Protein: SMYD5
Protein-lysine N-trimethyltransferase SMYD5 (EC 2.1.1.-) (Protein NN8-4AG) (Retinoic acid-induced protein 15) (SET and MYND domain-containing protein 5) ([histone H3]-lysine20 N-trimethyltransferase SMYD5) (EC 2.1.1.372) ([histone H4]-lysine36 N-trimethyltransferase SMYD5) (EC 2.1.1.359)

Gene: SMYD5
Organism: Homo sapiens
Interactions: 25
UniProt ID: Q6GMV2

Gene Ontology (top 5):
GO:0005737 - cytoplasm
GO:0008270 - zinc ion binding
GO:0016279 - protein-lysine N-methyltransferase activity
GO:0032259 - methylation
GO:0042799 - histone H4K20 methyltransferase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1232840

TRI67
Tripartite motif-containing protein 67

1

1

High-throughput

0.618

High

1232841

ZN417
Zinc finger protein 417

2

1

High-throughput

0.606

High

1232842

ZN587
Zinc finger protein 587

2

1

High-throughput

0.606

High

979829

H4
Histone H4

1

3

Small-scale

0.579

High

998434

H31
Histone H3.1

1

7

Small-scale

0.579

High

754878

H2B1B
Histone H2B type 1-B

1

0

Small-scale

0.541

High

987382

RL40
Ubiquitin-ribosomal protein eL40 fusion protein

1

2

High-throughput

0.536

High

1232845

ZN446
Zinc finger protein 446

1

1

High-throughput

0.536

High

1232847

MAST1
Microtubule-associated serine/threonine-protein kinase 1

1

1

High-throughput

0.536

High

897158

TUB
Tubby protein homolog

1

0

High-throughput

0.513

High

1232844

ZN430
Zinc finger protein 430

1

0

High-throughput

0.513

High

1232846

WWOX
WW domain-containing oxidoreductase

1

0

High-throughput

0.513

High

241995

PRKN
E3 ubiquitin-protein ligase parkin

1

2

High-throughput

0.479

High

537343

HSP7C
Heat shock cognate 71 kDa protein

1

0

High-throughput

0.458

High

1037205

H11
Histone H1.1

1

1

Small-scale

0.457

High

385848

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

2

High-throughput

0.437

High

559386

XRCC5
X-ray repair cross-complementing protein 5

1

0

High-throughput

0.279

Low

1010647

DCD
Dermcidin

1

0

High-throughput

0.279

Low

1175805

T132A
Transmembrane protein 132A

1

0

High-throughput

0.279

Low

1186997

TKFC
Triokinase/FMN cyclase

1

0

High-throughput

0.279

Low

1142794

PEA15
Astrocytic phosphoprotein PEA-15

1

0

High-throughput

0.269

Low

260082

BRD4
Bromodomain-containing protein 4

1

0

High-throughput

0.249

Low

768425

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

907469

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

1

0

Small-scale

0.249

Low

1232843

MLP3B
Microtubule-associated protein 1 light chain 3 beta

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025