Protein: L2GL2
LLGL scribble cell polarity complex component 2 (HGL) (Lethal(2) giant larvae protein homolog 2)

Gene: L2GL2, LLGL2
Organism: Homo sapiens
Interactions: 134
UniProt ID: Q6P1M3

Gene Ontology (top 5):
GO:0005096 - GTPase activator activity
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0005886 - plasma membrane
GO:0005912 - adherens junction

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

884352

UBE2A
Ubiquitin-conjugating enzyme E2 A

3

1

High-throughput

0.855

High

1241037

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

3

3

High-throughput

0.855

High

1240997

L2GL2
LLGL scribble cell polarity complex component 2

2

10

High-throughput

0.776

High

1241033

DDA1
DET1- and DDB1-associated protein 1

3

1

High-throughput

0.765

High

835694

KPCI
Protein kinase C iota type

11

9

Small-scale

0.757

High

1241035

PAR6B
Partitioning defective 6 homolog beta

9

8

Small-scale

0.755

High

1051255

KPCZ
Protein kinase C zeta type

9

9

High-throughput

0.752

High

1240998

BRWD3
Bromodomain and WD repeat-containing protein 3

2

18

High-throughput

0.726

High

1241034

PAR6G
Partitioning defective 6 homolog gamma

5

8

High-throughput

0.716

High

1241015

KBTB7
Kelch repeat and BTB domain-containing protein 7

5

3

Small-scale

0.709

High

1241043

PAR6A
Partitioning defective 6 homolog alpha

4

8

High-throughput

0.702

High

1241068

DCAF1
DDB1- and CUL4-associated factor 1

4

16

High-throughput

0.697

High

839295

MTOR
Serine/threonine-protein kinase mTOR

1

5

High-throughput

0.691

High

1157766

DDB1
DNA damage-binding protein 1

1

9

High-throughput

0.691

High

1241029

LYST
Lysosomal-trafficking regulator

1

8

High-throughput

0.691

High

1241044

BIRC6
Dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6

1

6

High-throughput

0.691

High

1241046

RAD18
E3 ubiquitin-protein ligase RAD18

4

1

High-throughput

0.691

High

561128

GILT
Gamma-interferon-inducible lysosomal thiol reductase

3

0

High-throughput

0.638

High

719558

NKTR
NK-tumor recognition protein

2

3

High-throughput

0.628

High

997794

CSK21
Casein kinase II subunit alpha

2

7

High-throughput

0.628

High

1095548

LIPA1
Liprin-alpha-1

2

3

High-throughput

0.628

High

1153497

RAB30
Ras-related protein Rab-30

2

4

High-throughput

0.628

High

1241003

KBTB6
Kelch repeat and BTB domain-containing protein 6

2

3

High-throughput

0.628

High

1241007

ZN687
Zinc finger protein 687

2

1

High-throughput

0.628

High

1241052

RCOR3
REST corepressor 3

2

3

High-throughput

0.628

High

1241060

ZMYD8
MYND-type zinc finger-containing chromatin reader ZMYND8

2

6

High-throughput

0.628

High

1159296

TAF9
Transcription initiation factor TFIID subunit 9

1

1

High-throughput

0.618

High

710308

EPHA2
Ephrin type-A receptor 2

1

6

High-throughput

0.618

High

975094

ARF6
ADP-ribosylation factor 6

1

4

High-throughput

0.618

High

258942

DNJA2
DnaJ homolog subfamily A member 2

2

13

High-throughput

0.611

High

1058088

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

2

0

High-throughput

0.602

High

1089217

TRI26
Tripartite motif-containing protein 26

2

0

High-throughput

0.602

High

1241014

CATIN
Splicing factor Cactin

2

0

High-throughput

0.602

High

1146308

L2GL1
Lethal(2) giant larvae protein homolog 1

2

3

High-throughput

0.601

High

375625

RASK
GTPase KRas

2

10

High-throughput

0.584

High

1241004

ZC3H3
Zinc finger CCCH domain-containing protein 3

1

0

High-throughput

0.578

High

1241010

DDX55
ATP-dependent RNA helicase DDX55

1

10

High-throughput

0.575

High

1241017

ZN592
Zinc finger protein 592

2

1

High-throughput

0.574

High

1241042

HM20A
High mobility group protein 20A

2

7

High-throughput

0.574

High

1241045

TOPRS
E3 ubiquitin-protein ligase Topors

2

1

High-throughput

0.574

High

1241057

RCOR1
REST corepressor 1

2

3

