Protein: TGS1
Trimethylguanosine synthase (EC 2.1.1.-) (Cap-specific guanine-N(2) methyltransferase) (snRNA/snoRNA cap hypermethylase)

Gene: TGS1
Organism: Saccharomyces cerevisiae S288C
Interactions: 16
UniProt ID: Q12052

Gene Ontology (top 5):
GO:0001510 - RNA methylation
GO:0005634 - nucleus
GO:0005730 - nucleolus
GO:0008033 - tRNA processing
GO:0008173 - RNA methyltransferase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

823087

SWM2
Nucleolar protein SWM2

6

0

Small-scale

0.705

High

1084200

TGS1
Trimethylguanosine synthase

1

1

Small-scale

0.680

High

817178

RSMB
Small nuclear ribonucleoprotein-associated protein B

2

2

Small-scale

0.595

High

744935

SLA1
Actin cytoskeleton-regulatory complex protein SLA1

1

1

High-throughput

0.541

High

1084202

NOP58
Nucleolar protein 58

1

1

Small-scale

0.501

High

656662

KC11
Casein kinase I homolog 1

1

0

High-throughput

0.458

High

713049

MCM2
DNA replication licensing factor MCM2

1

0

High-throughput

0.458

High

1044824

SCC2
Sister chromatid cohesion protein 2

1

0

High-throughput

0.458

High

1065108

NCBP2
Nuclear cap-binding protein subunit 2

1

0

High-throughput

0.458

High

1084201

RRP6
Exosome complex exonuclease RRP6

1

0

High-throughput

0.458

High

546655

SSB1
Ribosome-associated molecular chaperone SSB1

1

1

High-throughput

0.445

High

820062

SSB2
Ribosome-associated molecular chaperone SSB2

1

1

High-throughput

0.445

High

780912

YKH1
Uncharacterized oxidoreductase YKL071W

1

0

High-throughput

0.265

Low

751507

CBF5
H/ACA ribonucleoprotein complex subunit CBF5

1

0

Small-scale

0.261

Low

795259

NU170
Nucleoporin NUP170

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025