Protein: KLF5
Krueppel-like factor 5 (Basic transcription element-binding protein 2) (BTE-binding protein 2) (Colon krueppel-like factor) (GC-box-binding protein 2) (Intestinal-enriched krueppel-like factor) (Transcription factor BTEB2)

Gene: KLF5
Organism: Homo sapiens
Interactions: 197
UniProt ID: Q13887

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000785 - chromatin
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001228 - DNA-binding transcription activator activity, RNA polymerase II-specific

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

891532

GSK3B
Glycogen synthase kinase-3 beta

2

9

Small-scale

0.812

High

1118752

FBXW7
F-box/WD repeat-containing protein 7

6

13

Small-scale

0.735

High

1067307

EP300
Histone acetyltransferase p300

5

20

Small-scale

0.709

High

520578

RARA
Retinoic acid receptor alpha

4

20

Small-scale

0.692

High

891157

GSK3A
Glycogen synthase kinase-3 alpha

1

7

High-throughput

0.691

High

1118775

WWP1
NEDD4-like E3 ubiquitin-protein ligase WWP1

8

10

Small-scale

0.687

High

1094498

ZBT17
Zinc finger and BTB domain-containing protein 17

1

19

Small-scale

0.665

High

167262

KLF11
Krueppel-like factor 11

1

19

High-throughput

0.665

High

603264

KPCA
Protein kinase C alpha type

1

6

Small-scale

0.647

High

1118749

CBP
CREB-binding protein

3

20

Small-scale

0.647

High

940389

MAZ
Myc-associated zinc finger protein

1

17

High-throughput

0.646

High

1118782

SMUF2
E3 ubiquitin-protein ligase SMURF2

2

10

Small-scale

0.643

High

1118742

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

2

4

Small-scale

0.634

High

1118704

TRI25
E3 ubiquitin/ISG15 ligase TRIM25

2

17

Small-scale

0.624

High

278340

NCOR1
Nuclear receptor corepressor 1

2

20

Small-scale

0.620

High

1118800

NCOR2
Nuclear receptor corepressor 2

2

18

Small-scale

0.620

High

586294

ZEP1
Zinc finger protein 40

1

20

High-throughput

0.618

High

613031

EGR1
Early growth response protein 1

1

20

Small-scale

0.618

High

1118796

ZN148
Zinc finger protein 148

1

19

High-throughput

0.618

High

1118797

ZN281
Zinc finger protein 281

1

19

High-throughput

0.618

High

1118711

SMAD2
Mothers against decapentaplegic homolog 2

2

12

Small-scale

0.601

High

927287

ATX1
Ataxin-1

2

9

High-throughput

0.601

High

626224

NFKB1
Nuclear factor NF-kappa-B p105 subunit

2

20

Small-scale

0.584

High

764738

CTNB1
Catenin beta-1

2

12

Small-scale

0.584

High

862117

YAP1
Transcriptional coactivator YAP1

2

19

Small-scale

0.584

High

886839

CEBPA
CCAAT/enhancer-binding protein alpha

2

17

Small-scale

0.584

High

1047969

TLE3
Transducin-like enhancer protein 3

2

19

High-throughput

0.584

High

396078

ESR1
Estrogen receptor

1

20

Small-scale

0.561

High

487290

PARP1
Poly [ADP-ribose] polymerase 1

1

7

Small-scale

0.561

High

625813

RXRA
Retinoic acid receptor RXR-alpha

1

20

Small-scale

0.561

High

1029284

SET
Protein SET

1

6

Small-scale

0.561

High

1109706

HDAC1
Histone deacetylase 1

1

20

Small-scale

0.561

High

1118744

AN32B
Acidic leucine-rich nuclear phosphoprotein 32 family member B

1

4

Small-scale

0.561

High

1118745

ESR2
Estrogen receptor beta

1

20

Small-scale

0.561

High

606745

CEBPB
CCAAT/enhancer-binding protein beta

1

17

Small-scale

0.552

High

789493

PPARG
