HitPredict

Interactor 1: TCPB (P78371)
T-complex protein 1 subunit beta (TCP-1-beta) (EC 3.6.1.-) (CCT-beta) (Chaperonin containing T-complex polypeptide 1 subunit 2)
Gene: CCT2

Interactor 2: FBXW8 (Q8N3Y1)
F-box/WD repeat-containing protein 8 (F-box and WD-40 domain-containing protein 8) (F-box only protein 29)
Gene: FBXW8

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.79	0.60	0.691

Property	Details
Experiments	33961781, 37689310, 21572988, unassigned3799
Identification Methods	affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 535 Hs			1 598
+	Hs
		1325517 TCPH_HUMAN (4-532): 0: 591: 34.08		FBXW8_HUMAN (1-598): 3.04e-130: 396: 96.17
+	Hs
		1407533 TCPH_HUMAN (4-532): 0: 591: 34.08		TBL1Y_HUMAN (22-419): 3.38e-61: 213: 10.38
+	Hs
		1007231 TCPB_HUMAN (1-535): 0: 586: 100.00		TBL1Y_HUMAN (22-419): 3.38e-61: 213: 10.38
+	Hs
		1291941 TCPH_HUMAN (4-532): 0: 591: 34.08		WDR5B_HUMAN (40-372): 3.65e-55: 191: 13.70
+	Hs
		1007162 TCPB_HUMAN (1-535): 0: 586: 100.00		POC1B_HUMAN (360-593): 1.48e-54: 194: 15.00
+	Hs
		1007118 TCPB_HUMAN (1-535): 0: 586: 100.00		WDR5B_HUMAN (40-372): 3.65e-55: 191: 13.70
+	Hs
		1287302 TCPH_HUMAN (4-532): 0: 591: 34.08		WDR86_HUMAN (102-378): 4.44e-46: 168: 13.01
+	Hs
		1007114 TCPB_HUMAN (1-535): 0: 586: 100.00		WDR86_HUMAN (102-378): 4.44e-46: 168: 13.01
+	Hs
		1334162 TCPH_HUMAN (4-532): 0: 591: 34.08		POC1A_HUMAN (52-324): 2.63e-40: 153: 14.03
+	Hs
		1007146 TCPB_HUMAN (1-535): 0: 586: 100.00		POC1A_HUMAN (52-324): 2.63e-40: 153: 14.03
+	Hs
		1007186 TCPB_HUMAN (1-535): 0: 586: 100.00		FBXW7_HUMAN (417-592): 2.78e-37: 149: 16.85
+	Hs
		845257 TCPG_HUMAN (3-532): 0: 561: 28.33		LIS1_HUMAN (4-327): 1.35e-46: 170: 10.77
+	Hs
		1407634 TCPH_HUMAN (4-532): 0: 591: 34.08		FBW1A_HUMAN (421-593): 4.84e-32: 132: 17.22
+	Hs
		1007344 TCPB_HUMAN (1-535): 0: 586: 100.00		FBW1A_HUMAN (421-593): 4.84e-32: 132: 17.22
+	Hs
		1221017 TCPH_HUMAN (4-532): 0: 591: 34.08		FBW10_HUMAN (387-566): 1.88e-25: 114: 19.78
+	Hs
		1407594 TCPH_HUMAN (4-532): 0: 591: 34.08		NLE1_HUMAN (50-235): 4.2e-19: 92.6: 13.71
+	Hs
		1007305 TCPB_HUMAN (1-535): 0: 586: 100.00		NLE1_HUMAN (50-235): 4.2e-19: 92.6: 13.71
+	Hs
		965190 TCPH_HUMAN (4-532): 0: 591: 34.08		WDR5_HUMAN (110-238): 7.41e-12: 68.8: 9.42
+	Hs
		964840 TCPB_HUMAN (1-535): 0: 586: 100.00		WDR5_HUMAN (110-238): 7.41e-12: 68.8: 9.42
+	Hs
		881861 TCPG_HUMAN (3-532): 0: 561: 28.33		WDR5_HUMAN (110-238): 7.41e-12: 68.8: 9.42