Protein: XIAP
E3 ubiquitin-protein ligase XIAP (EC 2.3.2.27) (Baculoviral IAP repeat-containing protein 4) (IAP-like protein) (ILP) (hILP) (Inhibitor of apoptosis protein 3) (IAP-3) (hIAP-3) (hIAP3) (RING-type E3 ubiquitin transferase XIAP) (X-linked inhibitor of apoptosis protein) (X-linked IAP)

Gene: XIAP
Organism: Homo sapiens
Interactions: 239
UniProt ID: P98170

Gene Ontology (top 5):
GO:0004842 - ubiquitin-protein transferase activity
GO:0004869 - cysteine-type endopeptidase inhibitor activity
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

957787

DBLOH
Diablo IAP-binding mitochondrial protein

52

11

Small-scale

0.996

High

876972

CASP9
Caspase-9

35

20

Small-scale

0.995

High

788182

CASP3
Caspase-3

35

20

Small-scale

0.994

High

957683

XIAP
E3 ubiquitin-protein ligase XIAP

24

15

Small-scale

0.990

High

876939

CASP7
Caspase-7

18

20

Small-scale

0.989

High

201782

RIPK2
Receptor-interacting serine/threonine-protein kinase 2

14

20

Small-scale

0.988

High

849308

UB2D1
Ubiquitin-conjugating enzyme E2 D1

12

20

Small-scale

0.981

High

957710

TAB1
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1

9

6

Small-scale

0.977

High

919707

UB2D2
Ubiquitin-conjugating enzyme E2 D2

8

20

Small-scale

0.972

High

895777

UB2D3
Ubiquitin-conjugating enzyme E2 D3

7

20

Small-scale

0.968

High

475629

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

5

16

Small-scale

0.928

High

957696

BIRC2
Baculoviral IAP repeat-containing protein 2

5

16

Small-scale

0.925

High

177671

BIRC5
Baculoviral IAP repeat-containing protein 5

4

18

Small-scale

0.903

High

957755

BIRC7
Baculoviral IAP repeat-containing protein 7

4

15

Small-scale

0.895

High

957749

CASPA
Caspase-10

3

20

Small-scale

0.883

High

201301

M3K7
Mitogen-activated protein kinase kinase kinase 7

3

11

Small-scale

0.871

High

957767

BIRC8
Baculoviral IAP repeat-containing protein 8

3

15

High-throughput

0.861

High

957783

NOD2
Nucleotide-binding oligomerization domain-containing protein 2

3

9

Small-scale

0.857

High

957684

MDM2
E3 ubiquitin-protein ligase Mdm2

3

2

Small-scale

0.853

High

957695

BIRC3
Baculoviral IAP repeat-containing protein 3

3

15

Small-scale

0.839

High

851802

UB2E1
Ubiquitin-conjugating enzyme E2 E1

2

20

Small-scale

0.812

High

957754

UBE2W
Ubiquitin-conjugating enzyme E2 W

2

20

Small-scale

0.791

High

957698

RIPK1
Receptor-interacting serine/threonine-protein kinase 1

2

20

Small-scale

0.785

High

957734

PPM1K
Protein phosphatase Mn(2+)-dependent 1K

2

1

High-throughput

0.783

High

896414

UBE2N
Ubiquitin-conjugating enzyme E2 N

1

20

High-throughput

0.776

High

932500

UB2L3
Ubiquitin-conjugating enzyme E2 L3

2

20

Small-scale

0.768

High

203914

HTRA2
Serine protease HTRA2, mitochondrial

20

15

Small-scale

0.767

High

152869

APAF
Apoptotic protease-activating factor 1

2

8

Small-scale

0.754

High

338280

EGFR
Epidermal growth factor receptor

2

8

Small-scale

0.754

High

877014

CASP6
Caspase-6

2

20

Small-scale

0.754

