Protein: PFD6
Prefoldin subunit 6 (Genes involved in microtubule biogenesis protein 1) (Gim complex subunit 1) (GimC subunit 1)

Gene: PFD6, YKE2
Organism: Saccharomyces cerevisiae S288C
Interactions: 206
UniProt ID: P52553

Gene Ontology (top 5):
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0006457 - protein folding
GO:0007021 - tubulin complex assembly
GO:0015631 - tubulin binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

817376

PFD3
Prefoldin subunit 3

8

2

Small-scale

0.971

High

854670

PFD5
Prefoldin subunit 5

7

4

Small-scale

0.962

High

854649

PFD4
Prefoldin subunit 4

6

2

High-throughput

0.951

High

797206

BUD27
Bud site selection protein 27

8

0

Small-scale

0.916

High

766528

PFD2
Prefoldin subunit 2

4

2

Small-scale

0.896

High

810068

PFD1
Prefoldin subunit 1

3

0

High-throughput

0.764

High

558154

RPB3
DNA-directed RNA polymerase II subunit RPB3

3

1

Small-scale

0.640

High

593166

RPAB1
DNA-directed RNA polymerases I, II, and III subunit RPABC1

2

1

High-throughput

0.628

High

854638

PFD6
Prefoldin subunit 6

1

1

High-throughput

0.621

High

812414

NNF1
Kinetochore-associated protein NNF1

2

0

High-throughput

0.570

High

443944

CYAA
Adenylate cyclase

2

0

High-throughput

0.563

High

706037

NIP80
Protein NIP100

2

0

High-throughput

0.552

High

519973

TCPA
T-complex protein 1 subunit alpha

1

0

Small-scale

0.546

High

760655

TCPB
T-complex protein 1 subunit beta

1

0

High-throughput

0.546

High

491839

HSP71
Heat shock protein SSA1

1

1

High-throughput

0.536

High

744653

TAF5
Transcription initiation factor TFIID subunit 5

1

6

High-throughput

0.536

High

767251

TDA2
Topoisomerase I damage affected protein 2

1

0

High-throughput

0.518

High

854645

TBG
Tubulin gamma chain

1

7

Small-scale

0.515

High

501387

RPA1
DNA-directed RNA polymerase I subunit RPA190

1

3

High-throughput

0.481

High

561891

TUP1
General transcriptional corepressor TUP1

1

7

High-throughput

0.481

High

765473

LIS1
Nuclear distribution protein PAC1

1

6

High-throughput

0.481

High

375445

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

3

High-throughput

0.479

High

606702

RPC2
DNA-directed RNA polymerase III subunit RPC2

1

4

High-throughput

0.479

High

410014

NOT3
General negative regulator of transcription subunit 3

1

0

High-throughput

0.460

High

560733

BIP
Endoplasmic reticulum chaperone BiP

1

0

High-throughput

0.460

High

697968

SLA1
Actin cytoskeleton-regulatory complex protein SLA1

1

0

High-throughput

0.460

High

733080

NTR2
Pre-mRNA-splicing factor NTR2

1

0

High-throughput

0.460

High

752803

SYSM
Serine--tRNA ligase, mitochondrial

1

0

High-throughput

0.460

High

759242

END3
Actin cytoskeleton-regulatory complex protein END3

1

0

High-throughput

0.460

High

766806

SPC25
Kinetochore protein SPC25

1

0

High-throughput

0.460

High

805110

SAC3
Nuclear mRNA export protein SAC3

1

0

High-throughput

0.460

High

854660

ULP1
Ubiquitin-like-specific protease 1

1

0

High-throughput

0.460

High

854666

VPS64
Vacuolar protein sorting-associated protein 64

1

0

High-throughput

0.460

High

854704

SRN2