High-throughput

0.574

High

531088

KAP0
cAMP-dependent protein kinase type I-alpha regulatory subunit

2

2

High-throughput

0.571

High

988452

RAC1
Ras-related C3 botulinum toxin substrate 1

2

15

High-throughput

0.571

High

135639

DNM1L
Dynamin-1-like protein

1

2

High-throughput

0.536

High

183473

CASC3
Protein CASC3

1

3

High-throughput

0.536

High

239099

ZNRD2
Protein ZNRD2

1

1

High-throughput

0.536

High

336445

SVIL
Supervillin

1

2

High-throughput

0.536

High

583573

ATF2
Cyclic AMP-dependent transcription factor ATF-2

1

3

High-throughput

0.536

High

856747

BAG6
Large proline-rich protein BAG6

1

7

High-throughput

0.536

High

1008074

DEN2B
DENN domain-containing protein 2B

1

3

High-throughput

0.536

High

1086781

BPTF
Nucleosome-remodeling factor subunit BPTF

1

12

High-throughput

0.536

High

1098797

M3K1
Mitogen-activated protein kinase kinase kinase 1

1

2

High-throughput

0.536

High

1122799

DOCK1
Dedicator of cytokinesis protein 1

1

3

High-throughput

0.536

High

1134468

NOLC1
Nucleolar and coiled-body phosphoprotein 1

1

1

High-throughput

0.536

High

1144030

TEBP
Prostaglandin E synthase 3

1

3

High-throughput

0.536

High

1228795

FMN1
Formin-1

1

2

High-throughput

0.536

High

1240999

FIP1
Pre-mRNA 3'-end-processing factor FIP1

1

1

High-throughput

0.536

High

1241005

PHAR4
Phosphatase and actin regulator 4

1

3

High-throughput

0.536

High

1241012

NEK7
Serine/threonine-protein kinase Nek7

1

2

High-throughput

0.536

High

1241016

PALLD
Palladin

1

2

High-throughput

0.536

High

1241019

EFMT3
EEF1A lysine methyltransferase 3

1

1

High-throughput

0.536

High

1241022

ELMO3
Engulfment and cell motility protein 3

1

1

High-throughput

0.536

High

1241025

GCC1
GRIP and coiled-coil domain-containing protein 1

1

11

High-throughput

0.536

High

1241026

ELMO2
Engulfment and cell motility protein 2

1

1

High-throughput

0.536

High

1241032

MKNK1
MAP kinase-interacting serine/threonine-protein kinase 1

1

1

High-throughput

0.536

High

1241036

GTPB4
GTP-binding protein 4

1

3

High-throughput

0.536

High

1241040

E41LB
Band 4.1-like protein 4B

1

4

High-throughput

0.536

High

1241048

IMP3
U3 small nucleolar ribonucleoprotein protein IMP3

1

5

High-throughput

0.536

High

1241050

BCLF1
Bcl-2-associated transcription factor 1

1

4

High-throughput

0.536

High

1241056

DAPK2
Death-associated protein kinase 2

1

1

High-throughput

0.536

High

1241059

PKHG1
Pleckstrin homology domain-containing family G member 1

1

1

High-throughput

0.536

High

1241063

EXO1
Exonuclease 1

1

1

High-throughput

0.536

High

244982

KATIP
Katanin-interacting protein

1

0

High-throughput

0.513

High

573843

CCNB1
G2/mitotic-specific cyclin-B1

1

0

High-throughput

0.513

High

1151322

ZNHI3
Zinc finger HIT domain-containing protein 3

1

0

High-throughput

0.513

High

1206934

CEP78
Centrosomal protein of 78 kDa

1

0

High-throughput

0.513

High

1241006

ABCA7
Phospholipid-transporting ATPase ABCA7

1

0

High-throughput

0.513

High

1241009

NKAP
NF-kappa-B-activating protein

1

0

High-throughput

0.513

High

1241011

C99L2
CD99 antigen-like protein 2

1

0

High-throughput

0.513

High

1241030

ATP5S
ATP synthase subunit s, mitochondrial

1

0

High-throughput

0.513

High

1241031

ECSIT
Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial

1

0

High-throughput

0.513

High

1241053

IMPCT
Protein IMPACT

1

0

High-throughput

0.513

High

246689

KDM1A
Lysine-specific histone demethylase 1A

1

1

High-throughput

0.489

High

932887

P5CS
Delta-1-pyrroline-5-carboxylate synthase

1

5

High-throughput

0.489

High

1214633

RBM26
RNA-binding protein 26

1

2

High-throughput

0.489

High

1217867

BRE1A
E3 ubiquitin-protein ligase BRE1A

1

8

High-throughput

0.489

High

1228299

UTP25
U3 small nucleolar RNA-associated protein 25 homolog

