Protein: PRP6
Pre-mRNA-splicing factor 6

Gene: PRP6
Organism: Saccharomyces cerevisiae S288C
Interactions: 145
UniProt ID: P19735

Gene Ontology (top 5):
GO:0000244 - spliceosomal tri-snRNP complex assembly
GO:0000398 - mRNA splicing, via spliceosome
GO:0005634 - nucleus
GO:0005681 - spliceosomal complex
GO:0005682 - U5 snRNP

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

586387

PRP8
Pre-mRNA-splicing factor 8

4

10

Small-scale

0.892

High

586385

BRR2
Pre-mRNA-splicing helicase BRR2

9

20

Small-scale

0.751

High

586357

PRP4
U4/U6 small nuclear ribonucleoprotein PRP4

6

18

Small-scale

0.732

High

586423

PRP31
Pre-mRNA-processing factor 31

5

9

High-throughput

0.718

High

586436

PRP3
U4/U6 small nuclear ribonucleoprotein PRP3

5

2

High-throughput

0.718

High

586408

RSMB
Small nuclear ribonucleoprotein-associated protein B

4

9

High-throughput

0.691

High

586420

LSM8
U6 snRNA-associated Sm-like protein LSm8

4

20

Small-scale

0.687

High

586455

SNU66
66 kDa U4/U6.U5 small nuclear ribonucleoprotein component

4

3

Small-scale

0.684

High

586431

RUXF
Small nuclear ribonucleoprotein F

4

9

High-throughput

0.683

High

586432

LSM3
U6 snRNA-associated Sm-like protein LSm3

4

20

Small-scale

0.678

High

586391

SN114
Pre-mRNA-splicing factor SNU114

3

13

High-throughput

0.662

High

586429

LSM7
U6 snRNA-associated Sm-like protein LSm7

3

20

High-throughput

0.662

High

586435

SMD1
Small nuclear ribonucleoprotein Sm D1

3

3

High-throughput

0.662

High

586445

DIB1
Spliceosomal protein DIB1

3

3

High-throughput

0.653

High

586416

SMD3
Small nuclear ribonucleoprotein Sm D3

3

15

Small-scale

0.650

High

586412

RUXG
Small nuclear ribonucleoprotein G

3

20

High-throughput

0.643

High

586453

RUXE
Small nuclear ribonucleoprotein E

3

5

High-throughput

0.643

High

586399

SP381
Pre-mRNA-splicing factor SPP381

3

0

High-throughput

0.634

High

548506

GCN2
eIF-2-alpha kinase GCN2

2

4

High-throughput

0.621

High

586410

LSM5
U6 snRNA-associated Sm-like protein LSm5

2

2

High-throughput

0.621

High

586396

LSM2
U6 snRNA-associated Sm-like protein LSm2

2

15

High-throughput

0.611

High

586409

LSM4
U6 snRNA-associated Sm-like protein LSm4

2

7

High-throughput

0.611

High

510214

SSB1
Ribosome-associated molecular chaperone SSB1

2

13

High-throughput

0.584

High

586374

HS104
Heat shock protein 104

2

6

High-throughput

0.584

High

586448

NCBP2
Nuclear cap-binding protein subunit 2

2

15

High-throughput

0.584

High

376625

PABP
Polyadenylate-binding protein, cytoplasmic and nuclear

1

8

High-throughput

0.536

High

389048

SYDC
Aspartate--tRNA ligase, cytoplasmic

1

3

High-throughput

0.536

High

410305

SC160
Protein SCP160

1

9

High-throughput

0.536

High

534529

GCY1
Glycerol 2-dehydrogenase

1

1

High-throughput

0.536

High

546135

SYKC
Lysine--tRNA ligase, cytoplasmic

1

3

High-throughput

0.536

High

586360

UBA1
Ubiquitin-activating enzyme E1 1

1

3

High-throughput

0.536

High

586377

APE2
Aminopeptidase 2, mitochondrial

1

1

High-throughput

0.536

High

586402

SSZ1
Ribosome-associated complex subunit SSZ1

1

6

High-throughput

0.536

High

586443

LSM6
U6 snRNA-associated Sm-like protein LSm6

1

9

High-throughput

0.536

High

586447

KAR
NADPH-dependent alpha-keto amide reductase

1

2

High-throughput

0.536

High

586358

PRP2
Pre-mRNA-splicing factor ATP-dependent RNA helicase-like protein PRP2

1

17

High-throughput

0.515

High

336660

SODC
Superoxide dismutase [Cu-Zn]

