Protein: TMM59
Transmembrane protein 59 (Liver membrane-bound protein)

Gene: TMM59, TMEM59
Organism: Homo sapiens
Interactions: 227
UniProt ID: Q9BXS4

Gene Ontology (top 5):
GO:0000137 - Golgi cis cisterna
GO:0000138 - Golgi trans cisterna
GO:0000139 - Golgi membrane
GO:0004175 - endopeptidase activity
GO:0005764 - lysosome

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1249958

I20RB
Interleukin-20 receptor subunit beta

3

1

High-throughput

0.667

High

1227391

A16L1
Autophagy-related protein 16-1

3

0

Small-scale

0.636

High

1417254

SG196
Protein O-mannose kinase

3

1

High-throughput

0.604

High

212090

B4GT5
Beta-1,4-galactosyltransferase 5

2

4

High-throughput

0.601

High

316560

B3GA3
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3

2

2

High-throughput

0.601

High

1316365

AGRG5
Adhesion G-protein coupled receptor G5

2

1

High-throughput

0.601

High

1417295

PCDA8
Protocadherin alpha-8

2

2

High-throughput

0.601

High

1417267

CC50A
Cell cycle control protein 50A

2

0

High-throughput

0.585

High

1417268

B3GN2
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2

2

0

High-throughput

0.585

High

139306

UPK2
Uroplakin-2

2

0

High-throughput

0.576

High

1102750

PTPRS
Receptor-type tyrosine-protein phosphatase S

2

0

High-throughput

0.576

High

1417293

ZDHC9
Palmitoyltransferase ZDHHC9

2

0

High-throughput

0.576

High

1414291

ABHEA
Protein ABHD14A

2

1

High-throughput

0.549

High

1417280

DKKL1
Dickkopf-like protein 1

2

1

High-throughput

0.549

High

154878

ISLR
Immunoglobulin superfamily containing leucine-rich repeat protein

1

2

High-throughput

0.536

High

209385

SIA8C
Alpha-N-acetylneuraminate alpha-2,8-sialyltransferase ST8SIA3

1

2

High-throughput

0.536

High

239499

H6ST1
Heparan-sulfate 6-O-sulfotransferase 1

1

1

High-throughput

0.536

High

249264

MA1A2
Mannosyl-oligosaccharide 1,2-alpha-mannosidase IB

1

1

High-throughput

0.536

High

251114

B4GT3
Beta-1,4-galactosyltransferase 3

1

4

High-throughput

0.536

High

253892

TPST2
Protein-tyrosine sulfotransferase 2

1

1

High-throughput

0.536

High

541669

FGFR1
Fibroblast growth factor receptor 1

1

2

High-throughput

0.536

High

582398

B4GT1
Beta-1,4-galactosyltransferase 1

1

4

High-throughput

0.536

High

604184

CXA1
Gap junction alpha-1 protein

1

1

High-throughput

0.536

High

648651

FGFR4
Fibroblast growth factor receptor 4

1

2

High-throughput

0.536

High

664082

PRTN3
Myeloblastin

1

1

High-throughput

0.536

High

705988

CD1B
T-cell surface glycoprotein CD1b

1

4

High-throughput

0.536

High

755419

MA1A1
Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA

1

1

High-throughput

0.536

High

783054

CXG1
Gap junction gamma-1 protein

1

1

High-throughput

0.536

High

903002

MMP15
Matrix metalloproteinase-15

1

1

High-throughput

0.536

High

1111518

MTR1L
Melatonin-related receptor

1

1

High-throughput

0.536

High

1142168

P2RY6
P2Y purinoceptor 6

1

2

High-throughput

0.536

High

1159231

SGCA
Alpha-sarcoglycan

1

1

High-throughput

0.536

High

1207966

COL12
Collectin-12

1

1

High-throughput

0.536

High

1278317

LRP10
Low-density lipoprotein receptor-related protein 10

1

2

High-throughput

0.536

High

1290526

LAP4B