Peroxisome proliferator-activated receptor gamma

1

20

Small-scale

0.552

High

921335

CEBPG
CCAAT/enhancer-binding protein gamma

1

20

Small-scale

0.552

High

1118760

NED4L
E3 ubiquitin-protein ligase NEDD4-like

1

10

High-throughput

0.536

High

1118781

ARP5
Actin-related protein 5

1

10

High-throughput

0.536

High

1118793

AKP8L
A-kinase anchor protein 8-like

1

8

High-throughput

0.536

High

1118799

PUS1
Pseudouridylate synthase 1 homolog

1

1

High-throughput

0.536

High

1106528

SMAD4
Mothers against decapentaplegic homolog 4

1

12

Small-scale

0.534

High

1118778

ATX3L
Ataxin-3-like protein

1

1

Small-scale

0.528

High

507950

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

7

Small-scale

0.515

High

1014506

SMAD3
Mothers against decapentaplegic homolog 3

1

12

Small-scale

0.515

High

159970

IDLC
Axonemal dynein light intermediate polypeptide 1

1

1

High-throughput

0.515

High

274571

DNJB6
DnaJ homolog subfamily B member 6

1

8

High-throughput

0.515

High

856680

BAG6
Large proline-rich protein BAG6

1

20

High-throughput

0.515

High

1118753

COQA1
Collagen alpha-1(XXVI) chain

1

5

High-throughput

0.515

High

1118789

CTNL1
Alpha-catulin

1

2

Small-scale

0.504

High

429862

JUN
Transcription factor Jun

1

12

Small-scale

0.501

High

628777

TBP
TATA-box-binding protein

1

2

Small-scale

0.501

High

861605

NEDD4
E3 ubiquitin-protein ligase NEDD4

1

10

High-throughput

0.501

High

993560

UBC9
SUMO-conjugating enzyme UBC9

1

4

Small-scale

0.501

High

1025096

TF2B
Transcription initiation factor IIB

1

3

Small-scale

0.501

High

165325

PSA7
Proteasome subunit alpha type-7

1

15

High-throughput

0.500

High

475355

RS17
Small ribosomal subunit protein eS17

1

3

High-throughput

0.500

High

577750

PLAK
Junction plakoglobin

1

12

High-throughput

0.500

High

681158

PSA2
Proteasome subunit alpha type-2

1

18

High-throughput

0.500

High

766538

PHB1
Prohibitin 1

1

6

High-throughput

0.500

High

860514

RS5
Small ribosomal subunit protein uS7

1

10

High-throughput

0.500

High

875657

PRC2A
Protein PRRC2A

1

20

High-throughput

0.500

High

887651

PSB2
Proteasome subunit beta type-2

1

20

High-throughput

0.500

High

961722

RL37A
Large ribosomal subunit protein eL43

1

4

High-throughput

0.500

High

973433

RS11
Small ribosomal subunit protein uS17

1

6

High-throughput

0.500

High

982429

RS15
Small ribosomal subunit protein uS19

1

5

High-throughput

0.500

High

1005863

GTF2I
General transcription factor II-I

1

5

High-throughput

0.500

High

1089395

ILF2
Interleukin enhancer-binding factor 2

1

8

High-throughput

0.500

High

1118734

CCAR2
Cell cycle and apoptosis regulator protein 2

1

7

High-throughput

0.500

High

1118774

XRN2
5'-3' exoribonuclease 2

1

3

High-throughput

0.500

High

939492

FCGRN
IgG receptor FcRn large subunit p51

1

1

High-throughput

0.489

High

569101

T2FB
General transcription factor IIF subunit 2

1

0

Small-scale

0.480

High

708962

T2EB
Transcription initiation factor IIE subunit beta

1

0

Small-scale

0.480

High

1118770

PDIP3
Polymerase delta-interacting protein 3

1

0

High-throughput

0.479

High

139000

BCL9
B-cell CLL/lymphoma 9 protein

1

20

High-throughput

0.479

High

154690

ARI1A
AT-rich interactive domain-containing protein 1A

1

20

High-throughput

0.479

