Protein: TACC3
Transforming acidic coiled-coil-containing protein 3 (ERIC-1)

Gene: TACC3
Organism: Homo sapiens
Interactions: 146
UniProt ID: Q9Y6A5

Gene Ontology (top 5):
GO:0000226 - microtubule cytoskeleton organization
GO:0000922 - spindle pole
GO:0005737 - cytoplasm
GO:0005794 - Golgi apparatus
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

170457

AURKA
Aurora kinase A

5

20

Small-scale

0.718

High

1119936

CKAP5
Cytoskeleton-associated protein 5

5

13

Small-scale

0.714

High

1449701

TB22B
TBC1 domain family member 22B

4

3

High-throughput

0.698

High

1454328

SLAI2
SLAIN motif-containing protein 2

4

5

High-throughput

0.697

High

896678

VASP
Vasodilator-stimulated phosphoprotein

4

7

High-throughput

0.691

High

1428232

NDEL1
Nuclear distribution protein nudE-like 1

3

19

Small-scale

0.672

High

1331386

ENAH
Protein enabled homolog

3

9

High-throughput

0.662

High

1198557

CEP55
Centrosomal protein of 55 kDa

3

1

High-throughput

0.652

High

1178819

KIZ
Centrosomal protein kizuna

3

0

High-throughput

0.646

High

693385

ARNT
Aryl hydrocarbon receptor nuclear translocator

2

20

Small-scale

0.643

High

343510

SNP29
Synaptosomal-associated protein 29

3

0

High-throughput

0.638

High

1491822

TACC3
Transforming acidic coiled-coil-containing protein 3

1

14

High-throughput

0.637

High

217231

MS18B
Protein Mis18-beta

3

0

High-throughput

0.634

High

1392374

BORC6
BLOC-1-related complex subunit 6

4

2

High-throughput

0.633

High

1461953

FZR1
Fizzy-related protein homolog

2

14

Small-scale

0.631

High

1350828

PKHO2
Pleckstrin homology domain-containing family O member 2

4

6

High-throughput

0.630

High

538187

HSP7C
Heat shock cognate 71 kDa protein

2

8

High-throughput

0.628

High

1460151

EVL
Ena/VASP-like protein

2

6

High-throughput

0.628

High

1400590

CIB3
Calcium and integrin-binding family member 3

3

2

High-throughput

0.616

High

1028500

BEX3
Protein BEX3

2

1

High-throughput

0.606

High

1060596

KLC1
Kinesin light chain 1

2

4

High-throughput

0.606

High

1180834

KLH38
Kelch-like protein 38

2

8

High-throughput

0.606

High

1294649

CD20B
Cell division cycle protein 20 homolog B

2

13

High-throughput

0.606

High

1350755

CCHCR
Coiled-coil alpha-helical rod protein 1

2

17

High-throughput

0.606

High

1407510

GDIR3
Rho GDP-dissociation inhibitor 3

2

1

High-throughput

0.606

High

1408519

GDF15
Growth/differentiation factor 15

2

2

High-throughput

0.606

High

1417608

BEX2
Protein BEX2

2

1

High-throughput

0.606

High

1042720

KIME
Mevalonate kinase

2

0

High-throughput

0.602

High

1199060

KLH12
Kelch-like protein 12

2

7

High-throughput

0.601

High

364099

EGFR
Epidermal growth factor receptor

1

20

Small-scale

0.582

High

1349460

MIEAP
Mitochondria-eating protein

2

0

High-throughput

0.580

High

1388073

DRC10
Dynein regulatory complex protein 10

2

0

High-throughput

0.580

High

597819

CRIS2
Cysteine-rich secretory protein 2

2

1

High-throughput

0.574

High

1246443

CORO6
Coronin-6

2

9

High-throughput

0.574

High

63280

VP37C
Vacuolar protein sorting-associated protein 37C

1

11

High-throughput

0.573

High

1419772

ASPC1
Tether containing UBX domain for GLUT4

1

1

High-throughput

0.573

High

1217939

BRE1A
E3 ubiquitin-protein ligase BRE1A

2

18

High-throughput

0.553

High

1276181

NUP54
Nucleoporin p54

2

4

High-throughput

0.553

High

1410557

KXDL1
KxDL motif-containing protein 1

2

4

High-throughput

0.549

High

302129

CDKL5
Cyclin-dependent kinase-like 5

1

17

High-throughput

0.541

High

1438508

ARNT2
Aryl hydrocarbon receptor nuclear translocator 2

1

20

High-throughput

0.541

High

299808

MPDZ
Multiple PDZ domain protein

1

10

High-throughput

0.536

High

347443

BAG2
BAG family molecular chaperone regulator 2

1

4

High-throughput

0.536

High

709036

T2EB
Transcription initiation factor IIE subunit beta

1

1

High-throughput

0.536

High

789257

NUP62
Nuclear pore glycoprotein p62

1

11

High-throughput

0.536

High

814893

CUX1
Homeobox protein cut-like 1

1

20

High-throughput

0.536

High

893544

GNAQ
Guanine nucleotide-binding protein G(q) subunit alpha

1

1

High-throughput