Protein SRN2

1

0

High-throughput

0.460

High

662771

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.458

High

759499

MPT5
Suppressor protein MPT5

1

0

High-throughput

0.458

High

854694

RRP6
Exosome complex exonuclease RRP6

1

0

High-throughput

0.458

High

454401

TBA1
Tubulin alpha-1 chain

1

6

Small-scale

0.445

High

454634

TBA3
Tubulin alpha-3 chain

1

7

High-throughput

0.445

High

472555

YD15B
Transposon Ty1-DR6 Gag-Pol polyprotein

1

1

High-throughput

0.445

High

494453

HSP72
Heat shock protein SSA2

1

1

High-throughput

0.445

High

571910

SKI3
Superkiller protein 3

1

1

High-throughput

0.445

High

604587

RPA2
DNA-directed RNA polymerase I subunit RPA135

1

4

High-throughput

0.445

High

630086

SNT1
Probable DNA-binding protein SNT1

1

1

High-throughput

0.445

High

692321

PRP19
Pre-mRNA-processing factor 19

1

5

High-throughput

0.445

High

695099

HSP7F
Heat shock protein homolog SSE1

1

2

High-throughput

0.445

High

774056

NDC80
Kinetochore protein NDC80

1

1

High-throughput

0.445

High

810875

MTR4
ATP-dependent RNA helicase DOB1

1

1

High-throughput

0.445

High

854654

ACT
Actin

1

2

Small-scale

0.445

High

854668

YM13B
Transposon Ty1-MR1 Gag-Pol polyprotein

1

1

High-throughput

0.445

High

854682

SWA2
Auxilin-like clathrin uncoating factor SWA2

1

1

High-throughput

0.445

High

854683

CDC73
Cell division control protein 73

1

1

High-throughput

0.445

High

334750

G3P3
Glyceraldehyde-3-phosphate dehydrogenase 3

1

0

High-throughput

0.426

High

356597

H4
Histone H4

1

0

High-throughput

0.426

High

368222

EF1A
Elongation factor 1-alpha

1

0

High-throughput

0.426

High

404354

METE
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase

1

0

High-throughput

0.426

High

431388

LTE1
Guanine nucleotide exchange factor LTE1

1

0

High-throughput

0.426

High

446194

MYO1
Myosin-1

1

0

High-throughput

0.426

High

512003

SSB1
Ribosome-associated molecular chaperone SSB1

1

0

High-throughput

0.426

High

526273

KIN2
Serine/threonine-protein kinase KIN2

1

0

High-throughput

0.426

High

597257

PSA7
Probable proteasome subunit alpha type-7

1

0

High-throughput

0.426

High

613826

TKT1
Transketolase 1

1

0

High-throughput

0.426

High

620019

MPIP
M-phase inducer phosphatase

1

0

High-throughput

0.426

High

639236

MSH1
DNA mismatch repair protein MSH1, mitochondrial

1

0

High-throughput

0.426

High

667412

CHS3
Chitin synthase 3

1

0

High-throughput

0.426

High

675535

MCM4
DNA replication licensing factor MCM4

1

0

High-throughput

0.426

High

696231

STH1
Nuclear protein STH1/NPS1

1

0

High-throughput

0.426

High

698558

SLX5
E3 ubiquitin-protein ligase complex SLX5-SLX8 subunit SLX5

1

0

High-throughput

0.426

High

698598

MRE11
Double-strand break repair protein MRE11

1

0

High-throughput

0.426

High

700786

SMC1
Structural maintenance of chromosomes protein 1

1

0

High-throughput

0.426

High

701182

RPC6
DNA-directed RNA polymerase III subunit RPC6

1

0

High-throughput

0.426

High

703691

PRS6A
26S proteasome regulatory subunit 6A

1

0

High-throughput

0.426

High

703825

PRS6B
