Protein: TKFC
Triokinase/FMN cyclase (Bifunctional ATP-dependent dihydroxyacetone kinase/FAD-AMP lyase (cyclizing)) [Includes: ATP-dependent dihydroxyacetone kinase (DHA kinase) (EC 2.7.1.28) (EC 2.7.1.29) (Glycerone kinase) (Triokinase) (Triose kinase); FAD-AMP lyase (cyclizing) (EC 4.6.1.15) (FAD-AMP lyase (cyclic FMN forming)) (FMN cyclase)]

Gene: TKFC
Organism: Homo sapiens
Interactions: 64
UniProt ID: Q3LXA3

Gene Ontology (top 5):
GO:0004371 - glycerone kinase activity
GO:0005524 - ATP binding
GO:0005634 - nucleus
GO:0005829 - cytosol
GO:0005975 - carbohydrate metabolic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1186994

TKFC
Triokinase/FMN cyclase

1

2

Small-scale

0.647

High

291658

XRP2
Protein XRP2

3

0

High-throughput

0.638

High

947992

DEF1
Neutrophil defensin 1

2

0

High-throughput

0.602

High

1187007

SERB1
SERPINE1 mRNA-binding protein 1

2

0

High-throughput

0.585

High

388208

GLPA
Glycophorin-A

2

0

High-throughput

0.576

High

140290

SDCB1
Syntenin-1

1

0

High-throughput

0.549

High

274604

DNJB6
DnaJ homolog subfamily B member 6

1

1

High-throughput

0.536

High

679174

DNJB1
DnaJ homolog subfamily B member 1

1

1

High-throughput

0.536

High

956316

RAB2A
Ras-related protein Rab-2A

1

1

High-throughput

0.536

High

1187009

CHAC2
Glutathione-specific gamma-glutamylcyclotransferase 2

1

1

High-throughput

0.536

High

1187018

IFIH1
Interferon-induced helicase C domain-containing protein 1

1

0

Small-scale

0.525

High

239075

ZNRD2
Protein ZNRD2

1

0

High-throughput

0.513

High

280922

HYPM
Huntingtin-interacting protein M

1

0

High-throughput

0.513

High

762082

MPI
Mannose-6-phosphate isomerase

1

0

High-throughput

0.513

High

976300

RB11A
Ras-related protein Rab-11A

1

0

High-throughput

0.513

High

1043628

COAA1

1

0

High-throughput

0.513

High

1086364

AKP13
A-kinase anchor protein 13

1

0

High-throughput

0.513

High

1098707

NDK3
Nucleoside diphosphate kinase 3

1

0

High-throughput

0.513

High

1118218

BLMH
Bleomycin hydrolase

1

0

High-throughput

0.513

High

1132544

FXYD3
FXYD domain-containing ion transport regulator 3

1

0

High-throughput

0.513

High

1186996

SYT6
Synaptotagmin-6

1

0

High-throughput

0.513

High

1187002

STING
Stimulator of interferon genes protein

1

0

High-throughput

0.513

High

1187003

MYLK4
Myosin light chain kinase family member 4

1

0

High-throughput

0.513

High

1187010

SNR27
U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein

1

0

High-throughput

0.513

High

1187014

ARL8A
ADP-ribosylation factor-like protein 8A

1

0

High-throughput

0.513

High

1187016

SERC2
Serine incorporator 2

1

0

High-throughput

0.513

High

1187020

OSGEP
tRNA N6-adenosine threonylcarbamoyltransferase

1

0

High-throughput

0.513

High

1187022

CENPM
Centromere protein M

1

0

High-throughput

0.513

High

1187025

PSF2
DNA replication complex GINS protein PSF2

1

0

High-throughput

0.513

High

1187013

DACT3
Dapper homolog 3

1

1

High-throughput

0.489

High

573499

ENPL
Endoplasmin

1

2

High-throughput

0.479

High

241854

PRKN
E3 ubiquitin-protein ligase parkin

1

0

High-throughput

0.458

High

385802

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

0

High-throughput

0.458

High

400924

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

0

High-throughput

0.458

High

520102

ANDR
Androgen receptor

1

0

High-throughput

0.458

High

588832

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.458

High

695607

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.458

High

964992

WDR5
WD repeat-containing protein 5

1

0

High-throughput

0.458

High

1123251

DPYL3
Dihydropyrimidinase-related protein 3

1

0

High-throughput

0.458

High

1187008

NUP35
Nucleoporin NUP35

1

0

High-throughput

0.458

High

1187011

HDAC2
Histone deacetylase 2

1

0

High-throughput

0.458

High

1187023

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

1187015

RDH12
Retinol dehydrogenase 12

3

0

High-throughput

0.347

High

1063295

GOGA2
Golgin subfamily A member 2

1

0

High-throughput

0.279

Low

1186995

DACT2
Dapper homolog 2

1

0

High-throughput

0.279

Low

1186997

SMYD5
Protein-lysine N-trimethyltransferase SMYD5

1

0

High-throughput

0.279

Low

1186998

PAQR3
Progestin and adipoQ receptor family member 3

1

0

High-throughput

0.279

Low

1186999

KLH17
Kelch-like protein 17

1

0

High-throughput

0.279

Low

1187001

CMTD1
Catechol O-methyltransferase domain-containing protein 1

1

0

High-throughput

0.279

Low

1187004

IFT20
Intraflagellar transport protein 20 homolog

1

0

High-throughput

0.279

Low

1187005

IQCF1
IQ domain-containing protein F1

1

0

High-throughput

0.279

Low

1187006

THAP8
THAP domain-containing protein 8

1

0

High-throughput

0.279

Low

1187017

TX101
Testis-expressed protein 101

1

0

High-throughput

0.279

Low

1187021

TIDC1
Complex I assembly factor TIMMDC1, mitochondrial

1

0

High-throughput

0.279

Low

1187024

CC018
Uncharacterized protein C3orf18

1

0

High-throughput

0.279

Low

1187026

NTNG1
Netrin-G1

1

0

High-throughput

0.279

Low

1187027

WASC3
WASH complex subunit 3

1

0

High-throughput

0.279

Low

418173

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

0

High-throughput

0.249

Low

768333

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

1187000

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

1187019

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.249

Low

330180

VENTX
Homeobox protein VENTX

1

0

High-throughput

0.232

Low

1187012

P33MX
Putative monooxygenase p33MONOX

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025