1

0

High-throughput

0.513

High

423510

C1TC
C-1-tetrahydrofolate synthase, cytoplasmic

1

0

High-throughput

0.513

High

531656

DHAS
Aspartate-semialdehyde dehydrogenase

1

0

High-throughput

0.513

High

555744

THRC
Threonine synthase

1

0

High-throughput

0.513

High

586371

MPI
Mannose-6-phosphate isomerase

1

0

High-throughput

0.513

High

586373

CYS3
Cystathionine gamma-lyase

1

0

High-throughput

0.513

High

586398

HSL7
Protein arginine N-methyltransferase HSL7

1

0

High-throughput

0.513

High

586414

ERG10
Acetyl-CoA acetyltransferase

1

0

High-throughput

0.513

High

586422

ADK
Adenosine kinase

1

0

High-throughput

0.513

High

586427

ACS2
Acetyl-coenzyme A synthetase 2

1

0

High-throughput

0.513

High

586426

UBC9
SUMO-conjugating enzyme UBC9

1

2

High-throughput

0.508

High

562676

FUS3
Mitogen-activated protein kinase FUS3

1

2

High-throughput

0.501

High

586361

KC11
Casein kinase I homolog 1

1

4

High-throughput

0.501

High

586362

KC12
Casein kinase I homolog 2

1

4

High-throughput

0.501

High

586421

PTK2
Serine/threonine-protein kinase PTK2/STK2

1

4

High-throughput

0.501

High

334432

G3P2
Glyceraldehyde-3-phosphate dehydrogenase 2

1

3

High-throughput

0.500

High

365765

HSP82
ATP-dependent molecular chaperone HSP82

1

6

High-throughput

0.500

High

389365

HXKB
Hexokinase-2

1

3

High-throughput

0.500

High

424991

DHE4
NADP-specific glutamate dehydrogenase 1

1

1

High-throughput

0.500

High

449902

HSP73
Heat shock protein SSA3

1

12

High-throughput

0.500

High

560555

BIP
Endoplasmic reticulum chaperone BiP

1

6

High-throughput

0.500

High

586366

CDC48
Cell division control protein 48

1

2

High-throughput

0.500

High

586382

HSP79
Heat shock protein homolog SSE2

1

17

High-throughput

0.500

High

586389

BMH2
Protein BMH2

1

5

High-throughput

0.500

High

586390

EF1G2
Elongation factor 1-gamma 2

1

2

High-throughput

0.500

High

586441

NGK1
N-acetylglucosamine kinase

1

3

High-throughput

0.494

High

440135

ERG20
Farnesyl pyrophosphate synthase

1

1

High-throughput

0.489

High

450276

SYIC
Isoleucine--tRNA ligase, cytoplasmic

1

1

High-throughput

0.489

High

562313

PFKA2
ATP-dependent 6-phosphofructokinase subunit beta

1

1

High-throughput

0.489

High

567920

MDHM
Malate dehydrogenase, mitochondrial

1

2

High-throughput

0.489

High

586365

CDC10
Cell division control protein 10

1

2

High-throughput

0.489

High

586370

TRXB1
Thioredoxin reductase 1

1

1

High-throughput

0.489

High

586376

MDHP
Malate dehydrogenase, peroxisomal

1

2

High-throughput

0.489

High

586383

FIMB
Fimbrin

1

2

High-throughput

0.489

High

586392

PGM2
Phosphoglucomutase 2

1

1

High-throughput

0.489

High

586393

PUR92
Bifunctional purine biosynthesis protein ADE17 [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase

1

1

High-throughput

0.489

High

586394

SYG
Glycine--tRNA ligase 1, mitochondrial

1

1

High-throughput

0.489

High

586395

ARA1
D-arabinose dehydrogenase [NAD(P)+] heavy chain

1

1

High-throughput

0.489

High

586397

OLA1
Obg-like ATPase 1

1

3

High-throughput

0.489

High

586400

SYNC
Asparagine--tRNA ligase, cytoplasmic

1

3

High-throughput

0.489

High

586413

SYA
Alanine--tRNA ligase, mitochondrial

1

2

High-throughput

0.489

High

586425

IMDH3
Inosine-5'-monophosphate dehydrogenase 3

1

4

High-throughput

0.489

High

586434

TPS1
Alpha,alpha-trehalose-phosphate synthase [UDP-forming] 56 kDa subunit

1

2

High-throughput

0.489

High

586438

CLU
Clustered mitochondria protein 1

1

3

High-throughput

0.489

High

341765

IPYR
Inorganic pyrophosphatase

1

0

High-throughput

0.479

High

381420

GAL1
Galactokinase

1

0

High-throughput

0.479

High

410899

PDC1
Pyruvate decarboxylase isozyme 1

1

0

High-throughput

0.479

High

586372

DHOM
Homoserine dehydrogenase

1

0

High-throughput

0.479

High

586368

TF2B
Transcription initiation factor IIB

1

3

High-throughput

0.479

High

586369

BMH1
Protein BMH1

1

5

High-throughput

0.479

High

586379

PRP21
Pre-mRNA-splicing factor PRP21

1

6

High-throughput

0.479

High

586406

IFH1
Protein IFH1

1

1

High-throughput

0.479

High

586415

PFS2
Polyadenylation factor subunit 2

1

20

High-throughput

0.479

High

586424

SF3B1
U2 snRNP component HSH155

1

10

High-throughput

0.479

High

586437

CWC21
Pre-mRNA-splicing factor CWC21

1

2

Small-scale

0.479

High

586439

PDS5
Sister chromatid cohesion protein PDS5

1

4

High-throughput

0.479

High

586440

RSE1
Pre-mRNA-splicing factor RSE1

1

3

High-throughput

0.479

High

586442

SMD2
Small nuclear ribonucleoprotein Sm D2

1

5

High-throughput

0.479

High

586446

PRP11
Pre-mRNA-splicing factor PRP11

1

5

High-throughput

0.479

High

586449

RU2A
U2 small nuclear ribonucleoprotein A'