Lysosomal-associated transmembrane protein 4B

1

1

High-throughput

0.536

High

1293354

CHSS1
Chondroitin sulfate synthase 1

1

2

High-throughput

0.536

High

1329308

CGAT2
Chondroitin sulfate N-acetylgalactosaminyltransferase 2

1

1

High-throughput

0.536

High

1352302

RN128
E3 ubiquitin-protein ligase RNF128

1

2

High-throughput

0.536

High

1358440

LMBR1
Limb region 1 protein homolog

1

1

High-throughput

0.536

High

1362516

SIA8B
Alpha-2,8-sialyltransferase 8B

1

2

High-throughput

0.536

High

1381469

SIA7F
Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6

1

2

High-throughput

0.536

High

1398245

H6ST2
Heparan-sulfate 6-O-sulfotransferase 2

1

1

High-throughput

0.536

High

1417250

CHST8
Carbohydrate sulfotransferase 8

1

2

High-throughput

0.536

High

1417260

CHSTB
Carbohydrate sulfotransferase 11

1

2

High-throughput

0.536

High

1417261

B3GA2
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 2

1

2

High-throughput

0.536

High

1417263

CHSTC
Carbohydrate sulfotransferase 12

1

2

High-throughput

0.536

High

1417271

GGA3
ADP-ribosylation factor-binding protein GGA3

1

1

High-throughput

0.536

High

1417272

LRFN1
Leucine-rich repeat and fibronectin type III domain-containing protein 1

1

1

High-throughput

0.536

High

1417274

B4GT7
Beta-1,4-galactosyltransferase 7

1

4

High-throughput

0.536

High

1417275

B4GT6
Beta-1,4-galactosyltransferase 6

1

4

High-throughput

0.536

High

1417285

A4GCT
Alpha-1,4-N-acetylglucosaminyltransferase

1

1

High-throughput

0.536

High

1417294

LRP12
Low-density lipoprotein receptor-related protein 12

1

2

High-throughput

0.536

High

1360927

CLC4D
C-type lectin domain family 4 member D

1

2

High-throughput

0.515

High

1417264

TMPS4
Transmembrane protease serine 4

1

2

High-throughput

0.515

High

1417284

CLC4E
C-type lectin domain family 4 member E

1

2

High-throughput

0.515

High

136543

GOLI4
Golgi integral membrane protein 4

1

0

High-throughput

0.513

High

160832

TOR1B
Torsin-1B

1

0

High-throughput

0.513

High

163353

TR10B
Tumor necrosis factor receptor superfamily member 10B

1

0

High-throughput

0.513

High

219360

B4GA1
Beta-1,4-glucuronyltransferase 1

1

0

High-throughput

0.513

High

270137

FKTN
Ribitol-5-phosphate transferase FKTN

1

0

High-throughput

0.513

High

278552

VAMP4
Vesicle-associated membrane protein 4

1

0

High-throughput

0.513

High

321781

AGRL1
Adhesion G protein-coupled receptor L1

1

0

High-throughput

0.513

High

322163

GLCE
D-glucuronyl C5-epimerase

1

0

High-throughput

0.513

High

331916

GOSR1
Golgi SNAP receptor complex member 1

1

0

High-throughput

0.513

High

387457

APOE
Apolipoprotein E

1

0

High-throughput

0.513

High

463212

YES
Tyrosine-protein kinase Yes

1

0

High-throughput

0.513

High

506903

CFC1
Cryptic protein

1

0

High-throughput

0.513

High

520990

HLAC
HLA class I histocompatibility antigen, C alpha chain

1

0

High-throughput

0.513

High

624206

FUT1
Galactoside alpha-(1,2)-fucosyltransferase 1

1

0

High-throughput

0.513

High

687127

MGAT1
Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase

1

0

High-throughput

0.513

High

787243

BMR1A
Bone morphogenetic protein receptor type-1A

1

0

High-throughput

