Protein: FBXW8
F-box/WD repeat-containing protein 8 (F-box and WD-40 domain-containing protein 8) (F-box only protein 29)

Gene: FBXW8
Organism: Homo sapiens
Interactions: 153
UniProt ID: Q8N3Y1

Gene Ontology (top 5):
GO:0005737 - cytoplasm
GO:0005794 - Golgi apparatus
GO:0005814 - centriole
GO:0005829 - cytosol
GO:0006511 - ubiquitin-dependent protein catabolic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

992252

SKP1
S-phase kinase-associated protein 1

15

20

Small-scale

0.982

High

1134982

CUL7
Cullin-7

13

5

Small-scale

0.979

High

1112597

CUL1
Cullin-1

9

20

Small-scale

0.973

High

1114936

CUL4A
Cullin-4A

2

20

Small-scale

0.754

High

1325537

FBW1A
F-box/WD repeat-containing protein 1A

2

18

Small-scale

0.754

High

983883

RBX1
E3 ubiquitin-protein ligase RBX1

6

15

Small-scale

0.726

High

414198

P53
Cellular tumor antigen p53

6

8

Small-scale

0.725

High

1112914

CUL2
Cullin-2

1

20

Small-scale

0.691

High

1007137

TCPB
T-complex protein 1 subunit beta

4

20

Small-scale

0.691

High

882028

TCPG
T-complex protein 1 subunit gamma

3

20

Small-scale

0.675

High

1325517

TCPH
T-complex protein 1 subunit eta

3

20

Small-scale

0.675

High

772508

IRS1
Insulin receptor substrate 1

3

13

Small-scale

0.674

High

169258

CASQ2
Calsequestrin-2

3

10

High-throughput

0.667

High

1158135

MK14
Mitogen-activated protein kinase 14

3

10

High-throughput

0.667

High

1325497

TTC29
Tetratricopeptide repeat protein 29

3

6

High-throughput

0.667

High

1325523

CCDC8
Coiled-coil domain-containing protein 8

3

1

Small-scale

0.656

High

664776

CCND1
G1/S-specific cyclin-D1

2

12

Small-scale

0.624

High

634927

BCL3
B-cell lymphoma 3 protein

1

20

Small-scale

0.618

High

683485

IKBA
NF-kappa-B inhibitor alpha

1

20

Small-scale

0.618

High

1101851

SKP2
S-phase kinase-associated protein 2

1

4

Small-scale

0.618

High

1325494

FBXW8
F-box/WD repeat-containing protein 8

1

15

High-throughput

0.618

High

1325534

FBXW2
F-box/WD repeat-containing protein 2

1

16

Small-scale

0.618

High

272320

OBSL1
Obscurin-like protein 1

2

6

Small-scale

0.611

High

329084

KLHL2
Kelch-like protein 2

2

4

High-throughput

0.611

High

876064

TCPE
T-complex protein 1 subunit epsilon

2

20

High-throughput

0.611

High

372565

MYC
Myc proto-oncogene protein

1

20

High-throughput

0.594

High

1325533

FBX4
F-box only protein 4

1

0

Small-scale

0.586

High

1115296

CUL4B
Cullin-4B

1

20

High-throughput

0.575

High

171900

ZN263
Zinc finger protein 263

2

5

High-throughput

0.574

High

1325507

ZN669
Zinc finger protein 669

2

1

High-throughput

0.574

High

821446

TCPZ
T-complex protein 1 subunit zeta

1

20

Small-scale

0.536

High

885006

DGKG
Diacylglycerol kinase gamma

1

3

High-throughput

0.536

High

963325

PFD3
Prefoldin subunit 3

1

4

Small-scale

0.536

High

1066394

RBBP4
Histone-binding protein RBBP4

1

17

High-throughput

0.536

High

1154394

STK11
Serine/threonine-protein kinase STK11

1

4

High-throughput

0.536

High

1325499

SNX33
Sorting nexin-33

1

2

High-throughput

0.536

High

1325502

TCPW
T-complex protein 1 subunit zeta-2

1

20

Small-scale

0.536

High

1325515

