Protein: SPC3
Signal peptidase complex subunit 3 (Microsomal signal peptidase subunit 3)

Gene: SPC3
Organism: Saccharomyces cerevisiae S288C
Interactions: 26
UniProt ID: Q12133

Gene Ontology (top 5):
GO:0005783 - endoplasmic reticulum
GO:0005787 - signal peptidase complex
GO:0005789 - endoplasmic reticulum membrane
GO:0006465 - signal peptide processing
GO:0045047 - protein targeting to ER

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

583769

SEC11
Signal peptidase complex catalytic subunit SEC11

3

3

Small-scale

0.827

High

863349

SPC1
Signal peptidase complex subunit 1

2

1

Small-scale

0.759

High

808366

TAT2
Tryptophan permease

1

0

High-throughput

0.518

High

577241

SEC63
Protein translocation protein SEC63

1

1

High-throughput

0.479

High

597303

BIP
Endoplasmic reticulum chaperone BiP

1

1

High-throughput

0.479

High

726125

PMT2
Dolichyl-phosphate-mannose--protein mannosyltransferase 2

1

2

High-throughput

0.479

High

754667

OSTB
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit WBP1

1

1

High-throughput

0.479

High

754730

PMT1
Dolichyl-phosphate-mannose--protein mannosyltransferase 1

1

2

High-throughput

0.479

High

863386

PMT4
Dolichyl-phosphate-mannose--protein mannosyltransferase 4

1

2

High-throughput

0.479

High

641401

SEC62
Translocation protein SEC62

1

0

Small-scale

0.458

High

678026

CWH43
Protein CWH43

1

0

High-throughput

0.458

High

796552

ECM33
Cell wall protein ECM33

1

0

High-throughput

0.458

High

797084

PHO88
SRP-independent targeting protein 3

1

0

High-throughput

0.458

High

809037

STT3
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3

1

0

High-throughput

0.458

High

1050117

SPC2
Signal peptidase complex subunit 2

1

0

High-throughput

0.458

High

1059336

YET3
Endoplasmic reticulum transmembrane protein 3

1

0

High-throughput

0.458

High

580236

HSC82
ATP-dependent molecular chaperone HSC82

1

2

High-throughput

0.437

High

800925

NCB5R
NADH-cytochrome b5 reductase 1

1

1

High-throughput

0.437

High

393506

HSP82
ATP-dependent molecular chaperone HSP82

1

2

High-throughput

0.407

High

546692

SSB1
Ribosome-associated molecular chaperone SSB1

2

0

High-throughput

0.298

High

793372

PP2C4
Protein phosphatase 2C homolog 4

1

0

High-throughput

0.282

High

365710

PGK
Phosphoglycerate kinase

1

0

High-throughput

0.249

Low

795269

NU170
Nucleoporin NUP170

1

0

High-throughput

0.249

Low

802817

SYRM
Arginine--tRNA ligase, mitochondrial

1

0

High-throughput

0.249

Low

805719

YHS2
MIP18 family protein YHR122W

1

0

High-throughput

0.238

Low

864982

NOP9
Nucleolar protein 9

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025