0.513

High

834693

TNFL9
Tumor necrosis factor ligand superfamily member 9

1

0

High-throughput

0.513

High

885503

MA2A2
Alpha-mannosidase 2x

1

0

High-throughput

0.513

High

895365

S26A2
Sulfate transporter

1

0

High-throughput

0.513

High

957003

CXCR4
C-X-C chemokine receptor type 4

1

0

High-throughput

0.513

High

1022950

EFNB1
Ephrin-B1

1

0

High-throughput

0.513

High

1047243

ATP7A
Copper-transporting ATPase 1

1

0

High-throughput

0.513

High

1067037

MGT5A
Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A

1

0

High-throughput

0.513

High

1083145

GALT2
Polypeptide N-acetylgalactosaminyltransferase 2

1

0

High-throughput

0.513

High

1085378

SCAP
Sterol regulatory element-binding protein cleavage-activating protein

1

0

High-throughput

0.513

High

1085471

SRBP2
Sterol regulatory element-binding protein 2

1

0

High-throughput

0.513

High

1093411

TRI32
E3 ubiquitin-protein ligase TRIM32

1

0

High-throughput

0.513

High

1105771

ADAM9
Disintegrin and metalloproteinase domain-containing protein 9

1

0

High-throughput

0.513

High

1140141

IQCB1
IQ calmodulin-binding motif-containing protein 1

1

0

High-throughput

0.513

High

1157390

EXT1
Exostosin-1

1

0

High-throughput

0.513

High

1162310

AT2B3
Plasma membrane calcium-transporting ATPase 3

1

0

High-throughput

0.513

High

1162331

CEGT
Ceramide glucosyltransferase

1

0

High-throughput

0.513

High

1228848

LMBD2
G-protein coupled receptor-associated protein LMBRD2

1

0

High-throughput

0.513

High

1248254

KCNT2
Potassium channel subfamily T member 2

1

0

High-throughput

0.513

High

1253793

QSOX2
Sulfhydryl oxidase 2

1

0

High-throughput

0.513

High

1333491

GOLM1
Golgi membrane protein 1

1

0

High-throughput

0.513

High

1350000

SPPL3
Signal peptide peptidase-like 3

1

0

High-throughput

0.513

High

1356599

CHPT1
Cholinephosphotransferase 1

1

0

High-throughput

0.513

High

1407214

ABCA3
Phospholipid-transporting ATPase ABCA3

1

0

High-throughput

0.513

High

1411626

PGAP4
GPI-N-acetylgalactosamine transferase PGAP4

1

0

High-throughput

0.513

High

1413690

TMM43
Transmembrane protein 43

1

0

High-throughput

0.513

High

1417255

FKRP
Ribitol 5-phosphate transferase FKRP

1

0

High-throughput

0.513

High

1417256

CAHM2
Calcium homeostasis modulator protein 2

1

0

High-throughput

0.513

High

1417259

ABCB6
ATP-binding cassette sub-family B member 6

1

0

High-throughput

0.513

High

1417279

TM59L
Transmembrane protein 59-like

1

0

High-throughput

0.513

High

1417282

DSE
Dermatan-sulfate epimerase

1

0

High-throughput

0.513

High

1417283

VANG2
Vang-like protein 2

1

0

High-throughput

0.513

High

1417286

STX8
Syntaxin-8

1

0

High-throughput

0.513

High

1417288

UST
Uronyl 2-sulfotransferase

1

0

High-throughput

0.513

High

1417290

S27A6
Long-chain fatty acid transport protein 6

1

0

High-throughput

0.513

High

1417292

NSG2
Neuronal vesicle trafficking-associated protein 2

1

0

High-throughput

0.513

High

1417298

ENPP4
Bis(5'-adenosyl)-triphosphatase ENPP4

1

0

High-throughput

0.513

High

693077

DPP4
Dipeptidyl peptidase 4

1

0

High-throughput

0.493

High

127821

CORT
Cortistatin [Cleaved into: Cortistatin-29; Cortistatin-17]

