Protein: DCD
Dermcidin (EC 3.4.-.-) (Preproteolysin) [Cleaved into: Survival-promoting peptide; DCD-1]

Gene: DCD
Organism: Homo sapiens
Interactions: 237
UniProt ID: P81605

Gene Ontology (top 5):
GO:0003723 - RNA binding
GO:0005216 - monoatomic ion channel activity
GO:0005576 - extracellular region
GO:0006508 - proteolysis
GO:0008233 - peptidase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1010615

CUL3
Cullin-3

2

2

High-throughput

0.611

High

1010686

CSN5
COP9 signalosome complex subunit 5

2

1

High-throughput

0.611

High

640847

VDAC1
Non-selective voltage-gated ion channel VDAC1

2

0

High-throughput

0.595

High

371742

MYC
Myc proto-oncogene protein

3

1

High-throughput

0.585

High

1010704

ANM1
Protein arginine N-methyltransferase 1

2

1

Small-scale

0.584

High

353243

AGR2
Anterior gradient protein 2 homolog

2

0

Small-scale

0.559

High

1010631

LARP7
La-related protein 7

2

0

High-throughput

0.559

High

443301

CDK1
Cyclin-dependent kinase 1

1

1

High-throughput

0.536

High

488169

IFIT1
Antiviral innate immune response effector IFIT1

1

1

High-throughput

0.536

High

1010616

CUL4B
Cullin-4B

1

2

High-throughput

0.536

High

1010671

STAG2
Cohesin subunit SA-2

1

1

High-throughput

0.536

High

1010733

BAZ2A
Bromodomain adjacent to zinc finger domain protein 2A

1

2

High-throughput

0.536

High

241383

PRKN
E3 ubiquitin-protein ligase parkin

2

2

High-throughput

0.533

High

323317

TRI37
E3 ubiquitin-protein ligase TRIM37

2

2

High-throughput

0.533

High

1010605

IL24
Interleukin-24

1

0

High-throughput

0.518

High

1010739

MRCKB
Serine/threonine-protein kinase MRCK beta

1

1

High-throughput

0.515

High

135590

DNM1L
Dynamin-1-like protein

1

0

High-throughput

0.513

High

158691

UTY
Histone demethylase UTY

1

0

High-throughput

0.513

High

390011

ALBU
Albumin

1

0

High-throughput

0.513

High

484492

DLDH
Dihydrolipoyl dehydrogenase, mitochondrial

1

0

High-throughput

0.513

High

540400

LAMP1
Lysosome-associated membrane glycoprotein 1

1

0

High-throughput

0.513

High

563616

CFTR
Cystic fibrosis transmembrane conductance regulator

1

0

High-throughput

0.513

High

773858

SOAT1
Sterol O-acyltransferase 1

1

0

High-throughput

0.513

High

1010625

IQCB1
IQ calmodulin-binding motif-containing protein 1

1

0

High-throughput

0.513

High

1010654

COX15
Heme A synthase COX15

1

0

High-throughput

0.513

High

1010700

NED4L
E3 ubiquitin-protein ligase NEDD4-like

1

0

High-throughput

0.513

High

1010718

LN28A
Protein lin-28 homolog A

1

0

High-throughput

0.513

High

1010620

EI2BA
Translation initiation factor eIF2B subunit alpha

1

0

High-throughput

0.493

High

253498

ANM3
Protein arginine N-methyltransferase 3

1

1

High-throughput

0.489

High

1010599

RAD51
DNA repair protein RAD51 homolog 1

1

1

High-throughput

0.489

High

1010614

CUL2
Cullin-2

1

2

High-throughput

0.489

High

1010658

MTA70
N(6)-adenosine-methyltransferase catalytic subunit METTL3

1

1

High-throughput

0.489

High

1010668

FANCM
Fanconi anemia group M protein

1

3

High-throughput

0.489

High

1010720

MET14
N(6)-adenosine-methyltransferase non-catalytic subunit METTL14

1

1

High-throughput

0.489

High

1010731

WRP73
WD repeat-containing protein WRAP73

1

1

High-throughput

0.489

High

461357

HS90A