High

161465

KMT2D
Histone-lysine N-methyltransferase 2D

1

20

High-throughput

0.479

High

162566

ANM5
Protein arginine N-methyltransferase 5

1

5

Small-scale

0.479

High

172797

XPO1
Exportin-1

1

19

High-throughput

0.479

High

174352

ZN609
Zinc finger protein 609

1

15

High-throughput

0.479

High

180810

TIF1A
Transcription intermediary factor 1-alpha

1

20

High-throughput

0.479

High

185684

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

9

Small-scale

0.479

High

194563

KDM6A
Lysine-specific demethylase 6A

1

14

High-throughput

0.479

High

259927

BRD4
Bromodomain-containing protein 4

1

20

High-throughput

0.479

High

371984

MYC
Myc proto-oncogene protein

1

20

Small-scale

0.479

High

413804

P53
Cellular tumor antigen p53

1

12

Small-scale

0.479

High

505559

ATX1L
Ataxin-1-like

1

9

High-throughput

0.479

High

520027

ANDR
Androgen receptor

1

20

High-throughput

0.479

High

533661

CLUS
Clusterin

1

1

Small-scale

0.479

High

559758

NR2C1
Nuclear receptor subfamily 2 group C member 1

1

20

High-throughput

0.479

High

624254

TFE3
Transcription factor E3

1

18

High-throughput

0.479

High

787870

SRBP1
Sterol regulatory element-binding protein 1

1

20

Small-scale

0.479

High

841359

RBM34
RNA-binding protein 34

1

13

High-throughput

0.479

High

895834

CSRP3
Cysteine and glycine-rich protein 3

1

6

Small-scale

0.479

High

903153

SMCA2
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2

1

20

High-throughput

0.479

High

905401

HCFC1
Host cell factor 1

1

3

Small-scale

0.479

High

936514

AF10
Protein AF-10

1

2

High-throughput

0.479

High

943237

RBM11
Splicing regulator RBM11

1

8

High-throughput

0.479

High

951668

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

3

Small-scale

0.479

High

979632

H4
Histone H4

1

7

High-throughput

0.479

High

991321

SUMO1
Small ubiquitin-related modifier 1

1

3

Small-scale

0.479

High

1017419

FOXK1
Forkhead box protein K1

1

17

High-throughput

0.479

High

1045269

TF65
Transcription factor p65

1

17

High-throughput

0.479

High

1047813

TLE1
Transducin-like enhancer protein 1

1

19

High-throughput

0.479

High

1061691

TLE5
TLE family member 5

1

12

High-throughput

0.479

High

1087729

NFIA
Nuclear factor 1 A-type

1

20

High-throughput

0.479

High

1112287

PWP1
Periodic tryptophan protein 1 homolog

1

20

High-throughput

0.479

High

1118705

NCOA6
Nuclear receptor coactivator 6

1

20

High-throughput

0.479

High

1118707

MEF2D
Myocyte-specific enhancer factor 2D

1

6

High-throughput

0.479

High

1118708

RBBP5
Retinoblastoma-binding protein 5

1

12

High-throughput

0.479

High

1118709

SSXT
Protein SSXT

1

14

High-throughput

0.479

High

1118710

NCOA2
Nuclear receptor coactivator 2

1

14

High-throughput

0.479

High

1118713

ARI4B
AT-rich interactive domain-containing protein 4B

1

20

High-throughput

0.479

High

1118714

BCL7A
B-cell CLL/lymphoma 7 protein family member A

1

2

High-throughput

0.479

High

1118717

RBM20
RNA-binding protein 20

1

5

High-throughput

0.479

High

1118718

ZMYM4
Zinc finger MYM-type protein 4

1

20

High-throughput

0.479

High

1118719

ARID2
AT-rich interactive domain-containing protein 2

1

20

High-throughput

0.479

High

1118720

NIPBL
Nipped-B-like protein

1

16

High-throughput

0.479

High