0.536

High

913626

KIF11
Kinesin-like protein KIF11

1

10

High-throughput

0.536

High

937380

DSRAD
Double-stranded RNA-specific adenosine deaminase

1

10

High-throughput

0.536

High

996906

TBA1B
Tubulin alpha-1B chain

1

13

High-throughput

0.536

High

997582

TBB4B
Tubulin beta-4B chain

1

6

High-throughput

0.536

High

1052131

CALD1
Caldesmon

1

20

High-throughput

0.536

High

1126849

SLBP
Histone RNA hairpin-binding protein

1

1

High-throughput

0.536

High

1206182

TGO1
Transport and Golgi organization protein 1 homolog

1

17

High-throughput

0.536

High

1216042

M3K21
Mitogen-activated protein kinase kinase kinase 21

1

5

High-throughput

0.536

High

1220917

RN123
E3 ubiquitin-protein ligase RNF123

1

7

High-throughput

0.536

High

1241652

ANM9
Protein arginine N-methyltransferase 9

1

5

High-throughput

0.536

High

1307230

RN135
E3 ubiquitin-protein ligase RNF135

1

9

High-throughput

0.536

High

1315663

RN168
E3 ubiquitin-protein ligase RNF168

1

3

High-throughput

0.536

High

1336413

SLAI1
SLAIN motif-containing protein 1

1

5

High-throughput

0.536

High

1396482

WDR90
WD repeat-containing protein 90

1

9

High-throughput

0.536

High

1419475

PANK2
Pantothenate kinase 2, mitochondrial

1

1

High-throughput

0.536

High

1462089

PRP19
Pre-mRNA-processing factor 19

1

11

High-throughput

0.536

High

1491497

IPP
Actin-binding protein IPP

1

7

High-throughput

0.536

High

1491818

NFS1
Cysteine desulfurase

1

1

High-throughput

0.536

High

1458217

MBD2
Methyl-CpG-binding domain protein 2

1

0

Small-scale

0.529

High

1279504

SNX20
Sorting nexin-20

1

5

High-throughput

0.523

High

1247582

F111B
Serine protease FAM111B

1

0

High-throughput

0.513

High

1371172

CLP1
Polyribonucleotide 5'-hydroxyl-kinase Clp1

1

0

High-throughput

0.513

High

1462420

TTF2
Transcription termination factor 2

1

15

Small-scale

0.508

High

1369187

KAT2A
Histone acetyltransferase KAT2A

1

20

Small-scale

0.501

High

483284

CLCA
Clathrin light chain A

1

3

Small-scale

0.500

High

244802

ZC3H1
Zinc finger C3H1 domain-containing protein

1

1

High-throughput

0.489

High

936584

AF17
Protein AF-17

1

4

High-throughput

0.489

High

1201934

Q58EY0
RAR related orphan receptor B isoform 1

1

20

High-throughput

0.489

High

1338721

BD1L1
Biorientation of chromosomes in cell division protein 1-like 1

1

18

High-throughput

0.489

High

1400996

ARX
Homeobox protein ARX

1

13

High-throughput

0.489

High

1438959

MET14
N(6)-adenosine-methyltransferase non-catalytic subunit METTL14

1

1

High-throughput

0.489

High

1453414

HPBP1
Hsp70-binding protein 1

1

3

High-throughput

0.489

High

1454208

NHSL3
NHS-like protein 3

1

14

High-throughput

0.489

High

1325040

CLIP4
CAP-Gly domain-containing linker protein 4

1

12

High-throughput

0.481

High

1405793

EIF3C
Eukaryotic translation initiation factor 3 subunit C

1

1

High-throughput

0.481

High

1408567

AKAP9
A-kinase anchor protein 9

1

20

Small-scale

0.481

High

1438576

NOD2
Nucleotide-binding oligomerization domain-containing protein 2

1

4

Small-scale

0.481

High

243444

PRKN
E3 ubiquitin-protein ligase parkin

1

11

High-throughput

0.479

High

247059

KDM1A
Lysine-specific histone demethylase 1A

1

6

High-throughput

0.479

High

437050

K1C18
Keratin, type I cytoskeletal 18

1

12

High-throughput

0.479

High

607280

CEBPB
CCAAT/enhancer-binding protein beta

1

13

High-throughput

0.479

High

718669

CDC27
Cell division cycle protein 27 homolog

1

11

Small-scale

0.479

High

799617

BRCA1
Breast cancer type 1 susceptibility protein

1

14

Small-scale

0.479

High

831736

CCNF
Cyclin-F

1

10

High-throughput

0.479

High

920409

PLK1
Serine/threonine-protein kinase PLK1

1

12

High-throughput

0.479

High

957579

UBC12
NEDD8-conjugating enzyme Ubc12

1

8

High-throughput

0.479

High

971377

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

7

High-throughput

0.479

High

986842

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

2

High-throughput

0.479

High

1007813

RAE1L
mRNA export factor RAE1

1

12

Small-scale

0.479

High

1100653

DHRS2
Dehydrogenase/reductase SDR family member 2, mitochondrial

