Protein: PITX2
Pituitary homeobox 2 (ALL1-responsive protein ARP1) (Homeobox protein PITX2) (Paired-like homeodomain transcription factor 2) (RIEG bicoid-related homeobox transcription factor) (Solurshin)

Gene: PITX2
Organism: Homo sapiens
Interactions: 74
UniProt ID: Q99697

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000785 - chromatin
GO:0000976 - transcription cis-regulatory region binding
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1406443

PITX2
Pituitary homeobox 2

4

16

Small-scale

0.902

High

885379

HXA1
Homeobox protein Hox-A1

2

20

High-throughput

0.783

High

1406455

HEY1
Hairy/enhancer-of-split related with YRPW motif protein 1

2

1

High-throughput

0.783

High

1034698

MEF2A
Myocyte-specific enhancer factor 2A

1

1

Small-scale

0.713

High

230098

SAHH2
S-adenosylhomocysteine hydrolase-like protein 1

4

4

High-throughput

0.694

High

1406454

TBX22
T-box transcription factor TBX22

1

9

High-throughput

0.665

High

1406445

IER2
Immediate early response gene 2 protein

3

0

High-throughput

0.638

High

764989

CTNB1
Catenin beta-1

3

1

Small-scale

0.633

High

1125199

TRI25
E3 ubiquitin/ISG15 ligase TRIM25

2

7

Small-scale

0.619

High

406551

MYCN
N-myc proto-oncogene protein

1

6

High-throughput

0.618

High

1005635

PITX1
Pituitary homeobox 1

1

17

High-throughput

0.618

High

1393308

SAHH3
Adenosylhomocysteinase 3

3

4

High-throughput

0.609

High

71142

VGLL3
Transcription cofactor vestigial-like protein 3

2

1

High-throughput

0.606

High

700951

PSB4
Proteasome subunit beta type-4

2

1

High-throughput

0.606

High

1061841

TLE5
TLE family member 5

2

18

High-throughput

0.606

High

1093936

TRAF1
TNF receptor-associated factor 1

2

3

High-throughput

0.606

High

1372047

RBPMS
RNA-binding protein with multiple splicing

2

1

High-throughput

0.606

High

1402040

TRIB3
Tribbles homolog 3

2

5

High-throughput

0.606

High

1404644

PFD5
Prefoldin subunit 5

2

1

High-throughput

0.606

High

217186

MS18B
Protein Mis18-beta

2

0

High-throughput

0.580

High

991918

DYLT1
Dynein light chain Tctex-type 1

2

0

High-throughput

0.580

High

1139120

DAZP2
DAZ-associated protein 2

2

0

High-throughput

0.580

High

1160372

OBF1
POU domain class 2-associating factor 1

2

0

High-throughput

0.580

High

1397215

SMIP9
Protein SPMIP9

2

0

High-throughput

0.580

High

1406450

WWOX
WW domain-containing oxidoreductase

2

0

High-throughput

0.580

High

372952

MYC
Myc proto-oncogene protein

1

11

High-throughput

0.575

High

70437

CRTP1
Cysteine-rich tail protein 1

2

1

High-throughput

0.553

High

300474

KRT34
Keratin, type I cuticular Ha4

2

7

High-throughput

0.553

High

1186594

KRA61
Keratin-associated protein 6-1

2

1

High-throughput

0.553

High

1186906

KR195
Keratin-associated protein 19-5

2

1

High-throughput

0.553

High

1186971

KR151
Keratin-associated protein 15-1

2

2

High-throughput

0.553

High

1187909

KR197
Keratin-associated protein 19-7

2

2

High-throughput

0.553

High

1238972

UFSP1
Ufm1-specific protease 1

2

1

High-throughput

0.553

High

1307112

KRA71
Keratin-associated protein 7-1

2

1

High-throughput

0.553

High

1406446

KRA33