1118721

TET2
Methylcytosine dioxygenase TET2

1

1

High-throughput

0.479

High

1118723

BCOR
BCL-6 corepressor

1

20

High-throughput

0.479

High

1118725

PAXI1
PAX-interacting protein 1

1

9

High-throughput

0.479

High

1118728

LDB1
LIM domain-binding protein 1

1

1

High-throughput

0.479

High

1118729

PB1
Protein polybromo-1

1

20

High-throughput

0.479

High

1118731

FOXP4
Forkhead box protein P4

1

20

High-throughput

0.479

High

1118732

ARI3B
AT-rich interactive domain-containing protein 3B

1

20

High-throughput

0.479

High

1118733

MGAP
MAX gene-associated protein

1

12

High-throughput

0.479

High

1118735

RYBP
RING1 and YY1-binding protein

1

4

High-throughput

0.479

High

1118737

KMT2C
Histone-lysine N-methyltransferase 2C

1

20

High-throughput

0.479

High

1118738

ARI1B
AT-rich interactive domain-containing protein 1B

1

20

High-throughput

0.479

High

1118739

KDM2B
Lysine-specific demethylase 2B

1

11

High-throughput

0.479

High

1118740

MORC4
MORC family CW-type zinc finger protein 4

1

2

High-throughput

0.479

High

1118741

PHF10
PHD finger protein 10

1

20

High-throughput

0.479

High

1118743

MAML1
Mastermind-like protein 1

1

19

High-throughput

0.479

High

1118746

HDAC2
Histone deacetylase 2

1

20

Small-scale

0.479

High

1118747

DPF1
Zinc finger protein neuro-d4

1

20

High-throughput

0.479

High

1118748

REQU
Zinc finger protein ubi-d4

1

20

High-throughput

0.479

High

1118750

SMRD2
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2

1

11

High-throughput

0.479

High

1118751

SMCE1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1

1

12

High-throughput

0.479

High

1118754

ZBT10
Zinc finger and BTB domain-containing protein 10

1

19

High-throughput

0.479

High

1118755

SMRD1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1

1

5

High-throughput

0.479

High

1118757

FUBP3
Far upstream element-binding protein 3

1

11

High-throughput

0.479

High

1118758

EHMT2
Histone-lysine N-methyltransferase EHMT2

1

19

High-throughput

0.479

High

1118759

EP400
E1A-binding protein p400

1

20

High-throughput

0.479

High

1118762

PHF12
PHD finger protein 12

1

20

High-throughput

0.479

High

1118764

CIC
Protein capicua homolog

1

20

High-throughput

0.479

High

1118765

ARI3A
AT-rich interactive domain-containing protein 3A

1

20

High-throughput

0.479

High

1118766

MEP50
Methylosome protein WDR77

1

12

Small-scale

0.479

High

1118767

BCL7B
B-cell CLL/lymphoma 7 protein family member B

1

2

High-throughput

0.479

High

1118768

PCGF1
Polycomb group RING finger protein 1

1

20

High-throughput

0.479

High

1118771

GTPB4
GTP-binding protein 4

1

7

High-throughput

0.479

High

1118773

WWTR1
WW domain-containing transcription regulator protein 1

1

20

Small-scale

0.479

High

1118776

EPC1
Enhancer of polycomb homolog 1

1

10

High-throughput

0.479

High

1118777

FOXP1
Forkhead box protein P1

1

20

High-throughput

0.479

High

1118779

EGLN3
Prolyl hydroxylase EGLN3

1

1

High-throughput

0.479

High

1118784

BRD7
Bromodomain-containing protein 7

1

20

High-throughput

0.479

High

1118785

TF7L2
Transcription factor 7-like 2

1

20

High-throughput

0.479

High

1118788

NOP53
Ribosome biogenesis protein NOP53

1

8

High-throughput

0.479

High

1118790

TRPS1
Zinc finger transcription factor Trps1

