Protein: WAC
WW domain-containing adapter protein with coiled-coil

Gene: WAC
Organism: Homo sapiens
Interactions: 83
UniProt ID: Q9BTA9

Gene Ontology (top 5):
GO:0000993 - RNA polymerase II complex binding
GO:0003682 - chromatin binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005681 - spliceosomal complex

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

272742

BRE1B
E3 ubiquitin-protein ligase BRE1B

4

5

Small-scale

0.708

High

1217906

BRE1A
E3 ubiquitin-protein ligase BRE1A

4

5

Small-scale

0.703

High

1413291

WAC
WW domain-containing adapter protein with coiled-coil

1

6

High-throughput

0.698

High

618098

K1C15
Keratin, type I cytoskeletal 15

4

0

High-throughput

0.671

High

414524

P53
Cellular tumor antigen p53

3

6

Small-scale

0.640

High

1156701

NF2L2
Nuclear factor erythroid 2-related factor 2

2

7

High-throughput

0.628

High

1205966

MTUS2
Microtubule-associated tumor suppressor candidate 2

2

5

High-throughput

0.628

High

1394972

VCIP1
Deubiquitinating protein VCPIP1

2

0

Small-scale

0.603

High

843930

HD
Huntingtin

2

3

High-throughput

0.596

High

1351583

MIPT3
TRAF3-interacting protein 1

2

1

High-throughput

0.590

High

920246

PLK1
Serine/threonine-protein kinase PLK1

1

3

Small-scale

0.578

High

170320

AURKA
Aurora kinase A

1

2

Small-scale

0.561

High

443500

CDK1
Cyclin-dependent kinase 1

1

2

Small-scale

0.561

High

667428

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

1

Small-scale

0.561

High

935070

TERA
Transitional endoplasmic reticulum ATPase

1

1

Small-scale

0.561

High

166557

BACH1
Transcription regulator protein BACH1

1

5

High-throughput

0.541

High

923631

TTC3
E3 ubiquitin-protein ligase TTC3

1

7

High-throughput

0.541

High

682594

S100P
Protein S100-P

1

1

High-throughput

0.536

High

1413294

RBM12
RNA-binding protein 12

1

4

High-throughput

0.536

High

1242694

KLC3
Kinesin light chain 3

1

2

High-throughput

0.523

High

1408524

AKAP9
A-kinase anchor protein 9

1

5

High-throughput

0.523

High

1413302

T3JAM
TRAF3-interacting JNK-activating modulator

1

4

High-throughput

0.523

High

1307625

ZDH17
Palmitoyltransferase ZDHHC17

1

1

High-throughput

0.518

High

1413293

UBQL4
Ubiquilin-4

1

3

High-throughput

0.508

High

508536

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

3

Small-scale

0.501

High

300828

KRT38
Keratin, type I cuticular Ha8

1

1

High-throughput

0.489

High

464205

TPM2
Tropomyosin beta chain

1

2

High-throughput

0.489

High

592890

CBR1
Carbonyl reductase [NADPH] 1

1

1

High-throughput

0.489

High

706284

S10A2
Protein S100-A2

1

1

High-throughput

0.489

High

1393366

C2AIL
CDKN2AIP N-terminal-like protein

1

1

High-throughput

0.489

High

855928

CRKL
Crk-like protein

1

8

High-throughput

0.481

High

1413296

HM20B
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related

1

8

High-throughput

0.481

High

129380

MEN1
Menin

1

3

High-throughput

0.479

High

130600

SPT5H
Transcription elongation factor SPT5

1

8

High-throughput

0.479

High

373010

MYC
Myc proto-oncogene protein

1

7

High-throughput

0.479

High

520336

ANDR
Androgen receptor

1

16

High-throughput

0.479

High

558372

XRCC6
X-ray repair cross-complementing protein 6

1

2

High-throughput

0.479

High

589557

RFA2
Replication protein A 32 kDa subunit

1

4

High-throughput

0.479

High

696363

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

5

High-throughput

0.479

High

769035

RFA3
Replication protein A 14 kDa subunit