High

957707

CASP8
Caspase-8

2

20

Small-scale

0.754

High

198186

SEPT4
Septin-4

6

5

Small-scale

0.745

High

957798

NOD1
Nucleotide-binding oligomerization domain-containing protein 1

1

9

Small-scale

0.734

High

777843

RFC5
Replication factor C subunit 5

5

6

High-throughput

0.722

High

957758

DYL2
Dynein light chain 2, cytoplasmic

5

2

High-throughput

0.719

High

957722

XAF1
XIAP-associated factor 1

5

5

Small-scale

0.717

High

957694

UB2V1
Ubiquitin-conjugating enzyme E2 variant 1

1

20

High-throughput

0.698

High

957711

UB2V2
Ubiquitin-conjugating enzyme E2 variant 2

1

20

High-throughput

0.698

High

957765

UB2E2
Ubiquitin-conjugating enzyme E2 E2

1

20

High-throughput

0.698

High

957802

UB2D4
Ubiquitin-conjugating enzyme E2 D4

1

20

High-throughput

0.698

High

957713

LONF1
LON peptidase N-terminal domain and RING finger protein 1

4

9

High-throughput

0.698

High

957687

TLE3
Transducin-like enhancer protein 3

4

6

Small-scale

0.694

High

828984

UBE2A
Ubiquitin-conjugating enzyme E2 A

1

20

High-throughput

0.691

High

925191

RAC1
Ras-related C3 botulinum toxin substrate 1

3

11

Small-scale

0.678

High

928263

DYL1
Dynein light chain 1, cytoplasmic

3

2

High-throughput

0.675

High

957759

NTAQ1
Protein N-terminal glutamine amidohydrolase

3

2

High-throughput

0.672

High

203515

PPIH
Peptidyl-prolyl cis-trans isomerase H

3

2

High-throughput

0.671

High

895412

CKS1
Cyclin-dependent kinases regulatory subunit 1

4

0

High-throughput

0.668

High

957761

GMCL1
Germ cell-less protein-like 1

3

2

High-throughput

0.667

High

957770

PHB2
Prohibitin-2

3

6

High-throughput

0.667

High

957799

CLC11
C-type lectin domain family 11 member A

3

4

High-throughput

0.667

High

957805

TRAF6
TNF receptor-associated factor 6

3

20

Small-scale

0.666

High

374052

RAF1
RAF proto-oncogene serine/threonine-protein kinase

2

5

Small-scale

0.660

High

957801

M3K2
Mitogen-activated protein kinase kinase kinase 2

2

10

Small-scale

0.657

High

474994

UBB
Polyubiquitin-B [Cleaved into: Ubiquitin]

1

16

High-throughput

0.647

High

403190

LA
Lupus La protein

3

5

Small-scale

0.640

High

175428

SIVA
Apoptosis regulatory protein Siva

3

0

Small-scale

0.640

High

949083

HTRA3
Serine protease HTRA3

3

15

Small-scale

0.639

High

957717

ACTMP
Actin maturation protease

3

0

High-throughput

0.638

High

949005

HTRA4
Serine protease HTRA4

3

15

Small-scale

0.637

High

60565

VP37C
Vacuolar protein sorting-associated protein 37C

4

3

High-throughput

0.637

High

718755

PHB1
Prohibitin 1

2

6

High-throughput

0.634

High

957793

TBK1
Serine/threonine-protein kinase TBK1

2

17

Small-scale

0.633

High

957807

MAGD1
Melanoma-associated antigen D1

2

7

Small-scale

0.631

High

957747

HTRA1
Serine protease HTRA1

2

15

Small-scale

0.629

High

957719

DCA12
DDB1- and CUL4-associated factor 12

2

2

High-throughput

0.628

High

584582

ERCC3
General transcription and DNA repair factor IIH helicase/translocase subunit XPB

