Protein: SPC1
Signal peptidase complex subunit 1 (Microsomal signal peptidase subunit 1)

Gene: SPC1
Organism: Saccharomyces cerevisiae S288C
Interactions: 84
UniProt ID: P46965

Gene Ontology (top 5):
GO:0005783 - endoplasmic reticulum
GO:0005787 - signal peptidase complex
GO:0005789 - endoplasmic reticulum membrane
GO:0006465 - signal peptide processing
GO:0045047 - protein targeting to ER

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

863341

SPC2
Signal peptidase complex subunit 2

4

0

Small-scale

0.846

High

863349

SPC3
Signal peptidase complex subunit 3

2

1

Small-scale

0.759

High

863339

ERV41
ER-derived vesicles protein ERV41

4

2

High-throughput

0.693

High

583760

SEC11
Signal peptidase complex catalytic subunit SEC11

4

4

Small-scale

0.688

High

796972

PHO88
SRP-independent targeting protein 3

2

0

High-throughput

0.605

High

416716

CAN1
Arginine permease CAN1

1

2

High-throughput

0.541

High

528606

CP51
Lanosterol 14-alpha demethylase CYP51

1

2

High-throughput

0.541

High

613862

ERD2
ER lumen protein-retaining receptor

1

1

High-throughput

0.541

High

672818

ELO2
Fatty acid elongase 2

1

3

High-throughput

0.541

High

703831

LAC1
Ceramide synthase LAC1

1

2

High-throughput

0.541

High

793132

YRO2
Protein YRO2

1

1

High-throughput

0.541

High

793273

TAT1
Valine/tyrosine/tryptophan amino-acid permease 1

1

2

High-throughput

0.541

High

802486

LAG1
Ceramide synthase LAG1

1

2

High-throughput

0.541

High

808685

SUR2
Sphingolipid C4-hydroxylase SUR2

1

1

High-throughput

0.541

High

812878

ELO1
Fatty acid elongase 1

1

3

High-throughput

0.541

High

813906

ERV46
ER-derived vesicles protein ERV46

1

2

High-throughput

0.541

High

822309

ELO3
Fatty acid elongase 3

1

3

High-throughput

0.541

High

836160

BAP3
Valine amino-acid permease

1

2

High-throughput

0.541

High

863332

ERG25
C-4 methylsterol oxidase ERG25

1

1

High-throughput

0.541

High

863342

ERP1
Protein ERP1

1

1

High-throughput

0.541

High

863350

ERP4
Protein ERP4

1

2

High-throughput

0.541

High

470074

PSS
CDP-diacylglycerol--serine O-phosphatidyltransferase

1

0

High-throughput

0.518

High

577163

SEC63
Protein translocation protein SEC63

1

0

High-throughput

0.518

High

598517

ALG1
Chitobiosyldiphosphodolichol beta-mannosyltransferase

1

0

High-throughput

0.518

High

641380

SEC62
Translocation protein SEC62

1

0

High-throughput

0.518

High

668927

ERG6
Sterol 24-C-methyltransferase ERG6

1

0

High-throughput

0.518

High

677164

PBN1
Protein PBN1

1

0

High-throughput

0.518

High

776373

YET1
Endoplasmic reticulum transmembrane protein 1

1

0

High-throughput

0.518

High

780456

SRPB
Signal recognition particle receptor subunit beta

1

0

High-throughput

0.518

High

797411

MKAR
Very-long-chain 3-oxoacyl-CoA reductase

1

0

High-throughput

0.518

High

799708

CUE1
Coupling of ubiquitin conjugation to ER degradation protein 1

1

0

High-throughput

0.518

High

803035

YHE2
Putative uncharacterized protein YHL042W

1

0

High-throughput

0.518

High

823157

ALG5
Dolichyl-phosphate beta-glucosyltransferase

1

0

High-throughput

0.518

High

826249

SNL1
HSP70 co-chaperone SNL1

1

0

High-throughput

0.518

High

863208

PHO86
Inorganic phosphate transporter PHO86

1

0

High-throughput

0.518

High

863261

GPI2
Phosphatidylinositol N-acetylglucosaminyltransferase GPI2 subunit

1

0

High-throughput

0.518

High

863327

STE24
CAAX prenyl protease 1

1

0

High-throughput

0.518

High

863333

ERV29
ER-derived vesicles protein ERV29

1

0

High-throughput

0.518

High

863336

SHR3
Secretory component protein SHR3

1

0