Heat shock protein HSP 90-alpha

1

0

Small-scale

0.480

High

964218

SUMO2
Small ubiquitin-related modifier 2

1

0

High-throughput

0.480

High

1010589

DCD
Dermcidin

1

0

Small-scale

0.480

High

1010689

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

0

High-throughput

0.480

High

138068

PSDE
26S proteasome non-ATPase regulatory subunit 14

1

1

High-throughput

0.479

High

157233

CTRO
Citron Rho-interacting kinase

1

1

High-throughput

0.479

High

403976

GCR
Glucocorticoid receptor

1

1

Small-scale

0.479

High

755880

MCM5
DNA replication licensing factor MCM5

1

1

High-throughput

0.479

High

907376

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

1

2

High-throughput

0.479

High

926642

HIRA
Protein HIRA

1

2

Small-scale

0.479

High

984071

GBB2
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

1

1

High-throughput

0.479

High

1010604

CHD3
Chromodomain-helicase-DNA-binding protein 3

1

1

High-throughput

0.479

High

1010606

CACO2
Calcium-binding and coiled-coil domain-containing protein 2

1

1

Small-scale

0.479

High

1010618

DX39B
Spliceosome RNA helicase DDX39B

1

1

High-throughput

0.479

High

1010621

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

1

High-throughput

0.479

High

1010628

RBBP7
Histone-binding protein RBBP7

1

2

High-throughput

0.479

High

1010632

PAN2
PAN2-PAN3 deadenylation complex catalytic subunit PAN2

1

1

High-throughput

0.479

High

1010663

GOLI
E3 ubiquitin-protein ligase RNF130

1

1

High-throughput

0.479

High

1010694

RNF31
E3 ubiquitin-protein ligase RNF31

1

2

High-throughput

0.479

High

1010710

HOIL1
RanBP-type and C3HC4-type zinc finger-containing protein 1

1

1

High-throughput

0.479

High

1010711

DDX24
ATP-dependent RNA helicase DDX24

1

1

High-throughput

0.479

High

1010724

DCA13
DDB1- and CUL4-associated factor 13

1

1

High-throughput

0.479

High

1010730

MBD5
Methyl-CpG-binding domain protein 5

1

1

High-throughput

0.479

High

1010736

UBP20
Ubiquitin carboxyl-terminal hydrolase 20

1

2

Small-scale

0.479

High

1010738

UBP15
Ubiquitin carboxyl-terminal hydrolase 15

1

1

Small-scale

0.479

High

292341

RA51D
DNA repair protein RAD51 homolog 4

1

1

High-throughput

0.470

High

141420

DDX3X
ATP-dependent RNA helicase DDX3X

1

0

Small-scale

0.458

High

209531

SERA
D-3-phosphoglycerate dehydrogenase

1

0

Small-scale

0.458

High

239038

ZNRD2
Protein ZNRD2

1

0

High-throughput

0.458

High

319663

UFL1
E3 UFM1-protein ligase 1

1

0

High-throughput

0.458

High

336935

AHSA1
Activator of 90 kDa heat shock protein ATPase homolog 1

1

0

Small-scale

0.458

High

347642

BAG3
BAG family molecular chaperone regulator 3

1

0

High-throughput

0.458

High

378056

TNFA
Tumor necrosis factor

1

0

High-throughput

0.458

High

387648

APOC3
Apolipoprotein C-III

1

0

High-throughput

0.458

High

423633

ARGI1
Arginase-1

1

0

High-throughput

0.458

High

485060

ROA1
Heterogeneous nuclear ribonucleoprotein A1

1

0

High-throughput

0.458

High

507825

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

0

High-throughput

0.458

High

536960

HSP7C
Heat shock cognate 71 kDa protein

1

0

High-throughput

0.458

High

583283

FOLR1
Folate receptor alpha

1

0

High-throughput

0.458

High

623276

RO52
E3 ubiquitin-protein ligase TRIM21