Keratin-associated protein 3-3

2

1

High-throughput

0.553

High

994748

YBOX1
Y-box-binding protein 1

1

1

Small-scale

0.536

High

1054779

SUH
Recombining binding protein suppressor of hairless

1

2

High-throughput

0.536

High

1406444

FOXC2
Forkhead box protein C2

1

19

High-throughput

0.536

High

1406452

LEF1
Lymphoid enhancer-binding factor 1

1

20

Small-scale

0.527

High

1151328

ZNHI3
Zinc finger HIT domain-containing protein 3

1

0

High-throughput

0.518

High

1091143

FOXC1
Forkhead box protein C1

1

15

Small-scale

0.515

High

1289878

Q86V38
Atrophin 1

1

14

High-throughput

0.515

High

1406449

ANR10
Ankyrin repeat domain-containing protein 10

1

5

High-throughput

0.515

High

855189

NOP2
28S rRNA

1

0

High-throughput

0.513

High

1406451

HERC5
E3 ISG15--protein ligase HERC5

1

3

Small-scale

0.501

High

1200191

SMUG1
Single-strand selective monofunctional uracil DNA glycosylase

1

0

High-throughput

0.493

High

1386866

DDT4L
DNA damage-inducible transcript 4-like protein

1

0

High-throughput

0.493

High

928327

ATN1
Atrophin-1

1

20

High-throughput

0.481

High

1315911

ZNF34
Zinc finger protein 34

1

2

High-throughput

0.481

High

143213

NFIB
Nuclear factor 1 B-type

1

19

High-throughput

0.479

High

341659

EYA4
Protein phosphatase EYA4

1

10

High-throughput

0.479

High

474236

NFIC
Nuclear factor 1 C-type

1

20

High-throughput

0.479

High

651709

KAPCB
cAMP-dependent protein kinase catalytic subunit beta

1

5

High-throughput

0.479

High

769897

RFC2
Replication factor C subunit 2

1

3

High-throughput

0.479

High

965184

WDR5
WD repeat-containing protein 5

1

2

Small-scale

0.479

High

1014594

SMAD3
Mothers against decapentaplegic homolog 3

1

5

Small-scale

0.479

High

1067640

EP300
Histone acetyltransferase p300

1

17

High-throughput

0.479

High

1087972

NFIA
Nuclear factor 1 A-type

1

20

High-throughput

0.479

High

1110027

HDAC1
Histone deacetylase 1

1

2

Small-scale

0.479

High

1122143

UBP2L
Ubiquitin-associated protein 2-like

1

13

High-throughput

0.479

High

1158494

CDC37
Hsp90 co-chaperone Cdc37

1

1

High-throughput

0.479

High

1214474

MGLYR
Metabotropic glycine receptor

1

1

High-throughput

0.479

High

1388704

SIR1
NAD-dependent protein deacetylase sirtuin-1

1

5

High-throughput

0.479

High

1401365

CIC
Protein capicua homolog

1

20

High-throughput

0.479

High

1406448

WDR6
tRNA

1

4

High-throughput

0.479

High

1406453

FZR1
Fizzy-related protein homolog

1

4

High-throughput

0.479

High

537773

HSP7C
Heat shock cognate 71 kDa protein

1

5

High-throughput

0.445

High

620543

NUCL
Nucleolin

1

1

Small-scale

0.445

High

965844

HNRPK
Heterogeneous nuclear ribonucleoprotein K

1

2

Small-scale

0.445

High

1027692

HNRPU
Heterogeneous nuclear ribonucleoprotein U

1

4

Small-scale

0.445

High

468731

HS90B
Heat shock protein HSP 90-beta

1

0

High-throughput

0.426

High

1390918

LRC46
Leucine-rich repeat-containing protein 46

3

0

High-throughput

0.347

High

1406447

TINAL
Tubulointerstitial nephritis antigen-like

2

0

High-throughput

0.316

High


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Last updated: 11Aug2025