1

4

High-throughput

0.479

High

884391

UBE2A
Ubiquitin-conjugating enzyme E2 A

1

1

Small-scale

0.479

High

887183

CEBPA
CCAAT/enhancer-binding protein alpha

1

5

High-throughput

0.479

High

911664

NCBP2
Nuclear cap-binding protein subunit 2

1

1

High-throughput

0.479

High

980239

H4
Histone H4

1

4

High-throughput

0.479

High

990985

UBE2B
Ubiquitin-conjugating enzyme E2 B

1

1

Small-scale

0.479

High

1005036

RNF4
E3 ubiquitin-protein ligase RNF4

1

2

High-throughput

0.479

High

1033193

EWS
RNA-binding protein EWS

1

4

High-throughput

0.479

High

1048082

TLE3
Transducin-like enhancer protein 3

1

4

High-throughput

0.479

High

1097527

CBX3
Chromobox protein homolog 3

1

5

High-throughput

0.479

High

1128101

DHX8
ATP-dependent RNA helicase DHX8

1

1

High-throughput

0.479

High

1289589

NAA40
N-alpha-acetyltransferase 40

1

2

High-throughput

0.479

High

1313386

SMC5
Structural maintenance of chromosomes protein 5

1

3

High-throughput

0.479

High

1329842

SIR6
NAD-dependent protein deacylase sirtuin-6

1

4

Small-scale

0.479

High

1332707

ZBT38
Zinc finger and BTB domain-containing protein 38

1

1

Small-scale

0.479

High

1387529

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

1

5

High-throughput

0.479

High

1413299

ZRAN1
Ubiquitin thioesterase ZRANB1

1

3

High-throughput

0.479

High

1413300

XPO7
Exportin-7

1

2

High-throughput

0.479

High

1132323

GOGB1
Golgin subfamily B member 1

1

2

High-throughput

0.470

High

1413298

TFP11
Tuftelin-interacting protein 11

1

0

High-throughput

0.460

High

551231

PCNA
Proliferating cell nuclear antigen

1

0

High-throughput

0.458

High

573883

CCNB1
G2/mitotic-specific cyclin-B1

1

0

Small-scale

0.458

High

1229658

VIR
Protein virilizer homolog

1

0

High-throughput

0.458

High

1392630

CENPN
Centromere protein N

1

0

Small-scale

0.458

High

423024

A4
Amyloid-beta precursor protein

1

2

High-throughput

0.457

High

1156586

CCDC6
Coiled-coil domain-containing protein 6

1

7

High-throughput

0.439

High

1224894

TENS2
Tensin-2

1

5

High-throughput

0.439

High

1348467

LNX1
E3 ubiquitin-protein ligase LNX

1

4

Small-scale

0.439

High

1413295

NDE1
Nuclear distribution protein nudE homolog 1

1

3

High-throughput

0.439

High

318869

RHBT1
Rho-related BTB domain-containing protein 1

1

11

High-throughput

0.437

High

995795

ACTC
Actin, alpha cardiac muscle 1

1

6

High-throughput

0.437

High

1413292

RHBT2
Rho-related BTB domain-containing protein 2

1

11

High-throughput

0.437

High

1396570

C170L
Cep170-like protein

1

1

High-throughput

0.407

High

1359111

DYDC1
DPY30 domain-containing protein 1

2

0

High-throughput

0.330

High

1093941

TRAF1
TNF receptor-associated factor 1

1

0

High-throughput

0.299

High

1351797

SYTL5
Synaptotagmin-like protein 5

1

0

High-throughput

0.299

High

1413297

SLAI2
SLAIN motif-containing protein 2

1

0

High-throughput

0.279

Low

1118398

MOBP
Myelin-associated oligodendrocyte basic protein

1

0

High-throughput

0.251

Low

1158505

CDC37
Hsp90 co-chaperone Cdc37

1

0

High-throughput

0.251

Low

1365500

EDEM1
ER degradation-enhancing alpha-mannosidase-like protein 1

1

0

High-throughput

0.249

Low

947369

NAL12
NACHT, LRR and PYD domains-containing protein 12

1

0

Small-scale

0.238

Low

1367857

HTRA1
Serine protease HTRA1

1

0

Small-scale

0.238

Low

1413301

ATIF1
ATPase inhibitor, mitochondrial

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025