HitPredict
Protein: AK1C4
Aldo-keto reductase family 1 member C4 (EC 1.1.1.-) (EC 1.1.1.209) (EC 1.1.1.210) (EC 1.1.1.51) (EC 1.1.1.53) (EC 1.1.1.62) (3-alpha-hydroxysteroid dehydrogenase type I) (3-alpha-HSD1) (EC 1.1.1.357) (3alpha-hydroxysteroid 3-dehydrogenase) (Chlordecone reductase) (CDR) (EC 1.1.1.225) (Dihydrodiol dehydrogenase 4) (DD-4) (DD4) (HAKRA)

Gene: AK1C4, AKR1C4
Organism: Homo sapiens
Interactions: 11
UniProt ID: P17516

Gene Ontology (top 5):
GO:0001523 - retinoid metabolic process
GO:0001758 - retinal dehydrogenase (NAD+) activity
GO:0004032 - aldose reductase (NADPH) activity
GO:0004303 - estradiol 17-beta-dehydrogenase [NAD(P)+] activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score		 Confidence

605036

 AK1C2
Aldo-keto reductase family 1 member C2

5

11

High-throughput

 0.919

High

605035

 AK1C3
Aldo-keto reductase family 1 member C3

3

11

High-throughput

 0.861

High

605037

 AK1C1
Aldo-keto reductase family 1 member C1

1

11

High-throughput

 0.618

High

605039

 PXDC2
Plexin domain-containing protein 2

3

1

High-throughput

 0.599

High

347516

 BAG3
BAG family molecular chaperone regulator 3

1

0

High-throughput

 0.458

High

605040

 FXL13
F-box and leucine-rich repeat protein 13

1

0

Small-scale

 0.458

High

605041

 TMM59
Transmembrane protein 59

1

2

High-throughput

 0.445

High

605038

 EZH2
Histone-lysine N-methyltransferase EZH2

1

1

High-throughput

 0.437

High

261078

 NSMA
Sphingomyelin phosphodiesterase 2

1

3

High-throughput

 0.407

High

604989

 HXB6
Homeobox protein Hox-B6

1

2

High-throughput

 0.407

High

554148

 BMP4
Bone morphogenetic protein 4

1

0

High-throughput

 0.232

Low

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Last updated: 11Aug2025