Protein: PPARD
Peroxisome proliferator-activated receptor delta (PPAR-delta) (NUCI) (Nuclear hormone receptor 1) (NUC1) (Nuclear receptor subfamily 1 group C member 2) (Peroxisome proliferator-activated receptor beta) (PPAR-beta)

Gene: PPARD
Organism: Homo sapiens
Interactions: 122
UniProt ID: Q03181

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000785 - chromatin
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001223 - transcription coactivator binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1041755

NCOA1
Nuclear receptor coactivator 1

5

20

Small-scale

0.916

High

625797

RXRA
Retinoic acid receptor RXR-alpha

5

20

Small-scale

0.912

High

1041753

NCOA2
Nuclear receptor coactivator 2

2

20

Small-scale

0.778

High

1041812

NCOA3
Nuclear receptor coactivator 3

2

20

Small-scale

0.778

High

461380

HS90A
Heat shock protein HSP 90-alpha

2

17

Small-scale

0.757

High

704516

RXRB
Retinoic acid receptor RXR-beta

2

20

Small-scale

0.757

High

873151

RXRG
Retinoic acid receptor RXR-gamma

2

20

Small-scale

0.757

High

933936

NR1H2
Oxysterols receptor LXR-beta

1

20

Small-scale

0.692

High

1041747

NR1H3
Oxysterols receptor LXR-alpha

1

20

Small-scale

0.692

High

278310

NCOR1
Nuclear receptor corepressor 1

4

20

Small-scale

0.685

High

179712

MDM4
Protein Mdm4

3

8

High-throughput

0.667

High

507166

UBB
Polyubiquitin-B [Cleaved into: Ubiquitin]