1

1

High-throughput

0.489

High

548108

PSPC
Surfactant protein C

1

1

High-throughput

0.489

High

1164352

CGT
2-hydroxyacylsphingosine 1-beta-galactosyltransferase

1

1

High-throughput

0.489

High

1186227

CEA21
Cell adhesion molecule CEACAM21

1

1

High-throughput

0.489

High

1281269

TMED4
Transmembrane emp24 domain-containing protein 4

1

1

High-throughput

0.489

High

1292598

IFNE
Interferon epsilon

1

1

High-throughput

0.489

High

1315987

NRSN1
Neurensin-1

1

1

High-throughput

0.489

High

1417257

UD17
UDP-glucuronosyltransferase 1A7

1

1

High-throughput

0.489

High

1417265

CBLN4
Cerebellin-4

1

1

High-throughput

0.489

High

1417278

GGA1
ADP-ribosylation factor-binding protein GGA1

1

1

High-throughput

0.489

High

1417277

ERRFI
ERBB receptor feedback inhibitor 1

1

1

Small-scale

0.481

High

218725

TGON2
Trans-Golgi network integral membrane protein 2

1

1

High-throughput

0.479

High

412559

NTRK1
High affinity nerve growth factor receptor

1

2

High-throughput

0.479

High

466442

RHOC
Rho-related GTP-binding protein RhoC

1

3

High-throughput

0.479

High

506656

GPHRB
Golgi pH regulator B

1

1

High-throughput

0.479

High

601429

RHOQ
Rho-related GTP-binding protein RhoQ

1

5

High-throughput

0.479

High

761288

RYK
Tyrosine-protein kinase RYK

1

4

Small-scale

0.479

High

953649

RAC3
Ras-related C3 botulinum toxin substrate 3

1

4

High-throughput

0.479

High

978269

RHOB
Rho-related GTP-binding protein RhoB

1

4

High-throughput

0.479

High

1015738

RHOG
Rho-related GTP-binding protein RhoG

1

3

High-throughput

0.479

High

1151854

RHOH
Rho-related GTP-binding protein RhoH

1

5

High-throughput

0.479

High

1249189

LMBRL
Protein LMBR1L

1

1

High-throughput

0.479

High

1270978

RHOU
Rho-related GTP-binding protein RhoU

1

5

High-throughput

0.479

High

1286894

TM11B
Transmembrane protease serine 11B

1

2

High-throughput

0.479

High

1334543

RN149
E3 ubiquitin-protein ligase RNF149

1

2

High-throughput

0.479

High

1366873

RND1
Rho-related GTP-binding protein Rho6

1

4

High-throughput

0.479

High

1386687

AP2M1
AP-2 complex subunit mu

1

1

Small-scale

0.479

High

1417243

AP1M1
AP-1 complex subunit mu-1

1

1

Small-scale

0.479

High

1417253

RHOJ
Rho-related GTP-binding protein RhoJ

1

5

High-throughput

0.479

High

1417273

B3GA1
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1

1

2

High-throughput

0.479

High

560509

IFM1
Interferon-induced transmembrane protein 1

1

0

High-throughput

0.458

High

580687

AMPN
Aminopeptidase N

1

0

High-throughput

0.458

High

1108110

SQSTM
Sequestosome-1

1

0

High-throughput

0.458

High

1163413

CAH9
Carbonic anhydrase 9

1

0

High-throughput

0.458

High

1314542

TM192
Transmembrane protein 192

1

0

High-throughput

0.458

High

1348203

TIP
T-cell immunomodulatory protein

1

0

High-throughput

0.458

High

1417246

KPCD2
Serine/threonine-protein kinase D2

1

0

High-throughput

0.458

High

1417248

TOLIP
Toll-interacting protein

1

0

High-throughput

0.458

High

1417252

DNJC5
DnaJ homolog subfamily C member 5

1

0

High-throughput

0.458

High

85398

GPHRA
Golgi pH regulator A

1

1

High-throughput

0.445

High

161153

ABCD4
Lysosomal cobalamin transporter ABCD4

1

1

High-throughput

0.445

High

250945

TPST1
Protein-tyrosine sulfotransferase 1