1

0

High-throughput

0.458

High

629775

BTF3
Transcription factor BTF3

1

0

High-throughput

0.458

High

731197

STIP1
Stress-induced-phosphoprotein 1

1

0

High-throughput

0.458

High

914243

EFNA4
Ephrin-A4

1

0

High-throughput

0.458

High

990092

1433Z
14-3-3 protein zeta/delta

1

0

High-throughput

0.458

High

993070

KCNJ2
Inward rectifier potassium channel 2

1

0

Small-scale

0.458

High

1010591

VIGLN
Vigilin

1

0

High-throughput

0.458

High

1010594

FABP5
Fatty acid-binding protein 5

1

0

High-throughput

0.458

High

1010607

TADBP
TAR DNA-binding protein 43

1

0

High-throughput

0.458

High

1010608

AIMP2
Aminoacyl tRNA synthase complex-interacting multifunctional protein 2

1

0

High-throughput

0.458

High

1010609

G3BP1
Ras GTPase-activating protein-binding protein 1

1

0

High-throughput

0.458

High

1010610

ILK
Scaffold protein ILK

1

0

High-throughput

0.458

High

1010613

SQSTM
Sequestosome-1

1

0

High-throughput

0.458

High

1010624

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

0

High-throughput

0.458

High

1010627

EZH2
Histone-lysine N-methyltransferase EZH2

1

0

High-throughput

0.458

High

1010639

KPRP
Keratinocyte proline-rich protein

1

0

High-throughput

0.458

High

1010641

RC3H1
Roquin-1

1

0

High-throughput

0.458

High

1010650

PRP8
Pre-mRNA-processing-splicing factor 8

1

0

High-throughput

0.458

High

1010659

ZN598
E3 ubiquitin-protein ligase ZNF598

1

0

High-throughput

0.458

High

1010660

ZCH18
Zinc finger CCCH domain-containing protein 18

1

0

High-throughput

0.458

High

1010666

MILK2
MICAL-like protein 2

1

0

High-throughput

0.458

High

1010685

HDAC2
Histone deacetylase 2

1

0

High-throughput

0.458

High

1010706

INP5K
Inositol polyphosphate 5-phosphatase K

1

0

High-throughput

0.458

High

1010707

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

0

High-throughput

0.458

High

1010709

ACE2
Angiotensin-converting enzyme 2

1

0

High-throughput

0.458

High

1010712

PRD14
PR domain zinc finger protein 14

1

0

Small-scale

0.458

High

1010719

SENP2
Sentrin-specific protease 2

1

0

Small-scale

0.458

High

1010721

ISK5
Serine protease inhibitor Kazal-type 5

1

0

Small-scale

0.458

High

1010722

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

0

High-throughput

0.458

High

529615

TAU
Microtubule-associated protein tau

1

1

High-throughput

0.445

High

1010702

CK5P2
CDK5 regulatory subunit-associated protein 2

1

2

High-throughput

0.445

High

302479

RNF8
E3 ubiquitin-protein ligase RNF8

1

2

High-throughput

0.437

High

302809

CIAO1
Probable cytosolic iron-sulfur protein assembly protein CIAO1

1

2

High-throughput

0.437

High

335090

ARI2
E3 ubiquitin-protein ligase ARIH2

1

2

High-throughput

0.437

High

400647

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

1

High-throughput

0.437

High

406049

MYCN
N-myc proto-oncogene protein

1

1

High-throughput

0.437

High

521308

ARAF
Serine/threonine-protein kinase A-Raf

1

1

High-throughput

0.437

High

667766

CDK2
Cyclin-dependent kinase 2

1

1

High-throughput

0.437

High

887968

MCM2
DNA replication licensing factor MCM2

1

1

High-throughput

0.437

High

947161

NLRP6
NACHT, LRR and PYD domains-containing protein 6

1

1

High-throughput

0.437

High

964577

DCAF7
