Protein: MTHFS
5-formyltetrahydrofolate cyclo-ligase (EC 6.3.3.2) (5,10-methenyl-tetrahydrofolate synthetase) (MTHFS) (Methenyl-THF synthetase)

Gene: MTHFS
Organism: Homo sapiens
Interactions: 15
UniProt ID: P49914

Gene Ontology (top 5):
GO:0005524 - ATP binding
GO:0005542 - folic acid binding
GO:0005737 - cytoplasm
GO:0005739 - mitochondrion
GO:0005759 - mitochondrial matrix

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

892435

MTHFS
5-formyltetrahydrofolate cyclo-ligase

1

0

High-throughput

0.586

High

892440

PLCL2
Inactive phospholipase C-like protein 2

2

0

High-throughput

0.585

High

892442

T22D4
TSC22 domain family protein 4

1

0

High-throughput

0.518

High

655113

SFPQ
Splicing factor, proline- and glutamine-rich

1

0

High-throughput

0.493

High

890696

RGS4
Regulator of G-protein signaling 4

1

0

High-throughput

0.493

High

892436

ACTA
Actin, aortic smooth muscle

1

0

High-throughput

0.493

High

283823

NDUS3
NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial

1

0

High-throughput

0.458

High

567304

TCTP
Translationally-controlled tumor protein

1

0

High-throughput

0.458

High

892437

DYHC1
Cytoplasmic dynein 1 heavy chain 1

1

0

High-throughput

0.458

High

892439

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

892441

RUVB2
RuvB-like 2

1

0

High-throughput

0.458

High

371482

MYC
Myc proto-oncogene protein

1

0

High-throughput

0.249

Low

892438

RNF43
E3 ubiquitin-protein ligase RNF43

1

0

High-throughput

0.249

Low

892443

PCDG4
Protocadherin gamma-A4

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025