2

8

High-throughput

0.628

High

957784

NEK6
Serine/threonine-protein kinase Nek6

2

8

High-throughput

0.628

High

957800

ADIP
Afadin- and alpha-actinin-binding protein

2

1

High-throughput

0.628

High

545837

ERF3A
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A

2

6

Small-scale

0.624

High

835658

GSK3B
Glycogen synthase kinase-3 beta

2

6

Small-scale

0.624

High

890605

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

2

4

Small-scale

0.624

High

930141

UBC9
SUMO-conjugating enzyme UBC9

1

20

Small-scale

0.621

High

957733

UB2J2
Ubiquitin-conjugating enzyme E2 J2

1

20

High-throughput

0.621

High

957795

SRTD1
SERTA domain-containing protein 1

3

0

Small-scale

0.619

High

957737

COMD1
COMM domain-containing protein 1

2

2

Small-scale

0.618

High

122287

BMR1B
Bone morphogenetic protein receptor type-1B

1

7

Small-scale

0.618

High

159050

UB2L6
Ubiquitin/ISG15-conjugating enzyme E2 L6

1

20

Small-scale

0.618

High

227175

PRKN
E3 ubiquitin-protein ligase parkin

1

20

High-throughput

0.618

High

330243

BCL10
B-cell lymphoma/leukemia 10

1

5

Small-scale

0.618

High

830276

CASP4
Caspase-4

1

20

Small-scale

0.618

High

957688

FAK1
Focal adhesion kinase 1

1

14

Small-scale

0.618

High

957692

TRAF2
TNF receptor-associated factor 2

1

20

Small-scale

0.618

High

957712

NEDD8
NEDD8

1

5

Small-scale

0.618

High

957725

CASPC
Inactive caspase-12

1

20

Small-scale

0.618

High

957744

RFFL
E3 ubiquitin-protein ligase rififylin

1

13

Small-scale

0.618

High

957786

BIRC6
Baculoviral IAP repeat-containing protein 6

1

19

Small-scale

0.618

High

957794

UBQL2
Ubiquilin-2

1

4

High-throughput

0.618

High

957731

SIAH1
E3 ubiquitin-protein ligase SIAH1

2

7

Small-scale

0.612

High

150292

CCS
Copper chaperone for superoxide dismutase

2

1

Small-scale

0.611

High

307167

KLHL2
Kelch-like protein 2

2

1

High-throughput

0.611

High

670929

PRDX3
Thioredoxin-dependent peroxide reductase, mitochondrial

2

10

High-throughput

0.611

High

814421

SYQ
Glutamine--tRNA ligase

2

3

High-throughput

0.606

High

957689

MTG8
Protein CBFA2T1

2

2

High-throughput

0.606

High

957756

GCC1
GRIP and coiled-coil domain-containing protein 1

2

6

High-throughput

0.606

High

432659

HNRPC
Heterogeneous nuclear ribonucleoproteins C1/C2

2

9

Small-scale

0.601

High

849996

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

2

20

Small-scale

0.601

High

957685

E2F1
Transcription factor E2F1

2

6

Small-scale

0.601

High

325133

AIFM1
Apoptosis-inducing factor 1, mitochondrial

2

3

Small-scale

0.595

High

957741

UB2Q2
Ubiquitin-conjugating enzyme E2 Q2

1

3

High-throughput

0.590

High

804205

NOTC1
Neurogenic locus notch homolog protein 1

1

15

Small-scale

0.589

High

325689

LATS1
Serine/threonine-protein kinase LATS1

2

4

Small-scale

0.584

High

681790

AKT1
RAC-alpha serine/threonine-protein kinase

2

2

Small-scale

0.584

High

854772

GDIR1
Rho GDP-dissociation inhibitor 1

2

1

Small-scale

0.584

High

957788

FAIM1
Fas apoptotic inhibitory molecule 1

2

1

Small-scale

0.584

High

957760

PGAM5
Serine/threonine-protein phosphatase PGAM5, mitochondrial

2

3

Small-scale

0.584

High

957757

MCRS1
Microspherule protein 1

2

0

High-throughput

0.580

High

154168

CHK1
Serine/threonine-protein kinase Chk1

1

1

Small-scale

0.578

High

174805

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

10

High-throughput

