Protein: T22D4
TSC22 domain family protein 4 (TSC22-related-inducible leucine zipper protein 2)

Gene: T22D4, TSC22D4
Organism: Homo sapiens
Interactions: 133
UniProt ID: Q9Y3Q8

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0006970 - response to osmotic stress
GO:0030425 - dendrite

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

273297

T22D2
TSC22 domain family protein 2

4

16

High-throughput

0.892

High

1152503

T22D1
TSC22 domain family protein 1

4

14

High-throughput

0.892

High

1405420

T22D3
TSC22 domain family protein 3

4

10

High-throughput

0.892

High

1460142

NRBP
Nuclear receptor-binding protein

12

17

Small-scale

0.761

High

1449472

NRBP2
Nuclear receptor-binding protein 2

6

19

High-throughput

0.738

High

1121565

KEAP1
Kelch-like ECH-associated protein 1

6

2

Small-scale

0.729

High

1099831

MD2L1
Mitotic spindle assembly checkpoint protein MAD2A

5

0

High-throughput

0.696

High

1109427

PIN1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1

5

0

High-throughput

0.692

High

1420083

KPCD2
Serine/threonine-protein kinase D2

4

2

High-throughput

0.691

High

1433326

WNK1
Serine/threonine-protein kinase WNK1

4

17

High-throughput

0.691

High

1461016

FBW1B
F-box/WD repeat-containing protein 11

4

3

High-throughput

0.691

High

1490646

FBW1A
F-box/WD repeat-containing protein 1A

4

4

High-throughput

0.691

High

208922

ZBT24
Zinc finger and BTB domain-containing protein 24

3

1

High-throughput

0.675

High

261458

TBL1X
F-box-like/WD repeat-containing protein TBL1X

3

4

High-throughput

0.667

High

962663

RHOA
Transforming protein RhoA

3

12

High-throughput

0.667

High

1335937

PDPR
Pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial

3

2

High-throughput

0.667

High

1418965

WNK3
Serine/threonine-protein kinase WNK3

3

16

High-throughput

0.667

High

1459053

STK39
STE20/SPS1-related proline-alanine-rich protein kinase

3

2

High-throughput

0.667

High

1491265

WNK2
Serine/threonine-protein kinase WNK2

3

17

High-throughput

0.667

High

911896

GDS1
Rap1 GTPase-GDP dissociation stimulator 1

4

0

High-throughput

0.661

High

180443

RPAC1
DNA-directed RNA polymerases I and III subunit RPAC1

3

0

High-throughput

0.646

High

1136764

MD2BP
MAD2L1-binding protein

3

0

High-throughput

0.638

High

294638

ZMY10
Zinc finger MYND domain-containing protein 10

2

0

High-throughput

0.629

High

1379975

LHX4
LIM/homeobox protein Lhx4

2

8

High-throughput

0.628

High

1451335

PIHD1
PIH1 domain-containing protein 1

2

0

High-throughput

0.618

High

1392545

MTNB
Methylthioribulose-1-phosphate dehydratase

2

0

High-throughput

0.616

High

1112812

CUL1
Cullin-1

2

6

High-throughput

0.611

High

1181453

P3H1
Prolyl 3-hydroxylase 1

2

2

High-throughput

0.611

High

1420011

TBL1R
F-box-like/WD repeat-containing protein TBL1XR1

2

3

High-throughput

0.611

High

292039

CRTAP
Cartilage-associated protein

3

2

High-throughput

0.609

High

567119

P4HA1
Prolyl 4-hydroxylase subunit alpha-1

3

1

High-throughput

0.609

High

682123

RBTN1
Rhombotin-1

2

6

High-throughput

0.606

High

1438674

CBX8
Chromobox protein homolog 8

2

2

High-throughput

0.606

High

485537

ROA1
Heterogeneous nuclear ribonucleoprotein A1

2

9

High-throughput

0.601

High

1459107

LRWD1
Leucine-rich repeat and WD repeat-containing protein 1

2

0

High-throughput

0.585

High

348810

AIFM1
Apoptosis-inducing factor 1, mitochondrial

1

1

High-throughput

0.582

High

963394

PFD3
Prefoldin subunit 3

2

0

High-throughput

0.580

High

1411688

RHG09
Rho GTPase-activating protein 9

2

0

High-throughput

0.580

High

1014672

SMAD3
Mothers against decapentaplegic homolog 3

1

2

High-throughput

0.573

High

1146890

PCBP1
Poly(rC)-binding protein 1

1

1

