HitPredict

Interactor 1: PITX1 (P78337)
Pituitary homeobox 1 (Hindlimb-expressed homeobox protein backfoot) (Homeobox protein PITX1) (Paired-like homeodomain transcription factor 1)
Gene: PITX1

Interactor 2: TLE5 (Q08117)
TLE family member 5 (Amino-terminal enhancer of split) (Amino enhancer of split) (Gp130-associated protein GAM) (Grg-5) (Groucho-related protein 5) (Protein ESP1) (Protein GRG) (TLE family member 5, transcriptional modulator)
Gene: TLE5

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.61	0.60	0.606

Property	Details
Experiments	32296183, unassigned1304
Identification Methods	two hybrid, two hybrid prey pooling approach, two hybrid array, validated two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0001501 - skeletal system development GO:0005634 - nucleus GO:0045892 - negative regulation of DNA-templated transcription
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 314 Hs			1 197
+	Hs
		662217 PAX7_HUMAN (72-314): 1.12e-33: 130: 25.20		TLE4_HUMAN (2-191): 3.59e-112: 338: 68.59
+	Hs
		662215 PAX7_HUMAN (72-314): 1.12e-33: 130: 25.20		TLE1_HUMAN (2-197): 2.48e-111: 336: 64.50
+	Mm
		666052 PAX3_MOUSE (66-314): 1.22e-30: 122: 24.23		TLE4_MOUSE (2-191): 3.79e-112: 338: 68.59
+	Hs
		685164 PAX6_HUMAN (39-291): 6.77e-31: 122: 20.61		TLE4_HUMAN (2-191): 3.59e-112: 338: 68.59
+	Hs
		877510 LHX1_HUMAN (26-305): 1.19e-31: 123: 14.58		TLE1_HUMAN (2-197): 2.48e-111: 336: 64.50
+	Hs
		685162 PAX6_HUMAN (39-291): 6.77e-31: 122: 20.61		TLE1_HUMAN (2-197): 2.48e-111: 336: 64.50
+	Hs
		662216 PAX7_HUMAN (72-314): 1.12e-33: 130: 25.20		TLE3_HUMAN (2-197): 3.96e-105: 320: 61.50
+	Hs
		685163 PAX6_HUMAN (39-291): 6.77e-31: 122: 20.61		TLE3_HUMAN (2-197): 3.96e-105: 320: 61.50
+	Hs
		1061841 PITX2_HUMAN (61-312): 2.21e-41: 147: 71.21		TLE5_HUMAN (1-197): 3.11e-101: 292: 100.00
+	Hs
		662219 PAX7_HUMAN (72-314): 1.12e-33: 130: 25.20		TLE5_HUMAN (1-197): 3.11e-101: 292: 100.00
+	Hs
		1061835 ARX_HUMAN (50-310): 6.44e-32: 126: 31.02		TLE5_HUMAN (1-197): 3.11e-101: 292: 100.00
+	Hs
		685170 PAX6_HUMAN (39-291): 6.77e-31: 122: 20.61		TLE5_HUMAN (1-197): 3.11e-101: 292: 100.00
+	Dm
		594679 GSC_DROME (87-157): 3.63e-17: 83.2: 56.34		GROU_DROME (2-163): 3.56e-59: 198: 54.44
+	Ce
		146025 UNC4_CAEEL (30-172): 7.1e-30: 115: 31.47		UNC37_CAEEL (18-160): 8.47e-43: 153: 28.47
+	Ce
		146029 HM09_CAEEL (60-154): 9.07e-30: 112: 29.47		UNC37_CAEEL (18-160): 8.47e-43: 153: 28.47