3

8

High-throughput

0.667

High

1028157

MDM2
E3 ubiquitin-protein ligase Mdm2

3

8

High-throughput

0.667

High

1041788

RNF31
E3 ubiquitin-protein ligase RNF31

3

8

High-throughput

0.667

High

1041804

TRM6
tRNA

3

0

High-throughput

0.638

High

1041811

NCOR2
Nuclear receptor corepressor 2

2

20

Small-scale

0.625

High

1041749

HDAC1
Histone deacetylase 1

2

20

Small-scale

0.624

High

1041752

NR0B2
Nuclear receptor subfamily 0 group B member 2

1

20

High-throughput

0.621

High

468284

HS90B
Heat shock protein HSP 90-beta

1

17

High-throughput

0.618

High

1041740

PPARD
Peroxisome proliferator-activated receptor delta

1

20

Small-scale

0.618

High

1041787

ZN837
Zinc finger protein 837

2

1

High-throughput

0.606

High

1041803

PRGC1
Peroxisome proliferator-activated receptor gamma coactivator 1-alpha

2

20

Small-scale

0.602

High

188246

HDAC3
Histone deacetylase 3

2

20

Small-scale

0.595

High

1041743

EP300
Histone acetyltransferase p300

2

20

Small-scale

0.594

High

827749

STAT3
Signal transducer and activator of transcription 3

2

16

High-throughput

0.594

High

1041801

NSE4A
Non-structural maintenance of chromosomes element 4 homolog A

2

0

High-throughput

0.585

High

1041741

TF65
Transcription factor p65

2

20

Small-scale

0.584

High

246546

KDM1A
Lysine-specific histone demethylase 1A

1

18

High-throughput

0.573

High

1041759

OTUD3
OTU domain-containing protein 3

1

4

Small-scale

0.561

High

144254

ACACB
Acetyl-CoA carboxylase 2

1

1

High-throughput

0.536

High

159613

DVL2
Segment polarity protein dishevelled homolog DVL-2

1

8

High-throughput

0.536

High

161713

APAF
Apoptotic protease-activating factor 1

1

20

High-throughput

0.536

High

245691

GANP
Germinal-center associated nuclear protein

1

17

High-throughput

0.536

High

298593

RAD17
Cell cycle checkpoint protein RAD17

1

4

High-throughput

0.536

High

702931

DPOD1
DNA polymerase delta catalytic subunit

1

2

High-throughput

0.536

High

832511

ETV3
ETS translocation variant 3

1

5

High-throughput

0.536

High

896368

ERF
ETS domain-containing transcription factor ERF

1

5

High-throughput

0.536

High

1029662

FOXK2
Forkhead box protein K2

1

20

High-throughput

0.536

High

1041742

DPOE1
DNA polymerase epsilon catalytic subunit A

1

2

High-throughput

0.536

High

1041744

TBL3
Transducin beta-like protein 3

1

15

High-throughput

0.536

High

1041746

TRI32
E3 ubiquitin-protein ligase TRIM32

1

18

High-throughput

0.536

High

1041748

TBB3
Tubulin beta-3 chain

1

10

High-throughput

0.536

High

1041764

RICTR
Rapamycin-insensitive companion of mTOR

1

1

High-throughput

0.536

High

1041765

SAMD1
Sterile alpha motif domain-containing protein 1

1

16

High-throughput

0.536

High

1041766

DNMBP
Dynamin-binding protein

1

9

High-throughput

0.536

High

1041768

UBP34
Ubiquitin carboxyl-terminal hydrolase 34

1

9

High-throughput

0.536

High

1041769

TBA1A
Tubulin alpha-1A chain

1

16

High-throughput

0.536

High

1041772

IQGA3
Ras GTPase-activating-like protein IQGAP3

1

3

High-throughput

0.536

High

1041774

MEX3D
RNA-binding protein MEX3D

1

6

High-throughput

0.536

High

1041778

CTF18
Chromosome transmission fidelity protein 18 homolog

1

14

High-throughput

0.536

High

1041779

ARAP3
Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3

1

11

High-throughput

0.536

High

1041784

N42L2
NEDD4-binding protein 2-like 2

1

1

High-throughput

0.536

High

1041786

NACC2
Nucleus accumbens-associated protein 2

1

20

High-throughput

0.536

High

1041789

TONSL
Tonsoku-like protein

1

17

High-throughput

0.536

High

1041791

EHMT2
Histone-lysine N-methyltransferase EHMT2

1

16

High-throughput

0.536

High

1041792

IF140
Intraflagellar transport protein 140 homolog

1

8

High-throughput

0.536

High

1041797

IF122
Intraflagellar transport protein 122 homolog

1

20

High-throughput

0.536

High

1041798

TF7L2
Transcription factor 7-like 2

1

15

High-throughput

0.536

High

1041806

TTF2
Transcription termination factor 2

1

20

High-throughput

0.536

High

1041810

TF3C3
General transcription factor 3C polypeptide 3

1

13

High-throughput

0.536

High

950234

KR107
Keratin-associated protein 10-7

1

20

High-throughput

0.523

High

385668

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

17

High-throughput

0.515

High

843499

HD
Huntingtin

1

4

High-throughput

0.515

High

1041771

SPRE1
Sprouty-related, EVH1 domain-containing protein 1

1

8

High-throughput

0.515

High

187501

FANCA
Fanconi anemia group A protein

1

0

High-throughput

0.513

High

1041754

NAB2
NGFI-A-binding protein 2

1

0

High-throughput