DDB1- and CUL4-associated factor 7

1

3

High-throughput

0.437

High

1010601

RBBP4
Histone-binding protein RBBP4

1

2

High-throughput

0.437

High

1010611

IKZF1
DNA-binding protein Ikaros

1

2

High-throughput

0.437

High

1010619

TRI14
Tripartite motif-containing protein 14

1

1

High-throughput

0.437

High

1010623

TNIP1
TNFAIP3-interacting protein 1

1

2

High-throughput

0.437

High

1010629

MK06
Mitogen-activated protein kinase 6

1

1

High-throughput

0.437

High

1010635

DCA10
DDB1- and CUL4-associated factor 10

1

2

High-throughput

0.437

High

1010640

DCAF8
DDB1- and CUL4-associated factor 8

1

2

High-throughput

0.437

High

1010651

WDR82
WD repeat-containing protein 82

1

3

High-throughput

0.437

High

1010652

LRC31
Leucine-rich repeat-containing protein 31

1

1

High-throughput

0.437

High

1010653

TRI67
Tripartite motif-containing protein 67

1

2

High-throughput

0.437

High

1010674

COP1
E3 ubiquitin-protein ligase COP1

1

3

High-throughput

0.437

High

1010680

STAG1
Cohesin subunit SA-1

1

1

High-throughput

0.437

High

1010681

NALP7
NACHT, LRR and PYD domains-containing protein 7

1

1

High-throughput

0.437

High

1010692

MBD6
Methyl-CpG-binding domain protein 6

1

1

High-throughput

0.437

High

1010693

SPDLY
Protein Spindly

1

1

High-throughput

0.437

High

1010713

RNF38
E3 ubiquitin-protein ligase RNF38

1

1

Small-scale

0.437

High

1010715

TXNIP
Thioredoxin-interacting protein

1

1

Small-scale

0.437

High

1010726

RNF12
E3 ubiquitin-protein ligase RLIM

1

3

High-throughput

0.437

High

1010732

ZRAN1
Ubiquitin thioesterase ZRANB1

1

1

High-throughput

0.437

High

1010734

IKZF3
Zinc finger protein Aiolos

1

2

High-throughput

0.437

High

1010735

FBW1A
F-box/WD repeat-containing protein 1A

1

1

High-throughput

0.437

High

911549

NCBP2
Nuclear cap-binding protein subunit 2

1

0

High-throughput

0.426

High

948784

CD81
CD81 antigen

1

0

Small-scale

0.426

High

1010600

LG3BP
Galectin-3-binding protein

1

0

High-throughput

0.426

High

1010636

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

0

High-throughput

0.426

High

1010644

RNLS
Renalase

1

0

Small-scale

0.426

High

1010664

SULF2
Extracellular sulfatase Sulf-2

1

0

High-throughput

0.426

High

1010669

CNTRB
Centrobin

1

1

High-throughput

0.407

High

1010684

ESR2
Estrogen receptor beta

1

1

High-throughput

0.407

High

1010697

CEP63
Centrosomal protein of 63 kDa

1

1

High-throughput

0.407

High

1010603

ASPH
Aspartyl/asparaginyl beta-hydroxylase

2

0

High-throughput

0.316

High

227501

SPOP
Speckle-type POZ protein

2

0

High-throughput

0.305

High

413610

P53
Cellular tumor antigen p53

2

0

Small-scale

0.305

High

1010683

APBP2
Amyloid protein-binding protein 2

1

0

High-throughput

0.299

High

1010703

ZBT18
Zinc finger and BTB domain-containing protein 18

2

0

Small-scale

0.298

High

273421

KDM4A
Lysine-specific demethylase 4A

1

0

High-throughput

0.279

Low

351381

CBX7
Chromobox protein homolog 7

1

0

High-throughput

0.279

Low

732539

ARRB2
Beta-arrestin-2

1

0

High-throughput

0.279

Low

1010593

MDM2
E3 ubiquitin-protein ligase Mdm2

1

0

Small-scale

0.279

Low

1010622

FL2D
Pre-mRNA-splicing regulator WTAP

1

0

High-throughput

0.279

Low

1010642

SMBT2
Scm-like with four MBT domains protein 2

