueppel-like factor 6

1

1

High-throughput

0.479

High

227673

SPOP
Speckle-type POZ protein

1

0

High-throughput

0.458

High

401507

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

0

High-throughput

0.458

High

538473

EGR2
E3 SUMO-protein ligase EGR2

1

0

High-throughput

0.458

High

837093

ELK3
ETS domain-containing protein Elk-3

1

0

High-throughput

0.458

High

980351

H4
Histone H4

1

0

High-throughput

0.458

High

995278

CSK2B
Casein kinase II subunit beta

1

0

High-throughput

0.458

High

1045783

TF65
Transcription factor p65

1

0

High-throughput

0.458

High

1244834

FBX38
F-box only protein 38

1

0

High-throughput

0.458

High

1313440

SMC5
Structural maintenance of chromosomes protein 5

1

0

High-throughput

0.458

High

1385629

DCPS
m7GpppX diphosphatase

1

0

High-throughput

0.458

High

1420463

DPY30
Protein dpy-30 homolog

1

0

High-throughput

0.458

High

1437540

TLS1
Splicing factor C9orf78

1

0

High-throughput

0.458

High

1437543

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

1325599

ZCHC7
Zinc finger CCHC domain-containing protein 7

1

2

High-throughput

0.445

High

1327386

ZCHC9
Zinc finger CCHC domain-containing protein 9

1

2

High-throughput

0.445

High

1403288

RBM15
RNA-binding protein 15

1

1

High-throughput

0.445

High

1411094

BUD13
BUD13 homolog

1

1

High-throughput

0.445

High

1437550

RBMX2
RNA-binding motif protein, X-linked 2

1

1

High-throughput

0.445

High

182370

WDR46
WD repeat-containing protein 46

1

0

High-throughput

0.426

High

276003

DUS11
RNA/RNP complex-1-interacting phosphatase

1

0

High-throughput

0.426

High

1004408

NOP14
Nucleolar protein 14

1

0

High-throughput

0.426

High

1041857

CENPC
Centromere protein C

1

0

High-throughput

0.426

High

1117673

NOG2
Nucleolar GTP-binding protein 2

1

0

High-throughput

0.426

High

1168577

KNOP1
Lysine-rich nucleolar protein 1

1

0

High-throughput

0.426

High

1179373

TSR1
Pre-rRNA-processing protein TSR1 homolog

1

0

High-throughput

0.426

High

1193385

GLYR1
Cytokine-like nuclear factor N-PAC

1

0

High-throughput

0.426

High

1203909

NOM1
Nucleolar MIF4G domain-containing protein 1

1

0

High-throughput

0.426

High

1212093

SPOUT
28S rRNA

1

0

High-throughput

0.426

High

1219055

RSBN1
Lysine-specific demethylase 9

1

0

High-throughput

0.426

High

1239151

NEPRO
Nucleolus and neural progenitor protein

1

0

High-throughput

0.426

High

1257822

ACD11
Acyl-CoA dehydrogenase family member 11

1

0

High-throughput

0.426

High

1259027

CENPU
Centromere protein U

1

0

High-throughput

0.426

High

1279903

RBBP6
E3 ubiquitin-protein ligase RBBP6

1

0

High-throughput

0.426

High

1307487

MY18B
Unconventional myosin-XVIIIb

1

0

High-throughput

0.426

High

1312502

PHC2
Polyhomeotic-like protein 2

1

0

High-throughput

0.426

High

1388056

TRI44
Tripartite motif-containing protein 44

1

0

High-throughput

0.426

High

1393164

PRR11
Proline-rich protein 11

1

0

High-throughput

0.426

High

1400410

F111A
Serine protease FAM111A

1

0

High-throughput

0.426

High

1411890

UTP23
rRNA-processing protein UTP23 homolog

1

0

High-throughput

0.426

High

1417342

NUSAP
Nucleolar and spindle-associated protein 1

1

0

High-throughput

0.426

High

1428468

REXO4
RNA exonuclease 4

1

0

High-throughput

0.426

High

1429907

SP130
Histone deacetylase complex subunit SAP130

1

0

High-throughput

0.426

High

1437536

DDX28
Probable ATP-dependent RNA helicase DDX28

1

0

High-throughput

0.426

High

1437538

ARGL1
Arginine and glutamate-rich protein 1

1

0

High-throughput

0.426

High

1437541

RBM27
RNA-binding protein 27

1

0

High-throughput

0.426

High

1437544

NOL12
Nucleolar protein 12

1

0

High-throughput

0.426

High

1437545

TRM6
tRNA

1

0

High-throughput

0.426

High

1437551

UTP11
Probable U3 small nucleolar RNA-associated protein 11

1

0

High-throughput

0.426

High

1437533

PLAC1
Placenta-specific protein 1

3

0

High-throughput

0.347

High

1291740

SESD1
SEC14 domain and spectrin repeat-containing protein 1

3

0

High-throughput

0.345

High

1436601

PKHF2
Pleckstrin homology domain-containing family F member 2

2

0

High-throughput

0.339

High

1200592

CTSRT
Cation channel sperm-associated targeting subunit tau

2

0

High-throughput

0.316

High

938076

TPD52
Tumor protein D52

2

0

High-throughput

0.313

High

1419229

TRI54
Tripartite motif-containing protein 54

1

0

High-throughput

0.299

High

1290738

ZCH18
Zinc finger CCCH domain-containing protein 18

2

0

High-throughput

0.298

High

867429

CAPZB
F-actin-capping protein subunit beta

1

0

High-throughput

0.279

Low

650423

FGFR3
Fibroblast growth factor receptor 3

1

0

High-throughput

0.268

Low

686653

ELAV4
ELAV-like protein 4

1

0

High-throughput

0.268

Low

1252977

BAKOR
Beclin 1-associated autophagy-related key regulator

1

0

High-throughput

0.249

Low

1433929

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.249

Low

1008080

DEN2B
DENN domain-containing protein 2B

1

0

High-throughput

0.232

Low

1294426

SPAS2
Spermatogenesis-associated serine-rich protein 2

1

0

High-throughput

0.232

Low

1335727

MOT11
Monocarboxylate transporter 11

1

0

High-throughput

0.232

Low

1435727

CH033
UPF0488 protein C8orf33

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025