1

20

High-throughput

0.479

High

1118791

ZN608
Zinc finger protein 608

1

7

High-throughput

0.479

High

1118798

NOP16
Nucleolar protein 16

1

6

High-throughput

0.479

High

1118801

RT18B
Small ribosomal subunit protein mS40

1

5

High-throughput

0.479

High

1118802

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

1

4

Small-scale

0.479

High

1118803

NCOA3
Nuclear receptor coactivator 3

1

14

High-throughput

0.479

High

1118804

ZHX2
Zinc fingers and homeoboxes protein 2

1

20

High-throughput

0.479

High

842916

CDN2B
Cyclin-dependent kinase 4 inhibitor B

1

5

Small-scale

0.470

High

1118769

NUP58
Nucleoporin p58/p45

1

1

High-throughput

0.470

High

1118794

ICAM5
Intercellular adhesion molecule 5

1

2

High-throughput

0.470

High

182993

NKRF
NF-kappa-B-repressing factor

1

0

High-throughput

0.458

High

587078

ITF2
Transcription factor 4

1

0

Small-scale

0.458

High

1118780

MED20
Mediator of RNA polymerase II transcription subunit 20

1

0

Small-scale

0.458

High

635589

FILA
Filaggrin

1

13

High-throughput

0.457

High

1100763

G3BP1
Ras GTPase-activating protein-binding protein 1

1

5

High-throughput

0.457

High

1118715

FILA2
Filaggrin-2

1

19

High-throughput

0.457

High

1118722

LARP1
La-related protein 1

1

11

High-throughput

0.457

High

1118726

K2C74
Keratin, type II cytoskeletal 74

1

2

High-throughput

0.457

High

1118727

YTHD3
YTH domain-containing family protein 3

1

8

High-throughput

0.457

High

1118730

HORN
Hornerin

1

12

High-throughput

0.457

High

1118736

LS14A
Protein LSM14 homolog A

1

10

High-throughput

0.457

High

1118783

M1IP1
Mid1-interacting protein 1

1

1

High-throughput

0.457

High

1118786

ATD3A
ATPase family AAA domain-containing protein 3A

1

9

High-throughput

0.457

High

1118763

MAGI1
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1

1

5

High-throughput

0.445

High

175038

SC16A
Protein transport protein Sec16A

1

14

High-throughput

0.437

High

984626

RL39
Large ribosomal subunit protein eL39

1

4

High-throughput

0.437

High

1005445

RBM6
RNA-binding protein 6

1

8

High-throughput

0.437

High

1013991

RL36A
Large ribosomal subunit protein eL42

1

11

High-throughput

0.437

High

1118706

GSE1
Genetic suppressor element 1

1

2

High-throughput

0.437

High

1118712

QSER1
Glutamine and serine-rich protein 1

1

20

High-throughput

0.437

High

1118716

PRC2B
Protein PRRC2B

1

20

High-throughput

0.437

High

1118724

BAKOR
Beclin 1-associated autophagy-related key regulator

1

1

High-throughput

0.437

High

1118756

DDX27
Probable ATP-dependent RNA helicase DDX27

1

13

High-throughput

0.437

High

1118761

LENG8
Leukocyte receptor cluster member 8

1

7

High-throughput

0.437

High

1118772

DDX24
ATP-dependent RNA helicase DDX24

1

15

High-throughput

0.437

High

1118787

DDX18
ATP-dependent RNA helicase DDX18

1

20

High-throughput

0.437

High

1118792

PRR12
Proline-rich protein 12

1

20

High-throughput

0.437

High

1118795

RL26L
Ribosomal protein uL24-like

1

17

High-throughput

0.437

High

702581

NDUS1
NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial

1

0

High-throughput

0.268

Low

183642

RT12
Small ribosomal subunit protein uS12m

1

0

High-throughput

0.261

Low


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Last updated: 11Aug2025