PFD5
Prefoldin subunit 5

1

5

Small-scale

0.536

High

1325524

PDCL3
Phosducin-like protein 3

1

7

High-throughput

0.536

High

162363

PDCD5
Programmed cell death protein 5

1

0

Small-scale

0.513

High

1086172

CETN1
Centrin-1

1

0

High-throughput

0.513

High

957131

UB2D3
Ubiquitin-conjugating enzyme E2 D3

1

14

Small-scale

0.501

High

1325514

TRIB1
Tribbles homolog 1

1

9

Small-scale

0.501

High

1014923

ARF1
ADP-ribosylation factor 1

1

4

Small-scale

0.500

High

1151016

PCH2
Pachytene checkpoint protein 2 homolog

1

18

Small-scale

0.489

High

1153641

ZKSC8
Zinc finger protein with KRAB and SCAN domains 8

1

5

High-throughput

0.489

High

1325496

TTC9C
Tetratricopeptide repeat protein 9C

1

9

High-throughput

0.489

High

1325531

FBLN5
Fibulin-5

1

6

High-throughput

0.489

High

49971

RHG10
Rho GTPase-activating protein 10

1

6

High-throughput

0.479

High

137543

NR5A2
Nuclear receptor subfamily 5 group A member 2

1

14

High-throughput

0.479

High

173064

XPO1
Exportin-1

1

10

High-throughput

0.479

High

1310153

GCC2
GRIP and coiled-coil domain-containing protein 2

1

11

High-throughput

0.479

High

182156

PFD6
Prefoldin subunit 6

1

4

High-throughput

0.479

High

210990

PSMD3
26S proteasome non-ATPase regulatory subunit 3

1

1

High-throughput

0.479

High

213965

M3K7
Mitogen-activated protein kinase kinase kinase 7

1

4

Small-scale

0.479

High

252468

DIAP1
Protein diaphanous homolog 1

1

4

High-throughput

0.479

High

323754

AP2A2
AP-2 complex subunit alpha-2

1

5

High-throughput

0.479

High

461698

HS90A
Heat shock protein HSP 90-alpha

1

14

Small-scale

0.479

High

483605

CN37
2',3'-cyclic-nucleotide 3'-phosphodiesterase

1

2

High-throughput

0.479

High

531108

KAP0
cAMP-dependent protein kinase type I-alpha regulatory subunit

1

3

High-throughput

0.479

High

536351

MTAP2
Microtubule-associated protein 2

1

10

High-throughput

0.479

High

587735

DESP
Desmoplakin

1

17

High-throughput

0.479

High

610767

TCPA
T-complex protein 1 subunit alpha

1

20

Small-scale

0.479

High

637628

FLNA
Filamin-A

1

12

High-throughput

0.479

High

680946

PSA1
Proteasome subunit alpha type-1

1

4

High-throughput

0.479

High

691239

1433T
14-3-3 protein theta

1

20

High-throughput

0.479

High

697591

PYR1
Multifunctional protein CAD

1

4

High-throughput

0.479

High

701056

PSB6
Proteasome subunit beta type-6

1

3

High-throughput

0.479

High

761759

HSP74
Heat shock 70 kDa protein 4

1

12

Small-scale

0.479

High

837715

LAP2B
Lamina-associated polypeptide 2, isoforms beta/gamma

1

3

High-throughput

0.479

High

848800

MAGAA
Melanoma-associated antigen 10

1

8

High-throughput

0.479

High

881239

FAS
Fatty acid synthase

1

2

High-throughput

0.479

High

910986

IMA1
Importin subunit alpha-1

1

5

High-throughput

0.479

High

911638

NCBP2
Nuclear cap-binding protein subunit 2

1

16

High-throughput

0.479

High

952600

MYL6
Myosin light polypeptide 6

1

3

High-throughput

0.479

High

991062

2ABA
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform

1

2

High-throughput

0.479

High

995695

ACTC
Actin, alpha cardiac muscle 1

1

6

High-throughput

