Protein: SPC2
Signal peptidase complex subunit 2 (Microsomal signal peptidase subunit 2)

Gene: SPC2
Organism: Saccharomyces cerevisiae S288C
Interactions: 43
UniProt ID: Q04969

Gene Ontology (top 5):
GO:0005783 - endoplasmic reticulum
GO:0005787 - signal peptidase complex
GO:0005789 - endoplasmic reticulum membrane
GO:0006465 - signal peptide processing
GO:0045047 - protein targeting to ER

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

863341

SPC1
Signal peptidase complex subunit 1

4

0

Small-scale

0.846

High

641396

SEC62
Translocation protein SEC62

3

0

High-throughput

0.634

High

797056

PHO88
SRP-independent targeting protein 3

2

0

High-throughput

0.588

High

1038802

OSTD
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit SWP1

2

0

High-throughput

0.588

High

914901

SC6B1
Protein transport protein SBH1

2

1

Small-scale

0.586

High

583765

SEC11
Signal peptidase complex catalytic subunit SEC11

1

0

High-throughput

0.586

High

577212

SEC63
Protein translocation protein SEC63

2

0

Small-scale

0.561

High

618891

GAP1
General amino-acid permease GAP1

1

0

Small-scale

0.529

High

528638

CP51
Lanosterol 14-alpha demethylase CYP51

1

0

High-throughput

0.518

High

916778

ERG25
C-4 methylsterol oxidase ERG25

1

0

High-throughput

0.518

High

1050115

ORM2
Protein ORM2

1

0

High-throughput

0.518

High

932631

TMEDA
Endoplasmic reticulum vesicle protein 25

1

0

High-throughput

0.493

High

827050

MGA2
Protein MGA2

1

0

High-throughput

0.486

High

827101

GST1
Glutathione S-transferase 1

1

0

High-throughput

0.486

High

1042489

PEX29
Peroxisomal membrane protein PEX29

1

0

High-throughput

0.486

High

726116

PMT2
Dolichyl-phosphate-mannose--protein mannosyltransferase 2

1

2

High-throughput

0.479

High

754723

PMT1
Dolichyl-phosphate-mannose--protein mannosyltransferase 1

1

2

High-throughput

0.479

High

863385

PMT4
Dolichyl-phosphate-mannose--protein mannosyltransferase 4

1

2

High-throughput

0.479

High

914915

SC6B2
Protein transport protein SBH2

1

1

Small-scale

0.479

High

364736

CDK1
Cyclin-dependent kinase 1

1

0

High-throughput

0.458

High

677120

EMC1
ER membrane protein complex subunit 1

1

0

High-throughput

0.458

High

678024

CWH43
Protein CWH43

1

0

High-throughput

0.458

High

754416

SEC66
Translocation protein SEC66

1

0

High-throughput

0.458

High

754661

OSTB
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit WBP1

1

0

High-throughput

0.458

High

780363

MCD4
GPI ethanolamine phosphate transferase 1

1

0

High-throughput

0.458

High

809034

STT3
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3

1

0

High-throughput

0.458

High

816217

SPF1
Endoplasmic reticulum transmembrane helix translocase

1

0

High-throughput

0.458

High

822342

ELO3
Fatty acid elongase 3

1

0

High-throughput

0.458

High

924148

ALG9
Alpha-1,2-mannosyltransferase ALG9

1

0

High-throughput

0.458

High

1045187

CUE4
CUE domain-containing protein CUE4

1

0

High-throughput

0.458

High

1050116

YET3
Endoplasmic reticulum transmembrane protein 3

1

0

High-throughput

0.458

High

1050117

SPC3
Signal peptidase complex subunit 3

1

0

High-throughput

0.458

High

812933

UIP3
ULP1-interacting protein 3

1

0

High-throughput

0.265

Low

525136

HSP71
Heat shock protein SSA1

1

0

High-throughput

0.249

Low

752723

HSP78
Heat shock protein 78, mitochondrial

1

0

High-throughput

0.249

Low

358337

ADH1
Alcohol dehydrogenase 1

1

0

High-throughput

0.232

Low

386862

TBB
Tubulin beta chain

1

0

High-throughput

0.232

Low

486313

TBA1
Tubulin alpha-1 chain

1

0

High-throughput

0.232

Low

488632

RIR2
Ribonucleoside-diphosphate reductase small chain 1

1

0

High-throughput

0.232

Low

597555

EF3A
Elongation factor 3A

1

0

High-throughput

0.232

Low

885086

RL4B
Large ribosomal subunit protein uL4B

1

0

High-throughput

0.232

Low

1050118

YRA1
RNA annealing protein YRA1

1

0

High-throughput

0.232

Low

1050119

RL7B
Large ribosomal subunit protein uL30B

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025