1

1

High-throughput

0.445

High

380582

DRB1
HLA class II histocompatibility antigen, DRB1 beta chain

1

2

High-throughput

0.445

High

388452

B3AT
Band 3 anion transport protein

1

1

High-throughput

0.445

High

469724

MMP3
Stromelysin-1

1

1

High-throughput

0.445

High

605041

AK1C4
Aldo-keto reductase family 1 member C4

1

2

High-throughput

0.445

High

888985

TMEDA
Transmembrane emp24 domain-containing protein 10

1

1

High-throughput

0.445

High

1031854

LAT1
Large neutral amino acids transporter small subunit 1

1

1

High-throughput

0.445

High

1048471

AK1C1
Aldo-keto reductase family 1 member C1

1

2

High-throughput

0.445

High

1128947

I13R2
Interleukin-13 receptor subunit alpha-2

1

2

High-throughput

0.445

High

1136727

LAP4A
Lysosomal-associated transmembrane protein 4A

1

1

High-throughput

0.445

High

1273799

NIPA1
Magnesium transporter NIPA1

1

1

High-throughput

0.445

High

1330495

LRC52
Leucine-rich repeat-containing protein 52

1

2

High-throughput

0.445

High

1337939

ZNT7
Zinc transporter 7

1

4

High-throughput

0.445

High

1340560

MFSD8
Major facilitator superfamily domain-containing protein 8

1

2

High-throughput

0.445

High

1346775

ZNT5
Proton-coupled zinc antiporter SLC30A5

1

4

High-throughput

0.445

High

1381026

S35B4
Nucleotide sugar transporter SLC35B4

1

1

High-throughput

0.445

High

1391458

S35A4
Probable UDP-sugar transporter protein SLC35A4

1

1

High-throughput

0.445

High

1417245

S17A9
Voltage-gated purine nucleotide uniporter SLC17A9

1

1

High-throughput

0.445

High

1417247

S13A1
Solute carrier family 13 member 1

1

1

High-throughput

0.445

High

1417249

S35B3
Adenosine 3'-phospho 5'-phosphosulfate transporter 2

1

1

High-throughput

0.445

High

1417289

S35A3
UDP-N-acetylglucosamine transporter

1

1

High-throughput

0.445

High

1417296

PCDA3
Protocadherin alpha-3

1

3

High-throughput

0.445

High

1294253

GOLI
E3 ubiquitin-protein ligase RNF130

1

2

High-throughput

0.437

High

212483

SPIT2
Kunitz-type protease inhibitor 2

1

0

High-throughput

0.426

High

270048

XYLK
Glycosaminoglycan xylosylkinase

1

0

High-throughput

0.426

High

349638

TSN12
Tetraspanin-12

1

0

Small-scale

0.426

High

596526

CTLA4
Cytotoxic T-lymphocyte protein 4

1

0

High-throughput

0.426

High

1120498

SCRB2
Lysosome membrane protein 2

1

0

High-throughput

0.426

High

1251797

S39A5
Zinc transporter ZIP5

1

0

High-throughput

0.426

High

1309763

CTL2
Choline transporter-like protein 2

1

0

High-throughput

0.426

High

1413246

SYT11
Synaptotagmin-11

1

0

High-throughput

0.426

High

1417251

GCP60
Golgi resident protein GCP60

1

0

High-throughput

0.426

High

1417258

ANKH
Mineralization regulator ANKH

1

0

High-throughput

0.426

High

1417291

TMM98
Transmembrane protein 98

1

0

High-throughput

0.426

High

276224

LRRN2
Leucine-rich repeat neuronal protein 2

1

1

High-throughput

0.407

High

915031

AK1C2
Aldo-keto reductase family 1 member C2

1

2

High-throughput

0.407

High

943543

G6PT2
Glucose-6-phosphate exchanger SLC37A1

1

2

High-throughput

0.407

High

1208673

NTCP5
Sodium/bile acid cotransporter 5

1

1

High-throughput

0.407

High

1224950

S22AA
Solute carrier family 22 member 10

1

1

High-throughput

0.407

High

1239544

ZNT6
Zinc transporter 6

