Protein: M3K21
Mitogen-activated protein kinase kinase kinase 21 (EC 2.7.11.25) (Mitogen-activated protein kinase kinase kinase MLK4) (Mixed lineage kinase 4)

Gene: M3K21, MAP3K21
Organism: Homo sapiens
Interactions: 110
UniProt ID: Q5TCX8

Gene Ontology (top 5):
GO:0004672 - protein kinase activity
GO:0004706 - JUN kinase kinase kinase activity
GO:0005524 - ATP binding
GO:0005737 - cytoplasm
GO:0006468 - protein phosphorylation

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

729919

1433B
14-3-3 protein beta/alpha

7

20

High-throughput

0.968

High

966440

1433G
14-3-3 protein gamma

5

20

High-throughput

0.932

High

990327

1433Z
14-3-3 protein zeta/delta

5

20

High-throughput

0.932

High

1049390

1433F
14-3-3 protein eta

5

20

High-throughput

0.932

High

691099

1433T
14-3-3 protein theta

4

20

High-throughput

0.903

High

971620

1433E
14-3-3 protein epsilon

3

10

High-throughput

0.876

High

1038574

M3K10
Mitogen-activated protein kinase kinase kinase 10

2

19

High-throughput

0.817

High

1105960

FKBP5
Peptidyl-prolyl cis-trans isomerase FKBP5

2

3

High-throughput

0.789

High

1159128

M3K11
Mitogen-activated protein kinase kinase kinase 11

1

18

Small-scale

0.724

High

177889

IKKA
Inhibitor of nuclear factor kappa-B kinase subunit alpha

1

11

Small-scale

0.715

High

461582

HS90A
Heat shock protein HSP 90-alpha

1

20

High-throughput

0.691

High

468478

HS90B
Heat shock protein HSP 90-beta

1

20

High-throughput

0.691

High

1009762

M3K9
Mitogen-activated protein kinase kinase kinase 9

1

18

High-throughput

0.691

High

1158371

CDC37
Hsp90 co-chaperone Cdc37

1

4

High-throughput

0.691

High

1216029

HIF1N
Hypoxia-inducible factor 1-alpha inhibitor

4

0

High-throughput

0.667

High

889435

CLK1
Dual specificity protein kinase CLK1

1

4

High-throughput

0.647

High

167913

IKKB
Inhibitor of nuclear factor kappa-B kinase subunit beta

1

13

Small-scale

0.618

High

176835

DCLK1
Serine/threonine-protein kinase DCLK1

1

8

High-throughput

0.618

High

245235

MAST3
Microtubule-associated serine/threonine-protein kinase 3

1

5

High-throughput

0.618

High

269560

SRGP2
SLIT-ROBO Rho GTPase-activating protein 2

1

9

High-throughput

0.618

High

375597

RASK
GTPase KRas

1

6

High-throughput

0.618

High

440111

LCK
Tyrosine-protein kinase Lck

1

20

High-throughput

0.618

High

463574

LYN
Tyrosine-protein kinase Lyn

1

20

High-throughput

0.618

High

730654

1433S
14-3-3 protein sigma

1

20

High-throughput

0.618

High

978070

RHOB
Rho-related GTP-binding protein RhoB

1

20

High-throughput

0.618

High

1025555

CDK16
Cyclin-dependent kinase 16

1

10

High-throughput

0.618

High

1215997

SPD2A
SH3 and PX domain-containing protein 2A

1

12

High-throughput

0.618

High

1216006

RGPS2
Ras-specific guanine nucleotide-releasing factor RalGPS2

1

6

High-throughput

0.618

High

1216007

KSR1
Kinase suppressor of Ras 1

1

18

High-throughput

0.618

High

1216015

RHOV
Rho-related GTP-binding protein RhoV

1

20

High-throughput

0.618

High

1216018

TESK2
Dual specificity testis-specific protein kinase 2

1

13

High-throughput

0.618

High

1014857

HPCA
Neuron-specific calcium-binding protein hippocalcin

2

12

High-throughput

0.611

High

1216024

RTKN
