HitPredict - High confidence protein-protein interactions

Protein: HAND1
Heart- and neural crest derivatives-expressed protein 1 (Extraembryonic tissues, heart, autonomic nervous system and neural crest derivatives-expressed protein 1) (eHAND) (Helix-loop-helix transcription factor expressed in extraembryonic mesoderm and trophoblast) (Thing-1) (Th1)

Gene: HAND1
Organism: Mus musculus
Interactions: 12
UniProt ID: Q64279

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0001221 - transcription coregulator binding
GO:0001227 - DNA-binding transcription repressor activity, RNA polymerase II-specific
GO:0001228 - DNA-binding transcription activator activity, RNA polymerase II-specific

Download interactions: TXT MITAB-2.5

Interaction	Interactor	Experiments	Homologs	Category	Interaction Score	Confidence
1222210	HAND2 Heart- and neural crest derivatives-expressed protein 2	2	20	Small-scale	0.770	High
586117	TFE2 Transcription factor E2-alpha	1	20	Small-scale	0.653	High
1225435	HAND1 Heart- and neural crest derivatives-expressed protein 1	1	17	Small-scale	0.653	High
1034668	ASCL1 Achaete-scute homolog 1	1	20	Small-scale	0.621	High
1222612	HTF4 Transcription factor 12	1	20	High-throughput	0.621	High
266987	FHL2 Four and a half LIM domains protein 2	1	2	Small-scale	0.618	High
840136	NKX25 Homeobox protein Nkx-2.5	1	7	Small-scale	0.618	High
1225436	HEYL Hairy/enhancer-of-split related with YRPW motif-like protein	1	20	Small-scale	0.618	High
1225437	HEY2 Hairy/enhancer-of-split related with YRPW motif protein 2	1	20	Small-scale	0.618	High
846891	SOX15 Transcription factor SOX-15	1	9	Small-scale	0.479	High
901728	RAB7A Ras-related protein Rab-7a	1	0	High-throughput	0.426	High

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Last updated: 11Aug2025