High-throughput

0.573

High

248803

PEPL
Periplakin

1

4

High-throughput

0.573

High

681960

RBTN2
Rhombotin-2

1

6

High-throughput

0.573

High

930823

AAPK2
5'-AMP-activated protein kinase catalytic subunit alpha-2

1

1

High-throughput

0.573

High

1095488

AAPK1
5'-AMP-activated protein kinase catalytic subunit alpha-1

1

1

High-throughput

0.573

High

1315011

TEX11
Testis-expressed protein 11

2

1

High-throughput

0.559

High

1432604

CPVL
Probable serine carboxypeptidase CPVL

2

2

High-throughput

0.558

High

1458723

CTNL1
Alpha-catulin

2

1

High-throughput

0.553

High

1308836

P3H2
Prolyl 3-hydroxylase 2

2

2

High-throughput

0.549

High

1449197

CAH10
Carbonic anhydrase-related protein 10

2

1

High-throughput

0.549

High

1462771

SH2B3
SH2B adapter protein 3

2

8

High-throughput

0.549

High

159287

ABLM1
Actin-binding LIM protein 1

1

6

High-throughput

0.541

High

297042

CCNK
Cyclin-K

1

2

High-throughput

0.541

High

681090

PSA1
Proteasome subunit alpha type-1

1

5

High-throughput

0.541

High

993045

RACK1
Small ribosomal subunit protein RACK1

1

4

High-throughput

0.541

High

1086730

SNF5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1

1

1

High-throughput

0.541

High

1348594

LNX1
E3 ubiquitin-protein ligase LNX

1

5

High-throughput

0.541

High

1380281

FBXW7
F-box/WD repeat-containing protein 7

1

3

High-throughput

0.541

High

1380891

TRI63
E3 ubiquitin-protein ligase TRIM63

1

7

High-throughput

0.541

High

1398987

FRMD6
FERM domain-containing protein 6

1

5

High-throughput

0.541

High

1419339

TRI55
Tripartite motif-containing protein 55

1

7

High-throughput

0.541

High

1460905

ZN580
Zinc finger protein 580

1

1

High-throughput

0.541

High

165441

PSA7
Proteasome subunit alpha type-7

1

5

High-throughput

0.536

High

281268

CDC45
Cell division control protein 45 homolog

1

1

High-throughput

0.536

High

1445757

WDR6
tRNA

1

7

High-throughput

0.536

High

1314924

CC146
Coiled-coil domain-containing protein 146

1

2

High-throughput

0.523

High

1361438

MYLIP
E3 ubiquitin-protein ligase MYLIP

1

5

High-throughput

0.523

High

533802

CLUS
Clusterin

1

0

High-throughput

0.518

High

892442

MTHFS
5-formyltetrahydrofolate cyclo-ligase

1

0

High-throughput

0.518

High

900566

FXR2
RNA-binding protein FXR2

1

0

High-throughput

0.518

High

1142274

CD5R1
Cyclin-dependent kinase 5 activator 1

1

0

High-throughput

0.518

High

1358786

UBCP1
Ubiquitin-like domain-containing CTD phosphatase 1

1

0

High-throughput

0.518

High

1428866

NIF3L
NIF3-like protein 1

1

0

High-throughput

0.518

High

1453348

SACS
Sacsin

1

0

High-throughput

0.518

High

246196

KIF1B
Kinesin-like protein KIF1B

1

2

High-throughput

0.515

High

415956

HSPB1
Heat shock protein beta-1

1

4

High-throughput

0.515

High

1395473

MY15B
Unconventional myosin-XVB

1

3

High-throughput

0.515

High

1462105

UBQL1
Ubiquilin-1

1

3

High-throughput

0.515

High

1491172

RNF11
RING finger protein 11

1

1

High-throughput

0.515

High

228527

LANC1
Glutathione S-transferase LANCL1

1

0

High-throughput

0.513

High

940476

TCL1A
T-cell leukemia/lymphoma protein 1A

1

0

High-throughput

0.513

High

1136960

ABRX2
BRISC complex subunit Abraxas 2

1

0

High-throughput

0.513

High

1398996

ZN558
Zinc finger protein 558

1

0

High-throughput

0.513

High

1415339

NOC4L
Nucleolar complex protein 4 homolog

1

1

High-throughput

0.494

High

1436730

GORS2
Golgi reassembly-stacking protein 2

1

5

High-throughput

0.494

High

301775

WFS1
Wolframin

1

0

High-throughput

0.493

High

702512

CLAT
Choline O-acetyltransferase

1

0

High-throughput

0.493

High

326874

RIMB1
Peripheral-type benzodiazepine receptor-associated protein 1

1

4

High-throughput