1

0

High-throughput

0.279

Low

1010647

SMYD5
Protein-lysine N-trimethyltransferase SMYD5

1

0

High-throughput

0.279

Low

1010656

PIWL4
Piwi-like protein 4

1

0

High-throughput

0.279

Low

1010670

PARP8
Protein mono-ADP-ribosyltransferase PARP8

1

0

High-throughput

0.279

Low

1010675

RIN3
Ras and Rab interactor 3

1

0

High-throughput

0.279

Low

1010679

SETD7
Histone-lysine N-methyltransferase SETD7

1

0

High-throughput

0.279

Low

1010695

COQ2
4-hydroxybenzoate polyprenyltransferase, mitochondrial

1

0

High-throughput

0.279

Low

1010725

ASF1B
Histone chaperone ASF1B

1

0

High-throughput

0.279

Low

1010728

WWOX
WW domain-containing oxidoreductase

1

0

High-throughput

0.279

Low

335813

CD2B2
CD2 antigen cytoplasmic tail-binding protein 2

1

0

High-throughput

0.269

Low

352759

F107A
Actin-associated protein FAM107A

1

0

High-throughput

0.269

Low

1010698

FRMD6
FERM domain-containing protein 6

1

0

High-throughput

0.269

Low

1010590

2ABB
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform

1

0

High-throughput

0.253

Low

105753

APRIO
Alternative prion protein

1

0

High-throughput

0.249

Low

124591

EYA2
Protein phosphatase EYA2

1

0

High-throughput

0.249

Low

293550

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.249

Low

370288

CYTA
Cystatin-A

1

0

High-throughput

0.249

Low

411732

NTRK1
High affinity nerve growth factor receptor

1

0

High-throughput

0.249

Low

488450

UCHL1
Ubiquitin carboxyl-terminal hydrolase isozyme L1

1

0

Small-scale

0.249

Low

588455

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.249

Low

695199

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.249

Low

722777

AL3A1
Aldehyde dehydrogenase, dimeric NADP-preferring

1

0

Small-scale

0.249

Low

767950

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

830553

CCNF
Cyclin-F

1

0

High-throughput

0.249

Low

848239

MAGA3
Melanoma-associated antigen 3

1

0

Small-scale

0.249

Low

970320

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

0

High-throughput

0.249

Low

996656

TBA1B
Tubulin alpha-1B chain

1

0

High-throughput

0.249

Low

1004441

RNF4
E3 ubiquitin-protein ligase RNF4

1

0

High-throughput

0.249

Low

1010592

HSF1
Heat shock factor protein 1

1

0

High-throughput

0.249

Low

1010595

KIF23
Kinesin-like protein KIF23

1

0

High-throughput

0.249

Low

1010596

DSG1
Desmoglein-1

1

0

High-throughput

0.249

Low

1010597

TF65
Transcription factor p65

1

0

Small-scale

0.249

Low

1010598

K1C17
Keratin, type I cytoskeletal 17

1

0

High-throughput

0.249

Low

1010602

EP300
Histone acetyltransferase p300

1

0

High-throughput

0.249

Low

1010612

BIRC3
Baculoviral IAP repeat-containing protein 3

1

0

High-throughput

0.249

Low

1010617

APR
Phorbol-12-myristate-13-acetate-induced protein 1

1

0

High-throughput

0.249

Low

1010630

UVSSA
UV-stimulated scaffold protein A

1

0

Small-scale

0.249

Low

1010638

DCA12
DDB1- and CUL4-associated factor 12

1

0

High-throughput

0.249

Low

1010643

OTU1
Ubiquitin thioesterase OTU1

1

0

High-throughput

0.249

Low

1010645

RN123
E3 ubiquitin-protein ligase RNF123

1

0

High-throughput

0.249

Low

1010648

TET2
Methylcytosine dioxygenase TET2

1

0

Small-scale

0.249

Low

1010649

CDC73
Parafibromin

1

0

High-throughput

