Protein: M3K11
Mitogen-activated protein kinase kinase kinase 11 (EC 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline-rich kinase)

Gene: M3K11, MAP3K11
Organism: Homo sapiens
Interactions: 59
UniProt ID: Q16584

Gene Ontology (top 5):
GO:0000165 - MAPK cascade
GO:0004672 - protein kinase activity
GO:0004674 - protein serine/threonine kinase activity
GO:0004706 - JUN kinase kinase kinase activity
GO:0004709 - MAP kinase kinase kinase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

955218

CDC42
Cell division control protein 42 homolog

4

16

Small-scale

0.874

High

1159145

JIP1
C-Jun-amino-terminal kinase-interacting protein 1

2

9

Small-scale

0.834

High

162000

MP2K7
Dual specificity mitogen-activated protein kinase kinase 7

2

14

Small-scale

0.778

High

988397

RAC1
Ras-related C3 botulinum toxin substrate 1

2

16

Small-scale

0.757

High

1159138

M4K1
Mitogen-activated protein kinase kinase kinase kinase 1

2

9

Small-scale

0.757

High

167908

IKKB
Inhibitor of nuclear factor kappa-B kinase subunit beta

1

7

Small-scale

0.757

High

177882

IKKA
Inhibitor of nuclear factor kappa-B kinase subunit alpha

1

7

Small-scale

0.757

High

767224

MERL
Merlin

1

3

Small-scale

0.757

High

461529

HS90A
Heat shock protein HSP 90-alpha

2

17

Small-scale

0.754

High

349102

LATS1
Serine/threonine-protein kinase LATS1

1

6

Small-scale

0.747

High

728267

AKT1
RAC-alpha serine/threonine-protein kinase

1

4

Small-scale

0.747

High

1103696

JIP2
C-Jun-amino-terminal kinase-interacting protein 2

1

10

Small-scale

0.724

High

1159128

M3K21
Mitogen-activated protein kinase kinase kinase 21

1

18

Small-scale

0.724

High

1159132

SH3R1
E3 ubiquitin-protein ligase SH3RF1

1

9

Small-scale

0.724

High

891176

GSK3A
Glycogen synthase kinase-3 alpha

1

12

Small-scale

0.665

High

1087659

M4K2
Mitogen-activated protein kinase kinase kinase kinase 2

1

11

Small-scale

0.665

High

1159147

TRAF6
TNF receptor-associated factor 6

3

8

Small-scale

0.664

High

249143

DSCAM
Cell adhesion molecule DSCAM

1

0

High-throughput

0.663

High

853892

MP2K4
Dual specificity mitogen-activated protein kinase kinase 4

1

15

Small-scale

0.647

High

1015466

RHOG
Rho-related GTP-binding protein RhoG

1

16

Small-scale

0.647

High

699769

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

1

9

Small-scale

0.625

High

1090341

EPS8
Epidermal growth factor receptor kinase substrate 8

1

18

High-throughput

0.621

High

468420

HS90B
Heat shock protein HSP 90-beta

1

17

Small-scale

0.618

High

581073

RAC2
Ras-related C3 botulinum toxin substrate 2

1

16

High-throughput

0.618

High

891585

GSK3B
Glycogen synthase kinase-3 beta

1

9

Small-scale

0.618

High

953471

RAC3
Ras-related C3 botulinum toxin substrate 3

1

14

High-throughput

0.618

High

990272

1433Z
14-3-3 protein zeta/delta

1

20

Small-scale

0.618

High

1006073

DLG4
Disks large homolog 4

1

4

Small-scale

0.618

High

1158336

CDC37
Hsp90 co-chaperone Cdc37

1

4

Small-scale

0.618

High

1159127

M3K11
Mitogen-activated protein kinase kinase kinase 11

1

17

Small-scale

0.618

High

1090668

TRAF2
TNF receptor-associated factor 2

2

7

Small-scale

0.584

High

1159143

CHIP
E3 ubiquitin-protein ligase CHIP

1

5

Small-scale

0.578

High

853691

MK08
Mitogen-activated protein kinase 8

1

16

Small-scale

0.575

High

1159137

CSN5
COP9 signalosome complex subunit 5

1

1

High-throughput

0.541

High

422182

A4
Amyloid-beta precursor protein

1

2

Small-scale

0.501

High

1159144

JIP3
C-Jun-amino-terminal kinase-interacting protein 3

1

5

Small-scale

0.501

High

176612

KIF3B
Kinesin-like protein KIF3B

1

7

Small-scale

0.481

High

1159136

KIFA3
Kinesin-associated protein 3

1

4

Small-scale

0.481

High

1159142

KIF17
Kinesin-like protein KIF17

1

7

Small-scale

0.481

High

1159146

KIF3A
Kinesin-like protein KIF3A

1

7

Small-scale

0.481

High

136695

TRAF5
TNF receptor-associated factor 5

1

7

Small-scale

0.479

High

651345

CBL
E3 ubiquitin-protein ligase CBL

1

5

Small-scale

0.479

High

761695

HSP74
Heat shock 70 kDa protein 4

1

2

Small-scale

0.479

High

789637

HPCL1
Hippocalcin-like protein 1

1

12

High-throughput

0.479

High

962893

NCALD
Neurocalcin-delta

1

12

High-throughput

0.479

High

968634

NCS1
Neuronal calcium sensor 1

1

12

High-throughput

0.479

High

1014854

HPCA
Neuron-specific calcium-binding protein hippocalcin

1

12

High-throughput

0.479

High

1092403

GRIK2
Glutamate receptor ionotropic, kainate 2

1

2

Small-scale

0.479

High

1159131

ATG9A
Autophagy-related protein 9A

1

2

High-throughput

0.479

High

1159134

RBCC1
RB1-inducible coiled-coil protein 1

1

5

High-throughput

0.479

High

1159140

TRIM5
Tripartite motif-containing protein 5

1

2

Small-scale

0.479

High

1109280

PIN1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1

1

0

High-throughput

0.460

High

1159129

PLGT2
Protein O-glucosyltransferase 2

1

0

High-throughput

0.458

High

1159133

PELI3
E3 ubiquitin-protein ligase pellino homolog 3

1

0

Small-scale

0.458

High

1159139

SPTCS
Spatacsin

1

0

Small-scale

0.438

High

1159135

ESR2
Estrogen receptor beta

1

4

High-throughput

0.437

High

1159130

CLC4G
C-type lectin domain family 4 member G

1

0

High-throughput

0.265

Low

1159141

SPRTN
DNA-dependent metalloprotease SPRTN

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025