0.481

High

911167

IMA1
Importin subunit alpha-1

1

2

High-throughput

0.481

High

1061928

TLE5
TLE family member 5

1

3

High-throughput

0.481

High

1431887

GO45
Golgin-45

1

1

High-throughput

0.481

High

605861

KAPCA
cAMP-dependent protein kinase catalytic subunit alpha

1

4

High-throughput

0.479

High

651038

ROA2
Heterogeneous nuclear ribonucleoproteins A2/B1

1

8

High-throughput

0.479

High

849424

RANG
Ran-specific GTPase-activating protein

1

1

High-throughput

0.479

High

967059

1433G
14-3-3 protein gamma

1

15

High-throughput

0.479

High

986830

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

2

High-throughput

0.479

High

990907

1433Z
14-3-3 protein zeta/delta

1

15

High-throughput

0.479

High

1049938

1433F
14-3-3 protein eta

1

15

High-throughput

0.479

High

650503

FGFR3
Fibroblast growth factor receptor 3

1

2

High-throughput

0.470

High

404967

PRIO
Major prion protein

1

1

High-throughput

0.457

High

594149

NCK1
SH2/SH3 adapter protein NCK1

1

12

High-throughput

0.445

High

922345

LIMK2
LIM domain kinase 2

1

2

High-throughput

0.445

High

1233275

ELP2
Elongator complex protein 2

1

3

High-throughput

0.445

High

1462418

TTF2
Transcription termination factor 2

1

6

High-throughput

0.445

High

106905

APRIO
Alternative prion protein

1

3

High-throughput

0.439

High

1063725

GOGA2
Golgin subfamily A member 2

1

3

High-throughput

0.439

High

1230321

K1C40
Keratin, type I cytoskeletal 40

1

2

High-throughput

0.439

High

191422

P4HA2
Prolyl 4-hydroxylase subunit alpha-2

1

1

High-throughput

0.437

High

1147156

ELOC
Elongin-C

1

1

High-throughput

0.437

High

1147315

ELOB
Elongin-B

1

2

High-throughput

0.437

High

1313751

MILK2
MICAL-like protein 2

1

5

High-throughput

0.437

High

1459146

IF172
Intraflagellar transport protein 172 homolog

1

3

High-throughput

0.437

High

686544

RL13
Large ribosomal subunit protein eL13

1

0

High-throughput

0.426

High

1007904

X3CL1
Fractalkine

1

0

High-throughput

0.426

High

1491268

X5D7U3
Benzodiazapine receptor peripheral-associated protein 1 isoform K

1

3

High-throughput

0.417

High

1280187

RABEK
Rab9 effector protein with kelch motifs

1

2

High-throughput

0.407

High

1460736

CDC23
Cell division cycle protein 23 homolog

3

0

High-throughput

0.348

High

1339921

TTL
Tubulin--tyrosine ligase

3

0

High-throughput

0.347

High

167764

PCD17
Protocadherin-17

2

0

High-throughput

0.316

High

639661

SAT1
Diamine acetyltransferase 1

1

0

High-throughput

0.282

High

753938

CKS2
Cyclin-dependent kinases regulatory subunit 2

1

0

High-throughput

0.282

High

1328425

CCD33
Coiled-coil domain-containing protein 33

1

0

High-throughput

0.282

High

1397897

CCD42
Coiled-coil domain-containing protein 42

1

0

High-throughput

0.282

High

1412953

SYT17
Synaptotagmin-17

1

0

High-throughput

0.282

High

1430149

ENKD1
Enkurin domain-containing protein 1

1

0

High-throughput

0.282

High

430662

RPC4
DNA-directed RNA polymerase III subunit RPC4

1

0

High-throughput

0.279

Low

1218548

SPO16
Protein SPO16 homolog

1

0

High-throughput

0.279

Low

705621

GRN
Progranulin

1

0

High-throughput

0.268

Low

1491267

Q9Y649
GW128

1

0

High-throughput

0.268

Low

613900

LBP
Lipopolysaccharide-binding protein

1

0

High-throughput

0.251

Low

1336188

SMG8
Nonsense-mediated mRNA decay factor SMG8

1

0

High-throughput

0.249

Low

1357815

PTCD2
Pentatricopeptide repeat-containing protein 2, mitochondrial

1

0

High-throughput

0.232

Low

1491012

MTO1
5-taurinomethyluridine-[tRNA] synthase subunit MTO1, mitochondrial

1

0

High-throughput

0.232

Low

1491266

ORNT1
Mitochondrial ornithine transporter 1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025