HitPredict

Interactor 1: HPCA (P84074)
Neuron-specific calcium-binding protein hippocalcin (Calcium-binding protein BDR-2)
Gene: HPCA

Interactor 2: M3K21 (Q5TCX8)
Mitogen-activated protein kinase kinase kinase 21 (EC 2.7.11.25) (Mitogen-activated protein kinase kinase kinase MLK4) (Mixed lineage kinase 4)
Gene: MAP3K21

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	33961781, 36736316
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 193 Hs			1 1036
+	Hs
		789641 HPCL1_HUMAN (1-193): 2.81e-60: 188: 94.30		M3K21_HUMAN (1-1036): 0: 697: 100.00
+	Hs
		962896 NCALD_HUMAN (1-193): 3.56e-58: 182: 88.08		M3K21_HUMAN (1-1036): 0: 697: 100.00
+	Hs
		968636 NCS1_HUMAN (1-187): 3.46e-47: 154: 58.82		M3K21_HUMAN (1-1036): 0: 697: 100.00
+	Hs
		789631 HPCL1_HUMAN (1-193): 2.81e-60: 188: 94.30		M3K10_HUMAN (30-1021): 0: 558: 44.98
+	Hs
		789629 HPCL1_HUMAN (1-193): 2.81e-60: 188: 94.30		M3K9_HUMAN (38-1036): 6.77e-180: 555: 47.56
+	Hs
		1014850 HPCA_HUMAN (1-193): 1.45e-57: 181: 100.00		M3K10_HUMAN (30-1021): 0: 558: 44.98
+	Hs
		1009756 HPCA_HUMAN (1-193): 1.45e-57: 181: 100.00		M3K9_HUMAN (38-1036): 6.77e-180: 555: 47.56
+	Hs
		968629 NCS1_HUMAN (1-187): 3.46e-47: 154: 58.82		M3K9_HUMAN (38-1036): 6.77e-180: 555: 47.56
+	Hs
		789637 HPCL1_HUMAN (1-193): 2.81e-60: 188: 94.30		M3K11_HUMAN (32-882): 3.16e-142: 449: 44.69
+	Hs
		962893 NCALD_HUMAN (1-193): 3.56e-58: 182: 88.08		M3K11_HUMAN (32-882): 3.16e-142: 449: 44.69
+	Hs
		1014854 HPCA_HUMAN (1-193): 1.45e-57: 181: 100.00		M3K11_HUMAN (32-882): 3.16e-142: 449: 44.69
+	Hs
		968634 NCS1_HUMAN (1-187): 3.46e-47: 154: 58.82		M3K11_HUMAN (32-882): 3.16e-142: 449: 44.69