0.479

High

1053417

DEUP1
Deuterosome assembly protein 1

1

18

High-throughput

0.479

High

1054486

EXOS9
Exosome complex component RRP45

1

8

High-throughput

0.479

High

1063141

GOGA3
Golgin subfamily A member 3

1

9

High-throughput

0.479

High

1067505

EP300
Histone acetyltransferase p300

1

11

Small-scale

0.479

High

1085899

TWF1
Twinfilin-1

1

3

High-throughput

0.479

High

1095276

REST
RE1-silencing transcription factor

1

4

Small-scale

0.479

High

1100896

G3BP1
Ras GTPase-activating protein-binding protein 1

1

8

High-throughput

0.479

High

1121456

KEAP1
Kelch-like ECH-associated protein 1

1

4

High-throughput

0.479

High

1140554

KIF14
Kinesin-like protein KIF14

1

8

High-throughput

0.479

High

1157810

DDB1
DNA damage-binding protein 1

1

12

Small-scale

0.479

High

1180546

FHOD3
FH1/FH2 domain-containing protein 3

1

3

High-throughput

0.479

High

1193343

GLYR1
Cytokine-like nuclear factor N-PAC

1

7

High-throughput

0.479

High

1213776

KPRP
Keratinocyte proline-rich protein

1

2

High-throughput

0.479

High

1216046

TTBK1
Tau-tubulin kinase 1

1

20

High-throughput

0.479

High

1259117

LARP4
La-related protein 4

1

7

High-throughput

0.479

High

1279568

SPRE2
Sprouty-related, EVH1 domain-containing protein 2

1

1

High-throughput

0.479

High

1279864

RBBP6
E3 ubiquitin-protein ligase RBBP6

1

11

High-throughput

0.479

High

1286518

PHLB2
Pleckstrin homology-like domain family B member 2

1

18

High-throughput

0.479

High

1289945

LUZP1
Leucine zipper protein 1

1

20

High-throughput

0.479

High

1325498

PP4R1
Serine/threonine-protein phosphatase 4 regulatory subunit 1

1

5

High-throughput

0.479

High

1325501

DNJC9
DnaJ homolog subfamily C member 9

1

18

High-throughput

0.479

High

1325503

LPIN2
Phosphatidate phosphatase LPIN2

1

6

High-throughput

0.479

High

1325504

SEM4D
Semaphorin-4D

1

2

High-throughput

0.479

High

1325505

M4K1
Mitogen-activated protein kinase kinase kinase kinase 1

1

16

Small-scale

0.479

High

1325509

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

1

16

High-throughput

0.479

High

1325511

LRCH3
DISP complex protein LRCH3

1

8

High-throughput

0.479

High

1325513

ZDH15
Palmitoyltransferase ZDHHC15

1

2

High-throughput

0.479

High

1325516

ATX2
Ataxin-2

1

10

Small-scale

0.479

High

1325518

GORS1
Golgi reassembly-stacking protein 1

1

1

Small-scale

0.479

High

1325521

NLRP1
NACHT, LRR and PYD domains-containing protein 1

1

2

Small-scale

0.479

High

1325522

IF5A2
Eukaryotic translation initiation factor 5A-2

1

3

High-throughput

0.479

High

1325525

DOCK5
Dedicator of cytokinesis protein 5

1

5

High-throughput

0.479

High

1325530

SI1L2
Signal-induced proliferation-associated 1-like protein 2

1

8

High-throughput

0.479

High

1325535

G3BP2
Ras GTPase-activating protein-binding protein 2

1

9

High-throughput

0.479

High

1325500

PCNP
PEST proteolytic signal-containing nuclear protein

1

0

High-throughput

0.458

High

1325539

RT16
Small ribosomal subunit protein bS16m

1

0

High-throughput

0.458

High

1325540

MOFA1
MORF4 family-associated protein 1

1

0

Small-scale

0.458

High

256330

RT14