26S proteasome regulatory subunit 6B homolog

1

0

High-throughput

0.426

High

710568

UBX1
UBX domain-containing protein 1

1

0

High-throughput

0.426

High

715217

TOR1
Serine/threonine-protein kinase TOR1

1

0

High-throughput

0.426

High

715952

UTP20
U3 small nucleolar RNA-associated protein 20

1

0

High-throughput

0.426

High

732159

CAB3
Coenzyme A biosynthesis protein 3

1

0

High-throughput

0.426

High

742668

AAP1
Alanine/arginine aminopeptidase

1

0

High-throughput

0.426

High

743164

BOB1
Protein BOB1

1

0

High-throughput

0.426

High

743422

RIB1
GTP cyclohydrolase-2

1

0

High-throughput

0.426

High

748289

CENPU
Inner kinetochore subunit AME1

1

0

High-throughput

0.426

High

748892

REI1
Cytoplasmic 60S subunit biogenesis factor REI1

1

0

High-throughput

0.426

High

751469

MED31
Mediator of RNA polymerase II transcription subunit 31

1

0

High-throughput

0.426

High

753076

OSH3
Oxysterol-binding protein homolog 3

1

0

High-throughput

0.426

High

754974

RRP4
Exosome complex component RRP4

1

0

High-throughput

0.426

High

763433

MET10
Sulfite reductase [NADPH] flavoprotein component

1

0

High-throughput

0.426

High

766380

YEC5
Uncharacterized protein YEL025C

1

0

High-throughput

0.426

High

766990

CHZ1
Histone H2A.Z-specific chaperone CHZ1

1

0

High-throughput

0.426

High

771762

TBP6
Probable 26S proteasome subunit YTA6

1

0

High-throughput

0.426

High

772297

ATAD2
ATPase histone chaperone YTA7

1

0

High-throughput

0.426

High

773694

6P21
6-phosphofructo-2-kinase 1

1

0

High-throughput

0.426

High

773812

YIR7
Y' element ATP-dependent helicase YIL177C

1

0

High-throughput

0.426

High

774880

SER33
D-3-phosphoglycerate dehydrogenase 2

1

0

High-throughput

0.426

High

774888

SPO22
Sporulation-specific protein 22

1

0

High-throughput

0.426

High

774906

CSN11
Cop9 signalosome complex subunit 11

1

0

High-throughput

0.426

High

775417

VID28
Vacuolar import and degradation protein 28

1

0

High-throughput

0.426

High

804885

SYEC
Glutamate--tRNA ligase, cytoplasmic

1

0

High-throughput

0.426

High

810665

ALY2
Arrestin-related trafficking adapter 3

1

0

High-throughput

0.426

High

812257

EMC2
ER membrane protein complex subunit 2

1

0

High-throughput

0.426

High

812592

MET5
Sulfite reductase [NADPH] subunit beta

1

0

High-throughput

0.426

High

816951

GTO1
Glutathione S-transferase omega-like 1

1

0

High-throughput

0.426

High

837518

LGUL
Glyoxalase I

1

0

High-throughput

0.426

High

851024

ROM2
RHO1 GDP-GTP exchange protein 2

1

0

High-throughput

0.426

High

854641

MDS3
Negative regulator of sporulation MDS3

1

0

High-throughput

0.426

High

854642

MED5
Mediator of RNA polymerase II transcription subunit 5

1

0

High-throughput

0.426

High

854643

FMP48
Probable serine/threonine-protein kinase FMP48

1

0

High-throughput

0.426

High

854644

PIL1
Sphingolipid long chain base-responsive protein PIL1

1

0

High-throughput

0.426

High

854646

DCP2
m7GpppN-mRNA hydrolase

1

0

High-throughput

0.426

High

854648

GIS2
Zinc finger protein GIS2

1

0

High-throughput

0.426

High

854652

IDHH
Isocitrate dehydrogenase [NADP]