1

4

High-throughput

0.407

High

1242216

NPAL3
NIPA-like protein 3

1

1

High-throughput

0.407

High

1326978

SVOP
Synaptic vesicle 2-related protein

1

1

High-throughput

0.407

High

1333870

MFSD9
Major facilitator superfamily domain-containing protein 9

1

2

High-throughput

0.407

High

1228366

GL8D1
Glycosyltransferase 8 domain-containing protein 1

2

0

High-throughput

0.313

High

1417287

CP131
Centrosomal protein of 131 kDa

2

0

High-throughput

0.313

High

1115979

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

0

High-throughput

0.282

High

60741

F234B
Protein FAM234B

1

0

High-throughput

0.279

Low

226493

SNG3
Synaptogyrin-3

1

0

High-throughput

0.279

Low

228104

PM34
Peroxisomal membrane protein PMP34

1

0

High-throughput

0.279

Low

345214

ZMYM6
Zinc finger MYM-type protein 6

1

0

High-throughput

0.279

Low

388554

CRP

1

0

High-throughput

0.279

Low

631817

MCH
Pro-MCH [Cleaved into: Neuropeptide-glycine-glutamic acid

1

0

High-throughput

0.279

Low

774800

TIMP3
Metalloproteinase inhibitor 3

1

0

High-throughput

0.279

Low

814856

CUX1
Homeobox protein cut-like 1

1

0

High-throughput

0.279

Low

876276

NMU
Neuromedin-U [Cleaved into: Neuromedin precursor-related peptide 36

1

0

High-throughput

0.279

Low

895288

CPT1A
Carnitine O-palmitoyltransferase 1, liver isoform

1

0

High-throughput

0.279

Low

1127317

EP3A
Epididymal secretory protein E3-alpha

1

0

High-throughput

0.279

Low

1214122

DIK1A
Divergent protein kinase domain 1A

1

0

High-throughput

0.279

Low

1225730

LPCT4
Lysophospholipid acyltransferase LPCAT4

1

0

High-throughput

0.279

Low

1272977

FAKD5
FAST kinase domain-containing protein 5, mitochondrial

1

0

High-throughput

0.279

Low

1291536

FJX1
Four-jointed box protein 1

1

0

High-throughput

0.279

Low

1307971

EPHX4
Epoxide hydrolase 4

1

0

High-throughput

0.279

Low

1332760

PMGT2
Protein O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2

1

0

High-throughput

0.279

Low

1334318

SCPDL
Saccharopine dehydrogenase-like oxidoreductase

1

0

High-throughput

0.279

Low

1417244

EMIL2
EMILIN-2

1

0

High-throughput

0.279

Low

1417262

ENTP7
Ectonucleoside triphosphate diphosphohydrolase 7

1

0

High-throughput

0.279

Low

1417270

IL20
Interleukin-20

1

0

High-throughput

0.279

Low

1417281

POMT2
Protein O-mannosyl-transferase 2

1

0

High-throughput

0.279

Low

1417297

ALG5
Dolichyl-phosphate beta-glucosyltransferase

1

0

High-throughput

0.279

Low

1103582

PDE3B
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B

1

0

High-throughput

0.249

Low

1135087

CUL7
Cullin-7

1

0

High-throughput

0.249

Low

1367184

ESR2
Estrogen receptor beta

1

0

High-throughput

0.249

Low

1412973

CNPY3
Protein canopy homolog 3

1

0

Small-scale

0.249

Low

1417266

TYW1
S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase TYW1

1

0

High-throughput

0.249

Low

1417269

ELOV5
Very long chain fatty acid elongase 5

1

0

High-throughput

0.249

Low

1126359

PIGH
Phosphatidylinositol N-acetylglucosaminyltransferase subunit H

1

0

High-throughput

0.232

Low

1175897

TM241
UDP-N-acetylglucosamine transporter TMEM241

1

0

High-throughput

0.232

Low

1417276

PARP2
Poly [ADP-ribose] polymerase 2

1

0

Small-scale

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025