0.578

High

749376

BRCA1
Breast cancer type 1 susceptibility protein

1

4

Small-scale

0.578

High

893899

CDC42
Cell division control protein 42 homolog

1

11

Small-scale

0.578

High

957697

SQSTM
Sequestosome-1

1

12

Small-scale

0.578

High

383741

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

8

High-throughput

0.575

High

257258

ATS4
A disintegrin and metalloproteinase with thrombospondin motifs 4

2

4

High-throughput

0.574

High

259497

LRRN2
Leucine-rich repeat neuronal protein 2

2

2

High-throughput

0.574

High

957797

FAF1
FAS-associated factor 1

1

5

Small-scale

0.573

High

943192

TCPB
T-complex protein 1 subunit beta

1

12

Small-scale

0.561

High

957693

TRI32
E3 ubiquitin-protein ligase TRIM32

1

8

Small-scale

0.561

High

957751

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

9

High-throughput

0.561

High

957785

TF7L2
Transcription factor 7-like 2

1

2

Small-scale

0.561

High

840668

DYN2
Dynamin-2

1

1

High-throughput

0.560

High

363974

FETA
Alpha-fetoprotein

1

0

Small-scale

0.554

High

957803

BOLA1
BolA-like protein 1

2

6

High-throughput

0.553

High

607938

FGFR4
Fibroblast growth factor receptor 4

1

5

High-throughput

0.553

High

957748

SHIP1
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1

1

1

Small-scale

0.552

High

957776

STRAB
STE20-related kinase adapter protein beta

1

9

Small-scale

0.552

High

957738

DTX3
Probable E3 ubiquitin-protein ligase DTX3

1

1

High-throughput

0.541

High

957775

TRIM8
E3 ubiquitin-protein ligase TRIM8

1

5

High-throughput

0.541

High

957772

TCF25
Ribosome quality control complex subunit TCF25

1

0

Small-scale

0.537

High

489399

BCL2
Apoptosis regulator Bcl-2

1

1

Small-scale

0.536

High

957771

M3K3
Mitogen-activated protein kinase kinase kinase 3

1

11

Small-scale

0.536

High

957782

Q9H4D1
Protein kinase

1

17

Small-scale

0.536

High

621778

PRTN3
Myeloblastin

1

9

High-throughput

0.536

High

642934

S10A4
Protein S100-A4

1

4

High-throughput

0.536

High

668598

PML
Protein PML

1

6

High-throughput

0.536

High

957686

AMPD2
AMP deaminase 2

1

1

High-throughput

0.536

High

957701

CKAP5
Cytoskeleton-associated protein 5

1

5

High-throughput

0.536

High

957708

RNPS1
RNA-binding protein with serine-rich domain 1

1

5

High-throughput

0.536

High

957716

KR132
Keratin-associated protein 13-2

1

1

High-throughput

0.536

High

957724

SAMD1
Sterile alpha motif domain-containing protein 1

1

2

High-throughput

0.536

High

957729

OSTM1
Osteopetrosis-associated transmembrane protein 1

1

2

High-throughput

0.536

High

957773

DHRS6
Dehydrogenase/reductase SDR family member 6

1

1

High-throughput

0.536

High

957779

TOLIP
Toll-interacting protein

1

2

High-throughput

0.536

High

957804

RPGF2
Rap guanine nucleotide exchange factor 2

1

1

High-throughput

0.536

High

957806

RIPK3
Receptor-interacting serine/threonine-protein kinase 3

1

20

Small-scale

0.527

High

453289

ROA1
Heterogeneous nuclear ribonucleoprotein A1

1

7

Small-scale

0.515

High

957723

MORN3
MORN repeat-containing protein 3

1

1

High-throughput

0.515

High

957790

TAB2
TGF-beta-activated kinase 1 and MAP3K7-binding protein 2

1

4

Small-scale

0.515

High

856175

SPSY
Spermine synthase

1

0

High-throughput

0.513

High

928870

SKP1
S-phase kinase-associated protein 1

1

0

High-throughput

0.513

High

957739

KDF1
Keratinocyte differentiation factor 1

1

0

High-throughput