High-throughput

0.518

High

863340

GSF2
Glucose-signaling factor 2

1

0

High-throughput

0.518

High

863343

ORM2
Protein ORM2

1

0

High-throughput

0.518

High

863344

THI73
Thiamine pathway transporter THI73

1

0

High-throughput

0.518

High

636326

ACO1
Acyl-CoA desaturase 1

1

1

High-throughput

0.515

High

863337

TCB3
Tricalbin-3

1

1

High-throughput

0.515

High

863348

MRH1
Protein MRH1

1

1

High-throughput

0.515

High

863351

TCB1
Tricalbin-1

1

1

High-throughput

0.515

High

863352

TECR
Very-long-chain enoyl-CoA reductase

1

1

High-throughput

0.515

High

863334

YN8B
UPF0674 endoplasmic reticulum membrane protein YNR021W

1

0

High-throughput

0.493

High

827077

GST1
Glutathione S-transferase 1

1

0

High-throughput

0.486

High

863330

SC6B1
Protein transport protein SBH1

1

1

Small-scale

0.479

High

863331

SC6B2
Protein transport protein SBH2

1

1

Small-scale

0.479

High

420954

PMA1
Plasma membrane ATPase 1

1

2

High-throughput

0.470

High

828526

HACD
Very-long-chain

1

0

High-throughput

0.438

High

863346

INP54
Phosphatidylinositol 4,5-bisphosphate 5-phosphatase INP54

1

0

High-throughput

0.438

High

752430

HSP78
Heat shock protein 78, mitochondrial

2

0

High-throughput

0.298

High

863335

PMP3
Plasma membrane proteolipid 3

1

0

High-throughput

0.282

High

863338

GMC1
Putative multicopper oxidase GMC1

1

0

High-throughput

0.282

High

154187

RL36B
Large ribosomal subunit protein eL36B

1

0

High-throughput

0.269

Low

381552

H2B2
Histone H2B.2

1

0

High-throughput

0.269

Low

419790

H2A2
Histone H2A.2

1

0

High-throughput

0.269

Low

427581

RLA1
Large ribosomal subunit protein P1A

1

0

High-throughput

0.269

Low

435593

RS9B
Small ribosomal subunit protein uS4B

1

0

High-throughput

0.269

Low

672111

PUF4
Pumilio homology domain family member 4

1

0

High-throughput

0.269

Low

736567

RIM1
Single-stranded DNA-binding protein RIM1, mitochondrial

1

0

High-throughput

0.269

Low

750101

MRT4
Ribosome assembly factor MRT4

1

0

High-throughput

0.269

Low

794338

TXTP
Tricarboxylate transport protein

1

0

High-throughput

0.269

Low

796251

TCM62
Mitochondrial chaperone TCM62

1

0

High-throughput

0.269

Low

801069

FKS1
1,3-beta-glucan synthase component FKS1

1

0

High-throughput

0.269

Low

809351

STM1
Suppressor protein STM1

1

0

High-throughput

0.269

Low

816515

SNU13
13 kDa ribonucleoprotein-associated protein

1

0

High-throughput

0.269

Low

818434

FTR1
Plasma membrane iron permease

1

0

High-throughput

0.269

Low

818564

COG3
Conserved oligomeric Golgi complex subunit 3

1

0

High-throughput

0.269

Low

835823

RL10
Large ribosomal subunit protein uL16

1

0

High-throughput

0.269

Low

850434

ROG3
Protein ROG3

1

0

High-throughput

0.269

Low

863328

RL37A
Large ribosomal subunit protein eL37A

1

0

High-throughput

0.269

Low

863345

NOP12
Nucleolar protein 12

1

0

High-throughput

0.269

Low

863347

PEX27
Peroxisomal membrane protein PEX27

1

0

High-throughput

0.269

Low

513381

RL23B
Large ribosomal subunit protein uL14B

1

0

High-throughput

0.249

Low

514949

YA11A
Transposon Ty1-A Gag polyprotein

1

0

High-throughput

0.249

Low

803229

PHS
Putative pterin-4-alpha-carbinolamine dehydratase

1

0

High-throughput

0.249

Low

863329

TOM22
Mitochondrial import receptor subunit TOM22

1

0

High-throughput

0.249

Low

524371

HSP71
Heat shock protein SSA1

1

0

High-throughput

0.232

Low

545360

SSB1
Ribosome-associated molecular chaperone SSB1

1

0

High-throughput

0.232

Low

763458

MDJ1
DnaJ homolog 1, mitochondrial

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025