Rhotekin

1

0

High-throughput

0.586

High

1216022

SLX1
Structure-specific endonuclease subunit SLX1

2

1

High-throughput

0.574

High

789641

HPCL1
Hippocalcin-like protein 1

2

12

High-throughput

0.558

High

341078

DIRA3
GTP-binding protein Di-Ras3

1

2

High-throughput

0.553

High

953498

RAC3
Ras-related C3 botulinum toxin substrate 3

1

20

High-throughput

0.553

High

1092441

TIAM1
Rho guanine nucleotide exchange factor TIAM1

1

6

High-throughput

0.553

High

1144947

RAB35
Ras-related protein Rab-35

1

2

High-throughput

0.553

High

1215999

AN34A
Ankyrin repeat domain-containing protein 34A

1

3

High-throughput

0.553

High

1216001

PKHA7
Pleckstrin homology domain-containing family A member 7

1

17

High-throughput

0.553

High

1216005

PHLB2
Pleckstrin homology-like domain family B member 2

1

7

High-throughput

0.553

High

1216031

LRFN1
Leucine-rich repeat and fibronectin type III domain-containing protein 1

1

5

High-throughput

0.553

High

1216039

AGAP1
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1

1

3

High-throughput

0.553

High

1216038

CHIP
E3 ubiquitin-protein ligase CHIP

1

4

Small-scale

0.536

High

274619

DNJB6
DnaJ homolog subfamily B member 6

1

3

High-throughput

0.536

High

968636

NCS1
Neuronal calcium sensor 1

1

12

High-throughput

0.536

High

1010313

BASP1
Brain acid soluble protein 1

1

2

High-throughput

0.536

High

1022871

EFNB1
Ephrin-B1

1

2

High-throughput

0.536

High

1216013

USP9X
Ubiquitin carboxyl-terminal hydrolase 9X

1

4

High-throughput

0.536

High

1216019

TCPQM
T-complex protein 1 subunit theta-like 2

1

5

High-throughput

0.536

High

1216020

DNJC7
DnaJ homolog subfamily C member 7

1

1

High-throughput

0.536

High

1216025

CHODL
Chondrolectin

1

1

High-throughput

0.536

High

1216042

TACC3
Transforming acidic coiled-coil-containing protein 3

1

5

High-throughput

0.536

High

1216043

KCNE3
Potassium voltage-gated channel subfamily E member 3

1

1

High-throughput

0.536

High

976322

RB11A
Ras-related protein Rab-11A

1

0

High-throughput

0.517

High

1054469

EXOS9
Exosome complex component RRP45

1

0

High-throughput

0.513

High

483118

CLCA
Clathrin light chain A

1

5

High-throughput

0.489

High

483347

CLCB
Clathrin light chain B

1

4

High-throughput

0.489

High

551089

PCNA
Proliferating cell nuclear antigen

1

2

High-throughput

0.489

High

962896

NCALD
Neurocalcin-delta

1

12

High-throughput

0.489

High

1129816

EPN4
Clathrin interactor 1

1

1

High-throughput

0.489

High

1216008

DJC10
DnaJ homolog subfamily C member 10

1

1

High-throughput

0.489

High

159690

DVL2
Segment polarity protein dishevelled homolog DVL-2

1

10

High-throughput

0.479

High

208677

SI1L1
Signal-induced proliferation-associated 1-like protein 1

1

1

High-throughput

0.479

High

230536

KIF1C
Kinesin-like protein KIF1C

1

7

High-throughput

0.479

High

637906

NF1
Neurofibromin

1

4

High-throughput

0.479

High

719228

MPIP2
M-phase inducer phosphatase 2

1

1

High-throughput

0.479

High

719335

MPIP3
M-phase inducer phosphatase 3

1

1

High-throughput

0.479

High

799198

BRCA1
Breast cancer type 1 susceptibility protein

1

5

High-throughput

0.479

High

940990

HDAC4
Histone deacetylase 4