0.513

High

957769

SORT
Sortilin

1

0

High-throughput

0.513

High

957691

GOGA2
Golgin subfamily A member 2

1

6

High-throughput

0.512

High

957721

SCAR3
Scavenger receptor class A member 3

1

1

Small-scale

0.504

High

261243

FLNB
Filamin-B

1

8

High-throughput

0.501

High

414861

CDK1
Cyclin-dependent kinase 1

1

6

Small-scale

0.501

High

418938

TPM3
Tropomyosin alpha-3 chain

1

1

High-throughput

0.501

High

438074

HS90B
Heat shock protein HSP 90-beta

1

7

High-throughput

0.501

High

531120

EF2
Elongation factor 2

1

5

High-throughput

0.501

High

538520

CCNB1
G2/mitotic-specific cyclin-B1

1

4

Small-scale

0.501

High

545321

RAC2
Ras-related C3 botulinum toxin substrate 2

1

11

Small-scale

0.501

High

598066

FLNA
Filamin-A

1

8

High-throughput

0.501

High

653224

PYR1
Multifunctional protein CAD

1

3

High-throughput

0.501

High

682165

AKT2
RAC-beta serine/threonine-protein kinase

1

2

Small-scale

0.501

High

806821

RS9
Small ribosomal subunit protein uS4

1

1

High-throughput

0.501

High

827341

EFTU
Elongation factor Tu, mitochondrial

1

6

High-throughput

0.501

High

892316

RAC3
Ras-related C3 botulinum toxin substrate 3

1

11

Small-scale

0.501

High

957702

IKKE
Inhibitor of nuclear factor kappa-B kinase subunit epsilon

1

13

Small-scale

0.501

High

957705

NCOA6
Nuclear receptor coactivator 6

1

6

High-throughput

0.501

High

957740

SYNE1
Nesprin-1

1

5

High-throughput

0.501

High

957792

LIMA1
LIM domain and actin-binding protein 1

1

6

High-throughput

0.501

High

957796

CHIP
E3 ubiquitin-protein ligase CHIP

1

6

Small-scale

0.501

High

448996

GROA
Growth-regulated alpha protein

1

4

High-throughput

0.489

High

957746

CCL17
C-C motif chemokine 17

1

2

High-throughput

0.489

High

957750

PTPR2
Receptor-type tyrosine-protein phosphatase N2

1

2

High-throughput

0.489

High

957764

FIMP
Fertilization-influencing membrane protein

1

1

High-throughput

0.489

High

957743

PIBF1
Progesterone-induced-blocking factor 1

1

2

High-throughput

0.481

High

957781

BOLA2
BolA-like protein 2

1

6

High-throughput

0.481

High

118273

HAX1
HCLS1-associated protein X-1

1

2

Small-scale

0.479

High

301374

UBP19
Ubiquitin carboxyl-terminal hydrolase 19

1

20

Small-scale

0.479

High

301763

TRI37
E3 ubiquitin-protein ligase TRIM37

1

8

Small-scale

0.479

High

359002

CRYAB
Alpha-crystallin B chain

1

3

Small-scale

0.479

High

394537

A4
Amyloid-beta precursor protein

1

4

Small-scale

0.479

High

443460

VIME
Vimentin

1

9

Small-scale

0.479

High

485058

GLI2
Zinc finger protein GLI2

1

1

Small-scale

0.479

High

518640

IMDH2
Inosine-5'-monophosphate dehydrogenase 2

1

1

High-throughput

0.479

High

685665

PRDX2
Peroxiredoxin-2

1

10

Small-scale

0.479

High

714184

HSP74
Heat shock 70 kDa protein 4

1

9

Small-scale

0.479

High

738443

ACV1B
Activin receptor type-1B

1

8

Small-scale

0.479

High

738529

TGFR1
TGF-beta receptor type-1

1

7

Small-scale

0.479

High

846746

SMCA2
Probable global transcription activator SNF2L2

1

4

High-throughput

0.479

High

881137

CTBP2
C-terminal-binding protein 2

1

6

Small-scale

0.479

High

883482

RIPK4
Receptor-interacting serine/threonine-protein kinase 4

1

20

Small-scale

0.479

High

904444

1433G
14-3-3 protein gamma

1

2

High-throughput

0.479

High

957690

BAX
Apoptosis regulator BAX

1

1

Small-scale

0.479

High

957699

CUL3
Cullin-3

1

10