1

12

High-throughput

0.479

High

586450

YL11B
Transposon Ty1-LR1 Gag-Pol polyprotein

1

1

High-throughput

0.479

High

586451

YRA1
RNA annealing protein YRA1

1

10

High-throughput

0.479

High

586384

RU1A
U1 small nuclear ribonucleoprotein A

1

0

High-throughput

0.458

High

586433

PRP38
Pre-mRNA-splicing factor 38

1

0

High-throughput

0.458

High

586454

SNU23
23 kDa U4/U6.U5 small nuclear ribonucleoprotein component

1

0

High-throughput

0.458

High

586444

SP382
Pre-mRNA-splicing factor SPP382

1

3

High-throughput

0.457

High

334886

G3P1
Glyceraldehyde-3-phosphate dehydrogenase 1

1

3

High-throughput

0.457

High

342655

ENO1
Enolase 1

1

2

High-throughput

0.457

High

378279

LEU3
3-isopropylmalate dehydrogenase

1

2

High-throughput

0.457

High

389218

HXKA
Hexokinase-1

1

3

High-throughput

0.457

High

430747

SYV
Valine--tRNA ligase, mitochondrial

1

1

High-throughput

0.457

High

485637

IF4A
ATP-dependent RNA helicase eIF4A

1

9

High-throughput

0.457

High

543167

HSC82
ATP-dependent molecular chaperone HSC82

1

6

High-throughput

0.457

High

555796

VATB
V-type proton ATPase subunit B

1

5

High-throughput

0.457

High

562176

PFKA1
ATP-dependent 6-phosphofructokinase subunit alpha

1

1

High-throughput

0.457

High

570664

HXKG
Glucokinase-1

1

3

High-throughput

0.457

High

572721

PDI
Protein disulfide-isomerase

1

4

High-throughput

0.457

High

586356

HSP60
Heat shock protein 60, mitochondrial

1

4

High-throughput

0.457

High

586367

IDH2
Isocitrate dehydrogenase [NAD] subunit 2, mitochondrial

1

1

High-throughput

0.457

High

586375

EF2
Elongation factor 2

1

13

High-throughput

0.457

High

586380

CBS
Cystathionine beta-synthase

1

1

High-throughput

0.457

High

586401

6PGD1
6-phosphogluconate dehydrogenase, decarboxylating 1

1

1

High-throughput

0.457

High

586407

SAHH
Adenosylhomocysteinase

1

1

High-throughput

0.457

High

586417

ALDH4
Potassium-activated aldehyde dehydrogenase, mitochondrial

1

4

High-throughput

0.457

High

586418

SYEC
Glutamate--tRNA ligase, cytoplasmic

1

2

High-throughput

0.457

High

586428

ARO8
Aromatic/aminoadipate aminotransferase 1

1

1

High-throughput

0.457

High

586430

ALDH6
Magnesium-activated aldehyde dehydrogenase, cytosolic

1

4

High-throughput

0.457

High

490292

HSP71
Heat shock protein SSA1

1

12

High-throughput

0.445

High

586364

SIS1
Protein SIS1

1

7

High-throughput

0.445

High

586378

PRP19
Pre-mRNA-processing factor 19

1

18

Small-scale

0.445

High

586381

HSP7F
Heat shock protein homolog SSE1

1

17

High-throughput

0.445

High

586411

SSB2
Ribosome-associated molecular chaperone SSB2

1

13

High-throughput

0.445

High

586388

HSP78
Heat shock protein 78, mitochondrial

1

7

High-throughput

0.407

High

586405

TCPB
T-complex protein 1 subunit beta

1

7

High-throughput

0.407

High

586419

PFD1
Prefoldin subunit 1

1

2

High-throughput

0.407

High

417559

PHSG
Glycogen phosphorylase

1

0

High-throughput

0.279

Low

586363

IF5A1
Eukaryotic translation initiation factor 5A-1

1

0

High-throughput

0.279

Low

586403

BCA1
Branched-chain-amino-acid aminotransferase, mitochondrial

1

0

High-throughput

0.279

Low

586404

PUR4
Phosphoribosylformylglycinamidine synthase

1

0

High-throughput

0.279

Low

586452

LSP1
Sphingolipid long chain base-responsive protein LSP1

1

0

High-throughput

0.279

Low

342343

CISY1
Citrate synthase, mitochondrial

1

0

High-throughput

0.261

Low

381682

GAL10
Bifunctional protein GAL10 [Includes: UDP-glucose 4-epimerase

1

0

High-throughput

0.261

Low

404299

METE
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase

1

0

High-throughput

0.261

Low

410753

ILV5
Ketol-acid reductoisomerase, mitochondrial

1

0

High-throughput

0.261

Low

520908

G6PI
Glucose-6-phosphate isomerase

1

0

High-throughput

0.261

Low

537352

ALF
Fructose-bisphosphate aldolase

1

0

High-throughput

0.261

Low

584114

ACON
Aconitate hydratase, mitochondrial

1

0

High-throughput

0.261

Low

586359

CLH
Clathrin heavy chain

1

0

High-throughput

0.261

Low

586386

UGPA1
UTP--glucose-1-phosphate uridylyltransferase

1

0

High-throughput

0.261

Low


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Last updated: 15 Jul 2024