1

2

High-throughput

0.479

High

1133978

ZN638
Zinc finger protein 638

1

1

High-throughput

0.479

High

1216003

SYDE1
Rho GTPase-activating protein SYDE1

1

9

High-throughput

0.479

High

1216017

MAGI1
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1

1

7

High-throughput

0.479

High

1216026

KI13B
Kinesin-like protein KIF13B

1

7

High-throughput

0.479

High

1216027

I17RB
Interleukin-17 receptor B

1

1

Small-scale

0.479

High

1216034

NGAP
Ras GTPase-activating protein nGAP

1

4

High-throughput

0.479

High

1216037

PPM1H
Protein phosphatase 1H

1

5

High-throughput

0.479

High

252078

IF4E2
Eukaryotic translation initiation factor 4E type 2

1

0

High-throughput

0.458

High

293821

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.458

High

339081

NADK
NAD kinase

1

0

High-throughput

0.458

High

1004085

CXAR
Coxsackievirus and adenovirus receptor

1

0

High-throughput

0.458

High

1216021

SIN1
Target of rapamycin complex 2 subunit MAPKAP1

1

0

High-throughput

0.458

High

1216035

UBP21
Ubiquitin carboxyl-terminal hydrolase 21

1

0

High-throughput

0.458

High

1216040

CBY1
Protein chibby homolog 1

1

0

High-throughput

0.458

High

281335

GGYF1
GRB10-interacting GYF protein 1

1

1

High-throughput

0.437

High

562113

LAMP2
Lysosome-associated membrane glycoprotein 2

1

1

High-throughput

0.437

High

642921

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

2

High-throughput

0.437

High

1065711

CAMP2
Calmodulin-regulated spectrin-associated protein 2

1

5

High-throughput

0.437

High

1215998

DEN4C
DENN domain-containing protein 4C

1

4

High-throughput

0.437

High

1216000

LTOR1
Ragulator complex protein LAMTOR1

1

1

High-throughput

0.437

High

1216002

GGYF2
GRB10-interacting GYF protein 2

1

12

High-throughput

0.437

High

1216004

ATG9A
Autophagy-related protein 9A

1

2

High-throughput

0.437

High

1216009

F110B
Protein FAM110B

1

2

High-throughput

0.437

High

1216011

DEN1A
DENN domain-containing protein 1A

1

5

High-throughput

0.437

High

1216014

CK052
Uncharacterized protein C11orf52

1

1

High-throughput

0.437

High

1216023

F110A
Protein FAM110A

1

2

High-throughput

0.437

High

1216028

INP5E
Phosphatidylinositol polyphosphate 5-phosphatase type IV

1

6

High-throughput

0.437

High

1216032

CING
Cingulin

1

7

High-throughput

0.437

High

1216033

LIMA1
LIM domain and actin-binding protein 1

1

6

High-throughput

0.437

High

1216036

ZBT21
Zinc finger and BTB domain-containing protein 21

1

1

High-throughput

0.437

High

379525

IGHM
Immunoglobulin heavy constant mu

1

1

High-throughput

0.407

High

1216010

HAVR2
Hepatitis A virus cellular receptor 2

2

0

High-throughput

0.328

High

190383

COPT1
High affinity copper uptake protein 1

1

0

High-throughput

0.279

Low

1216016

OPALI
Opalin

1

0

High-throughput

0.279

Low

596147

H12
Histone H1.2

1

0

High-throughput

0.269

Low

189618

STX7
Syntaxin-7

1

0

High-throughput

0.249

Low

1216012

SRS12
Serine/arginine-rich splicing factor 12

1

0

High-throughput

0.249

Low

1216030

FA53C
Protein FAM53C

1

0

High-throughput

0.249

Low

1216041

KCTD3
BTB/POZ domain-containing protein KCTD3

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025