High-throughput

0.479

High

957700

BMPR2
Bone morphogenetic protein receptor type-2

1

11

Small-scale

0.479

High

957703

RBM39
RNA-binding protein 39

1

6

High-throughput

0.479

High

957704

IRF3
Interferon regulatory factor 3

1

3

Small-scale

0.479

High

957709

PCBP1
Poly(rC)-binding protein 1

1

6

Small-scale

0.479

High

957718

CE170
Centrosomal protein of 170 kDa

1

5

High-throughput

0.479

High

957726

TRI67
Tripartite motif-containing protein 67

1

12

High-throughput

0.479

High

957727

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

2

High-throughput

0.479

High

957730

RB6I2
ELKS/Rab6-interacting/CAST family member 1

1

6

Small-scale

0.479

High

957736

NIN
Ninein

1

12

High-throughput

0.479

High

957742

ATX2L
Ataxin-2-like protein

1

2

Small-scale

0.479

High

957745

GBF1
Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1

1

1

High-throughput

0.479

High

957752

RN166
E3 ubiquitin-protein ligase RNF166

1

17

Small-scale

0.479

High

957753

FUBP1
Far upstream element-binding protein 1

1

7

Small-scale

0.479

High

957762

UBP47
Ubiquitin carboxyl-terminal hydrolase 47

1

12

Small-scale

0.479

High

957763

SNX27
Sorting nexin-27

1

2

High-throughput

0.479

High

957774

CDCA4
Cell division cycle-associated protein 4

1

1

Small-scale

0.479

High

957791

ZRAN1
Ubiquitin thioesterase ZRANB1

1

10

High-throughput

0.479

High

759

A0A087WZT3
BOLA2-SMG1P6 readthrough

1

2

High-throughput

0.470

High

957715

Q4G0R1
PIBF1 protein

1

2

High-throughput

0.470

High

217157

EXTL3
Exostosin-like 3

1

0

Small-scale

0.458

High

660465

GRN
Progranulin

1

0

Small-scale

0.458

High

957706

MVP
Major vault protein

1

0

Small-scale

0.458

High

957728

NAA40
N-alpha-acetyltransferase 40

1

0

High-throughput

0.458

High

957778

IMUP
Immortalization up-regulated protein

1

0

Small-scale

0.458

High

677934

SDHA
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

1

3

High-throughput

0.457

High

816157

KCNJ6
G protein-activated inward rectifier potassium channel 2

1

1

Small-scale

0.457

High

957732

SPA12
Serpin A12

1

4

High-throughput

0.457

High

957735

RYBP
RING1 and YY1-binding protein

1

2

High-throughput

0.445

High

957780

PDCL3
Phosducin-like protein 3

1

2

Small-scale

0.445

High

957714

PKHN1
Pleckstrin homology domain-containing family N member 1

1

1

Small-scale

0.437

High

957777

BSSP4
Brain-specific serine protease 4

1

9

High-throughput

0.437

High

957789

KBTB4
Kelch repeat and BTB domain-containing protein 4

1

1

High-throughput

0.437

High

957768

NUDC1
NudC domain-containing protein 1

1

0

High-throughput

0.426

High

89959

D6R9G5
Kelch like family member 2

1

2

High-throughput

0.407

High

382390

HLAA
HLA class I histocompatibility antigen, A alpha chain

1

2

High-throughput

0.407

High

385864

CPNS1
Calpain small subunit 1

1

3

Small-scale

0.388

High

587524

NFKB1
Nuclear factor NF-kappa-B p105 subunit

1

20

Small-scale

0.381

High

957720

TTC23
Tetratricopeptide repeat protein 23

2

0

High-throughput

0.316

High

438745

SRPRA
Signal recognition particle receptor subunit alpha

1

0

High-throughput

0.279

Low

957766

ROBO3
Roundabout homolog 3

1

0

High-throughput

0.279

Low

429519

HEXB
Beta-hexosaminidase subunit beta

1

0

High-throughput

0.268

Low

819581

INAR2
Interferon alpha/beta receptor 2

1

0

Small-scale

0.249

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024