Small ribosomal subunit protein uS14m

1

1

High-throughput

0.437

High

294618

UDB17
UDP-glucuronosyltransferase 2B17

1

1

High-throughput

0.437

High

425738

PERM
Myeloperoxidase

1

1

High-throughput

0.437

High

443876

ATPB
ATP synthase F(1) complex subunit beta, mitochondrial

1

10

High-throughput

0.437

High

522460

ODP2
Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial

1

3

High-throughput

0.437

High

575799

MMP9
Matrix metalloproteinase-9

1

3

High-throughput

0.437

High

822202

CTRL
Chymotrypsin-like protease CTRL-1

1

1

High-throughput

0.437

High

937414

LAMB2
Laminin subunit beta-2

1

3

High-throughput

0.437

High

1133264

ARI5B
AT-rich interactive domain-containing protein 5B

1

7

High-throughput

0.437

High

1201949

BRDT
Bromodomain testis-specific protein

1

20

High-throughput

0.437

High

1217061

F222A
Protein FAM222A

1

3

High-throughput

0.437

High

1239452

H3C
Histone H3.3C

1

10

High-throughput

0.437

High

1240303

RUSD3
Mitochondrial mRNA pseudouridine synthase RPUSD3

1

2

High-throughput

0.437

High

1315876

GP135
G-protein coupled receptor 135

1

1

High-throughput

0.437

High

1325495

CBR4
3-oxoacyl-[acyl-carrier-protein] reductase

1

1

High-throughput

0.437

High

1325506

PTPR2
Receptor-type tyrosine-protein phosphatase N2

1

3

High-throughput

0.437

High

1325508

RUSD4
Pseudouridylate synthase RPUSD4, mitochondrial

1

2

High-throughput

0.437

High

1325510

DISP1
Protein dispatched homolog 1

1

1

High-throughput

0.437

High

1325512

YTDC1
YTH domain-containing protein 1

1

10

High-throughput

0.437

High

1325527

NANOG
Homeobox protein NANOG

1

17

Small-scale

0.437

High

1325528

ATD3A
ATPase family AAA domain-containing protein 3A

1

16

High-throughput

0.437

High

1325529

PAPD1
Poly(A) RNA polymerase, mitochondrial

1

2

High-throughput

0.437

High

1325536

RL26L
Ribosomal protein uL24-like

1

5

High-throughput

0.437

High

1325542

PCLO
Protein piccolo

1

2

High-throughput

0.437

High

94320

D6R9G5
Kelch like family member 2

1

5

High-throughput

0.407

High

244736

ZC3H1
Zinc finger C3H1 domain-containing protein

2

0

High-throughput

0.328

High

1325526

ZN408
Zinc finger protein 408

2

0

High-throughput

0.328

High

1198819

ZC21C
Zinc finger C2HC domain-containing protein 1C

1

0

High-throughput

0.279

Low

1325519

UTP23
rRNA-processing protein UTP23 homolog

1

0

High-throughput

0.279

Low

71087

SPMA1
Sperm microtubule associated protein 1

1

0

High-throughput

0.249

Low

283300

ERLN1
Erlin-1

1

0

High-throughput

0.249

Low

1030421

DIAC
Di-N-acetylchitobiase

1

0

High-throughput

0.249

Low

1253040

ACP7
Acid phosphatase type 7

1

0

High-throughput

0.249

Low

1287510

RM52
Large ribosomal subunit protein mL52

1

0

High-throughput

0.249

Low

1325520

SMAKA
Small membrane A-kinase anchor protein

1

0

High-throughput

0.249

Low

1325538

VWA7
von Willebrand factor A domain-containing protein 7

1

0

High-throughput

0.249

Low

1325541

COX11
Cytochrome c oxidase assembly protein COX11, mitochondrial

1

0

High-throughput

0.249

Low

1325532

SL9A2
Sodium/hydrogen exchanger 2

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025