1

1

High-throughput

0.489

High

1241021

PF21A
PHD finger protein 21A

1

6

High-throughput

0.489

High

1241024

ZN707
Zinc finger protein 707

1

1

High-throughput

0.489

High

1241028

IWS1
Protein IWS1 homolog

1

2

High-throughput

0.489

High

1241039

BHE41
Class E basic helix-loop-helix protein 41

1

2

High-throughput

0.489

High

1241051

HM20B
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related

1

5

High-throughput

0.489

High

1241055

HMGX4
HMG domain-containing protein 4

1

7

High-throughput

0.489

High

1241065

TR150
Thyroid hormone receptor-associated protein 3

1

5

High-throughput

0.489

High

242022

PRKN
E3 ubiquitin-protein ligase parkin

1

4

High-throughput

0.479

High

374687

RASH
GTPase HRas

1

8

High-throughput

0.479

High

679191

DNJB1
DnaJ homolog subfamily B member 1

1

13

High-throughput

0.479

High

727850

DNJA1
DnaJ homolog subfamily A member 1

1

13

High-throughput

0.479

High

1107834

SQSTM
Sequestosome-1

1

2

High-throughput

0.479

High

1137778

TNIP1
TNFAIP3-interacting protein 1

1

7

High-throughput

0.479

High

1241002

RBBP6
E3 ubiquitin-protein ligase RBBP6

1

5

High-throughput

0.479

High

1241013

PAR3L
Partitioning defective 3 homolog B

1

3

Small-scale

0.479

High

1241018

ESR2
Estrogen receptor beta

1

9

High-throughput

0.479

High

1241047

RN146
E3 ubiquitin-protein ligase RNF146

1

1

Small-scale

0.479

High

1241054

ZRAN1
Ubiquitin thioesterase ZRANB1

1

2

High-throughput

0.479

High

1241058

BAG5
BAG family molecular chaperone regulator 5

1

1

High-throughput

0.479

High

1241062

CHIP
E3 ubiquitin-protein ligase CHIP

1

6

High-throughput

0.479

High

1241064

NUDC
Nuclear migration protein nudC

1

6

High-throughput

0.479

High

1241066

SGT1
Protein SGT1 homolog

1

6

High-throughput

0.479

High

1106582

SMAD4
Mothers against decapentaplegic homolog 4

1

0

High-throughput

0.458

High

334424

SYFM
Phenylalanine--tRNA ligase, mitochondrial

1

1

High-throughput

0.445

High

1201981

H90B4
Putative heat shock protein HSP 90-beta 4

1

6

High-throughput

0.445

High

1241000

RN111
E3 ubiquitin-protein ligase Arkadia

1

5

High-throughput

0.445

High

1241049

SPHK1
Sphingosine kinase 1

1

1

Small-scale

0.445

High

1150738

SF01
Splicing factor 1

1

1

High-throughput

0.437

High

1241069

TIM13
Mitochondrial import inner membrane translocase subunit Tim13

1

1

High-throughput

0.437

High

116347

H3BSK8
RB binding protein 6, ubiquitin ligase

1

1

High-throughput

0.407

High

175710

SR140
U2 snRNP-associated SURP motif-containing protein

1

3

High-throughput

0.407

High

1004351

NOP14
Nucleolar protein 14

1

1

High-throughput

0.407

High

1241008

ZCHC9
Zinc finger CCHC domain-containing protein 9

1

3

High-throughput

0.407

High

1241023

PINX1
PIN2/TERF1-interacting telomerase inhibitor 1

1

1

High-throughput

0.407

High

1241041

ESF1
ESF1 homolog

1

1

High-throughput

0.407

High

1241061

ABT1
Activator of basal transcription 1

1

2

High-throughput

0.407

High

1241067

FCF1
rRNA-processing protein FCF1 homolog

1

1

High-throughput

0.407

High

1130629

GSE1
Genetic suppressor element 1

2

0

High-throughput

0.328

High

1241020

ARK2N
Protein ARK2N

2

0

High-throughput

0.328

High

65271

ZN316
Zinc finger protein 316

1

0

High-throughput

0.279

Low

1241001

NKAP1
Uncharacterized protein NKAPD1

1

0

High-throughput

0.279

Low

1241027

ZN668
Zinc finger protein 668

1

0

High-throughput

0.279

Low

1241038

LNP
Endoplasmic reticulum junction formation protein lunapark

1

0

High-throughput

0.279

Low

353393

AGR2
Anterior gradient protein 2 homolog

1

0

High-throughput

0.249

Low

377610

INS
Insulin [Cleaved into: Insulin B chain; Insulin A chain]

1

0

High-throughput

0.249

Low

116490

H7C0N4
Splicing factor 1

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025