0.249

Low

1010655

DET1
DET1 homolog

1

0

High-throughput

0.249

Low

1010657

WAPL
Wings apart-like protein homolog

1

0

High-throughput

0.249

Low

1010661

WDR5B
WD repeat-containing protein 5B

1

0

High-throughput

0.249

Low

1010662

FBX11
F-box only protein 11

1

0

Small-scale

0.249

Low

1010665

SMC5
Structural maintenance of chromosomes protein 5

1

0

High-throughput

0.249

Low

1010667

SLX4
Structure-specific endonuclease subunit SLX4

1

0

Small-scale

0.249

Low

1010673

TNIP2
TNFAIP3-interacting protein 2

1

0

High-throughput

0.249

Low

1010676

TP4AP
Short transient receptor potential channel 4-associated protein

1

0

High-throughput

0.249

Low

1010678

UBS3B
Ubiquitin-associated and SH3 domain-containing protein B

1

0

High-throughput

0.249

Low

1010682

TOPB1
DNA topoisomerase 2-binding protein 1

1

0

High-throughput

0.249

Low

1010687

TNR14
Tumor necrosis factor receptor superfamily member 14

1

0

High-throughput

0.249

Low

1010688

TF3B
Transcription factor IIIB 90 kDa subunit

1

0

Small-scale

0.249

Low

1010690

ZUP1
Zinc finger-containing ubiquitin peptidase 1

1

0

Small-scale

0.249

Low

1010691

DCPS
m7GpppX diphosphatase

1

0

High-throughput

0.249

Low

1010696

CI072
Guanine nucleotide exchange factor C9orf72

1

0

High-throughput

0.249

Low

1010699

SPB12
Serpin B12

1

0

High-throughput

0.249

Low

1010701

CIC
Protein capicua homolog

1

0

High-throughput

0.249

Low

1010705

OVOL2
Transcription factor Ovo-like 2

1

0

Small-scale

0.249

Low

1010708

FACD2
Fanconi anemia group D2 protein

1

0

High-throughput

0.249

Low

1010716

IFG15
Torsin-1A-interacting protein 2, isoform IFRG15

1

0

High-throughput

0.249

Low

1010717

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.249

Low

1010723

ANLN
Anillin

1

0

High-throughput

0.249

Low

1010729

MARH2
E3 ubiquitin-protein ligase MARCHF2

1

0

High-throughput

0.249

Low

1010737

AAR2
Protein AAR2 homolog

1

0

High-throughput

0.249

Low

1012

SIM26
Small integral membrane protein 26

1

0

High-throughput

0.232

Low

87425

OSCRI
SCRIB overlapping open reading frame protein

1

0

High-throughput

0.232

Low

213108

CP110
Centriolar coiled-coil protein of 110 kDa

1

0

High-throughput

0.232

Low

335980

MED26
Mediator of RNA polymerase II transcription subunit 26

1

0

High-throughput

0.232

Low

599936

ZNF12
Zinc finger protein 12

1

0

High-throughput

0.232

Low

1010626

T22D1
TSC22 domain family protein 1

1

0

Small-scale

0.232

Low

1010633

KLH22
Kelch-like protein 22

1

0

High-throughput

0.232

Low

1010634

ODFP2
Outer dense fiber protein 2

1

0

High-throughput

0.232

Low

1010637

CE170
Centrosomal protein of 170 kDa

1

0

High-throughput

0.232

Low

1010646

CP135
Centrosomal protein of 135 kDa

1

0

High-throughput

0.232

Low

1010672

POC5
Centrosomal protein POC5

1

0

High-throughput

0.232

Low

1010677

CE192
Centrosomal protein of 192 kDa

1

0

High-throughput

0.232

Low

1010714

GBRL1
Gamma-aminobutyric acid receptor-associated protein-like 1

1

0

High-throughput

0.232

Low

1010727

MED9
Mediator of RNA polymerase II transcription subunit 9

1

0

High-throughput

0.232

Low

886744

CEBPA
CCAAT/enhancer-binding protein alpha

1

0

High-throughput

0.213

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025