1

0

High-throughput

0.426

High

854653

UFD2
E4 ubiquitin-protein ligase UFD2

1

0

High-throughput

0.426

High

854657

SEN1
Helicase SEN1

1

0

High-throughput

0.426

High

854662

ESP1
Separin

1

0

High-throughput

0.426

High

854669

PDS5
Sister chromatid cohesion protein PDS5

1

0

High-throughput

0.426

High

854672

SWR1
Helicase SWR1

1

0

High-throughput

0.426

High

854675

YL278
Uncharacterized transcriptional regulatory protein YLR278C

1

0

High-throughput

0.426

High

854676

ECM22
Sterol regulatory element-binding protein ECM22

1

0

High-throughput

0.426

High

854678

VPS74
Vacuolar protein sorting-associated protein 74

1

0

High-throughput

0.426

High

854685

SYG2
Glycine--tRNA ligase 2

1

0

High-throughput

0.426

High

854686

YD144
Uncharacterized protein YDL144C

1

0

High-throughput

0.426

High

854688

NOC3
Nucleolar complex-associated protein 3

1

0

High-throughput

0.426

High

854689

AVO1
Target of rapamycin complex 2 subunit AVO1

1

0

High-throughput

0.426

High

854690

RRP40
Exosome complex component RRP40

1

0

High-throughput

0.426

High

854691

DIA2
Protein DIA2

1

0

High-throughput

0.426

High

854692

PUS7
Multisubstrate pseudouridine synthase 7

1

0

High-throughput

0.426

High

854693

NIP7
60S ribosome subunit biogenesis protein NIP7

1

0

High-throughput

0.426

High

854695

KPR5
Ribose-phosphate pyrophosphokinase 5

1

0

High-throughput

0.426

High

854696

INP53
Polyphosphatidylinositol phosphatase INP53

1

0

High-throughput

0.426

High

854697

HER1
HMG2-induced ER-remodeling protein 1

1

0

High-throughput

0.426

High

854699

SFI1
Protein SFI1

1

0

High-throughput

0.426

High

854701

KCS1
Inositol hexakisphosphate kinase 1

1

0

High-throughput

0.426

High

854702

DCP1
mRNA-decapping enzyme subunit 1

1

0

High-throughput

0.426

High

854705

DDP1
Diphosphoinositol polyphosphate phosphohydrolase DDP1

1

0

High-throughput

0.426

High

687613

DGR2
2-deoxy-glucose resistant protein 2

1

7

High-throughput

0.407

High

731250

YPT53
GTP-binding protein YPT53

1

1

High-throughput

0.407

High

854661

YP113
Putative 2-hydroxyacid dehydrogenase YPL113C

1

1

High-throughput

0.407

High

767526

TSC11
Target of rapamycin complex 2 subunit TSC11

2

0

High-throughput

0.300

High

784941

PXA1
Peroxisomal long-chain fatty acid import protein 2

1

0

High-throughput

0.282

High

854703

YB296
Uncharacterized protein YBR296C-A

1

0

High-throughput

0.282

High

805034

FAR3
Factor arrest protein 3

1

0

High-throughput

0.265

Low

711143

SEG2
Eisosome protein SEG2

1

0

High-throughput

0.251

Low

741309

VPP2
V-type proton ATPase subunit a, Golgi isoform

1

0

High-throughput

0.251

Low

747587

ATG14
Autophagy-related protein 14

1

0

High-throughput

0.251

Low

796917

GCN20
Protein GCN20

1

0

High-throughput

0.251

Low

837236

KEL2
Kelch repeat-containing protein 2

1

0

High-throughput

0.251

Low

854667

SHE9
Sensitive to high expression protein 9, mitochondrial

1

0

High-throughput

0.251

Low

854674

ENT2
Epsin-2

1

0

High-throughput

0.251

Low

854700

NCA2
Nuclear control of ATPase protein 2

1

0

High-throughput

0.251

Low

420059

TYSY
Thymidylate synthase

1

0

High-throughput

0.232

Low

471915

RL27B
Large ribosomal subunit protein eL27B

1

0

High-throughput

0.232

Low

527218

HAP3
Transcriptional activator HAP3

1

0

High-throughput

0.232

Low

541902

NSP1
Nucleoporin NSP1

1

0

High-throughput

0.232

Low

560347

ODPX
Pyruvate dehydrogenase complex protein X component, mitochondrial

1

0

High-throughput

0.232

Low

601090

RT28
Small ribosomal subunit protein uS15m

1

0

High-throughput

0.232

Low

630757

ADH7
NADP-dependent alcohol dehydrogenase 7

1

0

High-throughput

0.232

Low

630965

USO1
Intracellular protein transport protein USO1

1

0

High-throughput

0.232

Low

653813

PEP3
Vacuolar membrane protein PEP3

1

0

High-throughput

0.232

Low

679849

LDS1
Outer spore wall protein LDS1

