Protein: SPC25
Kinetochore protein Spc25 (hSpc25)

Gene: SPC25
Organism: Homo sapiens
Interactions: 62
UniProt ID: Q9HBM1

Gene Ontology (top 5):
GO:0000776 - kinetochore
GO:0000940 - outer kinetochore
GO:0005634 - nucleus
GO:0005829 - cytosol
GO:0007052 - mitotic spindle organization

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1334230

SPC24
Kinetochore protein Spc24

11

2

Small-scale

0.978

High

1433045

DSN1
Kinetochore-associated protein DSN1 homolog

6

0

High-throughput

0.900

High

164100

NDC80
Kinetochore protein NDC80 homolog

9

3

Small-scale

0.756

High

1419598

NUF2
Kinetochore protein Nuf2

8

3

High-throughput

0.750

High

1429543

MIS12
Protein MIS12 homolog

9

0

Small-scale

0.723

High

329979

ZWINT
Outer kinetochore KNL1 complex subunit ZWINT

7

0

High-throughput

0.714

High

1339887

KNL1
Outer kinetochore KNL1 complex subunit KNL1

6

0

Small-scale

0.699

High

839827

EPS15
Epidermal growth factor receptor substrate 15

3

1

High-throughput

0.667

High

1240780

PMF1
Polyamine-modulated factor 1

3

1

High-throughput

0.667

High

1438393

EP15R
Epidermal growth factor receptor substrate 15-like 1

3

1

High-throughput

0.667

High

1394507

NSL1
Kinetochore-associated protein NSL1 homolog

4

0

High-throughput

0.661

High

50038

F170A
Protein FAM170A

3

0

High-throughput

0.638

High

343477

SNP29
Synaptosomal-associated protein 29

3

0

High-throughput

0.638

High

1070516

FCHO2
F-BAR domain only protein 2

3

0

High-throughput

0.638

High

1229872

CYTSA
Cytospin-A

3

0

High-throughput

0.638

High

1326643

KIF2B
Kinesin-like protein KIF2B

2

0

High-throughput

0.602

High

1227489

A16L1
Autophagy-related protein 16-1

2

0

High-throughput

0.585

High

169759

HGS
Hepatocyte growth factor-regulated tyrosine kinase substrate

2

0

High-throughput

0.580

High

445264

S10A6
Protein S100-A6

1

3

High-throughput

0.536

High

682619

S100P
Protein S100-P

1

3

High-throughput

0.536

High

686869

S10A4
Protein S100-A4

1

3

High-throughput

0.536

High

224171

BUB1
Mitotic checkpoint serine/threonine-protein kinase BUB1

1

1

High-throughput

0.515

High

128477

PSMD9
26S proteasome non-ATPase regulatory subunit 9

1

0

High-throughput

0.513

High

712282

TKT
Transketolase

1

0

High-throughput

0.513

High

761888

HSP74
Heat shock 70 kDa protein 4

1

0

High-throughput

0.513

High

841960

LPPRC
Leucine-rich PPR motif-containing protein, mitochondrial

1

0

High-throughput

0.513

High

1271997

CENPQ
Centromere protein Q

1

0

High-throughput

0.513

High

1405866

DNJC7
DnaJ homolog subfamily C member 7

1

0

High-throughput

0.513

High

706318

S10A2
Protein S100-A2

1

3

High-throughput

0.489

High

755632

TTK
Dual specificity protein kinase TTK

1

0

Small-scale

0.479

High

1385066

CENPT
Centromere protein T

1

1

Small-scale

0.479

High

242985

PRKN
E3 ubiquitin-protein ligase parkin

1

0

High-throughput

0.458

High

289175

PRDM1
PR domain zinc finger protein 1

1

0

Small-scale

0.458

High

290160

OFD1
Centriole and centriolar satellite protein OFD1

1

0

High-throughput

0.458

High

344799

AP2A1
AP-2 complex subunit alpha-1

1

0

High-throughput

0.458

High

951441

SC61B
Protein transport protein Sec61 subunit beta

1

0

Small-scale

0.458

High

1086821

BPTF
Nucleosome-remodeling factor subunit BPTF

1

0

High-throughput

0.458

High

1138652

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

0

High-throughput

0.458

High

1278810

HDGR2
Hepatoma-derived growth factor-related protein 2

1

0

High-throughput

0.458

High

1310172

GCC2
GRIP and coiled-coil domain-containing protein 2

1

0

High-throughput

0.458

High

1403582

MMS19
MMS19 nucleotide excision repair protein homolog

1

0

High-throughput

0.458

High

1432689

BOLA2
BolA-like protein 2

1

0

High-throughput

0.458

High

1438394

U3KQ54
HCG2044777

1

1

High-throughput

0.445

High

1310427

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

0

Small-scale

0.438

High

1433938

PKHA4
Pleckstrin homology domain-containing family A member 4

1

1

High-throughput

0.437

High

787588

TNR3
Tumor necrosis factor receptor superfamily member 3

3

0

High-throughput

0.347

High

1169036

CSPP1
Centrosome and spindle pole-associated protein 1

2

0

High-throughput

0.328

High

1288796

KTN1
Kinectin

2

0

High-throughput

0.318

High

1365598

MY18A
Unconventional myosin-XVIIIa

2

0

High-throughput

0.318

High

1385585

CSTOS
Protein CUSTOS

2

0

High-throughput

0.318

High

914349

EFNA4
Ephrin-A4

1

0

High-throughput

0.279

Low

1158828

CART

1

0

High-throughput

0.279

Low

1211456

CF141
Uncharacterized protein C6orf141

1

0

High-throughput

0.279

Low

1313700

IFT20
Intraflagellar transport protein 20 homolog

1

0

High-throughput

0.279

Low

218801

TGON2
Trans-Golgi network integral membrane protein 2

1

0

High-throughput

0.249

Low

880703

LMAN1
Protein ERGIC-53

1

0

High-throughput

0.249

Low

1255615

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

1435644

AAMDC
Mth938 domain-containing protein

1

0

High-throughput

0.249

Low

1435790

MET17
Ribosome assembly protein METTL17, mitochondrial

1

0

High-throughput

0.249

Low

1438392

ARMX1
Armadillo repeat-containing X-linked protein 1

1

0

High-throughput

0.249

Low

789226

NUP62
Nuclear pore glycoprotein p62

1

0

High-throughput

0.232

Low

1352574

G6PT3
Glucose-6-phosphate exchanger SLC37A2

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025