HitPredict

Interactor 1: STK4 (Q13043)
Serine/threonine-protein kinase 4 (EC 2.7.11.1) (Mammalian STE20-like protein kinase 1) (MST-1) (STE20-like kinase MST1) (Serine/threonine-protein kinase Krs-2) [Cleaved into: Serine/threonine-protein kinase 4 37kDa subunit (MST1/N); Serine/threonine-protein kinase 4 18kDa subunit (MST1/C)]
Gene: STK4

Interactor 2: H2B2E (Q16778)
Histone H2B type 2-E (H2B-clustered histone 21) (Histone H2B-GL105) (Histone H2B.q) (H2B/q)
Gene: H2BC21

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.60	0.60	0.602

Property	Details
Experiments	21572393, 12757711
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 487 Hs			1 126
+	Hs
		617927 AKT2_HUMAN (3-353): 1.95e-134: 398: 21.88		H2B1O_HUMAN (1-126): 3.25e-54: 167: 99.21
+	Hs
		420807 AKT2_HUMAN (3-353): 1.95e-134: 398: 21.88		H2B1J_HUMAN (1-126): 7.8e-54: 166: 99.21
+	Hs
		682181 AKT2_HUMAN (3-353): 1.95e-134: 398: 21.88		H2B2E_HUMAN (1-126): 6.69e-54: 166: 100.00
+	Hs
		682137 AKT2_HUMAN (3-353): 1.95e-134: 398: 21.88		H2B1B_HUMAN (1-126): 1.74e-53: 165: 98.41
+	Mm
		682111 AKT1_MOUSE (3-350): 2.1e-132: 393: 20.89		H2B2B_MOUSE (1-126): 2.34e-54: 168: 97.62
+	Mm
		682113 AKT1_MOUSE (3-350): 2.1e-132: 393: 20.89		H2B1C_MOUSE (1-126): 1.18e-53: 166: 99.21
+	Hs
		682194 AKT2_HUMAN (3-353): 1.95e-134: 398: 21.88		H2B3B_HUMAN (1-126): 1.01e-51: 161: 96.03
+	Hs
		568756 KAPCA_HUMAN (14-319): 7.68e-123: 364: 26.90		H2B1H_HUMAN (1-126): 6.27e-54: 166: 98.41
+	Hs
		610760 KAPCB_HUMAN (14-319): 8.38e-123: 364: 25.63		H2B1H_HUMAN (1-126): 6.27e-54: 166: 98.41
+	Hs
		241440 KAPCA_HUMAN (14-319): 7.68e-123: 364: 26.90		H2B1K_HUMAN (1-126): 1.56e-53: 165: 98.41
+	Hs
		610687 KAPCB_HUMAN (14-319): 8.38e-123: 364: 25.63		H2B1B_HUMAN (1-126): 1.74e-53: 165: 98.41
+	Hs
		277601 PAK3_HUMAN (10-300): 1.05e-117: 358: 41.86		H2B1C_HUMAN (1-126): 1.18e-53: 166: 99.21
+	Hs
		241401 PAK3_HUMAN (10-300): 1.05e-117: 358: 41.86		H2B1K_HUMAN (1-126): 1.56e-53: 165: 98.41
+	Hs
		610761 KAPCB_HUMAN (14-319): 8.38e-123: 364: 25.63		H2B1A_HUMAN (1-126): 3.43e-46: 147: 85.04
+	Hs
		1087315 M4K1_HUMAN (17-281): 2.36e-74: 252: 45.22		H2B2E_HUMAN (1-126): 6.69e-54: 166: 100.00