1

0

High-throughput

0.232

Low

679925

PMT2
Dolichyl-phosphate-mannose--protein mannosyltransferase 2

1

0

High-throughput

0.232

Low

691829

EI2BB
Translation initiation factor eIF2B subunit beta

1

0

High-throughput

0.232

Low

698484

ZRT1
Zinc-regulated transporter 1

1

0

High-throughput

0.232

Low

707291

RT05
Small ribosomal subunit protein uS5m

1

0

High-throughput

0.232

Low

730403

PMIP
Mitochondrial intermediate peptidase

1

0

High-throughput

0.232

Low

730710

DHR2
Probable ATP-dependent RNA helicase DHR2

1

0

High-throughput

0.232

Low

731961

RT22
Ribosome assembly protein RSM22, mitochondrial

1

0

High-throughput

0.232

Low

733751

YK50
Mitochondrial hydrolase YKR070W

1

0

High-throughput

0.232

Low

744211

MAK5
ATP-dependent RNA helicase MAK5

1

0

High-throughput

0.232

Low

746651

FAT1
Very long-chain fatty acid transport protein

1

0

High-throughput

0.232

Low

747636

CCZ1
Vacuolar fusion protein CCZ1

1

0

High-throughput

0.232

Low

748788

POP4
RNases MRP/P 32.9 kDa subunit

1

0

High-throughput

0.232

Low

750118

YM8C
Uncharacterized deoxyribonuclease YMR262W

1

0

High-throughput

0.232

Low

753274

COS8
Protein COS8

1

0

High-throughput

0.232

Low

755305

RPF1
Ribosome production factor 1

1

0

High-throughput

0.232

Low

756228

LAM1
Membrane-anchored lipid-binding protein LAM1

1

0

High-throughput

0.232

Low

758569

HAL5
Serine/threonine-protein kinase HAL5

1

0

High-throughput

0.232

Low

762872

YAO0
Putative uncharacterized protein YAR070C

1

0

High-throughput

0.232

Low

772497

ATF1
Alcohol O-acetyltransferase 1

1

0

High-throughput

0.232

Low

784929

PTE1
Peroxisomal acyl-coenzyme A thioester hydrolase 1

1

0

High-throughput

0.232

Low

805151

STU2
Protein STU2

1

0

High-throughput

0.232

Low

811127

BBC1
Myosin tail region-interacting protein MTI1

1

0

High-throughput

0.232

Low

812525

YJ94
Uncharacterized membrane protein YJR124C

1

0

High-throughput

0.232

Low

812598

IML1
Vacuolar membrane-associated protein IML1

1

0

High-throughput

0.232

Low

816881

NOL10
Ribosome biogenesis protein ENP2

1

0

High-throughput

0.232

Low

853205

PPAD
Probable acid phosphatase DIA3

1

0

High-throughput

0.232

Low

854639

CWH41
Mannosyl-oligosaccharide glucosidase

1

0

High-throughput

0.232

Low

854640

SHE10
Outer spore wall assembly protein SHE10

1

0

High-throughput

0.232

Low

854647

PRM1
Plasma membrane fusion protein PRM1

1

0

High-throughput

0.232

Low

854650

YNI9
Putative uncharacterized protein YNL089C

1

0

High-throughput

0.232

Low

854651

SFB2
SED5-binding protein 2

1

0

High-throughput

0.232

Low

854655

CACM
Putative mitochondrial carnitine O-acetyltransferase

1

0

High-throughput

0.232

Low

854656

ATPJ
ATP synthase subunit e, mitochondrial

1

0

High-throughput

0.232

Low

854658

ACAC
Acetyl-CoA carboxylase

1

0

High-throughput

0.232

Low

854659

RSC4
Chromatin structure-remodeling complex subunit RSC4

1

0

High-throughput

0.232

Low

854663

TCB3
Tricalbin-3

1

0

High-throughput

0.232

Low

854664

GAS3
Probable 1,3-beta-glucanosyltransferase GAS3

1

0

High-throughput

0.232

Low

854665

AIM36
Altered inheritance of mitochondria protein 36, mitochondrial

1

0

High-throughput

0.232

Low

854671

YMI9
Putative uncharacterized protein YML089C

1

0

High-throughput

0.232

Low

854673

SGPL
Sphingosine-1-phosphate lyase

1

0

High-throughput

0.232

Low

854677

ATG39
Autophagy-related protein 39

1

0

High-throughput

0.232

Low

854679

TAZ
Tafazzin

1

0

High-throughput

0.232

Low

854680

SUE1
Protein SUE1, mitochondrial

1

0

High-throughput

0.232

Low

854681

YD306
F-box protein YDR306C

1

0

High-throughput

0.232

Low

854684

YP078
Uncharacterized protein YPR078C

1

0

High-throughput

0.232

Low

854687

BRE4
Protein BRE4

1

0

High-throughput

0.232

Low

854698

PST1
Cell wall mannoprotein PST1

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024