HitPredict

Interactor 1: HAND2 (Q61039)
Heart- and neural crest derivatives-expressed protein 2 (Deciduum, heart, autonomic nervous system and neural crest derivatives-expressed protein 2) (dHAND) (Helix-loop-helix transcription factor expressed in embryo and deciduum) (Thing-2)
Gene: HAND2

Interactor 2: HAND1 (Q64279)
Heart- and neural crest derivatives-expressed protein 1 (Extraembryonic tissues, heart, autonomic nervous system and neural crest derivatives-expressed protein 1) (eHAND) (Helix-loop-helix transcription factor expressed in extraembryonic mesoderm and trophoblast) (Thing-1) (Th1)
Gene: HAND1

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.59 1.00 0.770

The method score is based on:

Property Details
Experiments 12392994, 10924525
Identification Methods affinity chromatography technology, pull down, two hybrid
Interaction Type physical association

The annotation score is based on:

Property Details
Interacting Pfam domains HLH~HLH
Common GO terms GO:0001228 - DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0001525 - angiogenesis
GO:0001701 - in utero embryonic development
GO:0001947 - heart looping
GO:0003007 - heart morphogenesis
and 12 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 217
Mm

1 216
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Last updated: 11Aug2025