0.513

High

1041758

ZNG1C
Zinc-regulated GTPase metalloprotein activator 1C

1

0

High-throughput

0.513

High

1041763

BRAT1
Integrator complex assembly factor BRAT1

1

0

High-throughput

0.513

High

1041777

KNL1
Outer kinetochore KNL1 complex subunit KNL1

1

0

High-throughput

0.513

High

1041783

SYMPK
Symplekin

1

0

High-throughput

0.513

High

1041790

VCIP1
Deubiquitinating protein VCPIP1

1

0

High-throughput

0.513

High

1041807

FBX7
F-box only protein 7

1

0

High-throughput

0.513

High

1041809

TELO2
Telomere length regulation protein TEL2 homolog

1

0

High-throughput

0.513

High

181883

SMAD9
Mothers against decapentaplegic homolog 9

1

13

High-throughput

0.508

High

253499

ANM3
Protein arginine N-methyltransferase 3

1

19

High-throughput

0.508

High

728183

AKT1
RAC-alpha serine/threonine-protein kinase

1

15

High-throughput

0.506

High

332146

GA45G
Growth arrest and DNA damage-inducible protein GADD45 gamma

1

8

Small-scale

0.501

High

940925

HDAC4
Histone deacetylase 4

1

20

Small-scale

0.501

High

1041760

CE350
Centrosome-associated protein 350

1

7

Small-scale

0.501

High

1041782

CBP
CREB-binding protein

1

20

Small-scale

0.501

High

1041750

RIN1
Ras and Rab interactor 1

1

1

High-throughput

0.489

High

1041751

CUL7
Cullin-7

1

1

High-throughput

0.489

High

1041756

RGL3
Ral guanine nucleotide dissociation stimulator-like 3

1

2

High-throughput

0.489

High

1041761

PDXD1
Pyridoxal-dependent decarboxylase domain-containing protein 1

1

1

High-throughput

0.489

High

1041767

STXB4
Syntaxin-binding protein 4

1

7

High-throughput

0.489

High

1041773

HOOK3
Protein Hook homolog 3

1

14

High-throughput

0.489

High

1041775

RHPN2
Rhophilin-2

1

12

High-throughput

0.489

High

1041785

ARHG1
Rho guanine nucleotide exchange factor 1

1

13

High-throughput

0.489

High

1041796

K1671
Uncharacterized protein KIAA1671

1

1

High-throughput

0.489

High

1041799

ABCF3
ATP-binding cassette sub-family F member 3

1

2

High-throughput

0.489

High

481435

STP1
Spermatid nuclear transition protein 1

1

2

Small-scale

0.481

High

716277

PRDX6
Peroxiredoxin-6

1

7

High-throughput

0.481

High

760894

GLYM
Serine hydroxymethyltransferase, mitochondrial

1

1

High-throughput

0.481

High

968886

PRS8
26S proteasome regulatory subunit 8

1

18

High-throughput

0.481

High

1041781

PROX1
Prospero homeobox protein 1

1

3

High-throughput

0.481

High

1041793

RANB9
Ran-binding protein 9

1

14

High-throughput

0.481

High

138076

PSDE
26S proteasome non-ATPase regulatory subunit 14

1

6

High-throughput

0.479

High

578460

BRAF
Serine/threonine-protein kinase B-raf

1

8

High-throughput

0.479

High

612987

EGR1
Early growth response protein 1

1

4

Small-scale

0.479

High

626191

NFKB1
Nuclear factor NF-kappa-B p105 subunit

1

20

Small-scale

0.479

High

822625

VHL
von Hippel-Lindau disease tumor suppressor

1

3

Small-scale

0.479

High

838065

STAT1
Signal transducer and activator of transcription 1-alpha/beta

1

16

Small-scale

0.479

High

947170

NLRP6
NACHT, LRR and PYD domains-containing protein 6

1

4

High-throughput

0.479

High

1041780

HDAC2
Histone deacetylase 2

1

20

Small-scale

0.479

High

1041794

MINT
Msx2-interacting protein

1

20

Small-scale

0.479

High

1041805

APC7
Anaphase-promoting complex subunit 7

1

8

High-throughput

0.479

High

578654

GLNA
Glutamine synthetase

1

0

High-throughput

0.460

High

337465

PSMG1
Proteasome assembly chaperone 1

1

0

Small-scale

0.458

High

612065

ITB5
Integrin beta-5

1

1

High-throughput

0.439

High

949856

KR103
Keratin-associated protein 10-3

1

20

High-throughput

0.439

High

287555

LRP6
Low-density lipoprotein receptor-related protein 6

1

0

High-throughput

0.426

High

1041757

Q4KMX6
Anaphase-promoting complex subunit 7

1

8

High-throughput

0.407

High

1041770

ARMX2
Armadillo repeat-containing X-linked protein 2

1

7

High-throughput

0.407

High

1041802

ARMX1
Armadillo repeat-containing X-linked protein 1

1

2

High-throughput

0.407

High

322386

HAUS5
HAUS augmin-like complex subunit 5

1

0

High-throughput

0.279

Low

1041745

NPRL3
GATOR1 complex protein NPRL3

1

0

High-throughput

0.279

Low

1041762

VIP1
Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1

1

0

High-throughput

0.279

Low

1041776

SMG8
Nonsense-mediated mRNA decay factor SMG8

1

0

High-throughput

0.279

Low

1041795

TBCD
Tubulin-specific chaperone D

1

0

High-throughput

0.279

Low

1041808

TCAF1
TRPM8 channel-associated factor 1

1

0

High-throughput

0.279

Low

1041800

RIC8B
Chaperone Ric-8B

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025