1

2

High-throughput

0.479

High

1110226

HDAC1
Histone deacetylase 1

1

20

High-throughput

0.479

High

1114784

CUL3
Cullin-3

1

16

High-throughput

0.479

High

1152317

MARE1
Microtubule-associated protein RP/EB family member 1

1

11

High-throughput

0.479

High

1156254

ZYX
Zyxin

1

8

High-throughput

0.479

High

1229808

VIR
Protein virilizer homolog

1

3

High-throughput

0.479

High

1256305

TRI67
Tripartite motif-containing protein 67

1

20

High-throughput

0.479

High

1335124

SERB1
SERPINE1 mRNA-binding protein 1

1

1

High-throughput

0.479

High

1369235

KAT2B
Histone acetyltransferase KAT2B

1

17

Small-scale

0.479

High

1408406

SH3G2
Endophilin-A1

1

15

High-throughput

0.479

High

1409637

DHRS9
Dehydrogenase/reductase SDR family member 9

1

5

High-throughput

0.479

High

1417121

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

15

High-throughput

0.479

High

1429040

WWTR1
WW domain-containing transcription regulator protein 1

1

19

High-throughput

0.479

High

1433330

WNK1
Serine/threonine-protein kinase WNK1

1

9

High-throughput

0.479

High

1450655

ARL8B
ADP-ribosylation factor-like protein 8B

1

8

High-throughput

0.479

High

1459492

ZRAN1
Ubiquitin thioesterase ZRANB1

1

12

High-throughput

0.479

High

1461367

BAG5
BAG family molecular chaperone regulator 5

1

4

High-throughput

0.479

High

276802

TBCA
Tubulin-specific chaperone A

1

0

High-throughput

0.458

High

1259608

TBA1A
Tubulin alpha-1A chain

1

13

High-throughput

0.445

High

297720

PIAS1
E3 SUMO-protein ligase PIAS1

1

7

High-throughput

0.437

High

412901

NTRK1
High affinity nerve growth factor receptor

1

20

High-throughput

0.437

High

552101

ADT1
ADP/ATP translocase 1

1

3

High-throughput

0.437

High

1049218

RON
Macrophage-stimulating protein receptor

1

20

High-throughput

0.437

High

1226567

DCA15
DDB1- and CUL4-associated factor 15

1

3

High-throughput

0.437

High

1277054

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

5

High-throughput

0.437

High

1312344

MIRO1
Mitochondrial Rho GTPase 1

1

20

High-throughput

0.437

High

1384492

PF21A
PHD finger protein 21A

1

16

High-throughput

0.437

High

1418561

ACE2
Angiotensin-converting enzyme 2

1

2

Small-scale

0.437

High

1450989

KBTB4
Kelch repeat and BTB domain-containing protein 4

1

9

High-throughput

0.437

High

91893

C9JZP6
Dehydrogenase/reductase 2

1

4

High-throughput

0.407

High

666736

TENA
Tenascin

1

8

High-throughput

0.407

High

1167137

WHAL1
Putative WASP homolog-associated protein with actin, membranes and microtubules-like protein 1

1

1

High-throughput

0.407

High

1349415

ADA32
Disintegrin and metalloproteinase domain-containing protein 32

1

6

High-throughput

0.407

High

1454432

ARMX1
Armadillo repeat-containing X-linked protein 1

1

1

High-throughput

0.407

High

1459975

ATS1
A disintegrin and metalloproteinase with thrombospondin motifs 1

1

3

High-throughput

0.407

High

1332458

CBY2
Protein chibby homolog 2

2

0

High-throughput

0.328

High

1200602

CTSRT
Cation channel sperm-associated targeting subunit tau

2

0

High-throughput

0.316

High

238764

TIM8A
Mitochondrial import inner membrane translocase subunit Tim8 A

1

0

High-throughput

0.279

Low

239904

PCDH7
Protocadherin-7

1

0

High-throughput

0.279

Low

321945

FRYL
Protein furry homolog-like

1

0

High-throughput

0.279

Low

1180206

TUSC1
Tumor suppressor candidate gene 1 protein

1

0

High-throughput

0.279

Low

1216590

PR14L
Protein PRR14L

1

0

High-throughput

0.279

Low

1281684

ZER1
Protein zer-1 homolog

1

0

High-throughput

0.279

Low

1331330

CB069
Mitochondrial protein C2orf69

1

0

High-throughput

0.279

Low

1340063

SVIP
Small VCP/p97-interacting protein

1

0

High-throughput

0.279

Low

1400716

DEPD7
DEP domain-containing protein 7

1

0

High-throughput

0.279

Low

1438294

DEFM
Peptide deformylase, mitochondrial

1

0

High-throughput

0.279

Low

1458323

ORC3
Origin recognition complex subunit 3

1

0

High-throughput

0.279

Low

1458420

S53A1
Solute carrier family 53 member 1

1

0

High-throughput

0.279

Low


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Last updated: 11Aug2025