Protein: IL2
Interleukin-2 (IL-2) (T-cell growth factor) (TCGF) (Aldesleukin)

Gene: IL2
Organism: Homo sapiens
Interactions: 29
UniProt ID: P60568

Gene Ontology (top 5):
GO:0002250 - adaptive immune response
GO:0002366 - leukocyte activation involved in immune response
GO:0002639 - positive regulation of immunoglobulin production
GO:0002903 - negative regulation of B cell apoptotic process
GO:0005125 - cytokine activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

378618

IL2RA
Interleukin-2 receptor subunit alpha

10

1

Small-scale

0.970

High

575822

IL2RB
Interleukin-2 receptor subunit beta

7

2

Small-scale

0.962

High

728671

IL2RG
Cytokine receptor common subunit gamma

4

2

Small-scale

0.887

High

429614

JUN
Transcription factor Jun

3

2

Small-scale

0.640

High

952405

CREM
cAMP-responsive element modulator

3

1

Small-scale

0.640

High

952413

IL17
Interleukin-17A

3

0

High-throughput

0.638

High

340861

NFAC1
Nuclear factor of activated T-cells, cytoplasmic 1

2

6

Small-scale

0.584

High

370616

FOS
Protein c-Fos

2

2

Small-scale

0.584

High

593069

CREB1
Cyclic AMP-responsive element-binding protein 1

2

1

Small-scale

0.584

High

952406

TF65
Transcription factor p65

2

6

Small-scale

0.584

High

952407

REL
Proto-oncogene c-Rel

2

6

Small-scale

0.584

High

952412

NFAC2
Nuclear factor of activated T-cells, cytoplasmic 2

2

6

Small-scale

0.584

High

952404

FOXK2
Forkhead box protein K2

1

0

Small-scale

0.493

High

445156

S10A6
Protein S100-A6

1

0

Small-scale

0.480

High

557997

XRCC6
X-ray repair cross-complementing protein 6

1

3

Small-scale

0.479

High

559291

XRCC5
X-ray repair cross-complementing protein 5

1

3

Small-scale

0.479

High

612958

EGR1
Early growth response protein 1

1

1

Small-scale

0.479

High

952408

EGR4
Early growth response protein 4

1

1

Small-scale

0.479

High

952410

ILF3
Interleukin enhancer-binding factor 3

1

1

Small-scale

0.479

High

952411

NFAC3
Nuclear factor of activated T-cells, cytoplasmic 3

1

6

Small-scale

0.479

High

369648

A2MG
Alpha-2-macroglobulin

1

0

Small-scale

0.458

High

464891

SP1
Transcription factor Sp1

1

0

Small-scale

0.458

High

601611

HMGA1
High mobility group protein HMG-I/HMG-Y

1

0

Small-scale

0.458

High

617209

ATF4
Cyclic AMP-dependent transcription factor ATF-4

1

0

Small-scale

0.458

High

658065

RS3
Small ribosomal subunit protein uS3

1

0

Small-scale

0.458

High

683817

MOES
Moesin

1

0

Small-scale

0.458

High

952409

EP300
Histone acetyltransferase p300

1

0

Small-scale

0.458

High

952414

IKZF3
Zinc finger protein Aiolos

1

0

Small-scale

0.458

High

563509

CFTR
Cystic fibrosis transmembrane conductance regulator

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025